{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:55:56Z","timestamp":1782888956256,"version":"3.54.5"},"reference-count":11,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.rbmo.2022.07.004","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T02:54:12Z","timestamp":1657767252000},"page":"1061-1063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Revisiting the impact of varicocele and its treatments on male fertility"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-1572","authenticated-orcid":false,"given":"Sheena E.M.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.rbmo.2022.07.004_bib0001","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrurol.2012.197","article-title":"Sandro C Esteves Insight into oxidative stress in varicocele-associated male infertility","volume":"9","author":"Agarwal","year":"2012","journal-title":"Nat. Rev. Urol."},{"issue":"5","key":"10.1016\/j.rbmo.2022.07.004_bib0002","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/humrep\/deab004","article-title":"Should we be measuring DNA damage in human spermatozoa? New light on an old question","volume":"36","author":"Aitken","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2022.07.004_bib0003","doi-asserted-by":"crossref","first-page":"e05439","DOI":"10.1016\/j.heliyon.2020.e05439","article-title":"The benefits of varicocele repair for achieving pregnancy in male infertility: A systematic review and meta-analysis","volume":"6","author":"Birowo","year":"2020","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.rbmo.2022.07.004_bib0004","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4103\/1008-682X.163269","article-title":"Outcome of assisted reproductive technology in men with treated and untreated varicocele: systematic review and meta-analysis","volume":"18","author":"Esteves","year":"2016","journal-title":"Asian J. Androl."},{"issue":"2","key":"10.1016\/j.rbmo.2022.07.004_bib0005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11255-013-0394-2","article-title":"Onder Yaman Effect of performing varicocelectomy before intracytoplasmic sperm injection on clinical outcomes in non-azoospermic males","volume":"45","author":"Gokce","year":"2013","journal-title":"Int. Urol. Nephrol."},{"issue":"2","key":"10.1016\/j.rbmo.2022.07.004_bib0006","first-page":"234","article-title":"Ranjith Ramasamy Percutaneous embolization of varicocele: technique, indications, relative contraindications, and complication Asian","author":"Halpern","year":"2016","journal-title":"J. Andrology"},{"key":"10.1016\/j.rbmo.2022.07.004_bib0007","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1590\/s1677-5538.ibju.2019.0827","article-title":"Oxidative origin of sperm DNA fragmentation in the adult varicocele","volume":"47","author":"Jeremias","year":"2021","journal-title":"Int. Braz J. Urol."},{"issue":"6","key":"10.1016\/j.rbmo.2022.07.004_bib0008","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.fertnstert.2016.07.1093","article-title":"Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligozoospermic men with a varicocele: a systematic review and meta-analysis","volume":"106","author":"Kirby","year":"2016","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.rbmo.2022.07.004_bib0009","article-title":"Barbara Nussbaumer-Streit Surgical or radiological treatment for varicoceles in subfertile men","author":"Persad","year":"2021","journal-title":"Cochrane Database of Systematic Reviews Review \u2013 Intervention"},{"issue":"3","key":"10.1016\/j.rbmo.2022.07.004_bib0010","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.rbmo.2012.05.002","article-title":"Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis","volume":"25","author":"Wang","year":"2012","journal-title":"Reprod. Biomed. Online"},{"issue":"2","key":"10.1016\/j.rbmo.2022.07.004_bib0011","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/14647273.2019.1582807","article-title":"Should the current guidelines for the treatment of varicoceles in infertile men be re-evaluated?","volume":"24","author":"Yan","year":"2021","journal-title":"Hum. Fertil. (Camb)"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648322004898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648322004898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:25:45Z","timestamp":1761467145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648322004898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S1472648322004898"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2022.07.004","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revisiting the impact of varicocele and its treatments on male fertility","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2022.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}