{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:32:44Z","timestamp":1773376364982,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.radonc.2024.110220","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:24:05Z","timestamp":1710131045000},"page":"110220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-6480","authenticated-orcid":false,"given":"Efstratios","family":"Koutroumpakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah Sherif Radwan","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Chaftari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Gujral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serageldin","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Naser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifton D.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-1101","authenticated-orcid":false,"given":"Elie","family":"Mouhayar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2024.110220_b0005","first-page":"11","article-title":"The effect of radiation and chemoradiation therapy on the head and neck mucosal microbiome: A review","author":"Zagury-Orly","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0010","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1200\/JCO.2008.16.6546","article-title":"Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy","volume":"26","author":"Smith","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0015","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1200\/JCO.2002.20.1.282","article-title":"Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years","volume":"20","author":"Dorresteijn","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.oraloncology.2018.02.021","article-title":"The risk of carotid stenosis in head and neck cancer patients after radiation therapy","volume":"80","author":"Carpenter","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/hed.23280","article-title":"Incidence and risk factors of significant carotid artery stenosis in asymptomatic survivors of head and neck cancer after radiotherapy","volume":"36","author":"Dorth","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2024.110220_b0030","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1161\/01.ATV.20.6.1622","article-title":"Common carotid intima-media thickness predicts occurrence of carotid atherosclerotic plaques: longitudinal results from the Aging Vascular Study (EVA) study","volume":"20","author":"Zureik","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.radonc.2024.110220_b0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1148\/radiology.213.1.r99oc07167","article-title":"Asymptomatic carotid arterial disease in young patients following neck radiation therapy for Hodgkin lymphoma","volume":"213","author":"King","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2024.110220_b0040","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1053\/ejvs.2002.1752","article-title":"Ultrasonic analysis of plaque characteristics and intimal-medial thickness in radiation-induced atherosclerotic carotid arteries","volume":"24","author":"Cheng","year":"2002","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.radonc.2024.110220_b0045","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.ejca.2005.01.020","article-title":"Increased carotid wall thickening after radiotherapy on the neck","volume":"41","author":"Dorresteijn","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.radonc.2024.110220_b0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-7120-8-8","article-title":"Effects of external irradiation of the neck region on intima media thickness of the common carotid artery","volume":"8","author":"Gianicolo","year":"2010","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.radonc.2024.110220_b0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.5551\/jat.45591","article-title":"Usefulness of carotid arterial strain values for evaluating the arteriosclerosis","volume":"26","author":"Iino","year":"2019","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.radonc.2024.110220_b0060","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ultras.2011.09.006","article-title":"Arterial stiffness identification of the human carotid artery using the stress-strain relationship in vivo","volume":"52","author":"Khamdaeng","year":"2012","journal-title":"Ultrasonics"},{"key":"10.1016\/j.radonc.2024.110220_b0065","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/ejechocard\/jeq033","article-title":"Ultrasonographic strain imaging is superior to conventional non-invasive measures of vascular stiffness in the detection of age-dependent differences in the mechanical properties of the common carotid artery","volume":"11","author":"Bj\u00e4llmark","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.radonc.2024.110220_b0070","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1148\/radiol.2292030516","article-title":"Carotid artery stenosis: gray-scale and Doppler US diagnosis\u2013Society of Radiologists in ultrasound consensus conference","volume":"229","author":"Grant","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2024.110220_b0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13014-022-02101-7","article-title":"Assessing radiation-induced carotid vasculopathy using ultrasound after unilateral irradiation: a cross-sectional study","volume":"17","author":"Pruijssen","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0080","doi-asserted-by":"crossref","first-page":"683","DOI":"10.6004\/jadpro.2022.13.7.4","article-title":"Ultrasound evaluation of carotid artery intima-media thickness: effective early marker of carotid artery disease in adult head and neck cancer patients after neck radiation?","volume":"13","author":"Randolph","year":"2022","journal-title":"J Adv Pract Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0085","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jcu.21971","article-title":"Sonographic assessment of acute changes in plaque size and echogenicity and in intima-media thickness of carotid arteries after neck radiation therapy","volume":"40","author":"Toprak","year":"2012","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.radonc.2024.110220_b0090","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s12094-013-1023-3","article-title":"Intimal-medial thickness and carotid arteries lumen in irradiated patients for head and neck cancer: preliminary data of an observational study","volume":"15","author":"Faruolo","year":"2013","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.radonc.2010.03.026","article-title":"A prospective, comparative study on the early effects of local and remote radiation therapy on carotid intima-media thickness and vascular cellular adhesion molecule-1 in patients with head and neck and prostate tumors","volume":"101","author":"Pereira Lima","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.radonc.2014.10.012","article-title":"Progression of carotid intima media thickness after radiotherapy: a long-term prospective cohort study","volume":"113","author":"Wilbers","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110220_b0105","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/0003319715589520","article-title":"Arterial stiffness as a biomarker of radiation-induced carotid atherosclerosis","volume":"67","author":"Gujral","year":"2015","journal-title":"Angiology"},{"key":"10.1016\/j.radonc.2024.110220_b0110","article-title":"Long-term risk of carotid stenosis and cerebrovascular disease after radiation therapy for head and neck cancer","author":"Carpenter","year":"2023","journal-title":"Cancer"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024001427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024001427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T12:38:08Z","timestamp":1741437488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814024001427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":22,"alternative-id":["S0167814024001427"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110220","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.18.23295583","asserted-by":"object"}]},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110220"}}