{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:30:55Z","timestamp":1770496255841,"version":"3.49.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.radonc.2024.110617","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T02:41:49Z","timestamp":1730860909000},"page":"110617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["What is the incidence and non-union rate of radiation-associated fractures? \u2013 A systematic review of the literature"],"prefix":"10.1016","volume":"202","author":[{"given":"Argen","family":"Omurzakov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Rampam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos R.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago A.","family":"Lozano-Calderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2024.110617_b0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00000658-198209000-00009","article-title":"The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy","volume":"196","author":"Rosenberg","year":"1982","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2024.110617_b0010","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/1097-0142(19820915)50:6<1076::AID-CNCR2820500610>3.0.CO;2-U","article-title":"Soft tissue sarcomas of the extremities: survival and patterns of failure with conservative surgery and postoperative irradiation compared to surgery alone","volume":"50","author":"Leibel","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0015","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1628::AID-CNCR13>3.0.CO;2-1","article-title":"Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals","volume":"80","author":"Janjan","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0020","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/cncr.22298","article-title":"Complications of combined modality treatment of primary lower extremity soft-tissue sarcomas","volume":"107","author":"Cannon","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2307\/3573324","article-title":"Long-Term Effects of Radiation on the Vascularity of Rat Bone: Quantitative Measurements with a New Technique","volume":"48","author":"Cutright","year":"1971","journal-title":"Radiation Research Radiation Research Society"},{"key":"10.1016\/j.radonc.2024.110617_b0030","doi-asserted-by":"crossref","unstructured":"Sternheim A, Saidi K, Lochab J, O\u2019Donnell PW, Eward WC, Griffin A, Wunder JS, Ferguson P. Internal fixation of radiation-induced pathological fractures of the femur has a high rate of failure. Bone Joint J. 2013 Aug;95-B(8):1144\u20131148. PMID: 23908434.","DOI":"10.1302\/0301-620X.95B8.31832"},{"key":"10.1016\/j.radonc.2024.110617_b0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00003086-200108000-00023","article-title":"Pathologic fractures after surgery and radiation for soft tissue tumors","volume":"389","author":"Helmstedter","year":"2001","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"10.1016\/j.radonc.2024.110617_b0040","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ijrobp.2011.09.047","article-title":"Dose\u2013effect relationships for femoral fractures after multimodality limb-sparing therapy of soft-tissue sarcomas of the proximal lower extremity","volume":"83","author":"Pak","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110617_b0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s13566-013-0123-6","article-title":"Post-radiation fractures in the setting of lower extremity soft-tissue sarcoma treatment","volume":"3","author":"Syed","year":"2014","journal-title":"J Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0050","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"29","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.radonc.2024.110617_b0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.radonc.2024.110617_b0060","first-page":"464","article-title":"Treatment and Outcomes of Fungal Prosthetic Joint Infections: A Systematic Review of 225 Cases","volume":"S0883\u20135403","author":"Gonzalez","year":"2023","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.radonc.2024.110617_b0065","first-page":"239","article-title":"Complications and Functional Outcomes after Reconstruction of the Proximal Humerus with Allograft-Prosthetic Composite - A Systematic Review of the Literature","volume":"S1058\u20132746","author":"Rampam","year":"2024","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.radonc.2024.110617_b0070","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.22.00232","article-title":"Surgical Management of Metastatic Pathologic Subtrochanteric Fractures: Treatment Modalities and Associated Outcomes","author":"Inchaustegui","year":"2023","journal-title":"JBJS Rev"},{"key":"10.1016\/j.radonc.2024.110617_b0075","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/jso.27024","article-title":"Long-term experience with intraoperative electron radiation therapy boost in extremity sarcoma","volume":"126","author":"Laughlin","year":"2022","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0080","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/0360-3016(91)90324-W","article-title":"Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma","volume":"21","author":"Stinson","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110617_b0085","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0360-3016(96)00388-4","article-title":"Rapid course radiation therapy vs. more standard treatment: a randomized trial for bone metastases","volume":"36","author":"Niewald","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110617_b0090","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ijrobp.2012.01.074","article-title":"Long-term results following postoperative radiotherapy for soft tissue sarcomas of the extremity","volume":"84","author":"McGee","year":"2012","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.radonc.2024.110617_b0095","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/cam4.972","article-title":"The effect of radiation therapy in the treatment of adult soft tissue sarcomas of the extremities: a long-term community-based cancer center experience","volume":"6","author":"Kneisl","year":"2017","journal-title":"Cancer Med"},{"key":"10.1016\/j.radonc.2024.110617_b0100","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0360-3016(96)00145-9","article-title":"Local control and functional results after twice-daily radiotherapy for Ewing\u2019s sarcoma of the extremities","volume":"35","author":"Bolek","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110617_b0105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2106\/00004623-200502000-00012","article-title":"Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy","volume":"87","author":"Holt","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.radonc.2024.110617_b0110","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/(SICI)1097-0142(19980615)82:12<2356::AID-CNCR9>3.0.CO;2-Q","article-title":"Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma","volume":"82","author":"Lin","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0115","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1245\/s10434-019-07182-5","article-title":"Femoral Fracture in Primary Soft-Tissue Sarcoma of the Thigh and Groin Treated with Intensity-Modulated Radiation Therapy: Observed versus Expected Risk","volume":"26","author":"Folkert","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0120","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1007\/s11999-010-1405-6","article-title":"Site-dependent replacement or internal fixation for postradiation femur fractures after soft tissue sarcoma resection","volume":"468","author":"Kim","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.radonc.2024.110617_b0125","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00003086-199807000-00020","article-title":"Treatment of femoral fractures after irradiation","volume":"352","author":"Lin","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.radonc.2024.110617_b0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/03946320110241S207","article-title":"Side effects of radiation in musculoskeletal oncology: clinical evaluation of radiation-induced fractures","volume":"24","author":"Mavrogenis","year":"2011","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.radonc.2024.110617_b0135","doi-asserted-by":"crossref","first-page":"544","DOI":"10.2106\/00004623-200004000-00009","article-title":"Vascularized free fibular transfer combined with autografting for the management of fracture nonunions associated with radiation therapy","volume":"82","author":"Duffy","year":"2000","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.radonc.2024.110617_b0140","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jrr\/rrx038","article-title":"Fracture after radiation therapy for femoral metastasis: incidence, timing and clinical features","volume":"58","author":"Shimoyama","year":"2017","journal-title":"J Radiat Res"},{"key":"10.1016\/j.radonc.2024.110617_b0145","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ijrobp.2008.12.006","article-title":"Bone fractures following external beam radiotherapy and limb-preservation surgery for lower extremity soft tissue sarcoma: relationship to irradiated bone length, volume, tumor location and dose","volume":"75","author":"Dickie","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2024.110617_b0150","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1245\/s10434-020-09213-y","article-title":"Femoral Fracture in Primary Soft Tissue Sarcoma Treated with Intensity-Modulated Radiation Therapy with and Without Dose Constraints","volume":"28","author":"Casey","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0155","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.prro.2015.09.004","article-title":"Treatment-related fractures after combined modality therapy for soft tissue sarcomas of the proximal lower extremity: Can the risk be mitigated?","volume":"6","author":"Bishop","year":"2016","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0160","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/cncr.24949","article-title":"Prediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh","volume":"116","author":"Gortzak","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.radonc.2020.11.030","article-title":"Pelvic insufficiency fractures following carbon-ion radiotherapy for uterine carcinomas","volume":"156","author":"Miyasaka","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0170","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1007\/s00330-018-5325-2","article-title":"From radiation osteitis to osteoradionecrosis: incidence and MR morphology of radiation-induced sacral pathologies following pelvic radiotherapy","volume":"28","author":"Meixel","year":"2018","journal-title":"Eur Radiol"},{"key":"10.1016\/j.radonc.2024.110617_b0175","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1002\/cncr.33082","article-title":"Complication rate, functional outcomes, and risk factors associated with carbon ion radiotherapy for patients with unresectable pelvic bone sarcoma","volume":"126","author":"Takenaka","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0180","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s002640000154","article-title":"Intra-operative radiation therapy for osteosarcoma in the extremities","volume":"24","author":"Tsuboyama","year":"2000","journal-title":"Int Orthop"},{"key":"10.1016\/j.radonc.2024.110617_b0185","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.ejso.2018.04.012","article-title":"Fractures after multimodality treatment of soft tissue sarcomas with isolated limb perfusion and radiation; likely to occur and hard to heal","volume":"44","author":"Seinen","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0190","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11764-010-0144-8","article-title":"Pathologic femur fractures after limb-sparing treatment of soft-tissue sarcomas","volume":"4","author":"Blaes","year":"2010","journal-title":"J Cancer Surviv"},{"key":"10.1016\/j.radonc.2024.110617_b0195","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1245\/aso.2002.9.1.48","article-title":"Adjuvant brachytherapy for primary high-grade soft tissue sarcoma of the extremity","volume":"9","author":"Alektiar","year":"2002","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0200","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/cncr.23975","article-title":"Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh","volume":"115","author":"Rimner","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110617_b0205","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s11999-015-4566-5","article-title":"Sacral Insufficiency Fractures are Common After High-dose Radiation for Sacral Chordomas Treated With or Without Surgery","volume":"474","author":"Osler","year":"2016","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.radonc.2024.110617_b0210","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/jso.25399","article-title":"Other Members of the Sacral Tumor Society. Low dose radiotherapy is associated with local complications but not disease control in sacral chordoma","volume":"119","author":"Houdek","year":"2019","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0215","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.amjsurg.2005.09.007","article-title":"Late treatment-related complications in 214 patients with extremity soft-tissue sarcoma treated by surgery and postoperative radiation therapy","volume":"191","author":"Livi","year":"2006","journal-title":"Am J Surg"},{"key":"10.1016\/j.radonc.2024.110617_b0220","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bjps.2019.11.015","article-title":"Utility of free vascularized fibular flaps to treat radiation-associated nonunions in the upper extremity","volume":"73","author":"Claxton","year":"2020","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.radonc.2024.110617_b0225","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-8140(99)00110-3","article-title":"The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study","volume":"52","author":"Steenland","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0230","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.injury.2020.12.010","article-title":"Treatment options in femoral radiation fractures following soft tissue sarcoma: Incidence, risk factors, failures and flowchart of treatment","volume":"52","author":"Muratori","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.radonc.2024.110617_b0235","doi-asserted-by":"crossref","first-page":"361","DOI":"10.21873\/anticanres.13120","article-title":"Risk Factors for Sacral Insufficiency Fractures in Cervical Cancer After Whole Pelvic Radiation Therapy","volume":"39","author":"Sakaguchi","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.radonc.2024.110617_b0240","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00402-020-03549-6","article-title":"Pathological fractures of the femur after radiation therapy for soft tissue tumor: a case series of seven patients treated with repeated internal fixation","volume":"141","author":"Lee","year":"2021","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.radonc.2024.110617_b0245","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/0284186X.2023.2252168","article-title":"Pelvic insufficiency fractures and pelvic bone metastases after neoadjuvant (chemo)radiotherapy for rectal cancer","volume":"62","author":"Rijpma-Jacobs","year":"2023","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0250","doi-asserted-by":"crossref","unstructured":"Bostel T, Mattke M, Nicolay NH, Welzel T, Wollschl\u00e4ger D, Akbaba S, Mayer A, Sprave T, Debus J, Uhl M. High-dose carbon-ion based radiotherapy of primary and recurrent sacrococcygeal chordomas: long-term clinical results of a single particle therapy center. Radiat Oncol. 2020 Aug 24;15(1):206. PMCID: PMC7447564.","DOI":"10.1186\/s13014-020-01647-8"},{"key":"10.1016\/j.radonc.2024.110617_b0255","first-page":"8877567","article-title":"Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas","volume":"15","author":"Bartelstein","year":"2021","journal-title":"Sarcoma"},{"key":"10.1016\/j.radonc.2024.110617_b0260","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.20.00275","article-title":"Treatment of Radiation-Associated Fractures: A Critical Analysis Review","author":"Sabharwal","year":"2021","journal-title":"JBJS Rev"},{"key":"10.1016\/j.radonc.2024.110617_b0265","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1102\/1470-7330.2004.0003","article-title":"Intensity-modulated radiotherapy\u2013what is it?","volume":"4","author":"Taylor","year":"2004","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.radonc.2024.110617_b0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clon.2009.12.003","article-title":"Stereotactic body radiotherapy: a review","volume":"22","author":"Martin","year":"2010","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.radonc.2024.110617_b0275","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.suc.2016.05.005","article-title":"Epidemiology and Etiology of Sarcomas","volume":"96","author":"Hui","year":"2016","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.radonc.2024.110617_b0280","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0360-3016(95)02139-6","article-title":"Pelvic fractures following irradiation for endometrial carcinoma","volume":"35","author":"Konski","year":"1996","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"key":"10.1016\/j.radonc.2024.110617_b0285","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/00005131-199012000-00011","article-title":"Nonunion of the proximal humerus. A review of 25 cases","volume":"4","author":"Healy","year":"1990","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.radonc.2024.110617_b0290","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/1759720X11430858","article-title":"Aging and bone loss: new insights for the clinician","volume":"4","author":"Demontiero","year":"2012","journal-title":"Therapeutic Advances in Musculoskeletal"},{"key":"10.1016\/j.radonc.2024.110617_b0295","doi-asserted-by":"crossref","unstructured":"Slemenda C, Longcope C, Peacock M, Hui S, Johnston CC. Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women. J Clin Invest. 1996 Jan 1;97(1):14\u201321.","DOI":"10.1172\/JCI118382"},{"key":"10.1016\/j.radonc.2024.110617_b0300","first-page":"37","article-title":"Surgical margins in the management of extremity soft tissue sarcoma. Chin","volume":"7","author":"Endo","year":"2018","journal-title":"Clin Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0305","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1245\/s10434-018-07143-4","article-title":"Response and Toxicity of Repeated Isolated Limb Perfusion (re-ILP) for Patients With In-Transit Metastases of Malignant Melanoma","volume":"26","author":"Belgrano","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2024.110617_b0310","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.2106\/JBJS.L.00803","article-title":"The devastating effects of tibial nonunion on health-related quality of life","volume":"95","author":"Brinker","year":"2013","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.radonc.2024.110617_b0315","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1097\/BOT.0000000000000736","article-title":"Debilitating Effects of Femoral Nonunion on Health-Related Quality of Life","volume":"31","author":"Brinker","year":"2017","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.radonc.2024.110617_b0320","doi-asserted-by":"crossref","DOI":"10.4081\/or.2017.7261","article-title":"The role of postoperative radiation and coordination of care in patients with metastatic bone disease of the appendicular skeleton","author":"Summers","year":"2018","journal-title":"Orthop Rev (Pavia) [Internet]"},{"key":"10.1016\/j.radonc.2024.110617_b0325","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/00006534-200010000-00015","article-title":"The effects of ionizing radiation on osteoblast-like cells in vitro","volume":"106","author":"Dudziak","year":"2000","journal-title":"Plast Reconstr Surg"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024042798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024042798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:30:52Z","timestamp":1734586252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814024042798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":65,"alternative-id":["S0167814024042798"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110617","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What is the incidence and non-union rate of radiation-associated fractures? \u2013 A systematic review of the literature","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110617"}}