{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:38:55Z","timestamp":1792132735395,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.rbmo.2017.03.023","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T15:15:19Z","timestamp":1493046919000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"title":["Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-1951","authenticated-orcid":false,"given":"Malin","family":"Nylander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Fr\u00f8ssing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle V.","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kistorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven O.","family":"Skouby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2017.03.023_bib0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0378-5122(80)90044-4","article-title":"Interrelationships between sex hormone-binding globulin and testosterone, 5 alpha-dihydrotestosterone and oestradiol-17 beta in blood of normal men","volume":"2","author":"Bartsch","year":"1980","journal-title":"Maturitas"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0015","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3109\/09513590.2016.1169267","article-title":"Effect of sleeve gastrectomy bariatric surgery-induced weight loss on serum AMH levels in reproductive aged women","volume":"32","author":"Bhandari","year":"2016","journal-title":"Gynecol. Endocrinol"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0020","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humupd\/dmw027","article-title":"Interactions between androgens, FSH, anti-M\u00fcllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary","volume":"22","author":"Dewailly","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12958-015-0134-9","article-title":"Role of Anti-M\u00fcllerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: a review","volume":"13","author":"Dumont","year":"2015","journal-title":"Reprod. Biol. Endocrinol"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0035","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1210\/jc.2013-2040","article-title":"Renaming PCOS-a two-state solution","volume":"98","author":"Dunaif","year":"2013","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0040","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1210\/jc.2008-0115","article-title":"Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome","volume":"93","author":"Elkind-Hirsch","year":"2008","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0045","first-page":"254","article-title":"The LIPT-Study: on risk markers of vascular thrombosis in polycystic ovary syndrome. A randomized, double-blind, placebo-controlled study of the effect of Liraglutide","volume":"5","author":"Fr\u00f8ssing","year":"2015","journal-title":"J. Obes. Weight Loss Ther"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0050","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1093\/humrep\/dem202","article-title":"Ultrasound in polycystic ovary syndrome \u2013 the measuring of ovarian stroma and relationship with circulating androgens: results of a multicentric study","volume":"22","author":"Fulghesu","year":"2007","journal-title":"Hum. Repro"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0055","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13048-015-0161-3","article-title":"Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study","volume":"8","author":"Jensterle","year":"2015","journal-title":"J. Ovarian Res"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF03401383","article-title":"A 12-week treatment with the long-acting glucagon-like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polycystic ovary syndrome","volume":"14","author":"Jensterle","year":"2015","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/07435800.2014.966385","article-title":"Short-term intervention with liraglutide improved eating behavior in obese women with polycystic ovary syndrome","volume":"40","author":"Jensterle","year":"2015","journal-title":"Endocr. Res"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0070","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3892\/etm.2016.3081","article-title":"Metformin as an initial adjunct to low-dose liraglutide enhances the weight-decreasing potential of liraglutide in obese polycystic ovary syndrome: Randomized control study","volume":"11","author":"Jensterle","year":"2016","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0075","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12902-015-0005-6","article-title":"The effects of treatment with liraglutide on atherothrombotic risk in obese young women with polycystic ovary syndrome and controls","volume":"15","author":"Kahal","year":"2015","journal-title":"BMC Endocr. Disord"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0080","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.fertnstert.2014.02.039","article-title":"Influence of oral contraceptives on anthropomorphometric, endocrine, and metabolic profiles of anovulatory polycystic ovary syndrome patients","volume":"101","author":"Mes-Krowinkel","year":"2014","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0085","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1210\/jc.2007-1188","article-title":"The use of anti-mullerian hormone in predicting menstrual response after weight loss in overweight women with polycystic ovary syndrome","volume":"92","author":"Moran","year":"2007","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1210\/jcem-72-1-83","article-title":"A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome","volume":"72","author":"Nestler","year":"1991","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0095","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.fertnstert.2011.09.006","article-title":"Randomized comparison of the influence of dietary management and\/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome","volume":"96","author":"Nybacka","year":"2011","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0100","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.fertnstert.2013.06.030","article-title":"Serum antim\u00fcllerian hormone in response to dietary management and\/or physical exercise in overweight\/obese women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial","volume":"100","author":"Nybacka","year":"2013","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0105","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/jc.2006-1582","article-title":"Granulosa cell production of anti-M\u00fcllerian hormone is increased in polycystic ovaries","volume":"92","author":"Pellatt","year":"2007","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0115","doi-asserted-by":"crossref","first-page":"E238","DOI":"10.1152\/ajpendo.90684.2008","article-title":"Anti-Mullerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels","volume":"296","author":"Piouka","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0120","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.fertnstert.2009.01.114","article-title":"Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial","volume":"93","author":"Romualdi","year":"2010","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0125","doi-asserted-by":"crossref","first-page":"E821","DOI":"10.1210\/jc.2010-1725","article-title":"The metabolic status modulates the effect of metformin on the antimullerian hormone-androgens-insulin interplay in obese women with polycystic ovary syndrome","volume":"96","author":"Romualdi","year":"2011","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0135","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1093\/humrep\/dep101","article-title":"The effect of weight loss on anti-M\u00fcllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment","volume":"24","author":"Thomson","year":"2009","journal-title":"Hum. Reprod"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0140","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1210\/jc.2011-2939","article-title":"Hyperinsulinemia amplifies GnRH agonist stimulated ovarian steroid secretion in women with polycystic ovary syndrome","volume":"97","author":"Tosi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11695-015-1729-0","article-title":"Roux-en-Y Gastric Bypass Surgery in Patients with Polycystic Ovary Syndrome and Metabolic Syndrome","volume":"26","author":"Turkmen","year":"2016","journal-title":"Obes. Surg"},{"key":"10.1016\/j.rbmo.2017.03.023_bib0150","doi-asserted-by":"crossref","first-page":"d7771","DOI":"10.1136\/bmj.d7771","article-title":"Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials","volume":"344","author":"Vilsb\u00f8ll","year":"2012","journal-title":"BMJ"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648317301943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648317301943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T15:40:54Z","timestamp":1569080454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648317301943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1472648317301943"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2017.03.023","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2017.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}