{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:35:27Z","timestamp":1790832927127,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.rbmo.2021.04.009","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T01:19:15Z","timestamp":1619227155000},"page":"52-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of homocysteine with IVF\/ICSI outcomes stratified by MTHFR C677T polymorphisms: a prospective cohort study"],"prefix":"10.1016","volume":"43","author":[{"given":"Luting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songchang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingshun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.rbmo.2021.04.009_bib0001","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","article-title":"5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review","volume":"151","author":"Botto","year":"2000","journal-title":"Am. J. Epidemiol."},{"issue":"9","key":"10.1016\/j.rbmo.2021.04.009_bib0002","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/humrep\/dep069","article-title":"Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction","volume":"24","author":"B\u00fclent","year":"2009","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1016\/j.rbmo.2021.04.009_bib0003","first-page":"55","article-title":"The effect of preconceptional multivitamin supplementation on fertility","volume":"66","author":"Czeizel","year":"1995","journal-title":"International Journal for Vitamin and Nutrition Research"},{"issue":"6","key":"10.1016\/j.rbmo.2021.04.009_bib0004","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.rbmo.2014.02.005","article-title":"MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women","volume":"28","author":"D'Elia","year":"2014","journal-title":"Reproductive BioMedicine Online"},{"issue":"7","key":"10.1016\/j.rbmo.2021.04.009_bib0005","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/humrep\/del081","article-title":"Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple","volume":"21","author":"Ebisch","year":"2006","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1016\/j.rbmo.2021.04.009_bib0006","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/humupd\/dml054","article-title":"The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility","volume":"13","author":"Ebisch","year":"2007","journal-title":"Human Reproduction Update"},{"issue":"1","key":"10.1016\/j.rbmo.2021.04.009_bib0007","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/AOG.0000000000000343","article-title":"Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth","volume":"124","author":"Gaskins","year":"2014","journal-title":"Obstetrics and Gynecology"},{"issue":"5","key":"10.1016\/j.rbmo.2021.04.009_bib0008","first-page":"401","volume":"28","year":"2017","journal-title":"Chinese Journal of Reproductive Health"},{"issue":"3","key":"10.1016\/j.rbmo.2021.04.009_bib0009","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1521-6934(03)00009-9","article-title":"Homocysteine and pregnancy","volume":"17","author":"Hague","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.rbmo.2021.04.009_bib0010","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3945\/ajcn.111.016212","article-title":"Maternal homocysteine and small-for-gestational-age offspring: systematic review and meta-analysis","volume":"95","author":"Hogeveen","year":"2012","journal-title":"The American journal of clinical nutrition"},{"issue":"3","key":"10.1016\/j.rbmo.2021.04.009_bib0011","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1095\/biolreprod64.3.918","article-title":"Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes","volume":"64","author":"Khosla","year":"2001","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.rbmo.2021.04.009_bib0012","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/aje\/kwg024","article-title":"5,10-Methylenetetrahydrofolate reductase polymorphisms and leukaemia risk: a HuGE minireview","volume":"157","author":"Kim","year":"2003","journal-title":"American Journal of Epidemiology"},{"issue":"6","key":"10.1016\/j.rbmo.2021.04.009_bib0013","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.rbmo.2011.03.002","article-title":"Folate-metabolizing gene variants and pregnancy outcome of IVF","volume":"22","author":"Laanpere","year":"2011","journal-title":"Reproductive BioMedicine Online"},{"issue":"4","key":"10.1016\/j.rbmo.2021.04.009_bib0014","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.reprotox.2010.07.002","article-title":"Teratogenicity and underlying mechanisms of homocysteine in animal models: a review","volume":"30","author":"Mil","year":"2010","journal-title":"Reproductive Toxicology"},{"issue":"53","key":"10.1016\/j.rbmo.2021.04.009_bib0015","first-page":"105","article-title":"Homocysteine in pregnancy","volume":"53","author":"Murphy","year":"2011","journal-title":"Advances in Clinical Chemistry"},{"issue":"6","key":"10.1016\/j.rbmo.2021.04.009_bib0016","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.rbmo.2014.01.017","article-title":"Stavreus-Evers A. Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility","volume":"28","author":"Murto","year":"2014","journal-title":"Reproductive Biomedicine Online"},{"issue":"4","key":"10.1016\/j.rbmo.2021.04.009_bib0017","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/humrep\/15.4.954","article-title":"Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss","volume":"15","author":"Nelen","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2021.04.009_bib0018","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.reprotox.2017.12.003","article-title":"Homocysteine pathway andin vitro fertilization outcome","volume":"76","author":"Paffoni","year":"2018","journal-title":"Reproductive toxicology (Elmsford, NY)"},{"issue":"3","key":"10.1016\/j.rbmo.2021.04.009_bib0030","first-page":"401","article-title":"Guideline for the prevention of neural tube defects by periconceptional folic acid supplementation (2017)","volume":"28","author":"Ren","year":"2017","journal-title":"Chinese Journal of Reproductive Health"},{"issue":"3","key":"10.1016\/j.rbmo.2021.04.009_bib0019","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/aje\/kwm078","article-title":"Preconception B-vitamin and homocysteine status, conception, and early pregnancy loss","volume":"166","author":"Ronnenberg","year":"2007","journal-title":"American Journal of Epidemiology"},{"issue":"6","key":"10.1016\/j.rbmo.2021.04.009_bib0020","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0026-0495(03)00032-5","article-title":"Serum homocysteine levels are increased in women with gestational diabetes mellitus","volume":"52","author":"Seghieri","year":"2003","journal-title":"Metabolism-clinical and Experimental"},{"issue":"2","key":"10.1016\/j.rbmo.2021.04.009_bib0021","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/cge.12910","article-title":"Maternal genetic polymorphisms and unexplained recurrent miscarriage: a systematic review and meta-analysis","volume":"91","author":"Shi","year":"2017","journal-title":"Clinical Genetics"},{"issue":"6","key":"10.1016\/j.rbmo.2021.04.009_bib0022","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/humupd\/dmt041","article-title":"The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism","volume":"19","author":"Steegers-Theunissen","year":"2013","journal-title":"Hum. Reprod. Update"},{"issue":"3","key":"10.1016\/j.rbmo.2021.04.009_bib0023","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1056\/NEJM199101173240315","article-title":"Neural-tube defects and derangement of homocysteine metabolism","volume":"324","author":"Steegers-Theunissen","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.rbmo.2021.04.009_bib0024","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0301-2115(02)00358-5","article-title":"Nutrient-gene interactions in early pregnancy: a vascular hypothesis","volume":"106","author":"Steegers-Theunissen","year":"2003","journal-title":"European Journal of Obstetrics Gynecology and Reproductive Biology"},{"issue":"4","key":"10.1016\/j.rbmo.2021.04.009_bib0025","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.reprotox.2010.07.002","article-title":"Teratogenicity and underlying mechanisms of homocysteine in animal models: a review","volume":"30","author":"van Mil","year":"2010","journal-title":"Reproductive toxicology (Elmsford, NY)"},{"issue":"12","key":"10.1016\/j.rbmo.2021.04.009_bib0026","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-0528.2006.01109.x","article-title":"Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease","volume":"113","author":"Verkleij-Hagoort","year":"2006","journal-title":"Bjog"},{"issue":"4","key":"10.1016\/j.rbmo.2021.04.009_bib0027","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ajcn\/71.4.962","article-title":"Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study","volume":"71","author":"Vollset","year":"2000","journal-title":"American Journal of Clinical Nutrition"},{"issue":"3","key":"10.1016\/j.rbmo.2021.04.009_bib0028","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/cge.12929","article-title":"Geographical and ethnic distribution of MTHFR gene polymorphisms and their associations with diseases among Chinese population","volume":"92","author":"Yang","year":"2017","journal-title":"Clin. Genet."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321001851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321001851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:21:09Z","timestamp":1761466869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648321001851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1472648321001851"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.04.009","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of homocysteine with IVF\/ICSI outcomes stratified by MTHFR C677T polymorphisms: a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}