{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:50:16Z","timestamp":1787629816902,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100018925","name":"Henan Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.rbmo.2023.103727","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:39:53Z","timestamp":1699972793000},"page":"103727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Poorly controlled type 1 diabetes mellitus seriously impairs female reproduction via immune and metabolic disorders"],"prefix":"10.1016","volume":"48","author":[{"given":"Shenghui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-8907","authenticated-orcid":false,"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2023.103727_bib0001","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1210\/endo-108-4-1441","article-title":"Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells","volume":"108","author":"Adashi","year":"1981","journal-title":"Endocrinology"},{"key":"10.1016\/j.rbmo.2023.103727_bib0002","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9051426","article-title":"Experimental Diabetes Mellitus in Different Animal Models","volume":"2016","author":"Al-Awar","year":"2016","journal-title":"Journal of diabetes research"},{"key":"10.1016\/j.rbmo.2023.103727_bib0003","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720939127","article-title":"NOD Mice-Good Model for T1D but Not Without Limitations","volume":"29","author":"Aldrich","year":"2020","journal-title":"Cell Transplant"},{"key":"10.1016\/j.rbmo.2023.103727_bib0004","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1139\/cjpp-2019-0287","article-title":"Amelioration of estrogen-induced endometrial hyperplasia in female rats by hemin via heme-oxygenase-1 expression, suppression of iNOS, p38 MAPK, and Ki67","volume":"97","author":"Ali","year":"2019","journal-title":"Can. J. Physiol Pharmacol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0005","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.2337\/diacare.26.5.1456","article-title":"Low IGF-I and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects: the Oxford Regional Prospective Study","volume":"26","author":"Amin","year":"2003","journal-title":"Diabetes care"},{"key":"10.1016\/j.rbmo.2023.103727_bib0006","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.4049\/jimmunol.1900464","article-title":"T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein","volume":"205","author":"Bonami","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0007","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Br\u00fcning","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.rbmo.2023.103727_bib0008","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s10815-020-01955-8","article-title":"Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review","volume":"37","author":"Buzzaccarini","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.rbmo.2023.103727_bib0009","first-page":"11","article-title":"Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites","author":"Chen","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.rbmo.2023.103727_bib0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ando.2021.09.001","article-title":"Position statement on the diagnosis and management of premature\/primary ovarian insufficiency (except Turner Syndrome)","volume":"82","author":"Christin-Maitre","year":"2021","journal-title":"Ann Endocrinol (Paris)"},{"key":"10.1016\/j.rbmo.2023.103727_bib0011","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000173737","article-title":"Puberty and ovarian function in girls with type 1 diabetes mellitus","volume":"71","author":"Codner","year":"2009","journal-title":"Hormone research"},{"key":"10.1016\/j.rbmo.2023.103727_bib0012","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/humupd\/dms024","article-title":"Female reproduction and type 1 diabetes: from mechanisms to clinical findings","volume":"18","author":"Codner","year":"2012","journal-title":"Human reproduction update"},{"key":"10.1016\/j.rbmo.2023.103727_bib0013","first-page":"359","article-title":"Management of type 1 diabetes","volume":"28","author":"De Beaufort","year":"2018","journal-title":"Med Sante Trop"},{"key":"10.1016\/j.rbmo.2023.103727_bib0014","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.fertnstert.2019.02.005","article-title":"Inflammation and uterine fibrosis: the possible role of chronic endometritis","volume":"111","author":"de Ziegler","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2023.103727_bib0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bpobgyn.2019.07.008","article-title":"Premature ovarian insufficiency and autoimmune diseases","volume":"60","author":"Domniz","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0016","doi-asserted-by":"crossref","first-page":"17142","DOI":"10.1038\/s41598-021-96327-2","article-title":"Enhanced CD4(+) and CD8(+) T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses","volume":"11","author":"Dwyer","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.rbmo.2023.103727_bib0017","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1002\/cpz1.78","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"1","author":"Furman","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.rbmo.2023.103727_bib0018","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.fertnstert.2009.08.039","article-title":"Menstrual cycle irregularities and their relationship with HbA1c and insulin dose in adolescents with type 1 diabetes mellitus","volume":"94","author":"Gaete","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2023.103727_bib0019","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.2337\/db15-0492","article-title":"A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice","volume":"65","author":"Gill","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.rbmo.2023.103727_bib0020","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162995","article-title":"Regulatory T cells are paramount effectors in progesterone regulation of embryo implantation and fetal growth","author":"Green","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.rbmo.2023.103727_bib0021","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mce.2004.04.018","article-title":"Ovarian granulosa cell lines","volume":"228","author":"Havelock","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0022","doi-asserted-by":"crossref","first-page":"31319","DOI":"10.1073\/pnas.2019743117","article-title":"Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice","volume":"117","author":"Hu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rbmo.2023.103727_bib0023","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2183\/pjab.95.039","article-title":"Structure and function of the insulin receptor-a personal perspective","volume":"95","author":"Kasuga","year":"2019","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"10.1016\/j.rbmo.2023.103727_bib0024","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1007\/s10815-019-01572-0","article-title":"Premature ovarian insufficiency (POI) and autoimmunity-an update appraisal","volume":"36","author":"Kirshenbaum","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.rbmo.2023.103727_bib0025","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1152\/japplphysiol.91565.2008","article-title":"Diabetic myopathy differs between Ins2Akita+\/- and streptozotocin-induced Type 1 diabetic models","volume":"106","author":"Krause","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0026","article-title":"Insulin exposure during in vitro bovine oocyte maturation changes blastocyst gene expression and developmental potential","author":"Laskowski","year":"2016","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.rbmo.2023.103727_bib0027","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2337\/dc21-0342","article-title":"Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017","volume":"44","author":"Liu","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rbmo.2023.103727_bib0028","first-page":"35","article-title":"Menarcheal timing in intensively treated girls with type 1 diabetes mellitus. Nutrition, metabolism, and cardiovascular diseases","volume":"19","author":"Lombardo","year":"2009","journal-title":"NMCD"},{"key":"10.1016\/j.rbmo.2023.103727_bib0029","first-page":"11","article-title":"Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application","author":"Luo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.rbmo.2023.103727_bib0030","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s40618-020-01192-x","article-title":"Hormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis","volume":"43","author":"Marina","year":"2020","journal-title":"Journal of endocrinological investigation"},{"key":"10.1016\/j.rbmo.2023.103727_bib0031","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrendo.2017.39","article-title":"Insulin analogues in type 1 diabetes mellitus: getting better all the time","volume":"13","author":"Mathieu","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0032","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ecl.2013.07.007","article-title":"Diabetes and the female reproductive system","volume":"42","author":"Nandi","year":"2013","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.rbmo.2023.103727_bib0033","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/0002-9343(87)90945-4","article-title":"Hypogonadotropic secondary amenorrhea in diabetes: effects of central opiate blockade and improved metabolic control","volume":"83","author":"O'Hare","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.rbmo.2023.103727_bib0034","first-page":"205","article-title":"Sex-based differences in autoimmune diseases","volume":"52","author":"Ortona","year":"2016","journal-title":"Ann Ist Super Sanita"},{"key":"10.1016\/j.rbmo.2023.103727_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/B:MCBI.0000028736.00532.1e","article-title":"Effect of maternal diabetes and ethanol interactions on embryo development in the mouse","volume":"261","author":"Padmanabhan","year":"2004","journal-title":"Molecular and cellular biochemistry"},{"key":"10.1016\/j.rbmo.2023.103727_bib0036","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaut.2015.08.019","article-title":"The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes","volume":"66","author":"Pearson","year":"2016","journal-title":"J Autoimmun"},{"key":"10.1016\/j.rbmo.2023.103727_bib0037","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.fertnstert.2007.09.035","article-title":"Menarche in type 1 diabetes is still delayed despite good metabolic control","volume":"90","author":"Picardi","year":"2008","journal-title":"Fertility and sterility"},{"key":"10.1016\/j.rbmo.2023.103727_bib0038","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1530\/EJE-20-1284","article-title":"MANAGEMENT OF ENDOCRINE DISEASE: Thyroid and female infertility: more questions than answers?!","volume":"184","author":"Poppe","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0039","doi-asserted-by":"crossref","first-page":"H661","DOI":"10.1152\/ajpheart.00202.2020","article-title":"Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia","volume":"319","author":"Qu","year":"2020","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"10.1016\/j.rbmo.2023.103727_bib0040","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1172\/JCI122182","article-title":"Regulatory T cells in embryo implantation and the immune response to pregnancy","volume":"128","author":"Robertson","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.rbmo.2023.103727_bib0041","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.autrev.2014.01.003","article-title":"Autoimmune primary ovarian insufficiency","volume":"13","author":"Silva","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.rbmo.2023.103727_bib0042","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052594","article-title":"Autoimmune Diseases in Patients with Premature Ovarian Insufficiency-Our Current State of Knowledge","volume":"22","author":"Szeliga","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rbmo.2023.103727_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.01.021","article-title":"Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes","volume":"29","author":"Thompson","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.rbmo.2023.103727_bib0044","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2213-8587(19)30345-6","article-title":"Diabetes: a metabolic and reproductive disorder in women","volume":"8","author":"Thong","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.rbmo.2023.103727_bib0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.maturitas.2016.11.019","article-title":"Ovarian aging in women with diabetes: An overview","volume":"96","author":"Wellons","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.rbmo.2023.103727_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6581213","article-title":"The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells","volume":"2021","author":"Xiao","year":"2021","journal-title":"Journal of diabetes research"},{"key":"10.1016\/j.rbmo.2023.103727_bib0047","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/GME.0000000000001758","article-title":"Women with Type 1 diabetes (T1D) experience a shorter reproductive period compared with nondiabetic women: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study and the Study of Women's Health Across the Nation (SWAN)","volume":"28","author":"Yi","year":"2021","journal-title":"Menopause"},{"key":"10.1016\/j.rbmo.2023.103727_bib0048","first-page":"121","article-title":"Hyperandrogenism in adolescent girls with type 1 diabetes mellitus treated with intensive and continuous subcutaneous insulin therapy","volume":"64","author":"Zachurzok","year":"2013","journal-title":"Endokrynologia Polska"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264832300826X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264832300826X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:27:17Z","timestamp":1761467237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147264832300826X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S147264832300826X"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2023.103727","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poorly controlled type 1 diabetes mellitus seriously impairs female reproduction via immune and metabolic disorders","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2023.103727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103727"}}