{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:08:46Z","timestamp":1791673726324,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004914","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.rbmo.2021.09.002","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T19:35:15Z","timestamp":1631388915000},"page":"1126-1136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Barriers and factors associated with significant delays to initial consultation and treatment for infertile patients and partners of infertile patients"],"prefix":"10.1016","volume":"43","author":[{"given":"Alice","family":"Domar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Vassena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vegni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Collura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Markert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Samuelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Guiglotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Roitmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2021.09.002_bib0001","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.fertnstert.2012.05.032","article-title":"Diagnostic evaluation of the infertile female: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0002","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.fertnstert.2006.04.054","article-title":"What's the delay? A qualitative study of women's experiences of reaching a diagnosis of endometriosis","volume":"86","author":"Ballard","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0003","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/humrep\/dem046","article-title":"International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care","volume":"22","author":"Boivin","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0004","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.rbms.2018.10.012","article-title":"What makes people ready to conceive? Findings from the International Fertility Decision-Making Study","volume":"6","author":"Boivin","year":"2018","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0005","first-page":"623","article-title":"Grosse SD., US State-Level Infertility Insurance Mandates and Health Plan Expenditures on Infertility Treatments. Matern","volume":"23","author":"Boulet","year":"2019","journal-title":"Child Health J."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0006","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/humrep\/dep340","article-title":"When and why do subfertile couples discontinue their fertility care? A longitudinal cohort study in a secondary care subfertility population","volume":"24","author":"Brandes","year":"2009","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0007","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1093\/humrep\/dem057","article-title":"Decision-making about seeking medical advice in an internet sample of women trying to get pregnant","volume":"22","author":"Bunting","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0008","doi-asserted-by":"crossref","first-page":"hoz044","DOI":"10.1093\/hropen\/hoz044","article-title":"Survey on ART and IUI: legislation, regulation, funding and registries in European countries: The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)","volume":"1","author":"Calhaz-Jorge","year":"2020","journal-title":"Hum. Reprod. Open"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0009","first-page":"1","article-title":"Infertility service use in the United States: data from the National Survey of Family Growth, 1982-2010","volume":"73","author":"Chandra","year":"2014","journal-title":"National Health Statistics Reports"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0010","first-page":"598","article-title":"Long-term economic benefits attributed to IVF-conceived children: a lifetime tax calculation","volume":"9","author":"Connolly","year":"2008","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0011","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejogrb.2012.10.022","article-title":"Timing, characteristics and determinants of infertility diagnostic work up before admission to eleven second-level assisted reproductive techniques (ART) centres in Italy","volume":"167","author":"Costa","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0012","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/humrep\/des061","article-title":"Patients from across Europe have similar views on patient-centred care: an international multilingual qualitative study in infertility care","volume":"27","author":"Dancet","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0013","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1093\/humrep\/dew265","article-title":"Men's knowledge of their own fertility: a population-based survey examining the awareness of factors that are associated with male infertility","volume":"31","author":"Daumler","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0014","first-page":"102","article-title":"The economic impact of infertility on women in developing countries \u2011 a systematic review","volume":"4","author":"Dyer","year":"2012","journal-title":"Facts, Views Vis. Obgyn."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0015","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.fertnstert.2010.03.068","article-title":"Predictors of not pursuing infertility treatment after an infertility diagnosis: examination of a prospective U.S. cohort","volume":"94","author":"Eisenberg","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0016","unstructured":"EphMRA., 2017. Code of Conduct.https:\/\/www.ephmra.org\/media\/1785\/ephmra-2017-code-of-conduct-october-2017.pdf. Accessed 16\/09\/2021."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0017","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/humupd\/dms031","article-title":"Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment","volume":"18","author":"Gameiro","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0018","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/humupd\/dms045","article-title":"Why we should talk about compliance with assisted reproductive technologies (ART): a systematic review and meta-analysis of ART compliance rates","volume":"19","author":"Gameiro","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0019","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.pec.2013.08.015","article-title":"Patient centred care in infertility health care: direct and indirect associations with wellbeing during treatment","volume":"93","author":"Gameiro","year":"2013","journal-title":"Patient Educ. Couns."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.rbmo.2015.10.008","article-title":"Increasing fertility knowledge and awareness by tailored education: a randomized controlled trial","volume":"32","author":"Garc\u00eda","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0021","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/02646838.2010.544294","article-title":"Involuntarily childless men and the desire for fatherhood","volume":"29","author":"Hadley","year":"2011","journal-title":"J. Reprod. Infant Psychol."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0022","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/humrep\/deab040","article-title":"Patient willingness, preferences and decision making about planning for three complete cycles of IVF\/ICSI treatment","volume":"5","author":"Harrison","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0023","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/jhrs.JHRS_62_19","article-title":"Communication and Respect for Patient Value as Significant Factors in Patient-Centered Infertility Care: A Survey of Patients' Experiences in Two Infertility Centers","volume":"13","author":"Harzif","year":"2020","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0024","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.fertnstert.2005.01.118","article-title":"Disparities in access to infertility services in a state with mandated insurance coverage","volume":"84","author":"Jain","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171939","article-title":"How much is a child worth? Providers\u2019 and patients\u2019 views and responses concerning ethical and policy challenges in paying for ART","volume":"12","author":"Klitzman","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0027","doi-asserted-by":"crossref","unstructured":"Klitzman R., 2018. Impediments to communication and relationships between infertility care providers and patients. BMC Women's Health. 18. https:\/\/doi.org\/ 10.1186\/s12905-018-0572-6","DOI":"10.1186\/s12905-018-0572-6"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0028","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility: A review of literature","volume":"8","author":"Kumar","year":"2015","journal-title":"Journal of Hum. Reprod. Sci."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0029","doi-asserted-by":"crossref","first-page":"292","DOI":"10.5964\/ejop.v15i2.1736","article-title":"Extreme Desire for Motherhood: Analysis of Narratives From Women Undergoing Assisted Reproductive Technology (ART)","volume":"15","author":"Langher","year":"2019","journal-title":"Eur. J. Psychol."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/15265161.2015.1088973","article-title":"Sleepwalking into infertility: the need for a public health approach toward advanced maternal age","volume":"15","author":"Lemoine","year":"2015","journal-title":"Am. J. Bioeth."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0031","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/humrep\/dey293","article-title":"Two-year follow-up of a randomized controlled trial: knowledge and reproductive outcome after online fertility education","volume":"33","author":"Maeda","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0032","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.rbms.2016.04.001","article-title":"Long-term fiscal implications of funding assisted reproduction: a generational accounting model for Spain","volume":"2","author":"Matorras","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227063","article-title":"The delay of motherhood: Reasons, determinants, time used to achieve pregnancy, and maternal anxiety level","volume":"14","author":"Molina-Garc\u00eda","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0034","doi-asserted-by":"crossref","DOI":"10.1186\/s12992-020-00617-9","article-title":"Infertility policy analysis: a comparative study of selected low-middle-and high-income countries","volume":"16","author":"Morshed-Behbahani","year":"2020","journal-title":"Glob. Health."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0035","doi-asserted-by":"crossref","unstructured":"Mossialos E., Wenzl M., 2016. 2015 International Profiles of Health Care Systems International Profiles of Health Care Systems. The Commonwealth Fund. https:\/\/www.commonwealthfund.org\/sites\/default\/files\/documents\/___media_files_publications_fund_report_2016_jan_1857_mossialos_intl_profiles_2015_v7.pdf. Accessed: 22\/04\/2021.","DOI":"10.15868\/socialsector.25100"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0036","first-page":"71","article-title":"What do people know about fertility? A systematic review on fertility awareness and its associated factors. Ups","volume":"123","author":"Pedro","year":"2018","journal-title":"J. Med. Sci."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0037","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/S1679-45082012000100009","article-title":"Lag time between onset of symptoms and diagnosis of endometriosis","volume":"10","author":"Santos","year":"2012","journal-title":"Einstein (S\u00e3o Paulo)"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0038","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/humupd\/dmr040","article-title":"Demographic and medical consequences of the postponement of parenthood","volume":"18","author":"Schmidt","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2021.09.002_bib0039","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fertnstert.2011.04.054","article-title":"Socioeconomic disparities in the use and success of fertility treatments: analysis of data from a prospective cohort in the United States","volume":"96","author":"Smith","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0040","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/humrep\/deaa138","article-title":"Time as an outcome measure in fertility-related clinical studies: long-awaited","volume":"35","author":"Sunkara","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0041","first-page":"219","article-title":"Effect of publicly funded assisted reproductive technology on maternal and infant outcomes: a pre- and post-comparison study","volume":"1","author":"Wei","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0042","unstructured":"World Health Organization., 2004. Global prevalence of infertility, infecundity and childlessness.https:\/\/www.who.int\/reproductivehealth\/topics\/infertility\/burden\/en\/. Accessed 22\/04\/2021."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0043","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.fertnstert.2013.01.145","article-title":"Time costs of fertility care: the hidden hardship of building a family","volume":"99","author":"Wu","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.09.002_bib0044","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/humrep\/dep343","article-title":"The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology, 2009","volume":"24","author":"Zegers-Hochschild","year":"2009","journal-title":"Hum. Reprod."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321004326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321004326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:21:46Z","timestamp":1761466906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648321004326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1472648321004326"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.09.002","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Barriers and factors associated with significant delays to initial consultation and treatment for infertile patients and partners of infertile patients","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.","name":"copyright","label":"Copyright"}]}}