{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:01:01Z","timestamp":1777399261921,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.radonc.2024.110237","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T18:43:35Z","timestamp":1710960215000},"page":"110237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-1531","authenticated-orcid":false,"given":"Jenny","family":"Bertholet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul-Henry","family":"Mackeprang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes A.","family":"Loebner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvan","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian","family":"Guyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Frei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Volken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olgun","family":"Elicin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Aebersold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Fix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Manser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2024.110237_b0005","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00520-007-0300-5","article-title":"The influence of xerostomia after radiotherapy on quality of life","volume":"16","author":"Dirix","year":"2008","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2024.110237_b0010","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1002\/hed.25880","article-title":"Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy","volume":"41","author":"Baudelet","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2024.110237_b0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.radonc.2015.07.042","article-title":"Patterns of long-term swallowing dysfunction after definitive radiotherapy or chemoradiation","volume":"117","author":"Christianen","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0020","doi-asserted-by":"crossref","unstructured":"Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial 2011:127\u201336. doi: 10.1016\/S1470-2045(10)70290-4.","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"10.1016\/j.radonc.2024.110237_b0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1118\/1.2818738","article-title":"Volumetric modulated arc therapy: IMRT in a single gantry arc","volume":"35","author":"Otto","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0030","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1259\/bjr\/22373346","article-title":"Volumetric modulated arc therapy: a review of current literature and clinical use in practice","volume":"84","author":"Teoh","year":"2011","journal-title":"Br J Radiol"},{"key":"10.1016\/j.radonc.2024.110237_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-01602-7","article-title":"Dosimetric comparison between RapidArc and HyperArc techniques in salvage stereotactic body radiation therapy for recurrent nasopharyngeal carcinoma","volume":"15","author":"Ho","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0040","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.13561","article-title":"HyperArc VMAT stereotactic radiotherapy for locally recurrent previously-irradiated head and neck cancers: plan quality, treatment delivery accuracy, and efficiency","author":"Pokhrel","year":"2022","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/acm2.12164","article-title":"Multi-isocentric 4\u03c0 volumetric-modulated arc therapy approach for head and neck cancer","volume":"18","author":"Subramanian","year":"2017","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3857\/roj.2020.00143","article-title":"Dosimetric comparison of coplanar and non-coplanar volumetric-modulated arc therapy in head and neck cancer treated with radiotherapy","volume":"38","author":"Gayen","year":"2020","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.radonc.2024.110237_b0055","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1002\/mp.13086","article-title":"Part 1: optimization and evaluation of dynamic trajectory radiotherapy","volume":"45","author":"Fix","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0060","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.ijrobp.2010.10.016","article-title":"Choreographing couch and collimator in volumetric modulated arc therapy","volume":"80","author":"Yang","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0065","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1002\/mp.12270","article-title":"Trajectory optimization in radiotherapy using sectioning (TORUS)","volume":"44","author":"Locke","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0070","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.1088\/0031-9155\/58\/22\/8163","article-title":"Trajectory optimization for dynamic couch rotation during volumetric modulated arc radiotherapy","volume":"58","author":"Smyth","year":"2013","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2024.110237_b0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.radonc.2006.09.004","article-title":"Dynamic intensity-modulated non-coplanar arc radiotherapy (INCA) for head and neck cancer","volume":"81","author":"Krayenbuehl","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0080","doi-asserted-by":"crossref","first-page":"20180908","DOI":"10.1259\/bjr.20180908","article-title":"Recent developments in non-coplanar radiotherapy","volume":"92","author":"Smyth","year":"2019","journal-title":"Br J Radiol"},{"key":"10.1016\/j.radonc.2024.110237_b0085","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1118\/1.4914863","article-title":"Noncoplanar VMAT for nasopharyngeal tumors: plan quality versus treatment time","volume":"42","author":"Wild","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.radonc.2016.07.014","article-title":"Non-coplanar trajectories to improve organ at risk sparing in volumetric modulated arc therapy for primary brain tumors","volume":"121","author":"Smyth","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0095","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.meddos.2019.02.004","article-title":"Automated noncoplanar treatment planning strategy in stereotactic radiosurgery of multiple cranial metastases: HyperArc and CyberKnife dose distributions","volume":"44","author":"Kadoya","year":"2019","journal-title":"Med Dosim"},{"key":"10.1016\/j.radonc.2024.110237_b0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13014-022-02092-5","article-title":"Organ-at-risk sparing with dynamic trajectory radiotherapy for head and neck cancer: comparison with volumetric arc therapy on a publicly available library of cases","volume":"17","author":"Bertholet","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.radonc.2015.05.018","article-title":"Identifying patients who may benefit from adaptive radiotherapy: does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?","volume":"115","author":"Brouwer","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0110","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.radonc.2013.10.035","article-title":"Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy","volume":"110","author":"Sun","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.radonc.2017.10.016","article-title":"Delineation of the primary tumour clinical Target volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG","volume":"126","author":"Gr\u00e9goire","year":"2018","journal-title":"Oncol Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.radonc.2015.01.016","article-title":"Organs at risk in the brain and their dose-constraints in adults and in children: a radiation oncologist\u2019s guide for delineation in everyday practice","volume":"114","author":"Scoccianti","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0125","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ijrobp.2012.11.031","article-title":"Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors","volume":"85","author":"Gondi","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.radonc.2020.01.005","article-title":"Randomized clinical trial on reduction of radiotherapy dose to the elective neck in head and neck squamous cell carcinoma; update of the long-term tumor outcome","volume":"143","author":"Deschuymer","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0135","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ijrobp.2017.02.218","article-title":"Final report of a prospective randomized trial to evaluate the dose-response relationship for postoperative radiation therapy and pathologic risk groups in patients with head and neck cancer","volume":"98","author":"Rosenthal","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1470-2045(11)70346-1","article-title":"Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99\u201302): an open-label phase 3 randomised trial","volume":"13","author":"Bourhis","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0145","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.radonc.2021.01.013","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC group","volume":"156","author":"Lacas","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.14165","article-title":"Technical note: a collision prediction tool using blender","author":"Guyer","year":"2023","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0155","unstructured":"Landelijk Platform Protonentherapie (LPPT) Landelijk Platform Radiotherapie Hoofd-halstumoren (LPRHHT). Landelijk Indicatie Protocol Protonentherapie (versie 2.2) (LIPPv2.2); 2019."},{"key":"10.1016\/j.radonc.2024.110237_b0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.radonc.2021.01.024","article-title":"Comprehensive toxicity risk profiling in radiation therapy for head and neck cancer: a new concept for individually optimised treatment","volume":"157","author":"Van den Bosch","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0165","unstructured":"Mueller S, Volken W, Guyer G, Loebner H, Bertholet J, Frei D, et al. A phantom for dosimetric quality assurance of non-coplanar and mixed beam treatment techniques. In: 64th AAPM annual meeting and exhibition; 2022."},{"key":"10.1016\/j.radonc.2024.110237_b0170","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1118\/1.4903758","article-title":"Correcting lateral response artifacts from flatbed scanners for radiochromic film dosimetry","volume":"42","author":"Lewis","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0175","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1118\/1.3576105","article-title":"Multichannel film dosimetry with nonuniformity correction","volume":"38","author":"Micke","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0180","first-page":"6339","article-title":"An efficient protocol for radiochromic film dosimetry combining calibration and measurement in a single scan","volume":"39","author":"Lewis","year":"2012","journal-title":"Medical"},{"key":"10.1016\/j.radonc.2024.110237_b0185","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1118\/1.598248","article-title":"A technique for the quantitative evaluation of dose distributions","volume":"25","author":"Low","year":"1998","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0190","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1002\/mp.12810","article-title":"Tolerance limits and methodologies for IMRT measurement-based verification QA: recommendations of AAPM task group no. 218","volume":"45","author":"Miften","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2020.09.033","article-title":"Radiotherapy treatment plannINg study guidelines (RATING): a framework for setting up and reporting on scientific treatment planning studies","volume":"153","author":"Hansen","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0200","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.radonc.2012.07.005","article-title":"Dosimetric explanations of fatigue in head and neck radiotherapy: an analysis from the PARSPORT phase III trial","volume":"104","author":"Gulliford","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0205","article-title":"Fatigue in patients with head and neck cancer treated with radiation therapy: a prospective study of patient-reported outcomes and their association with radiation dose to the cerebellum","volume":"7","author":"Abel","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0210","doi-asserted-by":"crossref","first-page":"S446","DOI":"10.1016\/j.ijrobp.2011.06.742","article-title":"VMAT reduces moderate to high integral dose when compared to conventional IMRT for treatment of prostate cancer","volume":"81","author":"Lubbe","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.phro.2019.07.001","article-title":"The influence of a six degrees of freedom couch and an individual head support in patient positioning in radiotherapy of head and neck cancer","volume":"11","author":"Rodrigues","year":"2019","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110237_b0220","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.zemedi.2018.03.002","article-title":"Dose calculation of dynamic trajectory radiotherapy using Monte Carlo","volume":"29","author":"Manser","year":"2019","journal-title":"Z Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0225","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1002\/mp.16749","article-title":"Impact of the gradient in gantry-table rotation on dynamic trajectory radiotherapy plan quality","volume":"50","author":"Loebner","year":"2023","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2020.07.801","article-title":"Advanced dynamic trajectory radiotherapy using table translations and rotations","volume":"108","author":"Manser","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110237_b0235","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ac840d","article-title":"Enabling non-isocentric dynamic trajectory radiotherapy by integration of dynamic table translations","volume":"67","author":"Guyer","year":"2022","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2024.110237_b0240","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1002\/mp.13085","article-title":"Part 2: dynamic mixed beam radiotherapy (DYMBER): photon dynamic trajectories combined with modulated electron beams","volume":"45","author":"Mueller","year":"2018","journal-title":"Med Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024001592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024001592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T17:38:51Z","timestamp":1741455531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814024001592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":48,"alternative-id":["S0167814024001592"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110237","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110237","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110237"}}