{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:12:14Z","timestamp":1783728734382,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.rbmo.2017.08.020","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T08:47:19Z","timestamp":1503650839000},"page":"571-575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased insulin resistance in men with unexplained infertility"],"prefix":"10.1016","volume":"35","author":[{"given":"Ragaa","family":"Mansour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahia","family":"El-Faissal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Aboulserour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Aboulghar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Fahmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2017.08.020_bib0010","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2337\/diacare.26.4.1297","article-title":"American Association of Clinical Endocrinologists (AACE) consensus conference on the insulin resistance syndrome","volume":"26","author":"Bloomgarden","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/andr.12135","article-title":"Prevalence of male secondary hypogonadism in moderate to severe obesity and its relationship with insulin resistance and excess body weight","volume":"4","author":"Calder\u00f3n","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0020","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1745-7262.2006.00123.x","article-title":"Male idiopathic oligoasthenoteratozoospermia","volume":"8","author":"Cavallini","year":"2006","journal-title":"Asian J. Androl"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0025","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.fertnstert.2009.01.100","article-title":"Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormon levels among men attending an infertility clinic","volume":"93","author":"Chavarro","year":"2010","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0030","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/j.1939-4640.1999.tb02504.x","article-title":"Modulation of insulin-like growth factor-1 in the seminal plasma of infertile men","volume":"20","author":"Colombo","year":"1999","journal-title":"J. Androl"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0035","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1038\/ncomms9464","article-title":"Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome","volume":"6","author":"Day","year":"2015","journal-title":"Nat. Commun"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0040","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr. Rev"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4161\/epi.4.1.7311","article-title":"Perturbation of genomic imprinting in oligospermia","volume":"4","author":"Filliponi","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0050","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2337\/dc11-1833","article-title":"The association between IGF-I and insulin resistance: a general population study in Danish adults","volume":"35","author":"Friedrich","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0055","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/jmedgenet-2011-100427","article-title":"Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts","volume":"49","author":"Goodarzi","year":"2012","journal-title":"J. Med. Genet"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1742-4755-8-24","article-title":"Does weight loss improve semen quality and reproductive hormones? Results from a cohort of severely obese men","volume":"8","author":"H\u00e5konsen","year":"2011","journal-title":"Reprod. Health"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0065","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1038\/ncomms8502","article-title":"Genome- wide association of polycystic ovary syndrome implicates alterations in gonadotrophin secretion in European ancestry populations","volume":"8","author":"Hayes","year":"2015","journal-title":"Nat. Commun"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0070","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.fertnstert.2004.03.056","article-title":"Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men","volume":"82","author":"Jensen","year":"2004","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0075","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0080","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.rbmo.2017.08.020_bib0085","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0002-9343(01)00948-2","article-title":"Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome","volume":"111","author":"Legro","year":"2001","journal-title":"Am. J. Med"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0090","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1210\/jcem.87.5.8387","article-title":"Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome","volume":"87","author":"Legro","year":"2002","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0095","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/jc.2016-1659","article-title":"Benefit of delayed fertility therapy with preconception weight loss over immediate therapy in obese women with PCOS","volume":"101","author":"Legro","year":"2016","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1477-7827-12-34","article-title":"Obesity is associated with increased seminal insulin alongside reduced fertility parameters in a controlled male cohort","volume":"12","author":"Leisegang","year":"2014","journal-title":"Reprod. Biol. Endocrinol"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0105","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2016-2692","article-title":"Discovery of novel lipid profiles in PCOS: do insulin and androgen oppositely regulate bioactive lipid production?","author":"Li","year":"2016","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0110","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1093\/humrep\/deu282","article-title":"Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome","volume":"29","author":"Liu","year":"2014","journal-title":"Hum. Reprod"},{"issue":"3","key":"10.1016\/j.rbmo.2017.08.020_bib0115","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1016\/j.fertnstert.2013.07.1323","article-title":"Insulin resistance: a new diagnosis for the pathogenesis of idiopathic oligozoospermia and non-obstructive azoospermia","volume":"100","author":"Mansour","year":"2013","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.metabol.2012.08.012","article-title":"The complex interaction between obesity, metabolic syndrome and reproductive axis:a narrative review","volume":"62","author":"Michalakis","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0130","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched- chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0135","series-title":"Andrology","first-page":"457","article-title":"Empirical therapies for idiopathic male infertility","author":"Nieschlag","year":"2010"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0140","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1210\/jc.2008-0255","article-title":"Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood","volume":"93","author":"Recabarren","year":"2008","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0145","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1210\/jc.2007-2256","article-title":"Metabolic profile in sons of women with polycystic ovary syndrome","volume":"93","author":"Recabarren","year":"2008","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0150","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1365-2265.1996.674495.x","article-title":"Dyslipidaemia is associated with insulin resistance in women with polycystic ovaries","volume":"44","author":"Robinson","year":"1996","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0950-3552(97)80039-9","article-title":"Current concepts of polycystic ovary syndrome","volume":"11","author":"Rosenfield","year":"1997","journal-title":"Baillieres Clin. Obstet. Gynaecol"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0160","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The Pathogenesis of Polycystic Ovary Syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0165","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2337\/dc07-2190","article-title":"Metabolic phenotype in the brothers of women with polycystic ovary syndrome","volume":"31","author":"Sam","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0170","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2337\/diacare.28.1.120","article-title":"Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance","volume":"28","author":"Sesti","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0175","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","article-title":"Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome","volume":"44","author":"Shi","year":"2012","journal-title":"Nat. Genet"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0180","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00125-002-0836-3","article-title":"Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome","volume":"45","author":"Sir-Petermann","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0185","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1210\/jc.2016-1650","article-title":"Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23\u201325\u2009kg\/m2","volume":"101","author":"Takeno","year":"2016","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0190","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fertnstert.2016.03.029","article-title":"Increased antim\u00fcllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome","volume":"106","author":"Torchen","year":"2016","journal-title":"Fertil. Steril"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0195","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4081\/aiua.2014.1.5","article-title":"Is there any effect of insulin resistance on male reproductive system?","volume":"86","author":"Verit","year":"2014","journal-title":"Arch. Ital. Urol. Androl"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0200","series-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm-cervical Mucus Interaction","author":"WHO","year":"2010"},{"key":"10.1016\/j.rbmo.2017.08.020_bib0205","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1210\/jc.2002-021499","article-title":"Glucose intolerance, insulin resistance, and hyperandrogenemia in first degree relatives of women with polycystic ovary syndrome","volume":"88","author":"Yildiz","year":"2003","journal-title":"J. Clin. Endocrinol. Metab"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648317303826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648317303826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T13:44:24Z","timestamp":1719409464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648317303826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1472648317303826"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2017.08.020","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased insulin resistance in men with unexplained infertility","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2017.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.","name":"copyright","label":"Copyright"}]}}