{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:02:01Z","timestamp":1791993721925,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006489","name":"Commissariat \u00e0 l&apos;\u00c9nergie Atomique et aux \u00c9nergies Alternatives","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016036","name":"Electricit\u00e9 de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006289","name":"Groupe EDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.rbmo.2021.06.027","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T20:02:42Z","timestamp":1625342562000},"page":"799-809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mouse model of radiation-induced premature ovarian insufficiency reveals compromised oocyte quality: implications for fertility preservation"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-960X","authenticated-orcid":false,"given":"Vincent","family":"Puy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Barroca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Messiaen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Devanand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Moison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Justine","family":"Guerquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Livera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2021.06.027_bib0001","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ar.1090940210","article-title":"Estimation of nuclear population from microtome sections","volume":"94","author":"Abercrombie","year":"1946","journal-title":"Anat. Rec."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0002","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/humupd\/dmn063","article-title":"The current knowledge on radiosensitivity of ovarian follicle development stages","volume":"15","author":"Adriaens","year":"2009","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0003","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.0900975","article-title":"Cadmium Increases Human Fetal Germ Cell Apoptosis","volume":"118","author":"Angenard","year":"2010","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0004","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1667\/RR13776.1","article-title":"Mutagenic Effects of Ionizing Radiation on Immature Rat Oocytes","volume":"182","author":"Asakawa","year":"2014","journal-title":"rare"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0027-5107(71)90028-5","article-title":"Comparative aspects of the effects of radiation during oogenesis","volume":"11","author":"Baker","year":"1971","journal-title":"Mutat. Res."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0006","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1471-0528.2002.t01-1-01007.x","article-title":"Late effects of the treatment of childhood cancer on the female reproductive system and the potential for fertility preservation","volume":"109","author":"Bath","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0007","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2017.03.008","article-title":"Tridimensional Visualization and Analysis of Early Human Development","volume":"169","author":"Belle","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0008","first-page":"574","article-title":"[Assessment of the genetic risk of radiation by irradiation data from laboratory mammals]","volume":"21","author":"Benova","year":"1985","journal-title":"Genetika"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0009","series-title":"Cytotoxic Insult to Tissue Effects on Cell Lineages, part 2: the ovary","author":"Bianchi","year":"1983"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0010","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1247671","article-title":"Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway","volume":"343","author":"Bolcun-Filas","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0011","article-title":"Impact of cancer treatment on uterine function","volume":"64\u201368","author":"Critchley","year":"2005","journal-title":"J. Natl. Cancer Inst. Monographs"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0012","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1093\/brain\/awu230","article-title":"Diffusion tensor imaging and neurocognition in survivors of childhood acute lymphoblastic leukaemia","volume":"137","author":"Edelmann","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0013","doi-asserted-by":"crossref","DOI":"10.1177\/1559325820916572","article-title":"A Comparison of Cs-137 \u03b3 Rays and 320-kV X-Rays in a Mouse Bone Marrow Transplantation Model","volume":"18","author":"Gott","year":"2020","journal-title":"Dose Response"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0014","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ando.2010.02.021","article-title":"Human ovarian follicular development: from activation of resting follicles to preovulatory maturation","volume":"71","author":"Gougeon","year":"2010","journal-title":"Ann. Endocrinol. (Paris)"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0015","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ar.1091840409","article-title":"Folliculogenesis in the ovary of the mature mouse: A radioautographic study","volume":"184","author":"Hoage","year":"1976","journal-title":"Anat. Rec."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0016","unstructured":"IRSN, InVS, n.d. Doses d\u00e9livr\u00e9es aux patients en scanographie et en radiologie conventionnelle. 2020"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0017","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.ijrobp.2003.08.031","article-title":"Pregnancy outcomes after abdominal irradiation that included or excluded the pelvis in childhood Wilms tumor survivors: a report from the National Wilms Tumor Study","volume":"58","author":"Kalapurakal","year":"2004","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0018","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.molcel.2012.08.017","article-title":"DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa","volume":"48","author":"Kerr","year":"2012","journal-title":"Molecular Cell"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0019","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.3802\/jgo.2016.27.e22","article-title":"Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women","volume":"27","author":"Kim","year":"2016","journal-title":"J. Gynecol. Oncol."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1530\/REP-18-0089","article-title":"Radiation-induced ovarian follicle loss occurs without overt stromal changes","volume":"155","author":"Kimler","year":"2018","journal-title":"Reproduction"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0021","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-4320(00)00072-5","article-title":"Natural and radiation-induced degeneration of primordial and primary follicles in mouse ovary","volume":"59","author":"Lee","year":"2000","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0022","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1530\/REP-07-0054","article-title":"p63 null mutation protects mouse oocytes from radio-induced apoptosis","volume":"135","author":"Livera","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0023","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.celrep.2018.06.110","article-title":"Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence","volume":"24","author":"Miller","year":"2018","journal-title":"Cell Reports"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0024","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1095\/biolreprod.113.117077","article-title":"The ovarian reserve of primordial follicles and the dynamic reserve of antral growing follicles: what is the link?","volume":"90","author":"Monniaux","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0025","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3181\/00379727-109-27330","article-title":"Gamma-ray sensitivity of oocytes of immature mice","volume":"109","author":"Oakberg","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0026","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2009.10.007","article-title":"Whole-body or isolated ovary (60)Co irradiation: effects on in vivo and in vitro folliculogenesis and oocyte maturation","volume":"29","author":"Pesty","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0027","first-page":"1432","volume":"60","year":"1971","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0028","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"The Lancet"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0029","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00272479","article-title":"Chromosome anomalies in mouse oocytes after irradiation","volume":"28","author":"Reichert","year":"1975","journal-title":"Hum. Genet."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0030","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","article-title":"Megabase chromatin domains involved in DNA double-strand breaks in vivo","volume":"146","author":"Rogakou","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56881-2","article-title":"Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes","volume":"10","author":"Satoh","year":"2020","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.rbmo.2021.06.027_bib0032","first-page":"82","article-title":"Preserving fertility in prepubertal children","volume":"71","author":"Sauvat","year":"2009","journal-title":"Horm. Res."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0033","article-title":"A Comparison of in vivo Cellular Responses to CS-137 Gamma Rays and 320-KV X Rays. Dose-Response 11","volume":"1","author":"Scott","year":"2013","journal-title":"dose-response"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0034","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0027-5107(91)90010-L","article-title":"Specific-locus experiments show that female mice exposed near the time of birth to low-LET ionizing radiation exhibit both a low mutational response and a dose-rate effect","volume":"249","author":"Selby","year":"1991","journal-title":"Mutation Research\/Fundamental and Molecular Mechanisms of Mutagenesis"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0035","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0140-6736(10)60752-0","article-title":"Stillbirth and neonatal death in relation to radiation exposure before conception: a retrospective cohort study","volume":"376","author":"Signorello","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0036","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1073\/pnas.2001124117","article-title":"Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health","volume":"117","author":"Stringer","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0037","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nature05337","article-title":"p63 protects the female germ line during meiotic arrest","volume":"444","author":"Suh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0038","article-title":"ESHRE guideline: female fertility preservation\u2020","volume":"2020","author":"Anderson","year":"2020","journal-title":"Human Reproduction Open"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0039","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41594-018-0035-7","article-title":"Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63","volume":"25","author":"Tuppi","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF01331174","article-title":"Comparison of X-ray and gamma-ray dose-response curves for pink somatic mutations in Tradescantia clone 02","volume":"13","author":"Underbrink","year":"1976","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0041","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1259\/0007-1285-62-743-995","article-title":"Ovarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte","volume":"62","author":"Wallace","year":"1989","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.rbmo.2021.06.027_bib0042","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/humrep\/deg016","article-title":"The radiosensitivity of the human oocyte","volume":"18","author":"Wallace","year":"2003","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0043","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ijrobp.2004.11.038","article-title":"Predicting age of ovarian failure after radiation to a field that includes the ovaries","volume":"62","author":"Wallace","year":"2005","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0044","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0027-5107(85)90028-4","article-title":"Discrimination between the effects of X-ray irradiation of the mouse oocyte and uterus on the induction of dominant lethals and congenital anomaliesI. Embryo-transfer experiments","volume":"149","author":"West","year":"1985","journal-title":"Mutation Research\/Fundamental and Molecular Mechanisms of Mutagenesis"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/humupd\/dmy002","article-title":"The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing","volume":"24","author":"Winship","year":"2018","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0046","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1200\/JCO.2007.15.2884","article-title":"Spontaneous Abortion in a Danish Population-Based Cohort of Childhood Cancer Survivors","volume":"26","author":"Winther","year":"2008","journal-title":"JCO"},{"key":"10.1016\/j.rbmo.2021.06.027_bib0047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247501","article-title":"Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras","volume":"16","author":"Wittenborn","year":"2021","journal-title":"PLoS One"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321003114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321003114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:22:45Z","timestamp":1761466965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648321003114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1472648321003114"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.06.027","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mouse model of radiation-induced premature ovarian insufficiency reveals compromised oocyte quality: implications for fertility preservation","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}