{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:48:33Z","timestamp":1786996113750,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.radonc.2024.110239","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T19:33:25Z","timestamp":1711049605000},"page":"110239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Neutrophil-to-lymphocyte ratio for the prediction of soft tissue sarcomas response to pre-operative radiation therapy"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-9806","authenticated-orcid":false,"given":"Constanza","family":"Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-8439","authenticated-orcid":false,"given":"Rie N.","family":"Asso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelabh","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn R.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio L.","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2024.110239_b0005","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMra041866","article-title":"Soft-tissue sarcomas in adults","volume":"353","author":"Clark","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2024.110239_b0010","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s13193-012-0134-6","article-title":"Curent concepts in pathology of soft tissue sarcoma","volume":"2","author":"Husain","year":"2011","journal-title":"Indian J Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3322\/caac.21605","article-title":"Soft-tissue sarcoma in adults: an update on the current state of histiotype-specific management in an era of personalized medicine","volume":"70","author":"Gamboa","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2024.110239_b0020","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.ijrobp.2020.07.1001","article-title":"Hypofractionated radiotherapy in soft tissue Sarcomas \u2013 a single center Experience","volume":"108","author":"Araujo","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110239_b0025","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13014-018-1040-z","article-title":"The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies","volume":"13","author":"van Leeuwen","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0030","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/S1470-2045(22)00517-4","article-title":"Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial","volume":"23","author":"Tree","year":"2022","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0035","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","volume":"395","author":"Murray Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2024.110239_b0040","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/S0140-6736(02)09292-9","article-title":"Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial","volume":"359","author":"O'Sullivan","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2024.110239_b0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2004.12.020","article-title":"Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma","volume":"75","author":"Davis","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0050","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/S1470-2045(22)00638-6","article-title":"Hypofractionated, 3-week, preoperative radiotherapy for patients with soft tissue sarcomas (HYPORT-STS): a single-centre, open-label, single-arm, phase 2 trial","volume":"23","author":"Guadagnolo","year":"2022","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13014-022-02072-9","article-title":"Preoperative hypofractionated radiotherapy for soft tissue sarcomas: a systematic review","volume":"17","author":"Roohani","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0060","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1200\/JCO.2013.53.9452","article-title":"Comparison of local recurrence with conventional and intensity-modulated radiation therapy for primary soft-tissue sarcomas of the extremity","volume":"32","author":"Folkert","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0065","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1002\/cncr.25882","article-title":"Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity","volume":"117","author":"Alektiar","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110239_b0070","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/cncr.11365","article-title":"Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients","volume":"97","author":"Zagars","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110239_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.564852","article-title":"Heterogeneity of soft tissue Sarcomas and its implications in targeted therapy","volume":"10","author":"Du","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.radonc.2024.110239_b0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.radonc.2024.110239_b0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12885-021-09108-5","article-title":"Inflammation-scores as prognostic markers of overall survival in lung cancer: a register-based study of 6,210 danish lung cancer patients","volume":"22","author":"Winther-Larsen","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2024.110239_b0095","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1172\/JCI96313","article-title":"Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers","volume":"129","author":"Gruosso","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2024.110239_b0100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","article-title":"The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer","volume":"88","author":"Guthrie","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.radonc.2024.110239_b0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.euros.2021.11.011","article-title":"Role of serum lymphocyte-derived Biomarkers in nonmetastatic muscle-invasive bladder cancer patients treated with trimodal therapy","volume":"36","author":"Kool","year":"2022","journal-title":"Eur Urol Open Sci"},{"key":"10.1016\/j.radonc.2024.110239_b0110","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1245\/s10434-020-08302-2","article-title":"Dynamic neutrophil-to-lymphocyte ratio: a novel prognosis measure for triple-negative breast cancer","volume":"27","author":"Moldoveanu","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9092898","article-title":"Preoperative neutrophil-to-lymphocyte ratio as a prognostic factor in uterine Sarcoma","volume":"9","author":"Jeong","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.radonc.2024.110239_b0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3109\/1354750X.2012.699554","article-title":"Clinical implication of pretreatment neutrophil to lymphocyte ratio in soft tissue sarcoma","volume":"17","author":"Idowu","year":"2012","journal-title":"Biomarkers"},{"key":"10.1016\/j.radonc.2024.110239_b0125","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.suronc.2018.07.012","article-title":"Neutrophil\/lymphocyte ratio is associated with survival in synovial sarcoma","volume":"27","author":"Garc\u00eda-Ortega","year":"2018","journal-title":"Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0130","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1158\/1078-0432.CCR-22-2897","article-title":"Preoperative neutrophil-to-lymphocyte ratio and a new inflammatory biomarkers prognostic index for primary retroperitoneal Sarcomas: retrospective monocentric study","volume":"29","author":"Fiore","year":"2023","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2024.110239_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13246266","article-title":"Pre-treatment neutrophil-to-lymphocyte ratio (NLR) as a predictive Marker of pazopanib treatment for soft-tissue Sarcoma","volume":"13","author":"Sato","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.radonc.2024.110239_b0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s12885-023-10758-w","article-title":"Clinical markers of immunotherapy outcomes in advanced sarcoma","volume":"23","author":"Husain","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2024.110239_b0145","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju124","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis","volume":"106","author":"Templeton","year":"2014","journal-title":"JNCI: J Natl Cancer Institute"},{"key":"10.1016\/j.radonc.2024.110239_b0150","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratisl Lek Listy"},{"key":"10.1016\/j.radonc.2024.110239_b0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/emermed-2014-204071","article-title":"Neutrophil to lymphocyte count ratio as an early indicator of blood stream infection in the emergency department","volume":"32","author":"Lowsby","year":"2015","journal-title":"Emerg Med J"},{"key":"10.1016\/j.radonc.2024.110239_b0160","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in stroke: a systematic review and meta-analysis","volume":"12","author":"Li","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.radonc.2024.110239_b0165","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.amjcard.2016.07.072","article-title":"Relation between neutrophil-to-lymphocyte ratio and index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"118","author":"Lee","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.radonc.2024.110239_b0170","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s12916-020-01817-1","article-title":"Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies","volume":"18","author":"Cupp","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.radonc.2024.110239_b0175","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s12094-020-02324-8","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio and other inflammatory markers in patients with high-risk soft tissue sarcomas","volume":"22","author":"Vi\u00f1al","year":"2020","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0180","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jss.2020.01.008","article-title":"PLR and NLR are poor predictors of survival outcomes in Sarcomas: a new perspective from the USSC","volume":"251","author":"Schwartz","year":"2020","journal-title":"J Surg Res"},{"key":"10.1016\/j.radonc.2024.110239_b0185","doi-asserted-by":"crossref","first-page":"303","DOI":"10.21873\/cdp.10040","article-title":"Changes in neutrophil-to-lymphocyte ratio predict efficacy of trabectedin for soft-tissue Sarcoma","volume":"1","author":"Sato","year":"2021","journal-title":"Cancer Diagn Progn"},{"key":"10.1016\/j.radonc.2024.110239_b0190","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s11604-021-01129-1","article-title":"Impact of neutrophil-to-lymphocyte ratio throughout the course of chemoradiotherapy on overall survival and distant failure in unresectable stage III non-small cell lung cancer","volume":"39","author":"Kanzaki","year":"2021","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.radonc.2024.110239_b0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13014-022-02065-8","article-title":"Association of neutrophil-to-lymphocyte ratio, radiotherapy fractionation\/technique, and risk of development of distant metastasis among patients with locally advanced rectal cancer","volume":"17","author":"Yang","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110239_b0200","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3892\/mco.2022.2531","article-title":"Neutrophil-to-lymphocyte ratio as a prognostic predictor for patients with cancer treated with stereotactic body radiation therapy: a meta-analysis","volume":"16","author":"Yu","year":"2022","journal-title":"Mol Clin Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024001610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024001610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T12:38:48Z","timestamp":1741437528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814024001610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":40,"alternative-id":["S0167814024001610"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110239","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil-to-lymphocyte ratio for the prediction of soft tissue sarcomas response to pre-operative radiation therapy","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110239"}}