{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:34:06Z","timestamp":1792679646469,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023181","name":"Agencja Bada\u0144 Medycznych","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.radonc.2025.110788","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T02:58:38Z","timestamp":1739415518000},"page":"110788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Elective clinical target volume in early squamous cell anal canal cancer: A systematic review and meta-analysis of the risk of recurrence in untreated upper pelvic and external iliac lymph nodes"],"prefix":"10.1016","volume":"206","author":[{"given":"Joanna","family":"Socha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Paciorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Bujko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.110788_b0005","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ijrobp.2008.08.070","article-title":"Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas","volume":"74","author":"Myerson","year":"2009","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"key":"10.1016\/j.radonc.2025.110788_b0010","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ijrobp.2011.12.058","article-title":"Australasian gastrointestinal trials group (AGITG) contouring atlas and planning guidelines for intensity-modulated radiotherapy in anal cancer","volume":"83","author":"Ng","year":"2012","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"key":"10.1016\/j.radonc.2025.110788_b0015","doi-asserted-by":"crossref","unstructured":"Lee NY, Lu JJ. Target volume delineation and field setup: a practical guide for conformal and intensity modulated radiation therapy. Berlin, Heidelberg: Springer; 2013.","DOI":"10.1007\/978-3-642-28860-9"},{"key":"10.1016\/j.radonc.2025.110788_b0020","unstructured":"https:\/\/qarc.org\/ecog\/EA2182_Delineation%20of%20Target%20Volumes%20and%20Critical%20Structures_3%2020%2020combined.pdf (accessed 2025 Jan 15)."},{"key":"10.1016\/j.radonc.2025.110788_b0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.prro.2022.01.015","article-title":"ECOG-ACRIN guideline for contouring and treatment of early stage anal cancer using IMRT\/IGRT","volume":"12","author":"Damico","year":"2022","journal-title":"Practical Radiation Oncology"},{"key":"10.1016\/j.radonc.2025.110788_b0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.canrad.2021.11.015","article-title":"Radiotherapy of anal canal cancer","volume":"6","author":"Peiffert","year":"2022","journal-title":"Cancer Radiothrapie"},{"key":"10.1016\/j.radonc.2025.110788_b0035","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/0284186X.2023.2240490","article-title":"Nilsson Nordic anal cancer (NOAC) group consensus guidelines for risk-adapted delineation of the elective clinical target volume in anal cancer","volume":"62","author":"Nilsson","year":"2023","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.radonc.2025.110788_b0040","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/00000658-193611000-00008","article-title":"An anatomic restudy of the pelvic lymphatics","volume":"104","author":"Nesselrod","year":"1936","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.radonc.2025.110788_b0045","series-title":"Clinically Oriented Anatomy","author":"Moore","year":"2013"},{"key":"10.1016\/j.radonc.2025.110788_b0050","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJM200003163421107","article-title":"Carcinoma of the anal canal","volume":"342","author":"Ryan","year":"2000","journal-title":"New England J Med"},{"issue":"1","key":"10.1016\/j.radonc.2025.110788_b0055","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.radonc.2008.11.007","article-title":"Anatomical bases for the radiological delineation of lymph node areas. Part III: pelvis and lower limbs","volume":"92","author":"Lengele","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.110788_b0060","article-title":"Is the omission of the external iliac or upper pelvic lymph nodes from elective irradiation safe in selected anal canal squamous cell cancers?","volume":"203","author":"Paciorek","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.110788_b0065","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1016\/j.ijrobp.2011.12.062","article-title":"Chemoradiotherapy of anal carcinoma: survival and recurrence in an unselected national cohort","volume":"83","author":"Bentzen","year":"2012","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"key":"10.1016\/j.radonc.2025.110788_b0070","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.radonc.2025.110788_b0075","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute, 2011. Available from: https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed Dec 15, 2024."},{"issue":"4","key":"10.1016\/j.radonc.2025.110788_b0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/XEB.0000000000000141","article-title":"A new improved graphical and quantitative method for detecting bias in metaanalysis","volume":"16","author":"Furuya-Kanamori","year":"2018","journal-title":"Int J Evidence-Based Healthcare"},{"issue":"15","key":"10.1016\/j.radonc.2025.110788_b0085","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Metaanalysis of observational studies in epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"J Am Med Association"},{"key":"10.1016\/j.radonc.2025.110788_b0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2340\/1651-226X.2024.20336","article-title":"Reduction of elective lymph node volume in radiotherapy of early anal squamous cell cancer: a comparative study between two Swedish university hospitals","volume":"63","author":"Heyman","year":"2024","journal-title":"Acta Oncologica"},{"issue":"7","key":"10.1016\/j.radonc.2025.110788_b0095","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1080\/0284186X.2021.1918763","article-title":"Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer","volume":"60","author":"Sl\u00f8rdahl","year":"2021","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.radonc.2025.110788_b0100","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijrobp.2019.10.016","article-title":"Patterns and Predictors of Relapse Following Radical Chemoradiation Therapy Delivered Using Intensity Modulated Radiation Therapy With a Simultaneous Integrated Boost in Anal Squamous Cell Carcinoma","volume":"106","author":"Shakir","year":"2020","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"key":"10.1016\/j.radonc.2025.110788_b0105","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/codi.12951","article-title":"Clinicopathological and virological characteristics of superficially invasive squamous-cell carcinoma of the anus","volume":"17","author":"Arana","year":"2015","journal-title":"Colorectal Disease"},{"key":"10.1016\/j.radonc.2025.110788_b0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ijrobp.2011.07.007","article-title":"Twenty-five-year experience with radical chemoradiation for anal cancer","volume":"83","author":"Tomaszewski","year":"2012","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"key":"10.1016\/j.radonc.2025.110788_b0115","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0360-3016(96)00493-2","article-title":"Conservative treatment by irradiation of epidermoid cancers of the anal canal: prognostic factors of tumoral control and complications","volume":"37","author":"Peiffert","year":"1997","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"issue":"83","key":"10.1016\/j.radonc.2025.110788_b0120","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/0360-3016(83)90257-2","article-title":"Primary radiation therapy in the treatment of anal carcinoma","volume":"9","author":"Cantril","year":"1983","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"issue":"4","key":"10.1016\/j.radonc.2025.110788_b0125","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ijrobp.2009.09.029","article-title":"Squamous cell carcinoma of the anal canal: patterns and predictors of failure and implications for intensity-modulated radiation treatment planning","volume":"78","author":"Wright","year":"2010","journal-title":"Int J Radiation Oncology, Biology, Phys"},{"issue":"9","key":"10.1016\/j.radonc.2025.110788_b0130","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/ans.14398","article-title":"Radiotherapy for anal squamous cell carcinoma: must the upper pelvic nodes and the inguinal nodes be treated?","volume":"88","author":"Thompson","year":"2018","journal-title":"ANZ J Surgery"},{"key":"10.1016\/j.radonc.2025.110788_b0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13014-020-01567-7","article-title":"Patterns of recurrence in anal cancer: A detailed analysis","volume":"15","author":"Nilsson","year":"2020","journal-title":"Radiation Oncology"},{"issue":"1","key":"10.1016\/j.radonc.2025.110788_b0140","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s12885-021-08187-8","article-title":"Patterns of pathologic lymph nodes in anal cancer: a PET-CT-based analysis with implications for radiotherapy treatment volumes","volume":"21","author":"Frennered","year":"2021","journal-title":"BMC Cancer"},{"issue":"24","key":"10.1016\/j.radonc.2025.110788_b0145","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.3390\/cancers15245833","article-title":"Nodal Elective Volume Selection and Definition during Radiation Therapy for Early Stage (T1-T2 N0 M0) Perianal Squamous Cell Carcinoma: A Narrative Clinical Review and Critical Appraisal","volume":"15","author":"Spinelli","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.radonc.2025.110788_b0150","unstructured":"UICC. TNM Classification of Malignant Tumours 8th ed. New York, John Wiley & Sons, Ltd; 2017."}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025000830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025000830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:42:31Z","timestamp":1777552951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025000830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":30,"alternative-id":["S0167814025000830"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110788","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elective clinical target volume in early squamous cell anal canal cancer: A systematic review and meta-analysis of the risk of recurrence in untreated upper pelvic and external iliac lymph nodes","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110788"}}