{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:48:47Z","timestamp":1787165327972,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.radonc.2025.111068","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T23:56:24Z","timestamp":1753919784000},"page":"111068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Conditioned medium from brachytherapy-irradiated hepatocellular carcinoma cells drives SASP-mediated senescence in na\u00efve cellular counterparts"],"prefix":"10.1016","volume":"211","author":[{"given":"Josephine","family":"Naruhn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1965-7675","authenticated-orcid":false,"given":"Moritz N.","family":"Gr\u00f6per","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-3713","authenticated-orcid":false,"given":"Elif","family":"\u00d6cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Salvermoser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0860-8595","authenticated-orcid":false,"given":"Heidrun","family":"Hirner-Eppeneder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan N.","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp M.","family":"Kazmierczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Corradini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus-Christian","family":"Well","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Nahum","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stechele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-1662","authenticated-orcid":false,"given":"Marianna","family":"Alunni-Fabbroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.111068_b0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/02656730601094415","article-title":"Computer modeling of the effect of perfusion on heating patterns in radiofrequency tumor ablation","volume":"23","author":"Liu","year":"2007","journal-title":"Int J Hyperth"},{"key":"10.1016\/j.radonc.2025.111068_b0010","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.2217\/fon-2020-0669","article-title":"Systemic adjuvant treatment in hepatocellular carcinoma: tempted to do something rather than nothing","volume":"16","author":"Rizzo","year":"2020","journal-title":"Future Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0015","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdy308","article-title":"Hepatocellular carcinoma: ESMO Clinical Practice guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Vogel","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0020","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.trecan.2023.02.001","article-title":"Cell death, therapeutics, and the immune response in cancer","volume":"9","author":"Hanggi","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.radonc.2025.111068_b0025","doi-asserted-by":"crossref","unstructured":"Neophytou, C.M., I.P. Trougakos, N. Erin, and P. Papageorgis, Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance. Cancers (Basel), 2021. 13(17).","DOI":"10.3390\/cancers13174363"},{"key":"10.1016\/j.radonc.2025.111068_b0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.radonc.2025.111068_b0035","doi-asserted-by":"crossref","first-page":"16341","DOI":"10.1038\/s41598-023-42819-2","article-title":"Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation","volume":"13","author":"Markezana","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.radonc.2025.111068_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.101919","article-title":"CT-guided high dose rate brachytherapy can induce multiple systemic proteins of proliferation and angiogenesis predicting outcome in HCC","volume":"43","author":"Salvermoser","year":"2024","journal-title":"Transl Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0045","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13277-010-0042-8","article-title":"Radiation-induced cell death mechanisms","volume":"31","author":"Eriksson","year":"2010","journal-title":"Tumour Biol"},{"key":"10.1016\/j.radonc.2025.111068_b0050","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular Senescence: defining a Path Forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.radonc.2025.111068_b0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.radonc.2025.111068_b0060","article-title":"Radiation-induced bystander effect and its clinical implications","volume":"13","author":"Tang","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0065","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/febs.16381","article-title":"The role of cellular senescence and SASP in tumour microenvironment","volume":"290","author":"Takasugi","year":"2023","journal-title":"FEBS J"},{"key":"10.1016\/j.radonc.2025.111068_b0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12943-024-02096-7","article-title":"Cellular senescence and SASP in tumor progression and therapeutic opportunities","volume":"23","author":"Dong","year":"2024","journal-title":"Mol Cancer"},{"key":"10.1016\/j.radonc.2025.111068_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060860","article-title":"Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases","volume":"12","author":"Faggioli","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.radonc.2025.111068_b0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1748-717X-5-24","article-title":"Safety margin in irradiation of colorectal liver metastases: assessment of the control dose of micrometastases","volume":"5","author":"Seidensticker","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.radonc.2025.111068_b0090","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/acs.jproteome.0c00641","article-title":"Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-based Protein Profiling","volume":"20","author":"Petrera","year":"2021","journal-title":"J Proteome Res"},{"key":"10.1016\/j.radonc.2025.111068_b0095","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1038\/emm.2017.85","article-title":"Radiation-induced liver disease: current understanding and future perspectives","volume":"49","author":"Kim","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.radonc.2025.111068_b0100","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41420-021-00634-6","article-title":"Radiation-induced liver injury and hepatocyte senescence","volume":"7","author":"Zhu","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.radonc.2025.111068_b0105","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1002\/1878-0261.13042","article-title":"Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer","volume":"15","author":"Chambers","year":"2021","journal-title":"Mol Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2025.111068_b0115","article-title":"Cytokines: from Clinical significance to Quantification","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.radonc.2025.111068_b0120","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1002\/jps.22473","article-title":"Prolonged circulation half-life of interferon gamma activity by gene delivery of interferon gamma-serum albumin fusion protein in mice","volume":"100","author":"Miyakawa","year":"2011","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.radonc.2025.111068_b0125","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/mol.110.068486","article-title":"Different effects of the different natural CC chemokine receptor 2b ligands on beta-arrestin recruitment, Galphai signaling, and receptor internalization","volume":"79","author":"Berchiche","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.radonc.2025.111068_b0130","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1039\/C5SC03826J","article-title":"Systematic study of the dynamics and half-lives of newly synthesized proteins in human cells","volume":"7","author":"Chen","year":"2016","journal-title":"Chem Sci"},{"key":"10.1016\/j.radonc.2025.111068_b0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","article-title":"Oxidative stress in Cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.radonc.2025.111068_b0140","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1667\/RR13907.1","article-title":"Connecting radiation-induced bystander effects and senescence to improve radiation response prediction","volume":"183","author":"Poleszczuk","year":"2015","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2025.111068_b0145","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.radonc.2025.111068_b0150","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/s41419-021-04454-5","article-title":"Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma","volume":"12","author":"Schoetz","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.radonc.2025.111068_b0155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10599","article-title":"Senescence surveillance of pre-malignant hepatocytes limits liver cancer development","volume":"479","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2025.111068_b0160","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ccell.2016.09.003","article-title":"Distinct Functions of Senescence-Associated Immune responses in Liver Tumor Surveillance and Tumor Progression","volume":"30","author":"Eggert","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.radonc.2025.111068_b0165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13014-022-02184-2","article-title":"Radiation-induced senescence: therapeutic opportunities","volume":"18","author":"Kim","year":"2023","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111068_b0170","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1111\/cas.16184","article-title":"Senescence and senolysis in cancer: the latest findings","volume":"115","author":"Imawari","year":"2024","journal-title":"Cancer Sci"},{"key":"10.1016\/j.radonc.2025.111068_b0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41232-022-00197-8","article-title":"The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?","volume":"42","author":"Ohtani","year":"2022","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.radonc.2025.111068_b0180","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jconrel.2020.04.045","article-title":"Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic","volume":"323","author":"Galiana","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.radonc.2025.111068_b0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.exger.2017.01.026","article-title":"Rapamycin and the inhibition of the secretory phenotype","volume":"94","author":"Wang","year":"2017","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.radonc.2025.111068_b0190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12964-017-0172-3","article-title":"Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence\/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line","volume":"15","author":"Ortiz-Montero","year":"2017","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.radonc.2025.111068_b0195","doi-asserted-by":"crossref","first-page":"824","DOI":"10.14336\/AD.2023.0528","article-title":"Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-positive Generalized Myasthenia Gravis","volume":"15","author":"Jia","year":"2024","journal-title":"Aging Dis"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025045724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025045724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:02:22Z","timestamp":1759521742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025045724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":39,"alternative-id":["S0167814025045724"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.111068","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conditioned medium from brachytherapy-irradiated hepatocellular carcinoma cells drives SASP-mediated senescence in na\u00efve cellular counterparts","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.111068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111068"}}