{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:22:19Z","timestamp":1778617339228,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006544","name":"Ministry of Health, State of Israel","doi-asserted-by":"publisher","award":["3-15140"],"award-info":[{"award-number":["3-15140"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006544","name":"Ministry of Health, State of Israel","doi-asserted-by":"publisher","award":["15140-3"],"award-info":[{"award-number":["15140-3"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.rbmo.2024.103981","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T12:25:44Z","timestamp":1712233544000},"page":"103981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pigment epithelium-derived factor expression and role in follicular development"],"prefix":"10.1016","volume":"49","author":[{"given":"Rana","family":"Tarabeih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luba","family":"Nemerovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadas","family":"Bar-Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Eldar-Boock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Elmechaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ido","family":"Ben-Ami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-9907","authenticated-orcid":false,"given":"Ruth","family":"Shalgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2024.103981_bib0050","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.fertnstert.2009.01.111","article-title":"Vascular endothelial growth factor A and its two receptors in human preantral follicles from fetuses, girls, and women","volume":"93","author":"Abir","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2024.103981_bib0001","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/REP-15-0478","article-title":"Pigment epithelium-derived factor regulation by human chorionic gonadotropin in granulosa cells","volume":"151","author":"Bar-Joseph","year":"2016","journal-title":"REPRODUCTION"},{"key":"10.1016\/j.rbmo.2024.103981_bib0002","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.fertnstert.2014.06.012","article-title":"Pigment epithelium-derived factor exerts antioxidative effects in granulosa cells","volume":"102","author":"Bar-Joseph","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2024.103981_bib0003","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.rbmo.2020.03.024","article-title":"Pigment epithelium derived factor as a novel multi-target treatment for uterine fibroids","volume":"41","author":"Bar-Joseph","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2024.103981_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/830975","article-title":"Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications","volume":"2012","author":"Becerra","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/molehr\/2.6.391","article-title":"Expression of Ad4-BP\/cytochrome P450 side chain cleavage enzyme and induction of cell death in long-term cultures of human granulosa cells","volume":"2","author":"Breckwoldt","year":"1996","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2024.103981_bib0006","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0248-4900(05)80186-8","article-title":"Culture of human preovulatory granulosa cells: effect of extracellular matrix on steroidogenesis","volume":"77","author":"Bussenot","year":"1993","journal-title":"Biol. cell"},{"key":"10.1016\/j.rbmo.2024.103981_bib0007","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1530\/REP-14-0251","article-title":"Role of pigment epithelium-derived factor in the reproductive system","volume":"148","author":"Chuderland","year":"2014","journal-title":"REPRODUCTION"},{"key":"10.1016\/j.rbmo.2024.103981_bib0008","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/molehr\/gas046","article-title":"Hormonal regulation of pigment epithelium-derived factor (PEDF) in granulosa cells","volume":"19","author":"Chuderland","year":"2013","journal-title":"MHR Basic Sci. Reprod. Med."},{"key":"10.1016\/j.rbmo.2024.103981_bib0009","doi-asserted-by":"crossref","first-page":"E258","DOI":"10.1210\/jc.2012-3037","article-title":"The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice","volume":"98","author":"Chuderland","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2024.103981_bib0010","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/humrep\/det027","article-title":"A physiological approach for treating endometriosis by recombinant pigment epithelium-derived factor (PEDF)","volume":"28","author":"Chuderland","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2024.103981_bib0011","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1210\/endo.137.4.8625923","article-title":"Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor","volume":"137","author":"Chun","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.rbmo.2024.103981_bib0012","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1530\/REP-17-0421","article-title":"Regulation of AMH by oocyte-specific growth factors in human primary cumulus cells","volume":"154","author":"Convissar","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.rbmo.2024.103981_bib0013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1439-0531.2001.00261.x","article-title":"In vitro Follicle Growth: Achievements in Mammalian Species","volume":"36","author":"Cortvrindt","year":"2001","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.rbmo.2024.103981_bib0014","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/humupd\/dmt062","article-title":"The physiology and clinical utility of anti-M\u00fcllerian hormone in women","volume":"20","author":"Dewailly","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2024.103981_bib0015","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humupd\/dmw027","article-title":"Interactions between androgens, FSH, anti-M\u00fcllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary","volume":"22","author":"Dewailly","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2024.103981_bib0016","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/en.2007-1649","article-title":"Inhibition of Vascular Endothelial Growth Factor in the Primate Ovary Up-Regulates Hypoxia-Inducible Factor-1\u03b1 in the Follicle and Corpus Luteum","volume":"149","author":"Duncan","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.rbmo.2024.103981_bib0017","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/jcb.22072","article-title":"Characterization of PEDF: a multi-functional serpin family protein","volume":"106","author":"Filleur","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.rbmo.2024.103981_bib0018","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-4-18","article-title":"Regulation of the ovarian follicular vasculature","volume":"4","author":"Fraser","year":"2006","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0019","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1258\/0007142001903364","article-title":"Angiogenesis and its control in the female reproductive system","volume":"56","author":"Fraser","year":"2000","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.rbmo.2024.103981_bib0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.theriogenology.2021.02.006","article-title":"Hypoxia up-regulates VEGF ligand and downregulates VEGF soluble receptor mRNA expression in bovine granulosa cells in vitro","volume":"165","author":"Hern\u00e1ndez-Morales","year":"2021","journal-title":"Theriogenology"},{"key":"10.1016\/j.rbmo.2024.103981_bib0021","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cca.2017.06.009","article-title":"New biomarkers for diagnosis and management of polycystic ovary syndrome","volume":"471","author":"Karakas","year":"2017","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.rbmo.2024.103981_bib0022","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/jcp.22491","article-title":"Potential role of follicle-stimulating hormone (FSH) and transforming growth factor (TGF\u03b21) in the regulation of ovarian angiogenesis","volume":"226","author":"Kuo","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0023","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/molehr\/gat065","article-title":"Involvement of androgens in ovarian health and disease","volume":"19","author":"Lebbe","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2024.103981_bib0049","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/01.ATV.21.1.6","article-title":"Estrogen and Angiogenesis. Arterioscler","volume":"21","author":"Losordo","year":"2001","journal-title":"Thromb. Vasc. Biol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0024","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/ERC-19-0054","article-title":"Stem-like tumor cells involved in heterogeneous vasculogenesis in breast cancer","volume":"27","author":"Mao","year":"2020","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.rbmo.2024.103981_bib0025","first-page":"200","article-title":"Initial and Cyclic Recruitment of Ovarian Follicles","volume":"21","author":"McGee","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.rbmo.2024.103981_bib0026","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/JOE-19-0603","article-title":"Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features","volume":"245","author":"Miller","year":"2020","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0027","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1210\/jc.2016-1744","article-title":"The Dual Role of PEDF in the Pathogenesis of OHSS: Negating Both Angiogenic and Inflammatory Pathways","volume":"101","author":"Miller","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2024.103981_bib0028","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002443RR","article-title":"Pigment epithelium-derived factor negates oxidative stress in mouse oocytes","volume":"35","author":"Nemerovsky","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.rbmo.2024.103981_bib0029","doi-asserted-by":"crossref","first-page":"10359","DOI":"10.3390\/ijms231810359","article-title":"The Role of PEDF in Reproductive Aging of the Ovary","volume":"23","author":"Nemerovsky","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rbmo.2024.103981_bib0030","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1093\/humrep\/deq275","article-title":"Understanding follicle growth in vivo","volume":"25","author":"Oktem","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2024.103981_bib0031","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.repbio.2019.01.002","article-title":"An optimized model for hCG stimulation of human mural granulosa cell culture","volume":"19","author":"Ophir","year":"2019","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0032","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/rmb2.12371","article-title":"The role of pituitary gonadotropins and intraovarian regulators in follicle development: A mini-review","volume":"20","author":"Orisaka","year":"2021","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0033","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tem.2008.03.001","article-title":"Immune-like mechanisms in ovulation","volume":"19","author":"Richards","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2024.103981_bib0034","doi-asserted-by":"crossref","unstructured":"Rimon-Dahari, N., Yerushalmi-Heinemann, L., Alyagor, L., Dekel, N., 2016. Ovarian Folliculogenesis. pp. 167\u2013190. https:\/\/doi.org\/10.1007\/978-3-319-31973-5_7","DOI":"10.1007\/978-3-319-31973-5_7"},{"key":"10.1016\/j.rbmo.2024.103981_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212507","article-title":"Anti-M\u00fcllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS","volume":"22","author":"Rudnicka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rbmo.2024.103981_bib0036","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10815-015-0615-y","article-title":"The anti-M\u00fcllerian hormone (AMH) acts as a gatekeeper of ovarian steroidogenesis inhibiting the granulosa cell response to both FSH and LH","volume":"33","author":"Sacchi","year":"2016","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2024.103981_bib0037","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1210\/jcem.87.7.8676","article-title":"Stimulation of apoptosis in human granulosa cells from in vitro fertilization patients and its prevention by dexamethasone: involvement of cell contact and bcl-2 expression","volume":"87","author":"Sasson","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2024.103981_bib0038","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/cen.13517","article-title":"Anti-M\u00fcllerian hormone measurement for the diagnosis of polycystic ovary syndrome","volume":"88","author":"Sathyapalan","year":"2018","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.rbmo.2024.103981_bib0039","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/biolre\/ioy013","article-title":"The oocyte-to-embryo transition in mouse: past, present, and future","volume":"99","author":"Schultz","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.rbmo.2024.103981_bib0040","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0015-0282(16)58197-7","article-title":"Estrogen biosynthesis-regulation, action, remote effects, and value of monitoring in ovarian stimulation cycles","volume":"65","author":"Shoham","year":"1996","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2024.103981_bib0041","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1530\/JOE-19-0297","article-title":"Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models","volume":"244","author":"Silber","year":"2020","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-020-03576-x","article-title":"New insights into anti-M\u00fcllerian hormone role in the hypothalamic\u2013pituitary\u2013gonadal axis and neuroendocrine development","volume":"78","author":"Silva","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.rbmo.2024.103981_bib0043","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.1073\/pnas.211268598","article-title":"Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor","volume":"98","author":"Simonovic","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.rbmo.2024.103981_bib0044","doi-asserted-by":"crossref","first-page":"59.e1","DOI":"10.1016\/j.ajog.2014.02.026","article-title":"Characterization of women with elevated antim\u00fcllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes","volume":"211","author":"Tal","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0045","doi-asserted-by":"crossref","first-page":"F1166","DOI":"10.1152\/ajprenal.00375.2007","article-title":"Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy","volume":"294","author":"Wang","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.rbmo.2024.103981_bib0046","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-005-1094-8","article-title":"Pigment epithelium-derived factor (PEDF) blocks angiotensin II signaling in endothelial cells via suppression of NADPH oxidase: a novel anti-oxidative mechanism of PEDF","volume":"320","author":"Yamagishi","year":"2005","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.rbmo.2024.103981_bib0047","first-page":"5","article-title":"Gonadotropin receptors in human ovarian follicles and corpora lutea throughout the menstrual cycle","volume":"1","author":"Yamoto","year":"1992","journal-title":"Horm. Res. 37 Suppl"},{"key":"10.1016\/j.rbmo.2024.103981_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-2-31","article-title":"The physiology of follicle selection","volume":"2","author":"Zeleznik","year":"2004","journal-title":"Reprod. Biol. Endocrinol."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648324001706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648324001706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:54:28Z","timestamp":1778615668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648324001706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1472648324001706"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2024.103981","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pigment epithelium-derived factor expression and role in follicular development","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2024.103981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103981"}}