{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:53:44Z","timestamp":1793105624736,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515111112"],"award-info":[{"award-number":["2021A1515111112"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073330"],"award-info":[{"award-number":["82073330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872469"],"award-info":[{"award-number":["81872469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202946"],"award-info":[{"award-number":["82202946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.radonc.2024.110620","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T12:16:19Z","timestamp":1731413779000},"page":"110620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Risk factors of level Ib lymph node metastasis and clinical outcome of its selectively prophylactic irradiation in nasopharyngeal carcinoma: A real-world study"],"prefix":"10.1016","volume":"202","author":[{"given":"Man-yi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run-da","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-zhen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jing","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2024.110620_b0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.radonc.2014.02.003","article-title":"Evolution of treatment for nasopharyngeal cancer\u2013success and setback in the intensity-modulated radiotherapy era","volume":"110","author":"Lee","year":"2014","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0010","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.radonc.2013.10.020","article-title":"Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities","volume":"110","author":"Sun","year":"2014","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0015","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/cncr.24049","article-title":"The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma: analysis of the spread patterns in lymph nodes by magnetic resonance imaging","volume":"115","author":"Tang","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0020","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0140-6736(15)00055-0","article-title":"Nasopharyngeal carcinoma","volume":"387","author":"Chua","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.radonc.2024.110620_b0025","unstructured":"2010 Nasopharyngeal Carcinoma Intensity Modulated Radiotherapy Target and Dose Design Guidelines. Expert consensus., Chin J Radiat Oncol2011."},{"key":"10.1016\/j.radonc.2024.110620_b0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.radonc.2017.10.032","article-title":"International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma","volume":"126","author":"Lee","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0035","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2012.08.013","article-title":"A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma","volume":"104","author":"Peng","year":"2012","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejca.2019.07.007","article-title":"Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: long-term results of a phase III multicentre randomised controlled trial","volume":"119","author":"Yang","year":"2019","journal-title":"European Journal of Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0045","article-title":"Clinical outcomes and prognostic factors of 695 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy","volume":"2014","author":"Wang","year":"2014","journal-title":"Biomed Research International"},{"key":"10.1016\/j.radonc.2024.110620_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/bjc.2013.720","article-title":"Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors","volume":"110","author":"Zeng","year":"2014","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0055","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2008.04.008","article-title":"Sparing the contralateral submandibular gland in oropharyngeal cancer patients: a planning study","volume":"89","author":"Houweling","year":"2008","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0060","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2006.02.017","article-title":"Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer","volume":"78","author":"Saarilahti","year":"2006","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0065","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ijrobp.2010.07.1990","article-title":"Impact of salivary gland dosimetry on post-IMRT recovery of saliva output and xerostomia grade for head-and-neck cancer patients treated with or without contralateral submandibular gland sparing: a longitudinal study","volume":"81","author":"Wang","year":"2011","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.radonc.2024.110620_b0070","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ijrobp.2007.12.033","article-title":"Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy","volume":"72","author":"Murdochkinch","year":"2008","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.radonc.2024.110620_b0075","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1148\/radiology.177.2.2217772","article-title":"Cervical lymph node metastasis: assessment of radiologic criteria","volume":"177","author":"van den Brekel","year":"1990","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2024.110620_b0080","doi-asserted-by":"crossref","unstructured":"V. Gr\u00e9goire, K. Ang, W. Budach, C. Grau, M. Hamoir, J. Langendijk, et al., Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines, Radiother Oncol, 110 (2014) 172-181.","DOI":"10.1016\/j.radonc.2013.10.010"},{"key":"10.1016\/j.radonc.2024.110620_b0085","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/cncr.25754","article-title":"Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy","volume":"117","author":"Xiao","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0090","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.radonc.2024.110620_b0095","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<275::AID-HED10>3.0.CO;2-N","article-title":"Neck node metastases from nasopharyngeal carcinoma: MR imaging of patterns of disease","volume":"22","author":"King","year":"2000","journal-title":"Head & Neck"},{"key":"10.1016\/j.radonc.2024.110620_b0100","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00259-004-1498-9","article-title":"Nodal metastases of nasopharyngeal carcinoma: patterns of disease on MRI and FDG PET","volume":"31","author":"Ng","year":"2004","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/j.radonc.2024.110620_b0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2407-12-98","article-title":"Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence","volume":"12","author":"Ho","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.radonc.2015.02.017","article-title":"updated consensus guidelines for neck node levels","volume":"115","author":"Wang","year":"2013","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0115","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1186\/s12885-015-1669-z","article-title":"Investigation of the feasibility of elective irradiation to neck level Ib using intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma: a retrospective analysis","volume":"15","author":"Zhang","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0120","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13014-017-0869-x","article-title":"The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels","volume":"12","author":"Ou","year":"2017","journal-title":"Radiation Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0125","first-page":"789","article-title":"A risk score model for the metastasis of level Ib lymph node based on the clinicopathological features of nasopharyngeal carcinoma in a large sample, Molecular and Clinical","volume":"2","author":"Yi","year":"2014","journal-title":"Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.radonc.2021.05.020","article-title":"Correlation analysis of neck node levels in 960 cases of Nasopharyngeal carcinoma (NPC)","volume":"161","author":"Jiang","year":"2021","journal-title":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0135","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0360-3016(90)90014-B","article-title":"Nasopharyngeal carcinoma: orderly neck node spread","volume":"19","author":"Sham","year":"1990","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.radonc.2024.110620_b0140","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.anl.2018.10.012","article-title":"Risk factors and distribution features of level IB lymph nodes metastasis in nasopharyngeal carcinoma","volume":"46","author":"Zeng","year":"2019","journal-title":"Auris, Nasus, Larynx"},{"key":"10.1016\/j.radonc.2024.110620_b0145","unstructured":"International Commission on Radiation Units and Measurements.Prescribing, Recording and reporting photon beam therapy., ICRU, 2010."},{"key":"10.1016\/j.radonc.2024.110620_b0150","doi-asserted-by":"crossref","first-page":"579","DOI":"10.5732\/cjc.012.10095","article-title":"Locoregional extension patterns of nasopharyngeal carcinoma and suggestions for clinical target volume delineation","volume":"31","author":"Li","year":"2012","journal-title":"Chinese Journal of Cancer"},{"key":"10.1016\/j.radonc.2024.110620_b0155","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.ijrobp.2008.11.053","article-title":"Extension of local disease in nasopharyngeal carcinoma detected by magnetic resonance imaging: improvement of clinical target volume delineation","volume":"75","author":"Liang","year":"2009","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.radonc.2024.110620_b0160","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s10147-013-0650-6","article-title":"Sparing level Ib lymph nodes by intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma","volume":"19","author":"Chen","year":"2014","journal-title":"International Journal of Clinical Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0165","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20150621","article-title":"Effects of omitting elective neck irradiation to nodal Level IB in nasopharyngeal carcinoma patients with negative Level IB lymph nodes treated by intensity-modulated radiotherapy: a Phase 2 study","volume":"89","author":"Li","year":"2016","journal-title":"The British Journal of Radiology"},{"key":"10.1016\/j.radonc.2024.110620_b0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.radonc.2021.12.032","article-title":"Level Ib sparing intensity-modulated radiation therapy in selected nasopharyngeal carcinoma patients based on the International Guideline","volume":"167","author":"Guo","year":"2022","journal-title":"Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110027","article-title":"The feasibility of level Ib-sparing intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma and high-risk factors classified based on the International Guideline","volume":"191","author":"Meng","year":"2024","journal-title":"Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0180","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.radonc.2017.08.002","article-title":"Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life","volume":"126","author":"Hawkins","year":"2018","journal-title":"Radiotherapy and Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.oraloncology.2017.03.015","article-title":"Ten-year survival outcomes for patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy: an analysis of 614 patients from a single center","volume":"69","author":"Wu","year":"2017","journal-title":"Oral Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0190","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1200\/JCO.2007.11.5501","article-title":"Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients","volume":"25","author":"Kam","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.radonc.2024.110620_b0195","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"International Journal of Radiation Oncology, Biology, Physics"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024042828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814024042828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:20:40Z","timestamp":1777504840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814024042828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"alternative-id":["S0167814024042828"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110620","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors of level Ib lymph node metastasis and clinical outcome of its selectively prophylactic irradiation in nasopharyngeal carcinoma: A real-world study","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2024.110620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110620"}}