{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:25:00Z","timestamp":1774423500769,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.radonc.2025.110777","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T19:11:08Z","timestamp":1738696268000},"page":"110777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dose-volume constraints for severe acute gastrointestinal toxicity in cervical cancer patients receiving extended-field intensity-modulated radiotherapy and concurrent chemotherapy"],"prefix":"10.1016","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-7922","authenticated-orcid":false,"given":"Hui","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongchun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.110777_b0005","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/IGC.0000000000000177","article-title":"Pretreatment retroperitoneal para-aortic lymph node staging in advanced cervical cancer: a review","volume":"24","author":"Smits","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.radonc.2025.110777_b0010","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ijrobp.2008.01.035","article-title":"Multivariate analysis of para-aortic lymph node recurrence after definitive radiotherapy for stage IB-IVA squamous cell carcinoma of uterine cervix","volume":"72","author":"Huang","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0015","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.ijrobp.2012.10.004","article-title":"Duodenal and other gastrointestinal toxicity in cervical and endometrial cancer treated with extended-field intensity modulated radiation therapy to paraaortic lymph nodes","volume":"85","author":"Poorvu","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijrobp.2013.09.053","article-title":"Dosimetric predictors of duodenal toxicity after intensity modulated radiation therapy for treatment of the para-aortic nodes in gynecologic cancer","volume":"88","author":"Verma","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0025","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ygyno.2017.12.028","article-title":"Dose-volume effects in pathologic lymph nodes in locally advanced cervical cancer","volume":"148","author":"Bacorro","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12885-019-5594-4","article-title":"Does external beam radiation boost to pelvic lymph nodes improve outcomes in patients with locally advanced cervical cancer?","volume":"19","author":"Wujanto","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2025.110777_b0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ygyno.2023.03.003","article-title":"Acute and long-term toxicity of whole pelvis proton radiation therapy for definitive or adjuvant management of gynecologic cancers","volume":"172","author":"Berlin","year":"2023","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0040","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3748\/wjg.v29.i8.1344","article-title":"Establishment of a prediction model for severe acute radiation enteritis associated with cervical cancer radiotherapy","volume":"29","author":"Ma","year":"2023","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.radonc.2025.110777_b0045","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13014-019-1398-6","article-title":"Reduction of dose to duodenum with a refined delineation method of Para-aortic region in patients with locally advanced cervical Cancer receiving prophylactic extended-field radiotherapy","volume":"14","author":"Yang","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijrobp.2023.11.010","article-title":"Predictive factors for toxicity after primary chemoradiation for locally advanced cervical cancer: a systematic review","volume":"119","author":"Corbeau","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109682","article-title":"ESGO\/ESTRO\/ESP Guidelines for the management of patients with cervical cancer - Update 2023","volume":"184","author":"Cibula","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0060","unstructured":"National Cancer Institute NIoH, US Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. 2018."},{"key":"10.1016\/j.radonc.2025.110777_b0065","unstructured":"Chinese Preventive Medicine Association for Kidney D. [Guidelines for the early evaluation and management of chronic kidney disease in China]. Zhonghua Nei Ke Za Zhi. 2023;62:902-30.10.3760\/cma.j.cn112138-20221013-00755."},{"key":"10.1016\/j.radonc.2025.110777_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110230","article-title":"Pelvic bone marrow dose-volume predictors of late lymphopenia following pelvic lymph node radiation therapy for prostate cancer","volume":"195","author":"Pavarini","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijrobp.2023.11.037","article-title":"The role of thoracic vertebral body dosimetry in minimizing acute hematologic toxicities of patients with non-small cell lung cancer receiving lung radiation therapy and immunotherapy","volume":"119","author":"Ma","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0080","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.radonc.2021.08.020","article-title":"Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: an EMBRACE analysis","volume":"163","author":"Peters","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0085","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0360-3016(98)00132-1","article-title":"Twice-daily fractionation of external irradiation with brachytherapy and chemotherapy in carcinoma of the cervix with positive para-aortic lymph nodes: Phase II study of the Radiation Therapy Oncology Group 92-10","volume":"41","author":"Grigsby","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0090","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.ijrobp.2007.01.026","article-title":"Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of ARM 1 of RTOG 0116","volume":"68","author":"Small","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0095","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00066-021-01781-6","article-title":"Early morbidity and dose-volume effects in definitive radiochemotherapy for locally advanced cervical cancer: a prospective cohort study covering modern treatment techniques","volume":"197","author":"Seppenwoolde","year":"2021","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2025.110777_b0100","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/jrr\/rry054","article-title":"Dosimetric comparison of three-dimensional conformal radiotherapy versus volumetric-arc radiotherapy in cervical cancer treatment: applying the central-shielding principle to modern technology","volume":"59","author":"Tamaki","year":"2018","journal-title":"J Radiat Res"},{"key":"10.1016\/j.radonc.2025.110777_b0105","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ygyno.2011.12.432","article-title":"Intensity-modulated radiation therapy for advanced cervical cancer: a comparison of dosimetric and clinical outcomes with conventional radiotherapy","volume":"125","author":"Du","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0110","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.ijrobp.2008.02.063","article-title":"Prospective clinical trial of positron emission tomography\/computed tomography image-guided intensity-modulated radiation therapy for cervical carcinoma with positive para-aortic lymph nodes","volume":"72","author":"Esthappan","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0115","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/ajco.12049","article-title":"Small bowel toxicity in pelvic radiotherapy for postoperative gynecological cancer: comparison between conformal radiotherapy and intensity modulated radiotherapy","volume":"9","author":"Ray","year":"2013","journal-title":"Asia Pac J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0120","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/j.ijrobp.2012.01.023","article-title":"Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas","volume":"83","author":"Gay","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0125","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1186\/1471-2407-14-789","article-title":"Dose-volume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative intensity modulated radiotherapy for early-stage cervical cancer","volume":"14","author":"Chen","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2025.110777_b0130","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13014-015-0486-5","volume":"10","author":"Isohashi","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.prro.2013.06.004","article-title":"Upper abdominal normal organ contouring guidelines and atlas: a Radiation Therapy Oncology Group consensus","volume":"4","author":"Jabbour","year":"2014","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0140","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1016\/j.prro.2021.12.008","article-title":"Use of specific duodenal dose constraints during treatment planning reduces toxicity after definitive paraaortic radiation therapy for cervical cancer","volume":"12","author":"Lakomy","year":"2022","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0145","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ijrobp.2023.07.046","article-title":"Locoregional treatment in patients with metastatic cervical cancer: benefit of dose escalation strategies","volume":"118","author":"Laville","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110777_b0150","doi-asserted-by":"crossref","DOI":"10.21037\/jgo.2017.01.03","article-title":"Baseline hemoglobin and liver function predict tolerability and overall survival of patients receiving radioembolization for chemotherapy-refractory metastatic colorectal cancer","volume":"8","author":"Kennedy","year":"2017","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0155","article-title":"Predicting cisplatin tolerability in older adults with head and neck cancer - insights for improved chemoradiation outcomes","volume":"204","author":"Ruhle","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s44184-023-00026-x","article-title":"Mental health penalties of having a child: findings from the China family panel studies","volume":"2","author":"Shi","year":"2023","journal-title":"NPJ Ment Health Res"},{"key":"10.1016\/j.radonc.2025.110777_b0165","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2019.07.001","article-title":"Multiparity is associated with poorer cardiovascular health among women from the multi-ethnic study of atherosclerosis","volume":"221","author":"Ogunmoroti","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.radonc.2025.110777_b0170","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ygyno.2014.08.018","article-title":"Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in gynecologic oncology group trials of cisplatin-based chemoradiation","volume":"135","author":"Rose","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.radonc.2025.110777_b0175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/cam4.4418","article-title":"A modified delineation method of para-aortic nodal clinical target volume in patients with locally advanced cervical cancer","volume":"11","author":"Wang","year":"2022","journal-title":"Cancer Med"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025000726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025000726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:48:26Z","timestamp":1774417706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025000726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"alternative-id":["S0167814025000726"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110777","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-volume constraints for severe acute gastrointestinal toxicity in cervical cancer patients receiving extended-field intensity-modulated radiotherapy and concurrent chemotherapy","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110777","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110777"}}