{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:11:22Z","timestamp":1771333882051,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.rbmo.2020.03.016","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T02:49:09Z","timestamp":1588733349000},"page":"290-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early intervention for heterotopic caesarean scar pregnancy to preserve intrauterine pregnancy may improve outcomes: a retrospective cohort study"],"prefix":"10.1016","volume":"41","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziru","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.rbmo.2020.03.016_bib0001","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1055\/s-0035-1545918","article-title":"Operative Therapy for Heterotopic Scar Pregnancy and Successful Birth of the Intrauterine Foetus - Case Report and Review of the Literature","volume":"75","author":"Armbrust","year":"2015","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"01","key":"10.1016\/j.rbmo.2020.03.016_bib0002","first-page":"5","article-title":"Expert consensus of treatment on cesarean section pregnancy after cesarean section","volume":"15","year":"2017","journal-title":"Clinical Education of General Practice"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0003","first-page":"1341","article-title":"Expectant management of heterotopic cesarean scar pregnancy","volume":"125","author":"Bai","year":"2012","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0004","doi-asserted-by":"crossref","first-page":"417 e9-15","DOI":"10.1016\/j.fertnstert.2006.05.085","article-title":"Heterotopic pregnancy: two cases and a comparative review","volume":"87","author":"Barrenetxea","year":"2007","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/uog.17568","article-title":"Outcome of Cesarean scar pregnancy managed expectantly: systematic review and meta-analysis","volume":"51","author":"Cali","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.rbmo.2020.03.016_bib0006","article-title":"Management and pregnancy outcomes of heterotopic pregnancy","volume":"53","author":"Chen","year":"2018","journal-title":"Chinese Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0009","doi-asserted-by":"crossref","first-page":"727","DOI":"10.5603\/GP.2016.0076","article-title":"Successful treatment of spontaneous heterotopic caesarean scar pregnancy by local potassium chloride injection with preservation of the intrauterine pregnancy","volume":"87","author":"Czuczwar","year":"2016","journal-title":"Ginekol. Pol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0010","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.fertnstert.2008.01.067","article-title":"Laparoscopic management of heterotopic cesarean scar pregnancy with preservation of intrauterine gestation and delivery at term: case report","volume":"91","author":"Demirel","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0011","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/1471-0528.13060","article-title":"Laparoscopic management of extrauterine pregnancy in caesarean section scar: description of a surgical technique and review of the literature","volume":"122","author":"Fuchs","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0012","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3109\/01443615.2010.491565","article-title":"Heterotopic caesarean section scar pregnancy","volume":"30","author":"Gupta","year":"2010","journal-title":"Journal of Obstetrics and Gynaecology"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0013","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/humrep\/deh080","article-title":"Heterotopic Caesarean scar pregnancy combined with intrauterine pregnancy successfully treated with embryo aspiration for selective embryo reduction: case report","volume":"19","author":"Hsieh","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0014","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/uog.56","article-title":"First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment Cesarean section scar","volume":"21","author":"Jurkovic","year":"2003","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0015","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/jog.12326","article-title":"Successful full-term twin deliveries in heterotopic cesarean scar pregnancy in a spontaneous cycle with expectant management","volume":"40","author":"Kim","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0016","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0140-6736(90)91593-Y","article-title":"Conservative treatment of ectopic pregnancy with local injection of hyperosmolar glucose solution or prostaglandin-F2 alpha: a prospective randomised study","volume":"336","author":"Lang","year":"1990","journal-title":"lancet"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0017","doi-asserted-by":"crossref","first-page":"e2570","DOI":"10.1097\/MD.0000000000002570","article-title":"Management of Heterotopic Pregnancy: Experience From 1 Tertiary Medical Center","volume":"95","author":"Li","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0018","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/uog.12341","article-title":"Value of transvaginal sonography in diagnosing heterotopic pregnancy after in-vitro fertilization with embryo transfer","volume":"41","author":"Li","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6832094","article-title":"Uterine Rupture with Cesarean Scar Heterotopic Pregnancy with Survival of the Intrauterine Twin","author":"Lincenberg","year":"2016","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2010.05.025","article-title":"Successful management of a triplet heterotopic caesarean scar pregnancy after in vitro fertilization-embryo transfer","volume":"95","author":"Litwicka","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0021","first-page":"639","article-title":"Heterotopic caesarean scar pregnancy after IVF-ET: a case report","author":"Liu","year":"2015","journal-title":"Journal of practical obstetrics and gynecology"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0023","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00404-017-4384-y","article-title":"Diagnosis and management of heterotopic pregnancy following embryo transfer: clinical analysis of 55 cases from a single institution","volume":"296","author":"Lyu","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0024","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jmig.2017.05.019","article-title":"Cesarean Scar Pregnancies: A Systematic Review of Treatment Options","volume":"24","author":"Maheux-Lacroix","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jcu.22507","article-title":"Treatment of heterotopic caesarean scar pregnancy complicated with post termination increase in size of residual mass and morbidly adherent placenta","volume":"46","author":"Miyague","year":"2018","journal-title":"J. Clin. Ultrasound"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0026","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/0974-1208.39595","article-title":"Heterotopic pregnancy in natural conception","volume":"1","author":"Mj","year":"2008","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0027","doi-asserted-by":"crossref","first-page":"e12233","DOI":"10.1097\/MD.0000000000012233","article-title":"The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management","volume":"97","author":"Na","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0028","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.7863\/ultra.33.9.1533","article-title":"Heterotopic cesarean scar pregnancy: diagnosis, treatment, and prognosis","volume":"33","author":"OuYang","year":"2014","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0029","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tjog.2016.06.020","article-title":"The value of hysteroscopic management of cesarean scar pregnancy: a report of 44 cases","volume":"56","author":"Pan","year":"2017","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/j.2205-0140.2011.tb00122.x","article-title":"A heterotopic pregnancy involving a caesarean section scar","volume":"14","author":"Paoletti","year":"2011","journal-title":"Australas J. Ultrasound Med."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0031","first-page":"74","article-title":"Ultrasonic diagnosis of caesarean scar pregnancy combined with intrauterine pregnancy:a case report","volume":"21","author":"Sun","year":"2019","journal-title":"Journal of clinical ultrasound in medicine"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0032","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/humrep\/deg010","article-title":"Successful management of a heterotopic Caesarean scar pregnancy: potassium chloride injection with preservation of the intrauterine gestation: case report","volume":"18","author":"Salomon","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2008.09.072","article-title":"Successful expectant management for a cornual heterotopic pregnancy","volume":"91","author":"Sentilhes","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0034","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/01443615.2010.522749","article-title":"Heterotopic pregnancy","volume":"31","author":"Talbot","year":"2011","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0035","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/OGX.0b013e3181b8b144","article-title":"Heterotopic cesarean scar pregnancy: how should it be managed?","volume":"64","author":"Taskin","year":"2009","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0036","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6478589","article-title":"Selective Reduction of a Heterotopic Cesarean Scar Pregnancy Complicated by Septic Abortion","author":"Tymon-Rosario","year":"2018","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0037","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jmig.2012.05.006","article-title":"Management of cesarean heterotopic pregnancy with transvaginal ultrasound-guided potassium chloride injection and gestational sac aspiration, and review of the literature","volume":"19","author":"Ugurlucan","year":"2012","journal-title":"J. Minim. Invasive Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0038","doi-asserted-by":"crossref","first-page":"547","DOI":"10.7863\/jum.2013.32.3.547","article-title":"Spontaneous heterotopic cesarean scar pregnancy: conservative management by transvaginal sonographic guidance and successful pregnancy outcome","volume":"32","author":"Uysal","year":"2013","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0039","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/AOG.0000000000001514","article-title":"Surgical Management of a Heterotopic Cesarean Scar Pregnancy With Preservation of an Intrauterine Pregnancy","volume":"128","author":"Vetter","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13256-018-1713-0","article-title":"Normal vaginal delivery at term after expectant management of heterotopic caesarean scar pregnancy: a case report","volume":"12","author":"Vikhareva","year":"2018","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2010.02.039","article-title":"Hysteroscopic management of heterotopic cesarean scar pregnancy","volume":"94","author":"Wang","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2006.11.192","article-title":"Successful management of heterotopic cesarean scar pregnancy combined with intrauterine pregnancy after in vitro fertilization-embryo transfer","volume":"88","author":"Wang","year":"2007","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0043","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jmig.2014.01.009","article-title":"Nonsurgical management of live tubal ectopic pregnancy by ultrasound-guided local injection and systemic methotrexate","volume":"21","author":"Wang","year":"2014","journal-title":"J. Minim. Invasive Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0044","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijgo.2015.06.029","article-title":"Factors associated with successful transabdominal sonography-guided dilation and curettage for early cesarean scar pregnancy","volume":"131","author":"Wu","year":"2015","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0045","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/uog.1050","article-title":"An unusual case of heterotopic twin pregnancy managed successfully with selective feticide","volume":"23","author":"Yazicioglu","year":"2004","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2020.03.016_bib0051","first-page":"800","article-title":"Clinical analysis on the application of selective uterine artery embolization combined with hysteroscopic operation in treatment of exogenous type cesarean section for uterine scar pregnancy","volume":"16","author":"Ying-mei","year":"2017","journal-title":"Journal of Clinical and Experimental Medicine"},{"key":"10.1016\/j.rbmo.2020.03.016_bib0050","first-page":"397","article-title":"Heterotopic caesarean scar pregnancy: a case report","volume":"48","author":"Yiwen","year":"2013","journal-title":"Chinses journal of obstetrics and gynecology"},{"issue":"1","key":"10.1016\/j.rbmo.2020.03.016_bib0046","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12884-016-1171-x","article-title":"Successful selective reduction of a heterotopic cesarean scar pregnancy in the second trimester: a case report and review of the literature","volume":"16","author":"Yu","year":"2016","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648320301711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648320301711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:19:14Z","timestamp":1761466754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648320301711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1472648320301711"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2020.03.016","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early intervention for heterotopic caesarean scar pregnancy to preserve intrauterine pregnancy may improve outcomes: a retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2020.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}