{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:29:25Z","timestamp":1790393365430,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR003143"],"award-info":[{"award-number":["KL2TR003143"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","thegreenjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.radonc.2025.110884","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T17:52:02Z","timestamp":1744134722000},"page":"110884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Phase II trial of organ preservation program using short-course radiation and FOLFOXIRI for rectal cancer (SHORT-FOX): Two-Year primary outcome analysis"],"prefix":"10.1016","volume":"207","author":[{"given":"Daniella","family":"Klebaner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shagufta","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Heestand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Dawes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arden M.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Kirilcuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Kin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gahagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Ghanouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Vitzthum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Rahimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erqi L.","family":"Pollom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.110884_b0005","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2025.110884_b0010","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1200\/JCO.2011.40.1836","article-title":"Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO\/ARO\/AIO-94 randomized phase III trial after a median follow-up of 11 years","volume":"30","author":"Sauer","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0015","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1200\/JCO.2012.42.9597","article-title":"Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman radiation oncology group trial 01.04","volume":"30","author":"Ngan","year":"2012","journal-title":"J Clin Oncol Off J Am Soc Clinical Oncology"},{"key":"10.1016\/j.radonc.2025.110884_b0020","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djx095","article-title":"Tumor regression grading after preoperative chemoradiotherapy as a prognostic factor and individual-level surrogate for disease-free survival in rectal cancer","volume":"109","author":"Fokas","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2025.110884_b0025","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/S0140-6736(18)31078-X","article-title":"Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study","volume":"391","author":"van der Valk","year":"2018","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.radonc.2025.110884_b0030","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1097\/SLA.0b013e3182759f1c","article-title":"Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy","volume":"256","author":"Smith","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2025.110884_b0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","article-title":"Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis","volume":"17","author":"Renehan","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0040","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1200\/JCO.2011.37.7176","article-title":"Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer","volume":"29","author":"Maas","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0045","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw171","article-title":"Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer","volume":"108","author":"Martens","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2025.110884_b0050","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2025.110884_b0055","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.gassur.2006.09.005","article-title":"Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapy","volume":"10","author":"Habr-Gama","year":"2006","journal-title":"J Gastrointest Surg Off J Soc Surg Aliment Tract"},{"key":"10.1016\/j.radonc.2025.110884_b0060","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijrobp.2013.12.012","article-title":"Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control","volume":"88","author":"Habr-Gama","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.110884_b0065","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1470-2045(15)00120-5","article-title":"High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study","volume":"16","author":"Appelt","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0075","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1200\/JCO.2005.05.256","article-title":"Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial","volume":"23","author":"Marijnen","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0080","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/DCR.0000000000000475","article-title":"Outcomes of open, laparoscopic, and robotic abdominoperineal resections in patients with rectal cancer","volume":"58","author":"Moghadamyeghaneh","year":"2015","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.radonc.2025.110884_b0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1470-2045(09)70381-X","article-title":"Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial","volume":"11","author":"Chua","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0090","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1634\/theoncologist.2014-0233","article-title":"Preoperative chemotherapy in patients with intermediate-risk rectal adenocarcinoma selected by high-resolution magnetic resonance imaging: the GEMCAD 0801 Phase II Multicenter Trial","volume":"19","author":"Fernandez-Martos","year":"2014","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2025.110884_b0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1470-2045(20)30555-6","article-title":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial","volume":"22","author":"Bahadoer","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0100","first-page":"01012","article-title":"Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial","volume":"S0923\u20137534","author":"Conroy","year":"2024","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0105","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1200\/JCO.23.01208","article-title":"Long-Term results of organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy: the randomized phase II OPRA trial","volume":"42","author":"Verheij","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0110","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1200\/JCO.2006.09.0928","volume":"25","author":"Falcone","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0115","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1470-2045(17)30086-4","article-title":"Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial","volume":"18","author":"Erlandsson","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0120","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/annonc\/mdw062","article-title":"Long-course oxaliplatin-based preoperative chemoradiation versus 5 \u00d7 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study","volume":"27","author":"Bujko","year":"2016","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0125","doi-asserted-by":"crossref","DOI":"10.1093\/jncics\/pkae050","article-title":"Advancing clinical trial equity through integration of telehealth and decentralized treatment","volume":"8","author":"Brown","year":"2024","journal-title":"JNCI Cancer Spectr"},{"key":"10.1016\/j.radonc.2025.110884_b0130","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.2214\/AJR.11.8210","article-title":"MRI after treatment of locally advanced rectal cancer: how to report tumor response\u2014the MERCURY experience","volume":"199","author":"Patel","year":"2012","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.radonc.2025.110884_b0135","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s13063-017-2085-2","volume":"18","author":"Battersby","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.radonc.2025.110884_b0140","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1200\/JCO.2021.39.15_suppl.3509","article-title":"Survival and organ preservation according to clinical response after total neoadjuvant therapy in locally advanced rectal cancer patients: a secondary analysis from the organ preservation in rectal adenocarcinoma (OPRA) trial","volume":"39","author":"Thompson","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0145","doi-asserted-by":"crossref","first-page":"e766","DOI":"10.1097\/SLA.0000000000005799","article-title":"Locoregional failure during and after short-course radiotherapy followed by chemotherapy and surgery compared with long-course chemoradiotherapy and surgery: A 5-year follow-up of the RAPIDO trial","volume":"278","author":"Dijkstra","year":"2023","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2025.110884_b0150","first-page":"7","article-title":"Short-term outcomes of a prospective multicenter phase II trial of total neoadjuvant therapy for locally advanced rectal cancer in Japan (ENSEMBLE -1)","author":"Kagawa","year":"2023","journal-title":"Ann Gastroenterol Surg"},{"key":"10.1016\/j.radonc.2025.110884_b0155","unstructured":"31. Claus R\u00f6del. Short RT Versus RCT,Followed by Chemo.and Organ Preservation for Interm and High-Risk Rectal Cancer Patients. NCT04246684.; 2023. Accessed September 12, 2024. https:\/\/clinicaltrials.gov\/study\/NCT04246684."},{"key":"10.1016\/j.radonc.2025.110884_b0160","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1200\/JCO.21.01667","article-title":"Multicenter, randomized, phase III trial of short-term radiotherapy plus chemotherapy versus long-term chemoradiotherapy in locally advanced rectal cancer (STELLAR)","volume":"40","author":"Jin","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0165","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1016\/j.clcc.2021.03.003","article-title":"Nonoperative rectal cancer management with short-course radiation followed by chemotherapy: a nonrandomized control trial","volume":"20","author":"Kim","year":"2021","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.radonc.2025.110884_b0170","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","article-title":"Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data","volume":"11","author":"Maas","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0175","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.50903","article-title":"Organ preservation and survival by clinical response grade in patients with rectal cancer treated with total neoadjuvant therapy: a secondary analysis of the OPRA randomized clinical trial","volume":"7","author":"Thompson","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.radonc.2025.110884_b0180","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.5896","article-title":"assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy","volume":"5","author":"Smith","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0185","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2024.42.3_suppl.7","article-title":"Risks of organ preservation in rectal cancer: data from two international registries on rectal cancer","author":"Fernandez","year":"2024","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol."},{"key":"10.1016\/j.radonc.2025.110884_b0190","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S2468-1253(22)00392-2","article-title":"Neoadjuvant chemoradiotherapy with radiation dose escalation with contact x-ray brachytherapy boost or external beam radiotherapy boost for organ preservation in early cT2\u2013cT3 rectal adenocarcinoma (OPERA): a phase 3, randomised controlled trial","volume":"8","author":"Gerard","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.radonc.2025.110884_b0195","doi-asserted-by":"crossref","unstructured":"Matrajt L, Leung T. Evaluating the Effectiveness of Social Distancing Interventions to Delay or Flatten the Epidemic Curve of Coronavirus Disease - Volume 26, Number 8\u2014August 2020 - Emerging Infectious Diseases journal - CDC. doi:10.3201\/eid2608.201093.","DOI":"10.3201\/eid2608.201093"},{"key":"10.1016\/j.radonc.2025.110884_b0200","unstructured":"Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Rectal Cancer V.4.2024. \u00a9 National Comprehensive Cancer Network, Inc. 2024. All rights reserved."},{"key":"10.1016\/j.radonc.2025.110884_b0205","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.ijrobp.2021.10.004","article-title":"Clinical complete response in patients with rectal adenocarcinoma treated with short-course radiation therapy and nonoperative management","volume":"112","author":"Chin","year":"2022","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0210","doi-asserted-by":"crossref","unstructured":"42. Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR) | Journal of Clinical Oncology. Accessed October 3, 2024. doi: 10.1200\/JCO.21.01667.","DOI":"10.1200\/JCO.21.01667"},{"key":"10.1016\/j.radonc.2025.110884_b0215","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/annonc\/mdz186","article-title":"Long-course preoperative chemoradiation versus 5 \u00d7 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study","volume":"30","author":"Cise\u0142","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2025.110884_b0220","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-049119","article-title":"A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial","volume":"12","author":"Hudson","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.radonc.2025.110884_b0225","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.3390\/cancers14153665","article-title":"MORPHEUS Phase II\u2013III study: a pre-planned interim safety analysis and preliminary results","volume":"14","author":"Garant","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.radonc.2025.110884_b0230","unstructured":"Alliance A022104\/NRG-GI010: A randomized phase II trial testing the efficacy of triplet versus doublet chemotherapy to achieve clinical complete response in patients with locally advanced rectal cancer\u2014The Janus Rectal Cancer trial. | Journal of Clinical Oncology. Accessed October 8, 2024. https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2023.41.16_suppl.TPS3640."},{"key":"10.1016\/j.radonc.2025.110884_b0235","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S2468-1253(18)30301-7","article-title":"Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis","volume":"3","author":"Chadi","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.radonc.2025.110884_b0240","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000543","article-title":"Young patients with colorectal cancer have higher early mortality but better long-term survival","volume":"13","author":"Wang","year":"2022","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.radonc.2025.110884_b0245","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/bjs\/znab372","article-title":"Watch and wait after a clinical complete response in rectal cancer patients younger than 50 years","volume":"109","author":"Bahadoer","year":"2021","journal-title":"Br J Surg"},{"key":"10.1016\/j.radonc.2025.110884_b0250","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ejso.2011.01.025","article-title":"The clinical significance of circulating tumor cells in non-metastatic colorectal cancer \u2013 a review","volume":"37","author":"Thorsteinsson","year":"2011","journal-title":"Eur J Surg Oncol EJSO"},{"key":"10.1016\/j.radonc.2025.110884_b0255","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6219","article-title":"Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer","volume":"8","author":"Tie","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.radonc.2025.110884_b0260","first-page":"2723","article-title":"FDG-PET\/MRI for nonoperative management of rectal cancer: a prospective pilot study","volume":"8","author":"Ince","year":"2022","journal-title":"Tomogr Ann Arbor Mich"},{"key":"10.1016\/j.radonc.2025.110884_b0265","unstructured":"Stephen Rogalla. Study Details | Fluorescent Probe VGT-309 to ID Cancerous Colorectal Lesions During Augmented Colonoscopy | ClinicalTrials.Gov.; 2023. Accessed September 11, 2024. https:\/\/clinicaltrials.gov\/study\/NCT06034197."},{"key":"10.1016\/j.radonc.2025.110884_b0270","doi-asserted-by":"crossref","unstructured":"Alvarez J, Shi Q, Dasari A, et al. ALLIANCE A022104\/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II\/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer. medRxiv. Published online April 27, 2024:2024.04.25.24306396. doi:10.1101\/2024.04.25.24306396.","DOI":"10.1101\/2024.04.25.24306396"},{"key":"10.1016\/j.radonc.2025.110884_b0275","unstructured":"Optimisation of Response for Organ Preservation in Rectal Cancer\u00a0: Neoadjuvant Chemotherapy and Radiochemotherapy vs. Radiochemotherapy (GRECCAR12). NCT02514278.; 2024. Accessed September 12, 2024. https:\/\/clinicaltrials.gov\/study\/NCT02514278."}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025001793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025001793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:19:34Z","timestamp":1748002774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025001793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"alternative-id":["S0167814025001793"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110884","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase II trial of organ preservation program using short-course radiation and FOLFOXIRI for rectal cancer (SHORT-FOX): Two-Year primary outcome analysis","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110884"}}