{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:52:05Z","timestamp":1788292325895,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["10070012010002"],"award-info":[{"award-number":["10070012010002"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.radonc.2025.111063","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T14:57:36Z","timestamp":1753541856000},"page":"111063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effects of anatomical changes on dose and normal tissue complication probabilities and the benefit of replanning in photon and proton therapy of lung cancer patients"],"prefix":"10.1016","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-2877","authenticated-orcid":false,"given":"Djoya","family":"Hattu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4588-9769","authenticated-orcid":false,"given":"Vicki Trier","family":"Taasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Emans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije","family":"Velders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"van der Stoep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Vullings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"van den Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janou","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"van der Salm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"van Loon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-6567","authenticated-orcid":false,"given":"Dirk","family":"de Ruysscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9805","authenticated-orcid":false,"given":"Richard","family":"Canters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.111063_b0005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1088\/0031-9155\/42\/1\/008","article-title":"Adaptive radiation therapy","volume":"42","author":"Yan","year":"1997","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2025.111063_b0010","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.3109\/0284186X.2013.815798","article-title":"Dosimetric impact of respiratory motion, interfraction baseline shifts, and anatomical changes in radiotherapy of non-small cell lung cancer","volume":"52","author":"Schmidt","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.semradonc.2019.02.007","article-title":"Adaptive radiotherapy for anatomical changes","volume":"29","author":"Sonke","year":"2019","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0020","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.semradonc.2019.02.011","article-title":"Adaptive radiotherapy: moving into the future","volume":"29","author":"Brock","year":"2019","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0025","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/j.ijrobp.2008.06.1018","article-title":"Anatomical changes during radiotherapy of lung cancer patients","volume":"72","author":"van Zwienen","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.111063_b0030","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.radonc.2014.10.009","article-title":"Intra thoracic anatomical changes in lung cancer patients during the course of radiotherapy","volume":"113","author":"Kwint","year":"2014","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semradonc.2009.11.003","article-title":"Adaptive radiotherapy for lung cancer","volume":"20","author":"Sonke","year":"2010","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.770382","article-title":"Adaptive radiation therapy in the treatment of lung cancer: an overview of the current state of the field","volume":"11","author":"Piperdi","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0045","doi-asserted-by":"crossref","first-page":"S417","DOI":"10.1016\/j.jtho.2016.11.480","article-title":"MA13.03 analysis of intra-thoracic anatomical changes observed in clinical workflow of cone-beam CT guided radiotherapy for lung cancer","volume":"12","author":"Belderbos","year":"2017","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0050","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.radonc.2022.08.030","article-title":"A traffic light protocol workflow for image-guided adaptive radiotherapy in lung cancer patients","volume":"175","author":"Hattu","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phro.2021.04.003","article-title":"Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer","volume":"18","author":"Bjaan\u00e6s","year":"2021","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0060","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1200\/JCO.2016.70.0229","article-title":"Cardiac toxicity after radiotherapy for stage III non\u2013small-cell lung cancer: pooled analysis of dose-escalation trials delivering 70 to 90 Gy","volume":"35","author":"Wang","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0065","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jtho.2020.11.002","article-title":"Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions","volume":"16","author":"Banfill","year":"2021","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0070","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.radonc.2022.05.007","article-title":"Exposure of the heart in lung cancer radiation therapy: a systematic review of heart doses published during 2013 to 2020","volume":"172","author":"Kearney","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0075","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/j.ijrobp.2009.05.070","article-title":"Radiation dose-volume effects in the Esophagus","volume":"76","author":"Werner-Wasik","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.111063_b0080","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/j.ejca.2012.04.014","article-title":"Mature results of a phase II trial on individualised accelerated radiotherapy based on normal tissue constraints in concurrent chemo-radiation for stage III non-small cell lung cancer","volume":"48","author":"van Baardwijk","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.radonc.2025.111063_b0085","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/0284186X.2013.820341","article-title":"Towards individualized dose constraints: adjusting the QUANTEC radiation pneumonitis model for clinical risk factors","volume":"53","author":"Appelt","year":"2014","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.radonc.2015.08.010","article-title":"Multivariable normal-tissue complication modeling of acute esophageal toxicity in advanced stage non-small cell lung cancer patients treated with intensity-modulated (chemo-)radiotherapy","volume":"117","author":"Wijsman","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.radonc.2019.09.005","article-title":"Multifactorial risk factors for mortality after chemotherapy and radiotherapy for non-small cell lung cancer","volume":"152","author":"Defraene","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0100","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.radonc.2013.10.013","article-title":"Adaptive radiotherapy of lung cancer patients with pleural effusion or atelectasis","volume":"110","author":"M\u00f8ller","year":"2014","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0105","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1118\/1.4965807","article-title":"Effect of atelectasis changes on tissue mass and dose during lung radiotherapy","volume":"43","author":"Guy","year":"2016","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2025.111063_b0110","first-page":"531","article-title":"Tumor regression and positional changes in non-small cell lung cancer during radical radiotherapy","volume":"6","author":"Lim","year":"2011","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"10.1016\/j.radonc.2025.111063_b0115","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1080\/0284186X.2017.1352103","article-title":"Adaptive radiotherapy for locally advanced non-small cell lung cancer: dosimetric gain and treatment outcome prediction","volume":"56","author":"Berkovic","year":"2017","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2015.01.017","article-title":"Robust optimization in intensity-modulated proton therapy to account for anatomy changes in lung cancer patients","volume":"114","author":"Li","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0125","article-title":"Clinical evaluation of synthetic computed tomography methods in adaptive proton therapy of lung cancer patients","volume":"27","author":"Taasti","year":"2023","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0130","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2016.04.002","article-title":"Effects of anatomical changes on pencil beam scanning proton plans in locally advanced NSCLC patients","volume":"120","author":"Szeto","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110290","article-title":"Balancing robustness and adaptation rate for proton therapy of lung cancer patients","volume":"196","author":"Badiu","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0140","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1002\/mp.15067","article-title":"Treatment planning and 4D robust evaluation strategy for proton therapy of lung tumors with large motion amplitude","volume":"48","author":"Taasti","year":"2021","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2025.111063_b0145","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1118\/1.3556559","article-title":"Minimax optimization for handling range and setup uncertainties in proton therapy","volume":"38","author":"Fredriksson","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2025.111063_b0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2019.08.005","article-title":"Practical robustness evaluation in radiotherapy \u2013 a photon and proton-proof alternative to PTV-based plan evaluation","volume":"141","author":"Korevaar","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0155","unstructured":"NVRO \u2013 Dutch Society for Radiotherapy and Oncology. Landelijk Indicatie Protocol Protonen Therapie 2019. https:\/\/nvro.nl\/images\/documenten\/rapporten\/LIPP_longen_final_01122019.pdf."},{"key":"10.1016\/j.radonc.2025.111063_b0160","doi-asserted-by":"crossref","DOI":"10.1097\/00005382-199621000-00002","article-title":"Types and mechanisms of pulmonary atelectasis","volume":"11","author":"Woodring","year":"1996","journal-title":"J Thorac Imaging"},{"key":"10.1016\/j.radonc.2025.111063_b0165","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/03009731003695624","article-title":"Pulmonary atelectasis and survival in advanced non-small cell lung carcinoma","volume":"115","author":"Bulbul","year":"2010","journal-title":"Ups J Med Sci"},{"key":"10.1016\/j.radonc.2025.111063_b0170","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0272-5231(21)01157-6","article-title":"Pleural effusion in lung cancer","volume":"14","author":"Sahn","year":"1993","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.radonc.2025.111063_b0175","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/resp.12496","article-title":"Clinical features and survival of lung cancer patients with pleural effusions","volume":"20","author":"Porcel","year":"2015","journal-title":"Respirology"},{"key":"10.1016\/j.radonc.2025.111063_b0180","doi-asserted-by":"crossref","first-page":"97623","DOI":"10.18632\/oncotarget.18824","article-title":"Thoracic radiation-induced pleural effusion and risk factors in patients with lung cancer","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.radonc.2025.111063_b0185","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3109\/0284186X.2015.1061209","article-title":"Adaptive radiotherapy for locally advanced non-small cell lung cancer, can we predict when and for whom?","volume":"54","author":"Berkovic","year":"2015","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0190","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2013.05.007","article-title":"Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach","volume":"107","author":"Langendijk","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0195","article-title":"Comparison of CBCT based synthetic CT methods suitable for proton dose calculations in adaptive proton therapy","volume":"65","author":"Thummerer","year":"2020","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2025.111063_b0200","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13014-021-01928-w","article-title":"Generating synthetic CT from low-dose cone-beam CT by using generative adversarial networks for adaptive radiotherapy","volume":"16","author":"Gao","year":"2021","journal-title":"Radiat Oncol Lond Engl"},{"key":"10.1016\/j.radonc.2025.111063_b0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13014-023-02222-7","article-title":"Dosimetric benefits of adaptive radiation therapy for patients with stage III non-small cell lung cancer","volume":"18","author":"Hoppen","year":"2023","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111063_b0210","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/acm2.12793","article-title":"\u201cDose of the day\u201d based on cone beam computed tomography and deformable image registration for lung cancer radiotherapy","volume":"21","author":"Yuan","year":"2020","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2025.111063_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109488","article-title":"Inter- and intrafractional 4D dose accumulation for evaluating \u0394NTCP robustness in lung cancer","volume":"182","author":"Smolders","year":"2023","journal-title":"Radiother Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025045670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025045670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:02:16Z","timestamp":1759521736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025045670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":43,"alternative-id":["S0167814025045670"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.111063","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of anatomical changes on dose and normal tissue complication probabilities and the benefit of replanning in photon and proton therapy of lung cancer patients","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.111063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111063"}}