{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:20:00Z","timestamp":1793424000392,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.radonc.2025.111097","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:49:09Z","timestamp":1754891349000},"page":"111097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Prospective clinical trial of upright image-guided proton therapy for locally recurrent head and neck and brain malignancies"],"prefix":"10.1016","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-6862","authenticated-orcid":false,"given":"Philip","family":"Blumenfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-1808","authenticated-orcid":false,"given":"Alexander","family":"Pryanichnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Wajnryt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviad","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimshon","family":"Winograd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Wygoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Salhab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-6913","authenticated-orcid":false,"given":"Marcel","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Popovtzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2025.111097_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110278","article-title":"Re-irradiation versus systemic therapy for the management of local-regionally recurrent head and neck cancer","volume":"196","author":"Chen","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijrobp.2016.02.036","article-title":"Proton Beam Reirradiation for Recurrent Head and Neck Cancer: Multi-institutional Report on Feasibility and Early Outcomes","volume":"95","author":"Romesser","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.111097_b0015","first-page":"725","article-title":"Criteria for Re-Irradiation","volume":"121","author":"Willmann","year":"2024","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.radonc.2025.111097_b0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.radonc.2020.03.006","article-title":"Proton therapy for head and neck squamous cell carcinomas: a review of the physical and clinical challenges","volume":"147","author":"Beddok","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0025","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1088\/0031-9155\/57\/11\/R99","article-title":"Range uncertainties in proton therapy and the role of Monte Carlo simulations","volume":"57","author":"Paganetti","year":"2012","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2025.111097_b0030","article-title":"A single-center experience of the upright proton therapy for skull-base chordomas and chondrosarcomas: Updated results","volume":"48","author":"Lemaeva","year":"2024","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0035","first-page":"213","article-title":"Proton therapy re-irradiation for head and neck cancers: Outcomes and prognostic factors","volume":"127","author":"Deek","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2025.111097_b0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/pro6.1149","article-title":"A review of proton therapy - current status and future directions","volume":"6","author":"Mohan","year":"2022","journal-title":"Precis Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1756-9966-29-47","article-title":"Patient positioning in the proton radiotherapy era","volume":"29","author":"Devicienti","year":"2010","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.radonc.2025.111097_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.930850","article-title":"Considerations for upright particle therapy patient positioning and associated image guidance","volume":"12","author":"Volz","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0055","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijrobp.2015.09.033","article-title":"Reassessment of the necessity of the proton gantry: Analysis of beam orientations from 4332 treatments at the Massachusetts General Hospital proton center over the past 10 years","volume":"95","author":"Yan","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.111097_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1417393","article-title":"Commissioning of a novel gantry-less proton therapy system","volume":"14","author":"Feldman","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110572","article-title":"Study of upright patient positioning reproducibility in image-guided proton therapy for head and neck cancers","volume":"201","author":"Feldman","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0070","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3390\/cancers15092555","article-title":"Image-Guided Proton Therapy: a Comprehensive Review","volume":"15","author":"Lane","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.radonc.2025.111097_b0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.semradonc.2003.10.003","article-title":"Errors and margins in radiotherapy","volume":"14","author":"van Herk","year":"2004","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0080","first-page":"30","article-title":"Impact of type of treatment center and access to care on mortality and survival for skull base chordoma and chondrosarcoma","volume":"15","author":"Palm","year":"2020","journal-title":"J Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.14129","article-title":"Relative thoracic changes from supine to upright patient position: a proton collaborative group study","volume":"24","author":"Marano","year":"2023","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2025.111097_b0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tipsro.2022.11.003","article-title":"Upright patient positioning for pelvic radiotherapy treatments","volume":"24","author":"Boisbouvier","year":"2022","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0095","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1134\/S1547477118070592","article-title":"Some results of the Clinical use of the Proton Therapy complex \u201cPrometheus\u201d","volume":"15","author":"Pryanichnikov","year":"2018","journal-title":"Phys Part Nuclei Lett"},{"key":"10.1016\/j.radonc.2025.111097_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1348291","article-title":"Upright proton therapy for esthesioneuroblastoma: a single-institution experience","volume":"14","author":"Gordon","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2025.111097_b0105","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ijrobp.2016.07.037","volume":"96","author":"McDonald","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.111097_b0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2016.03.053","article-title":"Reirradiation of Head and Neck Cancers with Proton Therapy: Outcomes and analyses","volume":"96","author":"Phan","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2025.111097_b0115","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.50607","article-title":"Evaluation of Proton Therapy Reirradiation for patients with Recurrent Head and Neck Squamous Cell Carcinoma","volume":"6","author":"Lee","year":"2023","journal-title":"JAMA Netw Open"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025046018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814025046018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:03:06Z","timestamp":1759521786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814025046018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":23,"alternative-id":["S0167814025046018"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2025.111097","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective clinical trial of upright image-guided proton therapy for locally recurrent head and neck and brain malignancies","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2025.111097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111097"}}