{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:04:58Z","timestamp":1784541898889,"version":"3.55.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.rbmo.2024.103992","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T22:08:32Z","timestamp":1712959712000},"page":"103992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["IVF exposure induced intergenerational effects on metabolic phenotype in mice"],"prefix":"10.1016","volume":"49","author":[{"given":"Miaomiao","family":"Ban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanbing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-9169","authenticated-orcid":false,"given":"Linlin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.rbmo.2024.103992_bib0001","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1093\/humrep\/deaa205","article-title":"The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring","volume":"35","author":"Aljahdali","year":"2020","journal-title":"Human Reproduction"},{"issue":"8","key":"10.1016\/j.rbmo.2024.103992_bib0002","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0026-0495(03)00092-1","article-title":"Fat depot-specific expression of adiponectin is impaired in zucker fatty rats","volume":"52","author":"Altomonte","year":"2003","journal-title":"Metabolism"},{"key":"10.1016\/j.rbmo.2024.103992_bib0003","series-title":"Comprehensive Physiology","first-page":"1","article-title":"Triglyceride Metabolism in the Liver","author":"Alves-Bezerra","year":"2017"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110784","article-title":"Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos","volume":"39","author":"Bai","year":"2022","journal-title":"Cell Reports"},{"key":"10.1016\/j.rbmo.2024.103992_bib0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.placenta.2008.08.013","article-title":"Follow-up of Children Born after ART","volume":"29","author":"Basatemur","year":"2008","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.rbmo.2024.103992_bib0006","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/humupd\/dmac043","article-title":"Offspring physiology following the use of IVM, IVF and ICSI: a systematic review and meta-analysis of animal studies","volume":"29","author":"Beilby","year":"2023","journal-title":"Human Reproduction Update"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0007","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/03009734.2020.1729904","article-title":"Long-term health of children conceived after assisted reproductive technology","volume":"125","author":"Bergh","year":"2020","journal-title":"Upsala Journal of Medical Sciences"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0008","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/humupd\/dmz001","article-title":"The health of children conceived by ART: \u2018the chicken or the egg?","volume":"25","author":"Berntsen","year":"2019","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2024.103992_bib0009","doi-asserted-by":"crossref","unstructured":"Bj\u00f6rntorp, P. (2001). Do stress reactions cause abdominal obesity and comorbidities? (1467-7881 (Print)). doi: 10.1046\/j.1467-789x.2001.00027.x","DOI":"10.1046\/j.1467-789x.2001.00027.x"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0010","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-023-05681-8","article-title":"Altered local RAS in the liver increased the risk of NAFLD in male mouse offspring produced by in vitro fertilization","volume":"23","author":"Bo","year":"2023","journal-title":"BMC Pregnancy and Childbirth"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0011","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1017\/S0954422411000102","article-title":"Epigenetic mechanisms elicited by nutrition in early life","volume":"24","author":"Canani","year":"2011","journal-title":"Nutrition Research Reviews"},{"issue":"7","key":"10.1016\/j.rbmo.2024.103992_bib0012","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2010.12.008","article-title":"Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals","volume":"143","author":"Carone","year":"2010","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0013","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.fertnstert.2007.09.005","article-title":"Growth and development of children born after in vitro fertilization","volume":"90","author":"Ceelen","year":"2008","journal-title":"Fertility and Sterility"},{"issue":"10","key":"10.1016\/j.rbmo.2024.103992_bib0014","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1007\/s00125-020-05241-1","article-title":"Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology","volume":"63","author":"Cui","year":"2020","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0015","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/jc.2007-2432","article-title":"Cardiometabolic Differences in Children Born After in Vitro Fertilization: Follow-Up Study","volume":"93","author":"Delemarre-van de Waal","year":"2008","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"4","key":"10.1016\/j.rbmo.2024.103992_bib0016","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.113.113134","article-title":"In Vitro Fertilization Affects Growth and Glucose Metabolism in a Sex-Specific Manner in an Outbred Mouse Model1","volume":"90","author":"Donjacour","year":"2014","journal-title":"Biology of reproduction"},{"issue":"4","key":"10.1016\/j.rbmo.2024.103992_bib0017","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/mrd.22970","article-title":"Long term effects of ART: What do animals tell us?","volume":"85","author":"Duranthon","year":"2018","journal-title":"Molecular Reproduction and Development"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0018","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1530\/REP-08-0265","article-title":"Analysis of gene transcription alterations at the blastocyst stage related to the long-term consequences of in vitro culture in mice","volume":"137","author":"Fern\u00e1ndez-Gonz\u00e1lez","year":"2009","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0019","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1017\/S2040174415001105","article-title":"Embryos, DOHaD and David Barker","volume":"6","author":"Fleming","year":"2015","journal-title":"Journal of developmental origins of health and disease"},{"key":"10.1016\/j.rbmo.2024.103992_bib0020","doi-asserted-by":"crossref","unstructured":"Freedland, E. S. (2004). Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review. (1743-7075 (Print)). doi:10.1186\/1743-7075-1-12","DOI":"10.1186\/1743-7075-1-12"},{"issue":"10","key":"10.1016\/j.rbmo.2024.103992_bib0021","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1096\/fj.12-224048","article-title":"Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2generation and alters the transcriptional profile of testis and sperm microRNA content","volume":"27","author":"Fullston","year":"2013","journal-title":"The FASEB Journal"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0022","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-022-01869-9","article-title":"Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma","volume":"18","author":"Furse","year":"2022","journal-title":"Metabolomics"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0023","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.diabet.2008.04.002","article-title":"Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism","volume":"34","author":"Girard","year":"2008","journal-title":"Diabetes & metabolism"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0024","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1530\/REP-06-0247","article-title":"Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos","volume":"134","author":"Giritharan","year":"2007","journal-title":"Reproduction"},{"issue":"3","key":"10.1016\/j.rbmo.2024.103992_bib0025","first-page":"2022","article-title":"ART in Europe, 2018: results generated from European registries by ESHRE","author":"Gliozheni","year":"2022","journal-title":"Human Reproduction Open"},{"issue":"12","key":"10.1016\/j.rbmo.2024.103992_bib0026","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1194\/jlr.M300143-JLR200","article-title":"CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice","volume":"44","author":"Goudriaan","year":"2003","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.rbmo.2024.103992_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2015.10.020","article-title":"Paternal calorie restriction prior to conception alters anxiety-like behavior of the adult rat progeny","volume":"64","author":"Govic","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0028","doi-asserted-by":"crossref","first-page":"T105","DOI":"10.1530\/JOE-19-0009","article-title":"Epigenetic responses and the developmental origins of health and disease","volume":"242","author":"Goyal","year":"2019","journal-title":"Journal of Endocrinology"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0029","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cmet.2012.03.015","article-title":"Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c","volume":"15","author":"Hagiwara","year":"2012","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/j.rbmo.2024.103992_bib0030","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2015.122","article-title":"Regulation of glucose metabolism from a liver-centric perspective","volume":"48","author":"Han","year":"2016","journal-title":"Experimental & Molecular Medicine"},{"key":"10.1016\/j.rbmo.2024.103992_bib0031","doi-asserted-by":"crossref","unstructured":"Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021). Developmental origins of metabolic diseases. (1522-1210 (Electronic)). doi: 10.1152\/physrev.00002.2020","DOI":"10.1152\/physrev.00002.2020"},{"issue":"6","key":"10.1016\/j.rbmo.2024.103992_bib0032","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1301\/nr.2007.jun.S39-S46","article-title":"Lipid Mediators of Insulin Resistance","volume":"65","author":"Holland","year":"2007","journal-title":"Nutrition Reviews"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0033","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/humupd\/dmi022","article-title":"Assisted reproduction: the epigenetic perspective","volume":"11","author":"Horsthemke","year":"2005","journal-title":"Human Reproduction Update"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0034","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"11","author":"Ibrahim","year":"2009","journal-title":"Obesity Reviews"},{"issue":"4","key":"10.1016\/j.rbmo.2024.103992_bib0035","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.rbmo.2024.103992_bib0036","doi-asserted-by":"crossref","unstructured":"Ipsen, D. H., Lykkesfeldt, J., & Tveden-Nyborg, P. (2018). Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. (1420-9071 (Electronic)). doi:10.1007\/s00018-018-2860-6","DOI":"10.1007\/s00018-018-2860-6"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0037","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12778","article-title":"Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring","volume":"72","author":"Jia","year":"2021","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.rbmo.2024.103992_bib0038","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bpobgyn.2017.07.004","article-title":"Genetic and epigenetic risks of assisted reproduction","volume":"44","author":"Jiang","year":"2017","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"issue":"6","key":"10.1016\/j.rbmo.2024.103992_bib0039","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s00125-016-3940-5","article-title":"Hepatic glucose and lipid metabolism","volume":"59","author":"Jones","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.rbmo.2024.103992_bib0040","doi-asserted-by":"crossref","unstructured":"Kearney, A. A.-O., Norris, D. M., Ghomlaghi, M. A.-O., Kin Lok Wong, M., Humphrey, S. J., Carroll, L., \u2026 Burchfield, J. A.-O. (2021). Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. LID - 10.7554\/eLife.66942 [doi] LID - e66942. (2050-084X (Electronic)).","DOI":"10.7554\/eLife.66942.sa2"},{"issue":"6","key":"10.1016\/j.rbmo.2024.103992_bib0041","article-title":"Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos","volume":"10","author":"Knott","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2024.103992_bib0042","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhu, Y., Zhu, D., Shi, Y., Lu, L., Li, W., \u2026 Sun, M. (2022). GDF15 negatively regulates RGS16 to impair hepatic lipid metabolism in male mice offspring conceived by in vitro fertilization. (1943-8141 (Print)).","DOI":"10.21203\/rs.3.rs-1565536\/v1"},{"issue":"3","key":"10.1016\/j.rbmo.2024.103992_bib0043","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.fertnstert.2009.01.086","article-title":"Can we sense ART? The blinded examiner is not blind\u2014a problem with follow-up studies on children born after assisted reproduction","volume":"92","author":"Ludwig","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.rbmo.2024.103992_bib0044","doi-asserted-by":"crossref","unstructured":"Matthews Dr Fau - Hosker, J. P., Hosker Jp Fau - Rudenski, A. S., Rudenski As Fau - Naylor, B. A., Naylor Ba Fau - Treacher, D. F., Treacher Df Fau - Turner, R. C., & Turner, R. C. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. (0012-186X (Print)).","DOI":"10.1007\/BF00280883"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0045","doi-asserted-by":"crossref","DOI":"10.1038\/srep27010","article-title":"Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant\/vitamin food fortification in fathers","volume":"6","author":"McPherson","year":"2016","journal-title":"Scientific reports"},{"issue":"6","key":"10.1016\/j.rbmo.2024.103992_bib0046","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.rbmo.2010.02.016","article-title":"DNA methylation and gene expression in IVF","volume":"20","author":"Menezo","year":"2010","journal-title":"Reproductive BioMedicine Online"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0047","first-page":"11","article-title":"Embryo-fetal origin of diseases\u2013new approach on epigenetic reprogramming","volume":"16","author":"Motrenko","year":"2010","journal-title":"Arch Perinat Med"},{"issue":"7318","key":"10.1016\/j.rbmo.2024.103992_bib0048","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nature09491","article-title":"Chronic high-fat diet in fathers programs \u03b2-cell dysfunction in female rat offspring","volume":"467","author":"Ng","year":"2010","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.rbmo.2024.103992_bib0049","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1021\/pr301044b","article-title":"Comparative Analysis of Dynamic Proteomic Profiles between in Vivo and in Vitro Produced Mouse Embryos during Postimplantation Period","volume":"12","author":"Nie","year":"2013","journal-title":"Journal of Proteome Research"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humrep\/dez227","article-title":"Type 1 diabetes in children born after assisted reproductive technology: a register-based national cohort study","volume":"35","author":"Norrman","year":"2020","journal-title":"Human Reproduction"},{"issue":"7","key":"10.1016\/j.rbmo.2024.103992_bib0051","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00125-019-4909-y","article-title":"Type 2 diabetes: a multifaceted disease","volume":"62","author":"Pearson","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.rbmo.2024.103992_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.637781","article-title":"Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer","volume":"9","author":"Qin","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.rbmo.2024.103992_bib0053","doi-asserted-by":"crossref","unstructured":"Rondinone, C. M. (2006). Adipocyte-derived hormones, cytokines, and mediators. (1355-008X (Print)).","DOI":"10.1385\/ENDO:29:1:81"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0054","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.fertnstert.2009.09.049","article-title":"Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization","volume":"94","author":"Sakka","year":"2010","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1016\/j.rbmo.2024.103992_bib0055","first-page":"131","article-title":"Insulin signaling in health and disease","author":"Saltiel","year":"2021","journal-title":"Journal of Clinical Investigation"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0056","article-title":"Investigations on Transgenerational Epigenetic Response Down the Male Line in F2 Pigs","volume":"7","author":"Shioda","year":"2012","journal-title":"PLoS One"},{"issue":"7242","key":"10.1016\/j.rbmo.2024.103992_bib0057","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.rbmo.2024.103992_bib0058","first-page":"91","article-title":"Dynamic Proteomic Profiles of In Vivo- and In Vitro-Produced Mouse Postimplantation Extraembryonic Tissues and Placentas1","author":"Sui","year":"2014","journal-title":"Biology of reproduction"},{"issue":"2","key":"10.1016\/j.rbmo.2024.103992_bib0059","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1095\/biolreprod.103.026104","article-title":"In Vitro Embryo Production Efficiency in Cattle and Its Association with Oocyte Adenosine Triphosphate Content, Quantity of Mitochondrial DNA, and Mitochondrial DNA Haplogroup","volume":"71","author":"Tamassia","year":"2004","journal-title":"Biology of reproduction"},{"issue":"4","key":"10.1016\/j.rbmo.2024.103992_bib0060","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/dc12-1805","article-title":"Type 2 Diabetes","volume":"36","author":"Taylor","year":"2013","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2012.11.037","article-title":"Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach","volume":"99","author":"Thoma","year":"2013","journal-title":"Fertility and Sterility"},{"issue":"21","key":"10.1016\/j.rbmo.2024.103992_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Current Biology"},{"issue":"8","key":"10.1016\/j.rbmo.2024.103992_bib0063","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1210\/en.2002-0036","article-title":"Increased Hepatic Insulin Sensitivity Together with Decreased Hepatic Triglyceride Stores in Hormone-Sensitive Lipase-Deficient Mice","volume":"144","author":"Voshol","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.rbmo.2024.103992_bib0064","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.reprotox.2016.07.015","article-title":"Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse","volume":"68","author":"Vrooman","year":"2017","journal-title":"Reproductive Toxicology"},{"issue":"40","key":"10.1016\/j.rbmo.2024.103992_bib0065","doi-asserted-by":"crossref","first-page":"10064","DOI":"10.1073\/pnas.1806333115","article-title":"Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice","volume":"115","author":"Watkins","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.rbmo.2024.103992_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.749486","article-title":"Effect of Sperm Cryopreservation on miRNA Expression and Early Embryonic Development","volume":"9","author":"Xu","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"10","key":"10.1016\/j.rbmo.2024.103992_bib0067","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41580-018-0044-8","article-title":"Metabolites as regulators of insulin sensitivity and metabolism","volume":"19","author":"Yang","year":"2018","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"5","key":"10.1016\/j.rbmo.2024.103992_bib0068","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/07853890510037383","article-title":"Fat in the liver and insulin resistance","volume":"37","author":"Yki-J\u00e4rvinen","year":"2009","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.rbmo.2024.103992_bib0069","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.theriogenology.2021.05.022","article-title":"Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation","volume":"171","author":"Zacchini","year":"2021","journal-title":"Theriogenology"},{"issue":"3-4-5","key":"10.1016\/j.rbmo.2024.103992_bib0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1387\/ijdb.180402gp","article-title":"Assessing the epigenetic risks of assisted reproductive technologies: a way forward","volume":"63","author":"Zacchini","year":"2019","journal-title":"The International Journal of Developmental Biology"},{"issue":"3","key":"10.1016\/j.rbmo.2024.103992_bib0071","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s11427-018-9427-4","article-title":"Advances in research into gamete and embryo-fetal origins of adult diseases","volume":"62","author":"Zou","year":"2019","journal-title":"Science China Life Sciences"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648324001810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648324001810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T01:53:22Z","timestamp":1758678802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648324001810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1472648324001810"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2024.103992","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IVF exposure induced intergenerational effects on metabolic phenotype in mice","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2024.103992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103992"}}