{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:58:35Z","timestamp":1787507915618,"version":"build-2736575974"},"reference-count":8,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["BRC IS\u2013BRC\u20131215\u201320007"],"award-info":[{"award-number":["BRC IS\u2013BRC\u20131215\u201320007"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","award":["GN2494"],"award-info":[{"award-number":["GN2494"]}],"id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.rbmo.2022.05.003","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T05:15:11Z","timestamp":1652418911000},"page":"727-729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Homozygous missense variants in BMPR15 can result in primary ovarian insufficiency"],"prefix":"10.1016","volume":"45","author":[{"given":"Leigh A.M.","family":"Demain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Boetje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Martindale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Busby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-4678","authenticated-orcid":false,"given":"William G.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2022.05.003_bib0001","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.rbmo.2021.07.003","article-title":"Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency","volume":"43","author":"Demain","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2022.05.003_bib0002","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1086\/422103","article-title":"Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene","volume":"75","author":"Di Pasquale","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.rbmo.2022.05.003_bib0003","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/jmedgenet-2016-103837","article-title":"Molecular findings from 537 individuals with inherited retinal disease","volume":"53","author":"Ellingford","year":"2016","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.rbmo.2022.05.003_bib0004","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/cge.12970","article-title":"BMP15 \"knockout-like\" effect in familial premature ovarian insufficiency with persistent ovarian reserve","volume":"92","author":"Mayer","year":"2017","journal-title":"Clin. Genet."},{"key":"10.1016\/j.rbmo.2022.05.003_bib0005","first-page":"1009","article-title":"BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9","volume":"102","author":"Pati\u00f1o","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2022.05.003_bib0006","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/humupd\/dmu036","article-title":"The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders","volume":"20","author":"Persani","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2022.05.003_bib0007","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/humu.23988","article-title":"Funda mental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency","volume":"41","author":"Rossetti","year":"2020","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.rbmo.2022.05.003_bib0008","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.rbmo.2017.10.104","article-title":"A novel homozygous mutation of bone morphogenetic protein 15 identified in a consanguineous marriage family with primary ovarian insufficiency","volume":"36","author":"Zhang","year":"2018","journal-title":"Reprod. Biomed. Online"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648322003200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648322003200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:25:10Z","timestamp":1761467110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648322003200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1472648322003200"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2022.05.003","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homozygous missense variants in BMPR15 can result in primary ovarian insufficiency","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2022.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}