{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:50:09Z","timestamp":1770904209553,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.rbmo.2012.06.022","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T10:19:12Z","timestamp":1342779552000},"page":"415-424","source":"Crossref","is-referenced-by-count":95,"title":["Evidence that miR-133a causes recurrent spontaneous abortion by reducing HLA-G expression"],"prefix":"10.1016","volume":"25","author":[{"given":"Xiaohong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2012.06.022_b0005","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1101\/gr.2845604","article-title":"MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues","volume":"14","author":"Barad","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.rbmo.2012.06.022_b0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.rbmo.2012.06.022_b0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/humupd\/2.2.118","article-title":"Reproductive failure due to spontaneous abortion and recurrent miscarriage","volume":"2","author":"Bulletti","year":"1996","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2012.06.022_b0020","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.mehy.2011.02.017","article-title":"HLA-G and pregnancy adverse outcomes","volume":"76","author":"Cecati","year":"2011","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.rbmo.2012.06.022_b0025","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.bjc.6605570","article-title":"MiR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer","volume":"102","author":"Chiyomaru","year":"2010","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.rbmo.2012.06.022_b0030","first-page":"1","article-title":"Immunology of recurrent spontaneous abortion","volume":"20","author":"Chong","year":"1995","journal-title":"Female Patient"},{"key":"10.1016\/j.rbmo.2012.06.022_b0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2474-12-115","article-title":"Transgenic overexpression of miR-133a in skeletal muscle","volume":"12","author":"Deng","year":"2012","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.rbmo.2012.06.022_b0040","first-page":"656","article-title":"Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage","volume":"47","author":"Eiben","year":"1990","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.rbmo.2012.06.022_b0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrm2621","article-title":"MicroRNAs: key regulators of stem cells","volume":"10","author":"Gangaraju","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0050","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1122689","article-title":"Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs","volume":"312","author":"Giraldez","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.rbmo.2012.06.022_b0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/scbi.1998.0109","article-title":"The regulation of HLA class I expression: Is HLA-G the odd one out?","volume":"9","author":"Gobin","year":"1999","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0060","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0198-8859(00)00198-1","article-title":"Transcriptional regulation of the MHC class Ib genes HLA-E, HLA-F, and HLA-G","volume":"61","author":"Gobin","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0065","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/molehr\/6.6.535","article-title":"HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies","volume":"6","author":"Goldman-Wohl","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2012.06.022_b0170","unstructured":"Grifo, J., Rosenwaks, Z., Cohen, J., Munn\u00e9, S., 1994. Implantation failure of morphologically normal human embryos is due largely to aneuploidy. In: Abstracts of the Fiftieth Annual Meeting of the American Fertility Society, San Antonio, Texas, p. 3."},{"issue":"255","key":"10.1016\/j.rbmo.2012.06.022_b0075","first-page":"e251","article-title":"Reduced third-trimester levels of soluble human leukocyte antigen G protein in severe preeclampsia","volume":"197","author":"Hackmon","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0080","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/humupd\/dmi048","article-title":"HLA-G in human reproduction: aspects of genetics, function and pregnancy complications","volume":"12","author":"Hviid","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2012.06.022_b0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.rbmo.2012.06.022_b0090","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"Lim","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.rbmo.2012.06.022_b0095","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1073\/pnas.0337539100","article-title":"HLA-G gene repression is reversed by demethylation","volume":"100","author":"Moreau","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.rbmo.2012.06.022_b0100","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/humrep\/del036","article-title":"The miscarriage-associated HLA-G\u2013725G allele influences transcription rates in JEG-3 cells","volume":"21","author":"Ober","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2012.06.022_b0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00404-004-0706-y","article-title":"An update in recurrent spontaneous abortion","volume":"272","author":"Pandey","year":"2005","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.rbmo.2012.06.022_b0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/molehr\/7.4.373","article-title":"The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion","volume":"7","author":"Pfeiffer","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2012.06.022_b0115","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.leukres.2008.08.003","article-title":"Demethylating agent 5-aza-2\u2019-deoxycytidine activates HLA-G expression in human leukemia cell lines","volume":"33","author":"Polakova","year":"2009","journal-title":"Leuk. Res."},{"key":"10.1016\/j.rbmo.2012.06.022_b0120","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1096\/fj.09-150698","article-title":"Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells","volume":"24","author":"Rao","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.rbmo.2012.06.022_b0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1600-0897.2009.00742.x","article-title":"Soluble human leukocyte antigen-G isoforms in maternal plasma in early and late pregnancy","volume":"62","author":"Rizzo","year":"2009","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.rbmo.2012.06.022_b0135","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.4049\/jimmunol.1001081","article-title":"HLA-G expression in human embryonic stem cells and preimplantation embryos","volume":"186","author":"Verloes","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0140","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/bmj.286.6377.1542","article-title":"Method of sampling chorionic villi in first trimester of pregnancy under guidance of real time ultrasound","volume":"286","author":"Ward","year":"1983","journal-title":"Brit. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.rbmo.2012.06.022_b0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2407-12-51","article-title":"Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion","volume":"12","author":"Wu","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.rbmo.2012.06.022_b0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.8755-8920.2001.460203.x","article-title":"High NK cell activity in early pregnancy correlates with subsequent abortion with normal chromosomes in women with recurrent abortion","volume":"46","author":"Yamada","year":"2001","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0155","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.4049\/jimmunol.175.12.8379","article-title":"Differential expression of alternatively spliced transcripts of HLA-G in human preimplantation embryos and inner cell masses","volume":"175","author":"Yao","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.rbmo.2012.06.022_b0160","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/bjc.2011.23","article-title":"The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer","volume":"104","author":"Yoshino","year":"2011","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.rbmo.2012.06.022_b0165","doi-asserted-by":"crossref","first-page":"e591","DOI":"10.1016\/j.ajog.2010.03.002","article-title":"Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells","volume":"202","author":"Zhu","year":"2010","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264831200418X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264831200418X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T01:52:24Z","timestamp":1542851544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147264831200418X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S147264831200418X"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2012.06.022","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}