{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:36:26Z","timestamp":1791401786218,"version":"4.3.3"},"reference-count":64,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002966","name":"Sivas Cumhuriyet \u00dcniversitesi","doi-asserted-by":"publisher","award":["V-2022-126"],"award-info":[{"award-number":["V-2022-126"]}],"id":[{"id":"10.13039\/501100002966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.rbmo.2023.103778","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T13:49:45Z","timestamp":1703425785000},"page":"103778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-6214","authenticated-orcid":false,"given":"Mehmet","family":"Ekici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Burak","family":"Ate\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer","family":"Ba\u015f-Ekici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykut","family":"\u00d6zg\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2023.103778_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063044","article-title":"Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model","volume":"22","author":"Abogresha","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0002","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.toxicon.2021.01.020","article-title":"The effects of Nigella sativa seeds and thymoquinone on aflatoxin phase-2 detoxification through glutathione and glutathione-S-transferase alpha-3, and the relationship between aflatoxin B1-DNA adducts in broilers","volume":"193","author":"Ates","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.rbmo.2023.103778_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpurol.2021.03.031","article-title":"The effect of intratesticular dexpanthenol on experimentally-induced testicular ischaemia\/reperfusion injury","volume":"17","author":"Ayd\u0131n","year":"2021","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1172-1-9","article-title":"Premature ovarian failure","volume":"1","author":"Beck-Peccoz","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.rbmo.2023.103778_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2020.102532","article-title":"Effects of heat stress on ovarian development and the expression of HSP genes in mice","volume":"89","author":"Bei","year":"2020","journal-title":"J Therm Biol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0006","first-page":"4049","article-title":"Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity","volume":"16","author":"Bilgic","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.rbmo.2023.103778_bib0007","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bpobgyn.2011.11.008","article-title":"Chemotherapy and fertility","volume":"26","author":"Blumenfeld","year":"2012","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0009","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm2351","article-title":"Regulation of DNA repair throughout the cell cycle","volume":"9","author":"Branzei","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0010","first-page":"492","article-title":"Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review","volume":"41","author":"Cai","year":"2021","journal-title":"J Tradit Chin Med"},{"key":"10.1016\/j.rbmo.2023.103778_bib0011","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1262\/jrd.2022-001","article-title":"Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damage","volume":"68","author":"Chen","year":"2022","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.rbmo.2023.103778_bib0067","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1262\/jrd.2022-001","article-title":"Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damage","volume":"68","author":"Chen","year":"2022","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.rbmo.2023.103778_bib0012","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13287-018-0964-4","article-title":"Heat shock pretreatment of mesenchymal stem cells for inhibiting the apoptosis of ovarian granulosa cells enhanced the repair effect on chemotherapy-induced premature ovarian failure","volume":"9","author":"Chen","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.rbmo.2023.103778_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/6718592","article-title":"Preventive Electroacupuncture Alleviates Oxidative Stress and Inflammation via Keap1\/Nrf2\/HO-1 Pathway in Rats with Cyclophosphamide-Induced Premature Ovarian Insufficiency","volume":"2022","author":"Chen","year":"2022","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.rbmo.2023.103778_bib0015","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.rbmo.2023.103778_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189838","article-title":"Pi3k\/pten\/akt signaling pathways in germ cell development and their involvement in germ cell tumors and ovarian dysfunctions","author":"De Felici","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0017","doi-asserted-by":"crossref","first-page":"e22398","DOI":"10.1002\/jbt.22398","article-title":"Upregulation of FSHR and PCNA by administration of coenzyme Q10 on cyclophosphamide-induced premature ovarian failure in a mouse model","volume":"33","author":"Delkhosh","year":"2019","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0019","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tice.2016.05.001","article-title":"Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects","volume":"48","author":"Elfayomy","year":"2016","journal-title":"Tissue Cell"},{"key":"10.1016\/j.rbmo.2023.103778_bib0020","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0021","doi-asserted-by":"crossref","DOI":"10.1177\/0023677217738268","article-title":"On determining sample size in experiments involving laboratory animals","author":"Festing","year":"2018","journal-title":"Lab Anim"},{"key":"10.1016\/j.rbmo.2023.103778_bib0022","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.nut.2012.11.004","article-title":"Chemoprotective effect of ascorbic acid, \u03b1-tocopherol, and selenium on cyclophosphamide-induced toxicity in the rat ovarium","volume":"29","author":"G\u00fcrgen","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.rbmo.2023.103778_bib0023","author":"Hirshfield","year":"1991","journal-title":"Development of Follicles in the Mammalian Ovary"},{"key":"10.1016\/j.rbmo.2023.103778_bib0024","doi-asserted-by":"crossref","first-page":"16033","DOI":"10.1021\/acs.jmedchem.2c01070","article-title":"Targeting the PI3K\/AKT\/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions","volume":"65","author":"Huang","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.rbmo.2023.103778_bib0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4149\/gpb_2019059","article-title":"Cryptotanshinone decreases granulosa cell apoptosis and restores ovarian function in mice with premature ovarian failure","volume":"39","author":"Huang","year":"2020","journal-title":"Gen Physiol Biophys"},{"key":"10.1016\/j.rbmo.2023.103778_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126397","article-title":"Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K\/AKT\/mTOR Signaling Pathway in Developing Rat Ovaries","volume":"23","author":"Jalouli","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0027","first-page":"8321","article-title":"Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF","volume":"14","author":"Jiang","year":"2022","journal-title":"Aging"},{"key":"10.1016\/j.rbmo.2023.103778_bib0028","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s12032-023-02107-5","article-title":"The effects of STA-9090 (Ganetespib) and venetoclax (ABT-199) combination on apoptotic pathways in human cervical cancer cells","volume":"40","author":"Karademir","year":"2023","journal-title":"Med Oncol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0029","doi-asserted-by":"crossref","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative Stress in Atherosclerosis","author":"Kattoor","year":"2017","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.rbmo.2023.103778_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121789","article-title":"LCZ696 (sacubitril\/valsartan) mitigates cyclophosphamide-induced premature ovarian failure in rats; the role of TLR4\/NF-\u03baB\/NLRP3\/Caspase-1 signaling pathway","volume":"326","author":"Khallaf","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0031","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.rbmo.2023.103778_bib0032","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1582-4934.2008.00273.x","article-title":"Heat shock proteins: essential proteins for apoptosis regulation","volume":"12","author":"Lanneau","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.rbmo.2023.103778_bib0033","article-title":"Metabonomic analysis of follicular fluid in patients with diminished ovarian reserve","volume":"14","author":"Li","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.rbmo.2023.103778_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113789","article-title":"Zihuai recipe alleviates cyclophosphamide-induced diminished ovarian reserve via suppressing PI3K\/AKT-mediated apoptosis","volume":"277","author":"Liu","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0035","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.572388","article-title":"Chemotherapy Associated Ovarian Failure","volume":"11","author":"Mauri","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.rbmo.2023.103778_bib0037","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13048-018-0409-9","article-title":"Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model","volume":"11","author":"Melekoglu","year":"2018","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.rbmo.2023.103778_bib0038","doi-asserted-by":"crossref","DOI":"10.1111\/cas.15068","article-title":"Reactive oxygen species in cancer: Current findings and future directions","author":"Nakamura","year":"2021","journal-title":"Cancer Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0039","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1139\/y04-032","article-title":"Expression of prostaglandin G\/H synthase (PGHS) and heat shock protein-70 (HSP-70) in the corpus luteum (CL) of prostaglandin F2 alpha-treated immature superovulated rats","volume":"82","author":"Narayansingh","year":"2004","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0040","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/09513590.2021.1885643","article-title":"The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study","volume":"37","author":"Nie","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031838","article-title":"The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature","volume":"24","author":"Niinuma","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0042","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/1120009X.2021.1908650","article-title":"Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells","volume":"33","author":"\u00d6zg\u00fcr","year":"2021","journal-title":"J Chemother"},{"key":"10.1016\/j.rbmo.2023.103778_bib0043","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1007\/s11033-021-06392-z","article-title":"Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines","volume":"48","author":"\u00d6zg\u00fcr","year":"2021","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.rbmo.2023.103778_bib0044","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/1871520615666150821093747","article-title":"Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications","volume":"16","author":"\u00d6zg\u00fcr","year":"2016","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.rbmo.2023.103778_bib0045","series-title":"Genetic models for transforming growth factor \u03b2 superfamily signaling in ovarian follicle development","first-page":"83","author":"Pangas","year":"2004"},{"key":"10.1016\/j.rbmo.2023.103778_bib0046","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1177\/0192623308317428","article-title":"Ovarian follicle counts using proliferating cell nuclear antigen (PCNA) and semi-automated image analysis in rats","volume":"36","author":"Picut","year":"2008","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0047","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.fertnstert.2008.08.068","article-title":"A block in the road to fertility: autoantibodies to heat-shock protein 90-beta in human ovarian autoimmunity","volume":"92","author":"Pires","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2023.103778_bib0048","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.rbmo.2023.103778_bib0049","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00404-017-4287-y","article-title":"The effect of dexpanthenol on experimentally induced ovarian ischaemia\/reperfusion injury: a biochemical and histopathological evaluation","volume":"295","author":"Soylu Karapinar","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.rbmo.2023.103778_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms12010334","article-title":"The role of reactive-oxygen-species in microbial persistence and inflammation","author":"Spooner","year":"2011","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rbmo.2023.103778_bib0051","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.rbmo.2023.103778_bib0052","doi-asserted-by":"crossref","unstructured":"Tilly, J.L., 2003. Ovarian follicle counts-not as simple as 1, 2, 3.","DOI":"10.1186\/1477-7827-1-11"},{"key":"10.1016\/j.rbmo.2023.103778_bib0053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096801","article-title":"IHC profiler: An open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples","volume":"9","author":"Varghese","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2023.103778_bib0054","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0092-8674(84)90345-3","article-title":"hsp70: nuclear concentration during environmental stress and cytoplasmic storage during recovery","volume":"36","author":"Velazquez","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.rbmo.2023.103778_bib0055","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1159\/000495051","article-title":"Niacin Inhibits Apoptosis and Rescues Premature Ovarian Failure","volume":"50","author":"Wang","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.rbmo.2023.103778_bib0056","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3892\/ijo.2014.2399","article-title":"HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review)","volume":"45","author":"Wang","year":"2014","journal-title":"Int J Oncol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0057","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13048-019-0548-7","article-title":"Abnormal expression of HSP70 may contribute to PCOS pathology","volume":"12","author":"Wu","year":"2019","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.rbmo.2023.103778_bib0058","first-page":"41","article-title":"Melatonin Protects Against Cyclophosphamide-induced Premature Ovarian Failure in Rats","author":"Xu","year":"2022","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0059","first-page":"39","article-title":"Apoptosis and apoptotic body: disease message and therapeutic target potentials","author":"Xu","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.rbmo.2023.103778_bib0060","doi-asserted-by":"crossref","DOI":"10.1292\/jvms.001427","article-title":"Effects of Pantothenic Acid on Testicular Function in Male Rats","author":"Yamamoto","year":"2009","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.rbmo.2023.103778_bib0061","article-title":"Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0062","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.rbmo.2023.103778_bib0063","doi-asserted-by":"crossref","first-page":"11625","DOI":"10.1080\/21655979.2022.2070585","article-title":"Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice","volume":"13","author":"Zhao","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.rbmo.2023.103778_bib0064","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/bcpt.13696","article-title":"Effects of quercetin on ovarian function and regulation of the ovarian PI3K\/Akt\/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure","volume":"130","author":"Zheng","year":"2022","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2011.05.027","article-title":"Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary","volume":"356","author":"Zheng","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.rbmo.2023.103778_bib0066","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13048-017-0350-3","article-title":"Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K\/Akt\/mTOR Signaling Pathway in vivo","volume":"10","author":"Zhou","year":"2017","journal-title":"J Ovarian Res"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648323008775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648323008775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:54:29Z","timestamp":1778615669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648323008775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1472648323008775"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2023.103778","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2023.103778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103778"}}