{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:12:23Z","timestamp":1775981543517,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004635","name":"Mrs Berta Kamprad foundation for exploration and combat cancer","doi-asserted-by":"publisher","award":["FBKS-2021"],"award-info":[{"award-number":["FBKS-2021"]}],"id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["CAN2016\/809"],"award-info":[{"award-number":["CAN2016\/809"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["CAN2015\/428"],"award-info":[{"award-number":["CAN2015\/428"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"publisher","award":["APR20-0004"],"award-info":[{"award-number":["APR20-0004"]}],"id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.radonc.2024.110582","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T19:46:30Z","timestamp":1729280790000},"page":"110582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Patient reported fatigue after proton therapy for malignant brain tumours \u2013 Is there a relation between radiation dose and brain structures?"],"prefix":"10.1016","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-0887","authenticated-orcid":false,"given":"Ingrid","family":"Kristensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-579X","authenticated-orcid":false,"given":"Ulrica","family":"Langeg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bj\u00f6rk-Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Blomstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Brodin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-5581","authenticated-orcid":false,"given":"Per","family":"Fransson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Munck af","family":"Rosensch\u00f6ld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Olsson-Nevo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Sj\u00f6vall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Ahlberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2024.110582_b0005","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1007\/s00520-018-4318-7","article-title":"The pathophysiology of cancer-related fatigue: current controversies","volume":"26","author":"O'Higgins","year":"2018","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2024.110582_b0010","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/cncr.28058","article-title":"Cancer-related fatigue and its impact on functioning","volume":"1","author":"Minton","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110582_b0015","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0140-6736(03)14186-4","article-title":"Assessment and management of cancer-related fatigue in adults","volume":"362","author":"Ahlberg","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2024.110582_b0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijrobp.2019.01.003","article-title":"Impact of radiation target volume on health-related quality of life in patients with low-grade glioma in the 2-year period post treatment: a secondary analysis of the EORTC 22033\u201326033","volume":"104","author":"Dirven","year":"2019","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110582_b0025","first-page":"86","article-title":"Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours","volume":"27","author":"Haldbo-Classen","year":"2021","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0030","first-page":"921","article-title":"Relationship between fatigue and quality of life in patients with glioblastoma multiformae","volume":"26","author":"Lovely","year":"1999","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.radonc.2024.110582_b0035","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/S0959-8049(98)00268-8","article-title":"Quality of life after radiation therapy of cerebral low-grade gliomas of the adult: results of a randomised phase III trial on dose response (EORTC trial 22844). EORTC radiotherapy co-operative group","volume":"34","author":"Kiebert","year":"1998","journal-title":"Eur JCancer"},{"key":"10.1016\/j.radonc.2024.110582_b0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpainsymman.2020.07.037","article-title":"Prevalence of fatigue in patients with cancer: a systematic review and meta-analysis","volume":"61","author":"Al Maqbali","year":"2021","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.radonc.2024.110582_b0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2217\/cns-2015-0008","article-title":"Fatigue among patients with brain tumors","volume":"5","author":"Asher","year":"2016","journal-title":"CNS Oncol."},{"key":"10.1016\/j.radonc.2024.110582_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7785\/tcrt.2012.500276","article-title":"A comparison of critical structure dose and toxicity risks in patients with low grade gliomas treated with IMRT versus proton radiation therapy","volume":"12","author":"Dennis","year":"2013","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.radonc.2024.110582_b0055","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s00066-016-1007-7","article-title":"Intensity-modulated proton therapy, volumetric-modulated arc therapy, and 3D conformal radiotherapy in anaplastic astrocytoma and glioblastoma: a dosimetric comparison","volume":"192","author":"Adeberg","year":"2016","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2024.110582_b0060","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1097\/NCC.0b013e318269040f","article-title":"Comparison between patient-reported and clinician-observed symptoms in oncology","volume":"36","author":"Xiao","year":"2013","journal-title":"Cancer Nursing"},{"key":"10.1016\/j.radonc.2024.110582_b0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.clineuro.2018.08.003","article-title":"Proton therapy for low-grade gliomas in adults: a systematic review","volume":"174","author":"Thurin","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.radonc.2024.110582_b0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/0284186X.2023.2200150","article-title":"Transitioning from conventional photon therapy to proton therapy for primary brain tumors","volume":"62","author":"Ek","year":"2023","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0075","unstructured":"WHO Classification of Tumours Editorial Board. Central nervous system tumors [Internet]. Lyon (France): International Agency for Research on Cancer; 2021 [cited 2022 01 23]. (WHO classification of tumours series, 5th ed.; vol. 6). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/45."},{"key":"10.1016\/j.radonc.2024.110582_b0080","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1080\/02841860600897876","article-title":"\u201cDistributed proton radiation therapy\u201d\u2013a new concept for advanced competence support","volume":"45","author":"Karlsson","year":"2006","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0085","unstructured":"PRO-CNS protocol; https:\/\/clinicaltrials.gov\/study\/NCT02797366?locStr=Sweden&intr=radiotherapy&country=Sweden&term=pro-cns&aggFilters=status:rec&rank=1."},{"key":"10.1016\/j.radonc.2024.110582_b0090","doi-asserted-by":"crossref","unstructured":"Prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT): contents. J ICRU 2010;10:NP.","DOI":"10.1093\/jicru\/ndq002"},{"key":"10.1016\/j.radonc.2024.110582_b0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","article-title":"The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue","volume":"39","author":"Smets","year":"1995","journal-title":"J Psychosomatic Res"},{"key":"10.1016\/j.radonc.2024.110582_b0100","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2024.110582_b0110","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Medicine"},{"key":"10.1016\/j.radonc.2024.110582_b0115","article-title":"Fatigue in patients with head and neck cancer treated with radiation therapy: a prospective study of patient-reported outcomes and their association with radiation dose to the cerebellum","volume":"7","author":"Abel","year":"2022","journal-title":"Adv Rad Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0120","doi-asserted-by":"crossref","unstructured":"Ferris MJ, Zhong J, Switchenko JM, Higgins KA,Cassidy RJ 3rd, McDonald MW, et al. Brainstem dose is associated with patient-reported acute fatigue in head and neck cancer radiation therapy. Radiother Oncol 2018;126:100\u20136. doi: 10.1016\/j.radonc.2017.08.008. Epub 2017 Aug 18. PMID: 28826628; PMCID: PMC5841457.","DOI":"10.1016\/j.radonc.2017.08.008"},{"key":"10.1016\/j.radonc.2024.110582_b0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2021.01.004","article-title":"Modelling of late side-effects following cranial proton beam therapy","volume":"157","author":"Dutz","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0130","article-title":"Examination of the dose-effect relationship of radiation-induced hypopituitarism: results of a case-control study","volume":"6","author":"Vakilian","year":"2021","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0135","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.radonc.2022.01.018","article-title":"work package 1 of the taskforce \u201cEuropean Particle Therapy Network\u201d of ESTRO. The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation","volume":"168","author":"De Roeck","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0140","unstructured":"PRO-GLIO protocol; https:\/\/clinicaltrials.gov\/study\/NCT05190172?locStr=Norway&cond=Gliomas&intr=radiotherapy&country=Norway&term=pro-glio&aggFilters=status:rec&rank=1."},{"key":"10.1016\/j.radonc.2024.110582_b0145","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/neuonc\/noab040","article-title":"A prospective phase II randomized trial of proton radiotherapy vs intensity-modulated radiotherapy for patients with newly diagnosed glioblastoma","volume":"23","author":"Brown","year":"2021","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.radonc.2024.110582_b0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.radonc.2019.04.027","article-title":"Long-term outcomes and late adverse effects of a prospective study on proton radiotherapy for patients with low-grade glioma","volume":"137","author":"Tabrizi","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110582_b0155","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejca.2018.11.024","article-title":"General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States","volume":"107","author":"Nolte","year":"2019","journal-title":"Eur J Canc"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024035606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024035606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:29:23Z","timestamp":1734586163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814024035606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"alternative-id":["S0167814024035606"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110582","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient reported fatigue after proton therapy for malignant brain tumours \u2013 Is there a relation between radiation dose and brain structures?","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110582"}}