{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:32:14Z","timestamp":1787765534642,"version":"build-2784847793"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.rbmo.2023.103319","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T11:23:44Z","timestamp":1690629824000},"page":"103319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["A cohort study on IVF outcomes in infertile endometriosis patients: the effects of rapamycin treatment"],"prefix":"10.1016","volume":"48","author":[{"given":"Jiao","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-9407","authenticated-orcid":false,"given":"Yiping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2023.103319_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105730","article-title":"Sirolimus as a new drug to treat RIF patients with elevated Th17\/Treg ratio: A double-blind, phase II randomized clinical trial","volume":"74","author":"Ahmadi","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.rbmo.2023.103319_bib0002","doi-asserted-by":"crossref","first-page":"e13593","DOI":"10.1111\/aji.13593","article-title":"Oxidative stress-related effects on various aspects of endometriosis","volume":"88","author":"Ansariniya","year":"2022","journal-title":"Am. J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.rbmo.2023.103319_bib0004","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/humrep\/17.2.426","article-title":"Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial","volume":"17","author":"Bedaiwy","year":"2002","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/humupd\/8.1.79","article-title":"Mini symposium on pathogenesis of endometriosis and treatment of endometriosis-associated subfertility. Introduction: the endometriosis enigma","volume":"8","author":"Bergqvist","year":"2002","journal-title":"Hum. Reprod. Update"},{"issue":"6","key":"10.1016\/j.rbmo.2023.103319_bib0006","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s11357-019-00113-y","article-title":"Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial","volume":"41","author":"Chung","year":"2019","journal-title":"Geroscience"},{"issue":"2","key":"10.1016\/j.rbmo.2023.103319_bib0007","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/mrd.22943","article-title":"Oocyte oxidative DNA damage may be involved in minimal\/mild endometriosis-related infertility","volume":"85","author":"Da","year":"2018","journal-title":"Mol. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0008","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00441-016-2428-4","article-title":"Increased concentration of 8-hydroxy-2\u2032-deoxyguanosine in follicular fluid of infertile women with endometriosis","volume":"366","author":"Da","year":"2016","journal-title":"Cell. Tissue. Res."},{"issue":"3","key":"10.1016\/j.rbmo.2023.103319_bib0009","first-page":"257","article-title":"Endometriosis and subfertility treatment: a review","volume":"57","author":"De Hondt","year":"2005","journal-title":"Minerva. Ginecol."},{"issue":"8","key":"10.1016\/j.rbmo.2023.103319_bib0010","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1016\/j.fertnstert.2009.11.011","article-title":"Attenuated oocyte fertilization and embryo development associated with altered growth factor\/signal transduction induced by endometriotic peritoneal fluid","volume":"93","author":"Ding","year":"2010","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.rbmo.2023.103319_bib0013","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/01.tp.0000188947.56244.7d","article-title":"Pregnancy under sirolimus-based immunosuppression","volume":"81","author":"Guardia","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.rbmo.2023.103319_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9175806","article-title":"Epigenetics and Oxidative Stress in Aging","volume":"2017","author":"Guillaumet-Adkins","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.rbmo.2023.103319_bib0015","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/1471-0528.12366","article-title":"The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis","volume":"120","author":"Harb","year":"2013","journal-title":"BJOG"},{"issue":"7253","key":"10.1016\/j.rbmo.2023.103319_bib0016","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.rbmo.2023.103319_bib0017","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of Cellular Senescence","volume":"28","author":"Hernandez-Segura","year":"2018","journal-title":"Trends. Cell. Biol."},{"key":"10.1016\/j.rbmo.2023.103319_bib0018","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.redox.2016.12.001","article-title":"Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence","volume":"11","author":"H\u00f6hn","year":"2017","journal-title":"Redox. Biol."},{"issue":"10","key":"10.1016\/j.rbmo.2023.103319_bib0019","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1016\/j.transproceed.2004.11.102","article-title":"Absence of teratogenicity of sirolimus used during early pregnancy in a liver transplant recipient","volume":"36","author":"Jankowska","year":"2004","journal-title":"Transplant. Proc."},{"issue":"3","key":"10.1016\/j.rbmo.2023.103319_bib0020","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.fertnstert.2004.02.120","article-title":"Follicular blood flow is a better predictor of the outcome of in vitro fertilization-embryo transfer than follicular fluid vascular endothelial growth factor and nitric oxide concentrations","volume":"82","author":"Kim","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2023.103319_bib0021","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2017.12.026","article-title":"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects","volume":"105","author":"Kraig","year":"2018","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0022","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.fertnstert.2007.11.021","article-title":"Measurable serum markers of oxidative stress response in women with endometriosis","volume":"91","author":"Lambrinoudaki","year":"2009","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.rbmo.2023.103319_bib0023","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1172\/JCI64099","article-title":"Rapalogs and mTOR inhibitors as anti-aging therapeutics","volume":"123","author":"Lamming","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.rbmo.2023.103319_bib0024","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell. Metab."},{"key":"10.1016\/j.rbmo.2023.103319_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101431","article-title":"Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility","volume":"30","author":"Lin","year":"2020","journal-title":"Redox. Biol."},{"issue":"5","key":"10.1016\/j.rbmo.2023.103319_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052476","article-title":"Altered p16(Ink4a), IL-1\u03b2, and Lamin b1 Protein Expression Suggest Cellular Senescence in Deep Endometriotic Lesions","volume":"23","author":"Malvezzi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.rbmo.2023.103319_bib0027","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.fertnstert.2009.09.043","article-title":"Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility","volume":"94","author":"Mansour","year":"2010","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0028","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.transproceed.2013.09.029","article-title":"Successful maternal and fetal outcome in a kidney transplant patient with everolimus exposure throughout pregnancy: a case report","volume":"46","author":"Margoles","year":"2014","journal-title":"Transplant Proc"},{"issue":"2","key":"10.1016\/j.rbmo.2023.103319_bib0029","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/gerona\/glq178","article-title":"Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice","volume":"66","author":"Miller","year":"2011","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.rbmo.2023.103319_bib0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.exger.2014.11.004","article-title":"Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?","volume":"68","author":"Nacarelli","year":"2015","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0031","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0015-0282(01)02940-5","article-title":"Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility","volume":"77","author":"Osborn","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2023.103319_bib0032","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bpobgyn.2018.01.019","article-title":"Endometriosis, endometrioma, and ART results: Current understanding and recommended practices","volume":"51","author":"Prefumo","year":"2018","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"9","key":"10.1016\/j.rbmo.2023.103319_bib0033","article-title":"The effect of endometriosis on IVF\/ICSI and perinatal outcome: A systematic review and meta-analysis","volume":"51","author":"Qu","year":"2022","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0034","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3892\/etm.2016.3280","article-title":"Effect of rapamycin on endometriosis in mice","volume":"12","author":"Ren","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.rbmo.2023.103319_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13048-017-0341-4","article-title":"Is the oocyte quality affected by endometriosis? A review of the literature","volume":"10","author":"Sanchez","year":"2017","journal-title":"J. Ovarian. Res."},{"issue":"6","key":"10.1016\/j.rbmo.2023.103319_bib0036","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0015-0282(99)00145-4","article-title":"Autoantibodies to markers of oxidative stress are elevated in women with endometriosis","volume":"71","author":"Shanti","year":"1999","journal-title":"Fertil. Steril."},{"issue":"12","key":"10.1016\/j.rbmo.2023.103319_bib0038","doi-asserted-by":"crossref","first-page":"e82334","DOI":"10.1371\/journal.pone.0082334","article-title":"The effect of peritoneal fluid from patients with endometriosis on mitochondrial function and development of early mouse embryos","volume":"8","author":"Shu","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.rbmo.2023.103319_bib0039","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1097\/01.tp.0000252683.74584.29","article-title":"Pregnancy outcomes in solid organ transplant recipients with exposure to mycophenolate mofetil or sirolimus","volume":"82","author":"Sifontis","year":"2006","journal-title":"Transplantation."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648323004194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648323004194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:28:17Z","timestamp":1761467297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648323004194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1472648323004194"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2023.103319","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A cohort study on IVF outcomes in infertile endometriosis patients: the effects of rapamycin treatment","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2023.103319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103319"}}