{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:42:15Z","timestamp":1793194935834,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170568"],"award-info":[{"award-number":["81170568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.rbmo.2016.04.006","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T16:11:15Z","timestamp":1461946275000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome"],"prefix":"10.1016","volume":"33","author":[{"given":"Qiong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can-quan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2016.04.006_bib0010","first-page":"2434","article-title":"A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain","volume":"8","author":"Asunci\u00f3n","year":"2000","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0015","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0020","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/oxfordjournals.humrep.a138174","article-title":"Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin","volume":"8","author":"Balen","year":"1993","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.fertnstert.2008.12.032","article-title":"Female obesity impairs in vitro fertilization outcome without affecting embryo quality","volume":"93","author":"Bellver","year":"2010","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0030","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/humrep\/dep069","article-title":"Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction","volume":"24","author":"Berker","year":"2009","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0035","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S1472-6483(10)60037-5","article-title":"Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies","volume":"18","author":"Beydoun","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0040","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1002\/ajmg.a.31552","article-title":"High-throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with an an cillary FISH test for polyploidy","volume":"15","author":"Bruno","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tem.2010.12.002","article-title":"Metabolic syndrome and oocyte quality","volume":"22","author":"Cardozo","year":"2011","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0050","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/humrep\/den022","article-title":"Does free androgen index predict subsequent pregnancy outcome in women with recurrent miscarriage?","volume":"23","author":"Cocksedge","year":"2008","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0055","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/humrep\/13.2.290","article-title":"Polycystic ovary syndrome: anomalies in progesterone production","volume":"13","author":"Doldi","year":"1998","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1210\/er.2003-0021","article-title":"Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives","volume":"26","author":"Dosiou","year":"2005","journal-title":"Endocr. Rev"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0065","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1055\/s-2007-992925","article-title":"Oocyte quality in adult polycystic ovary syndrome","volume":"26","author":"Dumesic","year":"2008","journal-title":"Semin. Reprod. Med"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0070","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.2337\/db07-0074","article-title":"AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations","volume":"56","author":"Eng","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0075","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/humrep\/deq181","article-title":"Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome","volume":"25","author":"Harris","year":"2010","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0080","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bmj.297.6655.1024","article-title":"Influence of serum luteinizing hormone concentrations on ovulation, conception and early pregnancy loss in polycystic ovarian syndrome","volume":"297","author":"Homburg","year":"1988","journal-title":"BMJ"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0167-0115(93)90345-9","article-title":"Insulin-like growth factor regulation of human endometrial stromal cell function: coordinate effects on insulin-like growth factor binding protein-1, cell proliferation and prolactin secretion","volume":"48","author":"Irwin","year":"1993","journal-title":"Regul. Pept"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0090","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/pd.1970120705","article-title":"First trimester amniocentesis between the seventh and 13th weeks: evaluation of the earliest possible genetic diagnosis","volume":"12","author":"Kennerknecht","year":"1992","journal-title":"Prenat. Diagn"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0095","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1136\/jmg.2004.023671","article-title":"Screening for subtelomeric rearrangements in 210 patients with unexplained mental retardation using multiplex ligation dependent probe amplification (MLPA)","volume":"41","author":"Koolen","year":"2004","journal-title":"J. Med. Genet"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10815-009-9292-z","article-title":"Aneuploidy in abortuses following IVF and ICSI","volume":"26","author":"Kushnir","year":"2009","journal-title":"J. Assist. Reprod. Genet"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0105","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/humrep\/deq025","article-title":"Karyotype of miscarriages in relation to maternal weight","volume":"25","author":"Landres","year":"2010","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0110","first-page":"49","article-title":"Analysis of chromosome mosaicism in spontaneously aborted chorionic villus using an MLPA subtelomere assay with an ancillary FISH test","volume":"16","author":"Lei","year":"2008","journal-title":"Chin. J. Birth Health Hered"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0115","first-page":"253","article-title":"Genetic analysis of chorionic villi specimen in spontaneous abortion using various methods","volume":"44","author":"Lei","year":"2009","journal-title":"Zhong Hua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0120","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/09513591003632118","article-title":"Impact of overweight and underweight on IVF treatment in Chinese women","volume":"26","author":"Li","year":"2010","journal-title":"Gynecol. Endocrinol"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0125","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/humrep\/14.2.354","article-title":"Oocyte quality and treatment outcome in intracytoplasmic sperm injection cycles of polycystic ovarian syndrome patients","volume":"14","author":"Ludwig","year":"1999","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fertnstert.2009.07.989","article-title":"Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment","volume":"93","author":"Mart\u00ednez","year":"2010","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0135","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.fertnstert.2008.12.024","article-title":"The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, non hyper androgenemic polycystic ovary syndrome patients on in vitro fertilization outcome","volume":"93","author":"Nafiye","year":"2010","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0140","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0015-0282(98)00007-7","article-title":"Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function","volume":"69","author":"Okon","year":"1998","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-2008-1042958","article-title":"Implications of polycystic ovary syndrome on oocyte development","volume":"26","author":"Patel","year":"2008","journal-title":"Semin. Reprod. Med"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0150","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0140-6736(90)92765-A","article-title":"Hypersecretion of luteinizing hormone, infertility and miscarriage","volume":"336","author":"Regan","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0155","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0160","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1086\/421250","article-title":"Comparative genomic hybridization-array analysis enhances the detection of aneuploidies and submicroscopic imbalances in spontaneous miscarriages","volume":"74","author":"Schaeffer","year":"2004","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0165","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1093\/nar\/gnf056","article-title":"Relative quantification of 40nucleic acid sequences by multiplex ligation-dependent probe amplification","volume":"30","author":"Schouten","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0170","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/humrep\/12.3.474","article-title":"The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome","volume":"12","author":"Sengoku","year":"1997","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0175","series-title":"An International System for Human Cytogenetic Nomenclature (2013) ISCN 2013","author":"Shaffer","year":"2013"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/pd.1970030304","article-title":"Routine chromosome analysis on fetal blood micro aliquots obtained at fetoscopy","volume":"3","author":"Simoni","year":"1983","journal-title":"Prenat. Diagn"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0185","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s13353-013-0157-x","article-title":"First-trimester euploid miscarriages analysed by array-CGH","volume":"54","author":"Viaggi","year":"2013","journal-title":"J. Appl. Genet"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10815-010-9475-7","article-title":"Spindle and chromosome configurations of in vitro-matured oocytes from polycystic ovary syndrome and ovulatory infertile women: a pilot study","volume":"28","author":"Vieira","year":"2011","journal-title":"J. Assist. Reprod. Genet"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0195","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/GRF.0b013e318161719c","article-title":"Genetics of pregnancy loss","volume":"51","author":"Warren","year":"2008","journal-title":"Clin. Obstet. Gynecol"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0200","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.fertnstert.2006.12.018","article-title":"Lack of association between polycystic ovary syndrome and embryonic aneuploidy","volume":"88","author":"Weghofer","year":"2007","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0205","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/(SICI)1097-0223(199606)16:6<511::AID-PD904>3.0.CO;2-8","article-title":"Confined placental mosaicism for trisomies2, 3, 7, 8, 9, 16, and 22: their incidence, likely origins, and mechanisms for cell lineage compartmentalization","volume":"16","author":"Wolstenholme","year":"1996","journal-title":"Prenat. Diagn"},{"key":"10.1016\/j.rbmo.2016.04.006_bib0210","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1210\/jc.2006-2123","article-title":"Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis","volume":"92","author":"Wood","year":"2007","journal-title":"Clin. Endocrinol. Metab"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648316300694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648316300694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T23:27:07Z","timestamp":1536794827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648316300694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1472648316300694"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2016.04.006","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2016.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}