{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:44:39Z","timestamp":1790286279147,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2021\\u2013C-023"],"award-info":[{"award-number":["FEMH-2021\\u2013C-023"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\\u20132314-B-016\\u2013028"],"award-info":[{"award-number":["113\\u20132314-B-016\\u2013028"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\\u20132314-B-016\\u2013060"],"award-info":[{"award-number":["NSTC 112\\u20132314-B-016\\u2013060"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.radonc.2025.110976","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T19:22:55Z","timestamp":1749064975000},"page":"110976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Bao Yuan Gao vs. Calendula cream for radiotherapy-induced skin toxicity in head and neck cancer: A randomized controlled trial"],"prefix":"10.1016","volume":"209","author":[{"given":"Tsang-Ho","family":"Ngan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skye Hsin-Hsien","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ju","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-6375","authenticated-orcid":false,"given":"Chen-Xiong","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Fang","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsi","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Wei","family":"Shueng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.110976_b0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2407-14-53","article-title":"Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Chan","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2025.110976_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.738851","article-title":"Risk factors related to acute radiation dermatitis in breast cancer patients after radiotherapy: a systematic review and meta-analysis","volume":"11","author":"Xie","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2025.110976_b0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13555-016-0120-y","article-title":"Acute and chronic cutaneous reactions to Ionizing radiation therapy","volume":"6","author":"Bray","year":"2016","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.radonc.2025.110976_b0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13014-020-1463-1","article-title":"Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review","volume":"15","author":"Liu","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110976_b0025","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/cncr.24120","article-title":"Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy","volume":"115","author":"Tejwani","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2025.110976_b0030","first-page":"4663","article-title":"Comparison of clinical practice guidelines on radiation dermatitis: a narrative review","volume":"30","author":"Finkelstein","year":"2022","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2025.110976_b0035","first-page":"e172","article-title":"Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations","volume":"24","author":"Behroozian","year":"2023","journal-title":"LancetOncol"},{"key":"10.1016\/j.radonc.2025.110976_b0040","first-page":"5730","article-title":"Efficacy of kangfuxin liquidin the treatment of 60 cases with esophagitis","volume":"31","author":"Wu","year":"2010","journal-title":"Jilin Med J"},{"key":"10.1016\/j.radonc.2025.110976_b0045","first-page":"81","article-title":"Clinical observation of meibao burn ointment topical use inPreventing childen with radiodermatitis","volume":"52","author":"Wei","year":"2012","journal-title":"Shandong Med J"},{"key":"10.1016\/j.radonc.2025.110976_b0050","first-page":"67","article-title":"Clinal observation on the effect of self-made compound Aloe liquid on preventing radiation dermatitis in patients with Nasopharyngeal Carcinoma","volume":"20","author":"Zhu","year":"2013","journal-title":"J Nursing(China)"},{"key":"10.1016\/j.radonc.2025.110976_b0055","first-page":"1237","article-title":"Research Progress of antioxygenation in curcumin and its derivants","volume":"32","author":"Huang","year":"2016","journal-title":"J Prev Med Inf"},{"key":"10.1016\/j.radonc.2025.110976_b0060","first-page":"153","article-title":"Effect of compound ulcer oil on blood cytokines in patients with radiation dermatitis","volume":"22","author":"Zhao","year":"2016","journal-title":"Chin J Exp Tradit Med Formulae"},{"key":"10.1016\/j.radonc.2025.110976_b0065","first-page":"365","article-title":"Effect and mechnism study of shengjiyuhong cream on transdifferentiation and collagen production of normal human dermal fibroblasts","volume":"32","author":"Sun","year":"2016","journal-title":"Zhonghua Zheng Xing Wai Ke Za Zhi"},{"key":"10.1016\/j.radonc.2025.110976_b0070","first-page":"24","article-title":"Effect of shengjiyuhong ointment on pH value of wound after anal fistula operation","volume":"25","author":"Feng","year":"2008","journal-title":"J Gansu Coll Traditional Chin Med"},{"key":"10.1016\/j.radonc.2025.110976_b0075","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/467531","article-title":"A study of the wound healing mechanism of a traditional chinese medicine, Angelica sinensis, using a proteomic approach","volume":"2012","author":"Hsiao","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.radonc.2025.110976_b0080","first-page":"53","article-title":"Recent Research situation of shengjiyuhong ointment","volume":"24","author":"Dong","year":"2015","journal-title":"J External Treat Traditional Chin Med"},{"key":"10.1016\/j.radonc.2025.110976_b0085","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","article-title":"Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer","volume":"22","author":"Pommier","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.110976_b0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2407-11-37","article-title":"Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer","volume":"11","author":"Hsieh","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2025.110976_b0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12885-016-2165-9","article-title":"Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer","volume":"16","author":"Hsieh","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2025.110976_b0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13014-019-1302-4","article-title":"Prophylactic NS-21 maintains the skin moisture but does not reduce the severity of radiation dermatitis in patients with head and neck cancer: a randomized control trial","volume":"14","author":"Chou","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.110976_b0105","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1002\/jssc.202100566","article-title":"Untargeted metabolomics coupled with chemometric analysis deducing robust markers for discrimination of processing procedures: wine-processed Angelica sinensis as a case study","volume":"44","author":"Yin","year":"2021","journal-title":"J Sep Sci"},{"key":"10.1016\/j.radonc.2025.110976_b0110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12906-015-0889-8","article-title":"Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings","volume":"15","author":"Lee","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.radonc.2025.110976_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28247950","article-title":"Pharmacological effects of shikonin and its potential in skin repair: a review","volume":"28","author":"Song","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.radonc.2025.110976_b0120","article-title":"Evaluation of the wound healing potential of resina Draconis (Dracaena cochinchinensis) in animal models","author":"Liu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.radonc.2025.110976_b0125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/tropej\/fmh083","article-title":"Traditional massage of newborns in Nepal: implications for trials of improved practice","volume":"51","author":"Mullany","year":"2005","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.radonc.2025.110976_b0130","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.25085v2","article-title":"The effects of topical sesame (Sesamum indicum) oil on pain severity and amount of received non-steroid anti-inflammatory drugs in patients with upper or lower extremities trauma","volume":"5","author":"Bigdeli Shamloo","year":"2015","journal-title":"Anesthesiol Pain Med"},{"key":"10.1016\/j.radonc.2025.110976_b0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/09553002.2018.1440092","article-title":"Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications","volume":"94","author":"Najafi","year":"2018","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.radonc.2025.110976_b0140","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00129334-200209000-00007","article-title":"Wound care after radiation therapy","volume":"15","author":"Mendelsohn","year":"2002","journal-title":"Adv Skin Wound Care"},{"key":"10.1016\/j.radonc.2025.110976_b0145","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/antiox4020293","article-title":"A review of the use of topical Calendula in the prevention and treatment of radiotherapy-induced skin reactions","volume":"4","author":"Kodiyan","year":"2015","journal-title":"Antioxidants (Basel)"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025044809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025044809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:53:40Z","timestamp":1778673220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025044809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":29,"alternative-id":["S0167814025044809"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110976","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bao Yuan Gao vs. Calendula cream for radiotherapy-induced skin toxicity in head and neck cancer: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.110976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110976"}}