{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:00Z","timestamp":1790704860228,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.rbmo.2019.03.213","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T13:28:19Z","timestamp":1554470899000},"page":"211-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Triggering method in assisted reproduction alters the cumulus cell transcriptome"],"prefix":"10.1016","volume":"39","author":[{"given":"Noga","family":"Fuchs Weizman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon A","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itai","family":"Gat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Balakier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mugundhine","family":"Sangaralingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Kenigsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford L.","family":"Librach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2019.03.213_bib0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10815-010-9481-9","article-title":"The cumulus cell gene expression profile of oocytes with different nuclear maturity and potential for blastocyst formation","volume":"28","author":"Adriaenssens","year":"2011","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0002","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/humrep\/deq049","article-title":"Cumulus cell gene expression is associated with oocyte developmental quality and influenced by patient and treatment characteristics","volume":"25","author":"Adriaenssens","year":"2010","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190698","article-title":"Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy","volume":"13","author":"Alexander","year":"2018","journal-title":"PloS one"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0004","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biology"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0005","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/bioinformatics\/btu638","article-title":"Htseq\u2014a python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0006","author":"Andrews","year":"2010","journal-title":"Fastqc: A quality control tool for high throughput sequence data"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0007","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/molehr\/gaq032","article-title":"Human cumulus cells as biomarkers for embryo and pregnancy outcomes","volume":"16","author":"Assou","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0008","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/humrep\/dei475","article-title":"Serum inhibin a, vegf and tnfalpha levels after triggering oocyte maturation with gnrh agonist compared with hcg in women with polycystic ovaries undergoing ivf treatment: A prospective randomized trial","volume":"21","author":"Babayof","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0009","first-page":"453","article-title":"Gene expression during oogenesis and oocyte development in mammals","volume":"1","author":"Bachvarova","year":"1985","journal-title":"Dev. Biol. (N Y 1985)"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0010","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.fertnstert.2014.06.012","article-title":"Pigment epithelium-derived factor exerts antioxidative effects in granulosa cells","volume":"102","author":"Bar-Joseph","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0011","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/humrep\/deq290","article-title":"In vitro maturation of human germinal vesicle-stage oocytes: Role of epidermal growth factor-like growth factors in the culture medium","volume":"26","author":"Ben-Ami","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0012","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.rbmo.2017.03.009","article-title":"Live birth rates in various subgroups of poor ovarian responders fulfilling the bologna criteria","volume":"34","author":"Bozdag","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0013","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/bioinformatics\/btt015","article-title":"Scotty: A web tool for designing RNA-seq experiments to measure differential gene expression","volume":"29","author":"Busby","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0014","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10815-011-9704-8","article-title":"Empty follicle syndrome after gnrha triggering versus hcg triggering in cos","volume":"29","author":"Castillo","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0015","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1261\/rna.046011.114","article-title":"Power analysis and sample size estimation for RNA-seq differential expression","volume":"20","author":"Ching","year":"2014","journal-title":"RNA (New York, N.Y.)"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0016","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1530\/REP-14-0251","article-title":"Role of pigment epithelium-derived factor in the reproductive system","volume":"148","author":"Chuderland","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0017","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S1701-2163(15)30417-5","article-title":"The prevention of ovarian hyperstimulation syndrome","volume":"36","author":"Corbett","year":"2014","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0018","doi-asserted-by":"crossref","first-page":"D472","DOI":"10.1093\/nar\/gkt1102","article-title":"The reactome pathway knowledgebase","volume":"42","author":"Croft","year":"2014","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0019","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1210\/endo.142.7.8277","article-title":"Control of mouse cumulus cell-oocyte complex integrity before and after ovulation: Plasminogen activator synthesis and matrix degradation","volume":"142","author":"D'alessandris","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0020","first-page":"203","article-title":"Comparison of hcg triggering versus hcg in combination with a gnrh agonist: A prospective randomized controlled trial","volume":"6","author":"Decleer","year":"2014","journal-title":"Facts Views Vis. Obgyn."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0021","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1477-7827-2-44","article-title":"Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and fsh receptor mrna expression in equine cumulus-oocyte complexes cultured in vitro in the presence of fsh and precursors for hyaluronic acid synthesis","volume":"2","author":"Dell'aquila","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0022","first-page":"211","article-title":"Systematic review of data concerning etiopathology of ovarian hyperstimulation syndrome","volume":"47","author":"Delvigne","year":"2002","journal-title":"Int. J. Fertil. Womens Med."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0023","doi-asserted-by":"crossref","first-page":"e47106","DOI":"10.1371\/journal.pone.0047106","article-title":"Cumulus cells gene expression profiling in terms of oocyte maturity in controlled ovarian hyperstimulation using gnrh agonist or gnrh antagonist","volume":"7","author":"Devjak","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0024","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.fertnstert.2009.10.034","article-title":"Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting","volume":"94","author":"Diluigi","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01133025","article-title":"A randomized prospective study on the effect of short and long buserelin treatment in women with repeated unsuccessful in vitro fertilization (ivf) cycles due to inadequate ovarian response","volume":"8","author":"Dirnfeld","year":"1991","journal-title":"J. In Vitro Fert. Embryo Transf."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0026","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1530\/rep.0.1220829","article-title":"Oocyte control of ovarian follicular development and function in mammals","volume":"122","author":"Eppig","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0027","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/pmed.1994.1093","article-title":"Nested case-control studies","volume":"23","author":"Ernster","year":"1994","journal-title":"Preventive Medicine"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0028","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The reactome pathway knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0029","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/jcem.87.2.8197","article-title":"Endocrine profiles after triggering of final oocyte maturation with gnrh agonist after cotreatment with the gnrh antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization","volume":"87","author":"Fauser","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0030","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/humrep\/der092","article-title":"Eshre consensus on the definition of \u2018poor response' to ovarian stimulation for in vitro fertilization: The bologna criteria\u2020","volume":"26","author":"Ferraretti","year":"2011","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0031","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/humrep\/dem336","article-title":"Gene expression in human cumulus cells: One approach to oocyte competence","volume":"22","author":"Feuerstein","year":"2007","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humupd\/dmt044","article-title":"The transcriptome of follicular cells: Biological insights and clinical implications for the treatment of infertility","volume":"20","author":"Fragouli","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0033","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humupd\/dmm040","article-title":"Oocyte-secreted factors: Regulators of cumulus cell function and oocyte quality","volume":"14","author":"Gilchrist","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0034","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humupd\/dmi045","article-title":"Gnrh agonist for triggering final oocyte maturation in the gnrh antagonist ovarian hyperstimulation protocol: A systematic review and meta-analysis","volume":"12","author":"Griesinger","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0035","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fertnstert.2006.12.006","article-title":"Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles","volume":"88","author":"Griesinger","year":"2007","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0036","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.fertnstert.2014.04.028","article-title":"Dual trigger with gonadotropin-releasing hormone agonist and standard dose human chorionic gonadotropin to improve oocyte maturity rates","volume":"102","author":"Griffin","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176019","article-title":"Sliding scale hcg trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: Analysis of 10,427 ivf-icsi cycles","volume":"12","author":"Gunnala","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0038","doi-asserted-by":"crossref","first-page":"653-659 e1","DOI":"10.1016\/j.fertnstert.2016.06.002","article-title":"Standard human chorionic gonadotropin versus double trigger for final oocyte maturation results in different granulosa cells gene expressions: A pilot study","volume":"106","author":"Haas","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0039","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1210\/jc.2008-0127","article-title":"Gonadotropin-releasing hormones i and ii induce apoptosis in human granulosa cells","volume":"93","author":"Hong","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0303-7207(99)00219-1","article-title":"Role of lh and fsh in ovarian function","volume":"161","author":"Howles","year":"2000","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0041","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/humupd\/dml005","article-title":"Are endogenous lh levels during ovarian stimulation for ivf using gnrh analogues associated with the probability of ongoing pregnancy? A systematic review","volume":"12","author":"Humaidan","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0042","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/humupd\/dmr008","article-title":"a.T.W.G. Gnrh agonist for triggering of final oocyte maturation: Time for a change of practice?","volume":"17","author":"Humaidan","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0043","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.fertnstert.2014.04.047","article-title":"Human chorionic gonadotropin vs. Gonadotropin-releasing hormone agonist trigger in assisted reproductive technology\u2013\"the king is dead, long live the king!\"","volume":"102","author":"Humaidan","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0044","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"Kegg: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0045","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/09513590.2016.1193141","article-title":"Combined ovulation triggering with gnrh agonist and hcg in ivf patients","volume":"32","author":"Kasum","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0046","first-page":"89","article-title":"Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients","volume":"15","author":"Kenigsberg","year":"2009","journal-title":"MHR: Basic science of reproductive medicine"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0047","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/molehr\/gav032","article-title":"Characterization of fsh signalling networks in bovine cumulus cells: A perspective on oocyte competence acquisition","volume":"21","author":"Khan","year":"2015","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0048","first-page":"229","article-title":"The differential transcriptome and ontology profiles of floating and cumulus granulosa cells in stimulated human antral follicles","volume":"16","author":"K\u00f5ks","year":"2010","journal-title":"MHR: Basic science of reproductive medicine"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0049","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0974-1208.192056","article-title":"Gonadotropin-releasing hormone agonist trigger is a better alternative than human chorionic gonadotropin in pcos undergoing ivf cycles for an ohss free clinic: A randomized control trial","volume":"9","author":"Krishna","year":"2016","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0050","author":"Krueger","year":"2012","journal-title":"Trim galore!"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0051","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.fertnstert.2011.01.019","article-title":"Follicle-stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: A randomized, double-blind, placebo-controlled trial","volume":"95","author":"Lamb","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0052","author":"Leo","year":"1999","journal-title":"Ovarian kaleidoscope database"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0053","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.18632\/oncotarget.23916","article-title":"Dual trigger of triptorelin and hcg optimizes clinical outcome for high ovarian responder in gnrh-antagonist protocols","volume":"9","author":"Li","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0054","doi-asserted-by":"crossref","first-page":"e91796","DOI":"10.1371\/journal.pone.0091796","article-title":"Is a gnrh antagonist protocol better in pcos patients? A meta-analysis of rcts","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0055","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.fertnstert.2013.07.1976","article-title":"Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in gnrh-antagonist cycles","volume":"100","author":"Lin","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0056","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s10815-013-0061-7","article-title":"Role of gap junction-mediated communications in regulating large-scale chromatin configuration remodeling and embryonic developmental competence acquisition in fully grown bovine oocyte","volume":"30","author":"Lodde","year":"2013","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0057","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/mrd.20639","article-title":"Large-scale chromatin remodeling in germinal vesicle bovine oocytes: Interplay with gap junction functionality and developmental competence","volume":"74","author":"Lodde","year":"2007","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0058","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.4081\/ejh.2012.e37","article-title":"Large-scale chromatin morpho-functional changes during mammalian oocyte growth and differentiation","volume":"56","author":"Luciano","year":"2012","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0059","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0303-7207(99)00218-X","article-title":"Signal transduction mechanism for lh in the cumulus-oocyte complex","volume":"161","author":"Mattioli","year":"2000","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0060","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1093\/humrep\/deh535","article-title":"Human cumulus granulosa cell gene expression: A predictor of fertilization and embryo selection in women undergoing ivf","volume":"19","author":"Mckenzie","year":"2004","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0061","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.rbmo.2009.06.001","article-title":"Gnrh agonist versus recombinant hcg in an oocyte donation programme: A randomized, prospective, controlled, assessor-blind study","volume":"19","author":"Melo","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0062","doi-asserted-by":"crossref","first-page":"E1428","DOI":"10.1210\/jc.2015-2312","article-title":"Gnrh agonist triggering modulates pedf to vegf ratio inversely to hcg in granulosa cells","volume":"100","author":"Miller","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0063","first-page":"65","article-title":"Mechanism of mammalian ovulation","volume":"294","author":"Morioka","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0064","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1016\/S0021-9258(19)40704-7","article-title":"Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action","volume":"250","author":"Moyle","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/uog.14684","article-title":"Ovarian hyperstimulation syndrome: Pathophysiology, staging, prediction and prevention","volume":"45","author":"Nastri","year":"2015","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0066","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5935\/1518-0557.20160047","article-title":"Final oocyte maturation in assisted reproduction with human chorionic gonadotropin and gonadotropin-releasing hormone agonist (dual trigger)","volume":"20","author":"Oliveira","year":"2016","journal-title":"JBRA Assist. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0067","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.euf.2016.03.008","article-title":"Validation of gene expression signatures to identify low-risk clear-cell renal cell carcinoma patients at higher risk for disease-related death","volume":"2","author":"Parasramka","year":"2016","journal-title":"European Urology Focus"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0068","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.1092463","article-title":"Egf-like growth factors as mediators of lh action in the ovulatory follicle","volume":"303","author":"Park","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0069","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"Edger: A bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0071","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biology"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0072","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1477-7827-7-35","article-title":"The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: Fsh level predicts oocyte recovery","volume":"7","author":"Rosen","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0073","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/humupd\/dml062","article-title":"Molecular mechanisms of ovulation: Co-ordination through the cumulus complex","volume":"13","author":"Russell","year":"2007","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0074","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/humrep\/dev083","article-title":"Human cumulus-enclosed germinal vesicle oocytes from early antral follicles reveal heterogeneous cellular and molecular features associated with in vitro maturation capacity","volume":"30","author":"Sanchez","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0075","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.fertnstert.2007.07.1316","article-title":"Can pregnancy rate be improved in gonadotropin-releasing hormone (gnrh) antagonist cycles by administering gnrh agonist before oocyte retrieval? A prospective, randomized study","volume":"90","author":"Schachter","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0076","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2007.11.014","article-title":"Local production of the gonadotropic hormones in the rat ovary","volume":"282","author":"Schirman-Hildesheim","year":"2008","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0077","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0015-0282(16)46288-6","article-title":"Biological rhythm of the luteinizing hormone surge in women","volume":"37","author":"Seibel","year":"1982","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0078","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/oxfordjournals.humrep.a138520","article-title":"Induction of pre-ovulatory luteinizing hormone surge by gonadotrophin-releasing hormone agonist for women at risk for developing the ovarian hyperstimulation syndrome","volume":"9","author":"Shalev","year":"1994","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0079","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.fertnstert.2007.06.030","article-title":"Gonadotropin-releasing hormone agonist combined with a reduced dose of human chorionic gonadotropin for final oocyte maturation in fresh autologous cycles of in vitro fertilization","volume":"90","author":"Shapiro","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0080","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1016\/S0021-9258(17)33113-7","article-title":"Studies on the role of plasminogen activator in ovulation. In vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins","volume":"251","author":"Strickland","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0081","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0082","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1038\/s41598-017-07039-5","article-title":"Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence","volume":"7","author":"Sugimura","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0083","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/molehr\/gan069","article-title":"Chromatin configurations in the germinal vesicle of mammalian oocytes","volume":"15","author":"Tan","year":"2009","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0084","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology","volume":"25","author":"The Gene Ontology","year":"2000","journal-title":"Nature genetics"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0085","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the gene ontology knowledgebase and resources","volume":"45","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0086","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"Tophat: Discovering splice junctions with RNA-seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2013.01.129","article-title":"Cumulus and granulosa cell markers of oocyte and embryo quality","volume":"99","author":"Uyar","year":"2013","journal-title":"Fertility and sterility"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0088","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/humrep\/der036","article-title":"Cumulus cell gene expression predicts better cleavage-stage embryo or blastocyst development and pregnancy for icsi patients","volume":"26","author":"Wathlet","year":"2011","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0089","author":"Wingett","year":"2011","journal-title":"Fastq screen"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0090","first-page":"719","article-title":"Characterization of the human cumulus cell transcriptome during final follicular maturation and ovulation","volume":"20","author":"Yerushalmi","year":"2014","journal-title":"MHR: Basic science of reproductive medicine"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0091","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.rbmo.2017.09.002","article-title":"Dual trigger of final oocyte maturation in poor ovarian responders undergoing ivf\/icsi cycles","volume":"35","author":"Zhang","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0092","first-page":"399","article-title":"The signal pathway of gonadotrophins-induced mammalian oocyte meiotic resumption","volume":"15","author":"Zhang","year":"2009","journal-title":"MHR: Basic science of reproductive medicine"},{"key":"10.1016\/j.rbmo.2019.03.213_bib0093","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/09513590.2014.978850","article-title":"Co-administration of gnrh-agonist and hcg, for final oocyte maturation (double trigger), in patients with low proportion of mature oocytes","volume":"31","author":"Zilberberg","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0094","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mrd.1126","article-title":"Mouse xist expression begins at zygotic genome activation and is timed by a zygotic clock","volume":"61","author":"Zuccotti","year":"2002","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.rbmo.2019.03.213_bib0095","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/mrd.1080410410","article-title":"Chromatin organization during mouse oocyte growth","volume":"41","author":"Zuccotti","year":"1995","journal-title":"Mol. Reprod. Dev."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648319303724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648319303724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T09:45:58Z","timestamp":1663235158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648319303724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1472648319303724"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2019.03.213","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triggering method in assisted reproduction alters the cumulus cell transcriptome","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2019.03.213","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.","name":"copyright","label":"Copyright"}]}}