{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:28:52Z","timestamp":1791217732349,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.radonc.2023.110031","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T16:29:25Z","timestamp":1700843365000},"page":"110031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The first clinical implementation of real-time 6 degree-of-freedom image-guided radiotherapy for liver SABR patients"],"prefix":"10.1016","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-9777","authenticated-orcid":false,"given":"Chandrima","family":"Sengupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doan Trang","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-7416","authenticated-orcid":false,"given":"Trevor","family":"Moodie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Causer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sau Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7714-811X","authenticated-orcid":false,"given":"Lauren","family":"Inskip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4841-3571","authenticated-orcid":false,"given":"Maryam","family":"Hazem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-3021","authenticated-orcid":false,"given":"Menglei","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-0919","authenticated-orcid":false,"given":"Tim","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"van Gysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-6702","authenticated-orcid":false,"given":"Eireann","family":"Cosgriff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-7609","authenticated-orcid":false,"given":"Per","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-1109","authenticated-orcid":false,"given":"Jeremy","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Keall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2023.110031_b0005","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijrobp.2017.12.288","article-title":"Local control after stereotactic body radiation therapy for liver tumours","volume":"110","author":"Ohri","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijrobp.2017.12.290","article-title":"Radiation dose-volume effects for liver SBRT","volume":"110","author":"Miften","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0015","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.ijrobp.2011.09.045","article-title":"Accumulated dose in liver stereotactic body radiotherapy: positioning, breathing, and deformation effects","volume":"83","author":"Velec","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0020","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3109\/0284186X.2015.1062134","article-title":"Respiratory gating based on internal electromagnetic motion monitoring during stereotactic liver radiation therapy: first results","volume":"54","author":"Poulsen","year":"2015","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0025","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/S0360-3016(01)02653-0","article-title":"The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy","volume":"51","author":"Dawson","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0030","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1118\/1.598837","article-title":"Breathing-synchronized radiotherapy pro- gram at the University of California Davis Cancer center","volume":"27","author":"Kubo","year":"2000","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0035","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.ijrobp.2004.07.681","article-title":"Correlation of lung tumour motion with external surrogate indicators of respiration","volume":"60","author":"Hoisak","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0040","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s13246-020-00866-3","article-title":"Stereotactic ablative body radiation therapy (SABR) in NSW","volume":"43","author":"Mackonis","year":"2020","journal-title":"Phys Eng Sci Med"},{"key":"10.1016\/j.radonc.2023.110031_b0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/153303461000900502","article-title":"The CyberKnife\u00ae Robotic Radio- surgery System in 2010","volume":"9","author":"Kilby","year":"2010","journal-title":"Technol Cancer Res Treatment"},{"key":"10.1016\/j.radonc.2023.110031_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1130490","article-title":"Is MRI-Linac helpful in SABR treatments for liver cancer?","volume":"13","author":"Tallet","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0055","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/acm2.12978","article-title":"Evaluation of radixact motion synchrony for 3D respiratory motion: Modeling accuracy and dosimetric fidelity","volume":"21","author":"Ferris","year":"2020","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.radonc.2020.07.002","article-title":"The gimbaled-head radiotherapy system: Rise and downfall of a dedicated system for dynamic tumor tracking with real-time monitoring and dynamic WaveArc","volume":"153","author":"Hiraoka","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.radonc.2020.06.018","article-title":"Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part I: intra-fraction breathing motion man- agement","volume":"153","author":"Anastasi","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0070","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1016\/S0167-8140(16)32139-9","article-title":"Intra-fraction re-setup with Triggered Imaging allows for margin reduction in prostate treatments","volume":"119","author":"Van der Weide","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0075","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1088\/0031-9155\/53\/16\/008","article-title":"Three dimensional prostate position estimation with a single x-ray imager utilizing the spatial probability density","volume":"53","author":"Poulsen","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2023.110031_b0080","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ijrobp.2020.03.014","article-title":"Real-Time image guided ablative prostate cancer radiation-therapy: results from the TROG 15.01 SPARK trial","volume":"107","author":"Keall","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.radonc.2023.110031_b0085","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12885-021-08184-x","article-title":"Study protocol of the LARK (TROG 17.03) clinical trial: a phase II trial investigating the dosimetric impact of Liver Ablative Radiotherapy using Kilovoltage intrafraction monitoring","volume":"21","author":"Lee","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2023.110031_b0090","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1118\/1.3658566","article-title":"Robust automatic segmentation of multiple implanted cylin- drical gold fiducial markers in cone-beam CT projections","volume":"38","author":"Fledelius","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0095","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1118\/1.3555295","article-title":"A method for robust segmentation of arbitrarily shaped radiopaque structures in cone-beam CT projections","volume":"38","author":"Poulsen","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0100","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1088\/0031-9155\/58\/23\/8517","article-title":"Real-time estimation of prostate tumour rotation and translation with a kV imaging system based on an iterative closest point algorithm","volume":"58","author":"Tehrani","year":"2013","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2023.110031_b0105","doi-asserted-by":"crossref","DOI":"10.1118\/1.4898119","article-title":"Quality assurance for the clinical implementation of kilovoltage intrafraction monitoring for prostate cancer VMAT","volume":"41","author":"Ng","year":"2014","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0110","unstructured":"6DoF Robotic Motion Phantom. github.com\/ACRF-Image-X-Institute\/6-DoF-Robotic-Motion- Phantom; [accessed 6 February 2021]."},{"key":"10.1016\/j.radonc.2023.110031_b0115","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0360-3016(99)00056-5","article-title":"The use of active breathing control (ABC) to reduce margin for breathing motion","volume":"44","author":"Wong","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0120","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1002\/mp.13784","article-title":"The accuracy and precision of the KIM motion monitoring system used in the multi-institutional TROG 15.01 Stereotactic Prostate Ablative Radiotherapy with KIM (SPARK) trial","volume":"46","author":"Hewson","year":"2019","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0125","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1118\/1.4754297","article-title":"A method of dose reconstruction for moving targets compatible with dynamic treatments","volume":"39","author":"Poulsen","year":"2012","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0130","unstructured":"Motion-included dose Reconstruction on Pinnacle TPS. github.com\/ACRF-Image-X-Institute\/Motion- Included-Dose-Recon-on-Pinnacle-TPS; [accessed 10 February 2022]."},{"key":"10.1016\/j.radonc.2023.110031_b0135","unstructured":"International Commission on Radiation Units and Measurements. Determination of absorbed dose in a patient irradiated by beams of X or gamma rays in radiotherapy. ICRU; 1976. Report 24."},{"key":"10.1016\/j.radonc.2023.110031_b0140","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijrobp.2018.02.010","article-title":"A prospective cohort study of gated stereotactic liver radiation therapy using continuous internal electromagnetic motion monitoring","volume":"101","author":"Worm","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0145","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/aaae8b","article-title":"Automatic online and real-time tumour motion monitoring during stereotactic liver treatments on a conventional linac by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK)","volume":"63","author":"Bertholet","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2023.110031_b0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s13246-021-01007-0","article-title":"The first real-time intrafraction tar- get position monitoring in pancreas SBRT on an Elekta linear accelerator","volume":"44","author":"Arumugam","year":"2021","journal-title":"Phys Eng Sci Med"},{"key":"10.1016\/j.radonc.2023.110031_b0155","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijrobp.2014.05.007","article-title":"Quantifying rigid and nonrigid motion of liver tumors dur- ing stereotactic body radiation therapy","volume":"90","author":"Xu","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/mp.16094","article-title":"The dosimetric error due to uncorrected tumour rotation during real-time adaptive prostate stereotactic body radiation therapy","volume":"50","author":"Sengupta","year":"2023","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0165","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/mp.13519","article-title":"A deep learning framework for automatic detection of arbitrarily shaped fiducial markers in intrafraction fluoroscopic images","volume":"46","author":"Mylonas","year":"2019","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0170","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1118\/1.598355","article-title":"A tilt and roll device for automated correction of rotational setup errors","volume":"25","author":"Hornick","year":"1998","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0175","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/j.ijrobp.2011.06.1958","article-title":"Electromagnetic detection and real-time DMLC adaptation to target rotation during radiotherapy","volume":"82","author":"Wu","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.radonc.2023.110031_b0180","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ijrobp.2009.04.034","article-title":"Strategies for online organ motion correction for intensity- modulated radiotherapy of prostate cancer: prostate, rectum, and bladder dose effects","volume":"75","author":"Rijkhorst","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0185","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tipsro.2022.04.005","article-title":"Tumor site group for oligometastatic disease of the Elekta MR-Linac Consortium. First multicentre experience of SABR for lymph node and liver oligometastatic disease on the unity MR-Linac","volume":"22","author":"Janssen","year":"2022","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0190","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/1754-9485.13020","article-title":"Factors affecting target motion in stereotactic body radiotherapy of liver cancer using CyberKnife","volume":"64","author":"Lo","year":"2020","journal-title":"J Med Imaging Radiat Oncol"},{"key":"10.1016\/j.radonc.2023.110031_b0195","doi-asserted-by":"crossref","DOI":"10.1118\/1.4862509","article-title":"The first clinical implementation of electromagnetic transponder-guided MLC tracking","volume":"41","author":"Keall","year":"2014","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0200","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/mp.12104","article-title":"An experimentally validated couch and MLC tracking simulator used to investigate hybrid couch-MLC tracking","volume":"44","author":"Toftegaard","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2023.110031_b0205","unstructured":"Tapiovaara M, Lakkisto M, Servomaa A. PCXMC: A PC-based Monte Carlo program for calcu- lating patient doses in medical x-ray examinations. Report STUK-A139. Helsinki: Finnish centre for Radiation and Nuclear Safety; 1997. STUK - Radiation and Nuclear Safety Authority (2008). PCXMC Dose Calculations. Finland, STUK. Version 2.0."},{"key":"10.1016\/j.radonc.2023.110031_b0210","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.3748\/wjg.v27.i42.7387","article-title":"Long-term clinical outcomes of lipiodol marking using standard gastroscopy for image-guided radiotherapy of upper gastrointestinal cancers","volume":"27","author":"Be","year":"2021","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.radonc.2023.110031_b0215","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.1088\/0031-9155\/56\/17\/001","article-title":"Treatment precision of image-guided liver SBRT using implanted fiducial markers depends on marker- tumour distance","volume":"56","author":"Seppenwoolde","year":"2011","journal-title":"Phys Med Biol."},{"key":"10.1016\/j.radonc.2023.110031_b0220","doi-asserted-by":"crossref","first-page":"e549","DOI":"10.1016\/j.prro.2019.05.014","article-title":"The dosimetric impact of interfractional organ-at-risk movement during liver stereotactic body radiation therapy","volume":"9","author":"Schmid","year":"2019","journal-title":"Pract Radiat Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814023093386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814023093386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T09:09:40Z","timestamp":1734253780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814023093386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":44,"alternative-id":["S0167814023093386"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2023.110031","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The first clinical implementation of real-time 6 degree-of-freedom image-guided radiotherapy for liver SABR patients","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2023.110031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The University of Sydney. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110031"}}