{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:43:21Z","timestamp":1791729801395,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.rbmo.2019.04.017","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T20:13:18Z","timestamp":1556223198000},"page":"332-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"title":["GLP-1 receptor agonists versus metformin in PCOS: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"39","author":[{"given":"Yi","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2019.04.017_bib0001","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41574-018-0016-2","article-title":"Glucagon-like peptide 1 in health and disease","volume":"14","author":"Andersen","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0002","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0015-0282(01)01975-6","article-title":"Metformin directly inhibits androgen production in human thecal cells","volume":"76","author":"Attia","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0003","first-page":"104","article-title":"Polycystic ovary syndrome: current status and future perspective","volume":"6","author":"Barthelmess","year":"2014","journal-title":"Front. Biosci. (Elite Ed)."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0004","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mce.2012.10.010","article-title":"Adipocyte biology in polycystic ovary syndrome","volume":"373","author":"Barber","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0005","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/humrep\/13.6.1502","article-title":"Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment","volume":"13","author":"Clark","year":"1998","journal-title":"Ham. Reprod."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0006","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1530\/eje.0.1380269","article-title":"Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome","volume":"138","author":"Diamanti-Kandarakis","year":"1998","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0007","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/157488412800958686","article-title":"GLP-1 agonists exenatide and liraglutide: a review about their safety and efficacy","volume":"7","author":"Derosa","year":"2012","journal-title":"Curr. Clin. Pharmacol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0008","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1210\/jc.2008-0115","article-title":"Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome","volume":"93","author":"Elkind-Hirsch","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0009","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.fertnstert.2010.03.081","article-title":"Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions","volume":"94","author":"Farrell","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0010","first-page":"241","article-title":"Effect study of Exenatide on patients with polycystic ovary syndrome and type 2 diabetes in plateau area","volume":"25","author":"Fan","year":"2017","journal-title":"Chin. J. Diabetes."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0011","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0303-7207(98)00178-6","article-title":"Genetics of Polycystic Ovary Syndrome","volume":"145","author":"Franks","year":"1998","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0012","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/dmrr.499","article-title":"Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes","volume":"20","author":"Fineman","year":"2004","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0013","first-page":"539","article-title":"Pilot clinical study on the efficacy of liraglutide in treating polycystic ovary syndrome patients with type 2 diabetes mellitus","volume":"31","author":"Gao","year":"2016","journal-title":"Clinical. Focus."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0014","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0015","first-page":"S38","article-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration (Eds):","volume":"5","author":"Higgins","year":"2011","journal-title":"Naunyn-Schmiedebergs Archiv f\u00fcr experimentelle Pathologie und Pharmakologie"},{"key":"10.1016\/j.rbmo.2019.04.017_bib0016","first-page":"1470","article-title":"Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone","volume":"84","author":"Huber-Buchholz","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0017","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-nutr-071812-161201","article-title":"Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose","volume":"34","author":"Hayes","year":"2014","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0018","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1475-2840-10-109","article-title":"Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes","volume":"10","author":"Inoue","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0019","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1530\/EJE-13-0797","article-title":"Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin","volume":"170","author":"Jensterle","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF03401383","article-title":"A 12-week treatment with the long-acting glucagon-like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polycystic ovary syndrome","volume":"14","author":"Jensterle","year":"2015","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.rbmo.2019.04.017_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-015-0161-3","article-title":"Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study","volume":"8","author":"Jensterle","year":"2015","journal-title":"J. Ovarian. Res."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0022","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0023","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/cen.13454","article-title":"Efficacy of exenatide on weight loss, metabolic parameters and pregnancy in overweight\/obese polycystic ovary syndrome","volume":"87","author":"Liu","year":"2017","journal-title":"Clin. Endocrinol(Oxf)."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0024","article-title":"Comparison of treatment with exenatide and metformin in overweight women with polycystic ovary syndrome","author":"Lin","year":"2015","journal-title":"Fujian Medical University"},{"key":"10.1016\/j.rbmo.2019.04.017_bib0025","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1007\/s00125-012-2592-3","article-title":"Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes","volume":"55","author":"Lee","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.rbmo.2019.04.017_bib0026","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1210\/er.2002-0015","article-title":"Insulin-lowering agents in the management of polycystic ovary syndrome","volume":"24","author":"Leo","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0027","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1093\/humrep\/des335","article-title":"Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women","volume":"27","author":"Mart\u00ednez-garc\u00eda","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0028","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJM199608293350902","article-title":"Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome","volume":"335","author":"Nestler","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0029","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00404-015-3976-7","article-title":"A systematic review of GLP-1 agonists on the metabolic syndrome in women with polycystic ovaries","volume":"293","author":"Niafar","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0030","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.fertnstert.2017.06.026","article-title":"Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline","volume":"108","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0031","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/humrep\/dep466","article-title":"Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS) relationship to the ovulatory response","volume":"25","author":"Palomba","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0032","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0033","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jpeds.2012.11.019","article-title":"Using the androgen excess-PCOS society criteria to diagnose polycystic ovary syndrome and the risk of metabolic syndrome in adolescents","volume":"162","author":"Roe","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0034","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/dom.12593","article-title":"Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas","volume":"18","author":"Smits","year":"2016","journal-title":"Diabetes. Obes. Metab."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0035","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1177\/1933719116635278","article-title":"Effects of exenatide on metabolic changes, sexual hormones, inflammatory cytokines, adipokines, and weight change in a DHEA-Treated rat model","volume":"23","author":"Sun","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0036","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cen.13795","article-title":"International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"89","author":"Teede","year":"2018","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0037","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.molmet.2014.09.005","article-title":"2014. GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipo-genesis in insulin resistance","volume":"3","author":"Taher","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0039","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/obr.12720","article-title":"Pharmacologic therapy to induce weight loss in women who have obesity\/overweight with polycystic ovary syndrome: a systematic review and network meta-analysis","volume":"19","author":"Wang","year":"2018","journal-title":"Obes. Rev."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0040","article-title":"The study of GLP-1 analogue in PI3K\/AKT\/FoxO1 pathway in the ovaries of rats with polycystic ovary sydrome","author":"Yang","year":"2016","journal-title":"Guangxi Medical University"},{"key":"10.1016\/j.rbmo.2019.04.017_bib0041","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1345\/aph.1H060","article-title":"Exenatide: A new option for the treatment of type 2 diabetes","volume":"40","author":"Yoo","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0042","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.obmed.2017.06.003","article-title":"Short term monotherapy with exenatide is superior to metformin in weight loss, improving insulin resistance and inflammation in Chinese overweight\/obese PCOS women","volume":"7","author":"Zheng","year":"2017","journal-title":"Obes. Med."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0043","first-page":"1105","article-title":"Therapeutic effect of glucagon-like peptide-1 analogue-Exenatide on polycystic ovary syndrome rats","volume":"30","author":"Zhen","year":"2015","journal-title":"Maternal and Child Health Care of China"},{"key":"10.1016\/j.rbmo.2019.04.017_bib0044","first-page":"267","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","volume":"21","author":"Zawadzki","year":"1992","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.rbmo.2019.04.017_bib0045","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.3390\/ijms19102863","article-title":"Metformin: An Old Drug with New Applications","volume":"19","author":"Zhou","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648319303943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648319303943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:16:04Z","timestamp":1761466564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648319303943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1472648319303943"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2019.04.017","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GLP-1 receptor agonists versus metformin in PCOS: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2019.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}