{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:11:26Z","timestamp":1781651486737,"version":"3.54.5"},"reference-count":78,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003358","name":"Gedeon Richter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.rbmo.2021.12.006","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T02:27:33Z","timestamp":1640140053000},"page":"717-736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Co-treatment with letrozole during ovarian stimulation for IVF\/ICSI: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-7277","authenticated-orcid":false,"given":"Nathalie S\u00f8derhamn","family":"B\u00fclow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dreyer Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven Olaf","family":"Skouby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine","family":"Birch Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Lis Mikkelsen","family":"Englund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Stephen","family":"Macklon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2021.12.006_bib0001","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/humrep\/deg208","article-title":"Estradiol level has an important role in the prediction of OHSS","volume":"18","author":"Aboulghar","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0002","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/molehr\/gaw070","article-title":"Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle","volume":"23","author":"Andersen","year":"2017","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0003","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejogrb.2016.05.027","article-title":"A randomized, single-blind, prospective trial comparing three different gonadotropin doses with or without addition of letrozole during ovulation stimulation in patients with poor ovarian response","volume":"203","author":"Bastu","year":"2016","journal-title":"European Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0004","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/uog.17442","article-title":"Clomiphene citrate and letrozole to reduce follicle-stimulating hormone consumption during ovarian stimulation: systematic review and meta-analysis","volume":"50","author":"Bechtejew","year":"2017","journal-title":"Ultrasound in obstetrics & gynecology\u202f: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0005","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1210\/jc.2002-021953","article-title":"Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilizatio","volume":"88","author":"Beckers","year":"2003","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0006","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.fertnstert.2005.07.230","article-title":"The Outcome of 150 Babies Following the Treatment With Letrozole or Letrozole and Gonadotropins","volume":"84","author":"Biljan","year":"2005","journal-title":"Fertility and sterility"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0007","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.fertnstert.2009.10.044","article-title":"Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo","volume":"94","author":"Boomsma","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0008","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/humupd\/dmr051","article-title":"The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis","volume":"18","author":"Bosdou","year":"2012","journal-title":"Human reproduction update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0009","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF00682740","article-title":"Aromatase inhibitors\u202f? mechanisms for non-steroidal inhibitors","volume":"30","author":"Bossche","year":"1994","journal-title":"Breast Cancer Res. Tr."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0010","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/humupd\/dmg045","article-title":"The endometrium in stimulated cycles for IVF","volume":"9","author":"Bourgain","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0011","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/humupd\/dms041","article-title":"Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach","volume":"19","author":"Broer","year":"2013","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2013.04.024","article-title":"Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis","volume":"100","author":"Broer","year":"2013","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0013","first-page":"deab249","article-title":"Impact of letrozole co-treatment during ovarian stimulation with gonadotrophins for IVF: a multicentre, randomized, double-blinded placebo-controlled trial","author":"B\u00fclow","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0014","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/cncr.10908","article-title":"An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane","volume":"95","author":"Buzdar","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0015","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3109\/09513590.2014.893571","article-title":"The comparision of effect of microdose GnRH-a flare-up, GnRH antagonist\/aromatase inhibitor letrozole and GnRH antagonist\/clomiphene citrate protocols on IVF outcomes in poor responder patients","volume":"30","author":"Cenksoy","year":"2014","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0016","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0017","first-page":"1","article-title":"Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF\/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study","volume":"16","author":"D'Amato","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0018","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1028-4559(10)60064-2","article-title":"GnRH antagonist\/letrozole versus microdose GnRH agonist flare protocol in poor responders undergoing in vitro fertilization","volume":"49","author":"Davar","year":"2010","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0019","first-page":"101","article-title":"Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT","volume":"15","author":"Ebrahimi","year":"2017","journal-title":"International journal of reproductive biomedicine (Yazd, Iran)"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0020","first-page":"287","article-title":"Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT","volume":"18","author":"Eftekhar","year":"2020","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0021","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.fertnstert.2011.03.103","article-title":"Letrozole and gonadotropins versus luteal estradiol and gonadotropin-releasing hormone antagonist protocol in women with a prior low response to ovarian stimulation","volume":"95","author":"Elassar","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0022","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/humrep\/der092","article-title":"ESHRE working group on Poor Ovarian Response Definition. ESHRE consensus on the definition of \u201cpoor response\u201d to ovarian stimulation for in vitro fertilization: the Bologna criteria","volume":"26","author":"Ferraretti","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0023","doi-asserted-by":"crossref","unstructured":"Franik, S., Eltrop, S.M., Kremer, J.A., Kiesel, L., Farquhar, C. Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. In Cochrane Gynaecology and Fertility Group, editor.Cochrane Database of Systematic Reviews2018;113:218.","DOI":"10.1002\/14651858.CD010287.pub3"},{"issue":"Suppl 1","key":"10.1016\/j.rbmo.2021.12.006_bib0024","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1472-6483(11)60215-0","article-title":"Ovarian stimulation for IVF and endometrial receptivity\u2013the missing link","volume":"5","author":"van der Gaast","year":"2002","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0025","article-title":"Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews","volume":"13","author":"Gadalla","year":"2020","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0026","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fertnstert.2005.01.117","article-title":"The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: A pilot study","volume":"84","author":"Garcia-Velasco","year":"2005","journal-title":"Fertility and sterility"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0027","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1093\/humrep\/deh359","article-title":"A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report","volume":"19","author":"Goswami","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0028","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/bmj.38636.593461.68","article-title":"Effectiveness and efficiency of search methods in systematic reviews of complex evidence: Audit of primary sources","volume":"331","author":"Greenhalgh","year":"2005","journal-title":"British Medical Journal"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-018-0367-5","article-title":"The VEGF and PEDF levels in the follicular fluid of patients co- treated with LETROZOLE and gonadotropins during the stimulation cycle","volume":"16","author":"Haas","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0030","doi-asserted-by":"crossref","unstructured":"Haas J, Bassil R, Meriano J, Samara N, Barzilay E, Gonen N, Casper RF. Does daily co-administration of letrozole and gonadotropins during ovarian stimulation improve IVF outcome? 2017;1\u20135.","DOI":"10.1186\/s12958-017-0288-8"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0031","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/19396368.2014.957879","article-title":"Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval","volume":"60","author":"He","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0032","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0033","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1210\/jc.2008-0588","article-title":"Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications","volume":"93","author":"Horcajadas","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0034","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0974-1208.183515","article-title":"Effective treatment protocol for poor ovarian response: A systematic review and meta-analysis","volume":"9","author":"Jeve","year":"2016","journal-title":"Journal of Human Reproductive Sciences"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0035","doi-asserted-by":"crossref","unstructured":"Kamath, M.S., Maheshwari, A., Bhattacharya, S., Lor, K.Y., Gibreel, A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation. In Group CG and F, editor.Cochrane Database of Systematic Reviews2017;26:593.","DOI":"10.1002\/14651858.CD008528.pub3"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0036","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/humupd\/dmu011","article-title":"Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis","volume":"20","author":"Kasius","year":"2014","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0037","first-page":"13626","article-title":"Comparison of in vitro fertilization cycles stimulated with 20 mg letrozole daily versus high-dose gonadotropins in Rotterdam Consensus ultra-poor responders: A proof of concept","author":"Khojah","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0038","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/09513590.2019.1650338","article-title":"The effects of letrozole on women with endometriosis undergoing ovarian stimulation for in vitro fertilization","volume":"36","author":"Kim","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/581451","article-title":"Comparison of IVF Outcomes between Minimal Stimulation and High-Dose Stimulation for Patients with Poor Ovarian Reserve","volume":"2014","author":"Lazer","year":"2014","journal-title":"Int. J. Reprod. Med."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5468\/ogs.2014.57.3.216","article-title":"The effect of aromatase inhibitor letrozole incorporated in gonadotrophin-releasing hormone antagonist multiple dose protocol in poor responders undergoing in vitro fertilization","volume":"57","author":"Lee","year":"2014","journal-title":"Obstet. Gynecol. Sci."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0041","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.rbmo.2011.05.012","article-title":"Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial","volume":"23","author":"Lee","year":"2011","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0042","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00404-020-05513-6","article-title":"Mild stimulation protocol vs conventional controlled ovarian stimulation protocol in poor ovarian response patients: a prospective randomized controlled trial","volume":"301","author":"Liu","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00627","article-title":"Biological and clinical rationale for androgen priming in ovarian stimulation","volume":"11","author":"Lossl","year":"2020","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0044","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1073\/pnas.0530162100","article-title":"Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation","volume":"100","author":"Ma","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0045","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1210\/er.2005-0015","article-title":"The science behind 25 years of ovarian stimulation for in vitro fertilization","volume":"27","author":"Macklon","year":"2006","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0046","first-page":"305","article-title":"Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate","volume":"75","author":"Mitwally","year":"2001","journal-title":"FNS"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0047","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/09513590.2012.730569","article-title":"Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI","volume":"29","author":"Mohsen","year":"2013","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0048","first-page":"653","article-title":"Letrozole as co-treatment agent in ovarian stimulation antagonist protocol in poor responders: A double-blind randomized clinical trial","volume":"17","author":"Moini","year":"2019","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0049","doi-asserted-by":"crossref","first-page":"hoaa066","DOI":"10.1093\/hropen\/hoaa066","article-title":"Fresh and cumulative live birth rates in mild versus conventional stimulation for IVF cycles in poor ovarian responders: a systematic review and meta-analysis","volume":"2021","author":"Montoya-Botero","year":"2021","journal-title":"Human Reproduction Open"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0050","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0974-1208.101014","article-title":"Letrozole in a low-cost in vitro fertilization protocol in intracytoplasmic sperm injection cycles for male factor infertility: A randomized controlled trial","volume":"5","author":"Mukherjee","year":"2012","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0051","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5539\/gjhs.v8n4p166","article-title":"Comparison of GnRh Agonist Microdose Flare Up and GnRh Antagonist\/Letrozole in Treatment of Poor Responder Patients in Intra Cytoplaspic Sperm Injection: Randomized Clinical Trial","volume":"8","author":"Nabati","year":"2015","journal-title":"Glob. J. Health Sci."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0052","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/molehr\/gaq073","article-title":"In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA","volume":"17","author":"Nielsen","year":"2011","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0053","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1210\/jc.2006-0962","article-title":"Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy","volume":"91","author":"Oktay","year":"2006","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0054","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.rbmo.2009.05.007","article-title":"Use of aromatase inhibitors in poor-responder patients receiving GnRH antagonist protocols","volume":"19","author":"Ozmen","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0055","article-title":"Risk of foetal harm with letrozole use in fertility treatment: a systematic review and meta-analysis","author":"Pundir","year":"2020","journal-title":"Human reproduction update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2021.102139","article-title":"Effects of using letrozole in combination with the GnRH antagonist protocol for patients with poor ovarian response: A meta-analysis","volume":"50","author":"Qin","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0057","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.fertnstert.2012.09.022","article-title":"Ovarian stimulation and fertility preservation with the use of aromatase inhibitors in women with breast cancer","volume":"98","author":"Reddy","year":"2012","journal-title":"Fertility and sterility"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0058","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/humupd\/dmn033","article-title":"Use of letrozole in assisted reproduction: a systematic review and meta-analysis","volume":"14","author":"Requena","year":"2008","journal-title":"Human reproduction update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0059","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2007.02.013","article-title":"Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist\/letrozole protocol?","volume":"89","author":"Schoolcraft","year":"2008","journal-title":"Fertility and sterility"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0061","unstructured":"Sch\u00fcnemann, H., Bro\u017cek, J., Guyatt, G., Oxman, A.GRADE handbook for grading quality of evidence and strength of recommendations. Updated October 2013. The GRADE Working Group, 2013 [Internet]. 2014;Available from:https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0062","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0063","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13048-020-00666-z","article-title":"Does daily co administration of gonadotropins and letrozole during the ovarian stimulation improve IVF outcome for poor and sub optimal responders?","volume":"13","author":"Shapira","year":"2020","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0064","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.rbmo.2020.04.008","article-title":"The entire range of trigger-day endometrial thickness in fresh IVF cycles is independently correlated with live birth rate","volume":"41","author":"Simeonov","year":"2020","journal-title":"Reproductive BioMedicine Online"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0065","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/09513590.2017.1296128","article-title":"Mild versus conventional antagonist ovarian stimulation protocols in expected normal responders undergoing IVF\/ICSI: a case\u2013control study","volume":"33","author":"Siristatidis","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0066","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/09513590.2013.875997","article-title":"Effectiveness of the antagonist\/letrozole protocol for treating poor responders undergoing in vitro fertilization\/intracytoplasmic sperm injection: A systematic review and meta-analysis","volume":"30","author":"Song","year":"2014","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0067","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0068","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/humrep\/deu053","article-title":"Association between response to ovarian stimulation and miscarriage following IVF: an analysis of 124 351 IVF pregnancies","volume":"29","author":"Sunkara","year":"2014","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0069","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.rbmo.2011.01.015","article-title":"Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis","volume":"22","author":"Sunkara","year":"2011","journal-title":"Reproductive biomedicine online"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0070","unstructured":"Teede, H., Misso, M., Costello, M., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2018. 2018;1\u2013201."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/S1472-6483(10)60611-6","article-title":"Aromatase inhibitors in ovarian stimulation for IVF\/ICSI: a pilot study","volume":"13","author":"Verpoest","year":"2006","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0072","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1210\/jcem.84.8.5929","article-title":"Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development","volume":"84","author":"Weil","year":"1999","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0073","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12958-019-0483-x","article-title":"Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study","volume":"17","author":"Yang","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0074","first-page":"98","article-title":"Evaluation of low-dose letrozole addition to ovulation induction in IVF","volume":"40","author":"Yasa","year":"2013","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0075","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1177\/0300060518770346","article-title":"Comparison of modified agonist, mild-stimulation and antagonist protocols for in vitro fertilization in patients with diminished ovarian reserve","volume":"46","author":"Yu","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.rbmo.2021.12.006_bib0076","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/09513590.2014.920002","article-title":"Comparison of estradiol and progesterone priming\/antagonist\/letrozole and microdose flare-up protocols for poor responders undergoing intracytoplasmic sperm injection","volume":"30","author":"Yucel","year":"2014","journal-title":"Gynecological endocrinology\u202f: the official journal of the International Society of Gynecological Endocrinology"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0077","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/humupd\/dmz046","article-title":"Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: A systematic review and network meta-analysis","volume":"26","author":"Zhang","year":"2020","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2021.12.006_bib0078","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12978-020-01042-2","article-title":"Whether Letrozole could reduce the incidence of early ovary hyperstimulation syndrome after assisted reproductive technology? A systematic review and meta-analysis","volume":"17","author":"Zhao","year":"2020","journal-title":"Reprod. Health"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321006040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648321006040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T19:05:37Z","timestamp":1755025537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648321006040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1472648321006040"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.12.006","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-treatment with letrozole during ovarian stimulation for IVF\/ICSI: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2021.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}