{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:14:18Z","timestamp":1790892858337,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.rbmo.2010.01.007","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T04:28:34Z","timestamp":1263529714000},"page":"444-452","source":"Crossref","is-referenced-by-count":75,"title":["Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review"],"prefix":"10.1016","volume":"20","author":[{"given":"Panagiotis","family":"Peitsidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2010.01.007_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejogrb.2004.07.024","article-title":"Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow","volume":"1","author":"Abd El Aal","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.rbmo.2010.01.007_bib2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF01203820","article-title":"Follicular aspiration does not protect against the development of ovarian hyperstimulation syndrome after GnRH agonist\/HMG superovulation for in-vitro fertilization","volume":"9","author":"Aboulghar","year":"1992","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2010.01.007_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0015-0282(97)81908-5","article-title":"Vascular endothelial growth factor plasma levels correlate to the clinical picture in severe ovarian hyperstimulation syndrome","volume":"67","author":"Abramov","year":"1997","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0015-0282(98)00249-0","article-title":"Serum vascular endothelial growth factor and Doppler blood flow velocities in in-vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries","volume":"70","author":"Agrawal","year":"1998","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib6","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0015-0282(02)04242-5","article-title":"Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than in women with normal ovaries","volume":"78","author":"Agrawal","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/13.3.651","article-title":"Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries","volume":"13","author":"Agrawal","year":"1998","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0015-0282(16)58145-X","article-title":"Transvaginal colour Doppler determination of the ovarian and uterine blood flow characteristics in polycystic ovary disease","volume":"65","author":"Aleem","year":"1996","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib10","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0015-0282(02)04849-5","article-title":"Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor, and insulin-like growth factor-1 in women with polycystic ovary syndrome","volume":"79","author":"Amin","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib11","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0015-0282(98)00221-0","article-title":"Changes in vascular endothelial growth factor levels and the risk of ovarian hyperstimulation in women enrolled in an in-vitro fertilization program","volume":"70","author":"Artini","year":"1998","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/09513590600906607","article-title":"Vascular endothelial growth factor and basic fibroblast growth factor in polycystic ovary syndrome during controlled ovarian hyperstimulation","volume":"22","author":"Artini","year":"2006","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2010.01.007_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/14647270802621358","article-title":"Vascular endothelial growth factor and its soluble receptor in patients with polycystic ovary syndrome undergoing IVF","volume":"12","author":"Artini","year":"2009","journal-title":"Hum. Fertil. (Camb.)"},{"issue":"1","key":"10.1016\/j.rbmo.2010.01.007_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/14647270802621358","article-title":"Vascular endothelial growth factor and its soluble receptor in patients with polycystic ovary syndrome undergoing IVF","volume":"12","author":"Artini","year":"2009","journal-title":"Hum. Fertil. (Camb.)"},{"key":"10.1016\/j.rbmo.2010.01.007_bib14","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/humrep\/dei475","article-title":"Serum inhibin A, VEGF and TNFalpha levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial","volume":"21","author":"Babayof","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib15","unstructured":"Balen, A., 2005. Ovarian hyperstimulation syndrome \u2013 a short report for the HFEA."},{"key":"10.1016\/j.rbmo.2010.01.007_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0002-9378(95)90094-2","article-title":"The role of color Doppler imaging in the diagnosis of polycystic ovary syndrome","volume":"172","author":"Battaglia","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2010.01.007_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3109\/00016348909015746","article-title":"Ovarian hyperstimulation due to exogenous gonadotrophin administration","volume":"69","author":"Bider","year":"1989","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"1","key":"10.1016\/j.rbmo.2010.01.007_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1472-6483(10)60420-8","article-title":"Follicular oestradiol and VEGF after GnRH antagonists or GnRH agonists in women with PCOS","volume":"18","author":"Bokal","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2010.01.007_bib17","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/humrep\/deh789","article-title":"Prolonged HCG action affects angiogenic substances and improves follicular maturation, oocyte quality and fertilization competence in patients with polycystic ovarian syndrome","volume":"20","author":"Bokal","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib20","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0015-0282(16)59223-1","article-title":"Induction of ovulation in polycystic ovary syndrome with a combination of luteinizing hormone releasing hormone analogue and exogenous gonadotropins","volume":"47","author":"Charbonnel","year":"1987","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib23","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/oxfordjournals.humrep.a138260","article-title":"The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicenter study. I. Clinical and biological features","volume":"8","author":"Delvigne","year":"1993","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib24","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/oxfordjournals.humrep.a138261","article-title":"The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicenter study. II. Multiple discriminant analysis for risk prediction","volume":"8","author":"Delvigne","year":"1993","journal-title":"Hum. Reprod."},{"issue":"94","key":"10.1016\/j.rbmo.2010.01.007_bib1a","first-page":"209","article-title":"The role of VEGF in the regulation of physiological and pathological angiogenesis","author":"Ferrara","year":"2005","journal-title":"EXS."},{"key":"10.1016\/j.rbmo.2010.01.007_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/er.18.1.4","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.rbmo.2010.01.007_bib26","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0002-9440(10)64322-2","article-title":"Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries","volume":"162","author":"Ferrara","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.rbmo.2010.01.007_bib29","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0015-0282(98)00301-X","article-title":"Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential","volume":"70","author":"Friedman","year":"1998","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00001703-200306000-00007","article-title":"New concepts in the understanding of the ovarian hyperstimulation syndrome","volume":"15","author":"Garc\u00eda-Velasco","year":"2003","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2010.01.007_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0015-0282(00)00670-1","article-title":"Role of vascular endothelial growth factor in ovarian physiology and pathology","volume":"74","author":"Geva","year":"2002","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.rbmo.2010.01.007_bib1b","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/gb-2005-6-2-209","article-title":"The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease","volume":"6","author":"Holmes","year":"2005","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.rbmo.2010.01.007_bib33","first-page":"157","article-title":"Expression of vascular permeability factor\/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development","volume":"146","author":"Kamat","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.rbmo.2010.01.007_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0015-0282(16)58152-7","article-title":"Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report","volume":"65","author":"Krasnow","year":"1996","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib35","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.fertnstert.2007.06.049","article-title":"Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome","volume":"89","author":"Lee","year":"2008","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.rbmo.2010.01.007_bib36","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1172\/JCI4814","article-title":"Role of vascular endothelial cell growth factor in Ovarian Hyperstimulation Syndrome","volume":"102","author":"Levin","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.rbmo.2010.01.007_bib1c","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/oxfordjournals.humrep.a137702","article-title":"In-vitro fertilization and the ovarian hyperstimulation syndrome","volume":"7","author":"MacDougall","year":"1992","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/oxfordjournals.humrep.a138029","article-title":"A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization and the ovarian hyperstimulation syndrome","volume":"8","author":"MacDougall","year":"1993","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.rbmo.2010.01.007_bib2a","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0015-0282(01)01854-4","article-title":"Concentrations of angiogenic factors in follicular fluid and oocyte-cumulus complex culture medium from women undergoing in vitro fertilization: association with oocyte maturity and fertilization","volume":"76","author":"Malamitsi-Puchner","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(94)93001-5","article-title":"Vascular endothelial growth factor as a capillary permeability agent in ovarian hyperstimulation syndrome","volume":"344","author":"McClure","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.rbmo.2010.01.007_bib47","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0015-0282(02)04244-9","article-title":"Vascular endothelial growth factor, polycystic ovary syndrome, and ovarian hyperstimulation syndrome","volume":"78","author":"Meldrum","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/molehr\/4.3.203","article-title":"Secretion of vascular endothelial growth factor\/vascular permeability factor from human luteinized granulosa cells is human chorionic gonadotrophin dependent","volume":"4","author":"Neulen","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib40","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/humrep\/deh853","article-title":"Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome","volume":"7","author":"Ng","year":"2005","journal-title":"Hum. Reprod."},{"issue":"8","key":"10.1016\/j.rbmo.2010.01.007_bib2b","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/oxfordjournals.humrep.a137488","article-title":"Modern management of ovarian hyperstimulation syndrome","volume":"6","author":"Rizk","year":"1991","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0015-0282(16)43508-9","article-title":"Ovarian hyperstimulation syndrome: a current survey","volume":"30","author":"Schenker","year":"1978","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib42","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/oxfordjournals.humrep.a137223","article-title":"Incidence of severe ovarian hyperstimulation syndrome after GnRH-agonist\/HMG superovulation for in-vitro fertilization","volume":"5","author":"Smitz","year":"1990","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib43","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1210\/jc.2006-2846","article-title":"Insulin and insulin-like growth factor stimulation of vascular endothelial growth factor production by luteinized granulosa cells: comparison between polycystic ovarian syndrome (PCOS) and non-PCOS women","volume":"92","author":"Stanek","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2010.01.007_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1439-0531.2004.00505.x","article-title":"Angiogenesis in developing follicle and corpus luteum","volume":"39","author":"Tamanini","year":"2004","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.rbmo.2010.01.007_bib45","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0015-0282(00)00684-1","article-title":"Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome","volume":"74","author":"Tulandi","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2010.01.007_bib46","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/humrep\/12.5.1047","article-title":"The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics","volume":"12","author":"Van Blerkom","year":"1997","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2010.01.007_bib48","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/oxfordjournals.humrep.a136222","article-title":"Ovarian stromal blood flow in women with polycystic ovaries a possible new marker for diagnosis?","volume":"10","author":"Zaidi","year":"1995","journal-title":"Hum. Reprod."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264831000009X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264831000009X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T01:12:07Z","timestamp":1558746727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147264831000009X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S147264831000009X"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2010.01.007","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}