{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:35:42Z","timestamp":1790660142711,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101961"],"award-info":[{"award-number":["82101961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971447"],"award-info":[{"award-number":["81971447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201773"],"award-info":[{"award-number":["82201773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171608"],"award-info":[{"award-number":["82171608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30731"],"award-info":[{"award-number":["2023JJ30731"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30716"],"award-info":[{"award-number":["2023JJ30716"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30714"],"award-info":[{"award-number":["2023JJ30714"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702604"],"award-info":[{"award-number":["2022YFC2702604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.rbmo.2024.104733","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T21:36:44Z","timestamp":1732138604000},"page":"104733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Women with FSHR-inactivating mutations causing resistant ovarian syndrome benefit from oocyte in-vitro maturation"],"prefix":"10.1016","volume":"50","author":[{"given":"Xiao-Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Lan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Xiu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Qiu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-5075","authenticated-orcid":false,"given":"Wen-Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2024.104733_bib0001","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.fertnstert.2007.11.093","article-title":"Follicle-stimulating hormone receptor polymorphism (Thr307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women","volume":"91","author":"Achrekar","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2024.104733_bib0002","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(95)90275-9","article-title":"Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure","volume":"82","author":"Aittom\u00e4ki","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.rbmo.2024.104733_bib0003","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/humrep\/deg046","article-title":"A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics","volume":"18","author":"Allen","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.rbmo.2024.104733_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-81-322-1686-5_14","article-title":"Impact of mutations and polymorphisms of gonadotrophins and their receptors on the outcome of controlled ovarian stimulation","author":"Alviggi","year":"2015","journal-title":"Principles and Practice of controlled ovarian stimulation in ART"},{"key":"10.1016\/j.rbmo.2024.104733_bib0004","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1172\/JCI3795","article-title":"A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor","volume":"102","author":"Beau","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.rbmo.2024.104733_bib0005","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s10815-021-02249-3","article-title":"Utilization of in vitro maturation in cases with a FSH receptor mutation","volume":"38","author":"Benammar","year":"2021","journal-title":"J Assist Reprod Gen"},{"key":"10.1016\/j.rbmo.2024.104733_bib0006","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/humrep\/dew025","article-title":"A novel follicle-stimulating hormone receptor mutation causing primary ovarian failure: a fertility application of whole exome sequencing","volume":"31","author":"Bramble","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.rbmo.2024.104733_bib0007","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0015-0282(16)54068-0","article-title":"Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program","volume":"55","author":"Cha","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2024.104733_bib0008","article-title":"Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome","volume":"13","author":"Chen","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.rbmo.2024.104733_bib0009","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1472-6483(10)60511-1","article-title":"In-vitro maturation of human oocytes","volume":"8","author":"Chian","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.rbmo.2024.104733_bib0010","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1210\/jc.2011-1064","article-title":"Follicle-stimulating hormone receptor polymorphism (G-29A) is associated with altered level of receptor expression in Granulosa cells","volume":"96","author":"Desai","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2024.104733_bib0011","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/jcem.87.3.8319","article-title":"A Novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure","volume":"87","author":"Doherty","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2024.104733_bib0012","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10815-018-1394-z","article-title":"Successful in vitro maturation of oocytes in a woman with gonadotropin-resistant ovary syndrome associated with a novel combination of FSH receptor gene variants: a case report","volume":"36","author":"Flageole","year":"2019","journal-title":"J Assist Reprod Gen"},{"key":"10.1016\/j.rbmo.2024.104733_bib0013","series-title":"Towards Reproductive Certainty: Infertility and Genetics Beyond 1999","first-page":"378","article-title":"In vitro culture of human blastocyst","author":"Gardner","year":"1999"},{"key":"10.1016\/j.rbmo.2024.104733_bib0014","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1007\/s10815-018-1317-z","article-title":"In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation","volume":"35","author":"Galvao","year":"2018","journal-title":"J Assist Reprod Gen"},{"key":"10.1016\/j.rbmo.2024.104733_bib0015","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fertnstert.2023.02.010","article-title":"Oocyte in vitro maturation: physiological basis and application to clinical practice","volume":"119","author":"Gilchrist","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2024.104733_bib0016","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0303-7207(96)03949-4","article-title":"Functional and clinical consequences of mutations in the FSH receptor","volume":"125","author":"Gromoll","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.rbmo.2024.104733_bib0017","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1210\/jc.2013-1967","article-title":"First birth achieved after in vitro maturation of oocytes from a woman endowed with multiple antral follicles unresponsive to follicle-stimulating hormone","volume":"98","author":"Grynberg","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2024.104733_bib0018","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.rbmo.2018.11.011","article-title":"Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome","volume":"38","author":"He","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.rbmo.2024.104733_bib0019","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/jmedgenet-2017-104992","article-title":"DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing","volume":"55","author":"He","year":"2018","journal-title":"J Med Genet"},{"key":"10.1016\/j.rbmo.2024.104733_bib0020","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cellsig.2006.02.011","article-title":"FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A","volume":"18","author":"Hunzicker-Dunn","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.rbmo.2024.104733_bib0021","doi-asserted-by":"crossref","first-page":"e1082","DOI":"10.1002\/mgg3.1082","article-title":"Novel FSHR variants causing female resistant ovary syndrome","volume":"8","author":"Khor","year":"2020","journal-title":"Mol Genet Genom Med"},{"key":"10.1016\/j.rbmo.2024.104733_bib0022","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0015-0282(16)42792-5","article-title":"The \u201cgonadotropin-resistant ovary\u201d syndrome as a cause of secondary amenorrhea and infertility","volume":"28","author":"Koninckx","year":"1977","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2024.104733_bib0023","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s10815-021-02085-5","article-title":"The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy","volume":"38","author":"Kornilov","year":"2021","journal-title":"J Assist Reprod Gen"},{"key":"10.1016\/j.rbmo.2024.104733_bib0024","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ejhg.2009.244","article-title":"An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance","volume":"18","author":"Kuechler","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.rbmo.2024.104733_bib0025","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1472-6483(10)61169-8","article-title":"Comparison of open and closed methods for vitrification of human embryos and the elimination of potential contamination","volume":"11","author":"Kuwayama","year":"2005","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.rbmo.2024.104733_bib0026","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13048-016-0263-6","article-title":"Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes","volume":"9","author":"Li","year":"2016","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.rbmo.2024.104733_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2017.09.010","article-title":"A novel homozygous mutation in the FSHR gene is causative for primary ovarian insufficiency","volume":"108","author":"Liu","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2024.104733_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.05.005","article-title":"Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency","volume":"492","author":"Liu","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.rbmo.2024.104733_bib0029","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1210\/jc.2003-030217","article-title":"Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies","volume":"88","author":"Meduri","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2024.104733_bib0030","article-title":"Resistant ovary syndrome: Pathogenesis and management strategies","volume":"9","author":"Mu","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.rbmo.2024.104733_bib0031","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.rbmo.2024.104733_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101596","article-title":"Genetic variants of gonadotrophins and their receptors: Impact on the diagnosis and management of the infertile patient","volume":"36","author":"Rivero-Muller","year":"2022","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2024.104733_bib0033","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/aji.12306","article-title":"Effective ovarian stimulation in a patient with resistant ovary syndrome and antigonadotrophin antibodies","volume":"73","author":"Rogenhofer","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.rbmo.2024.104733_bib0034","first-page":"140","article-title":"Gonadotropin-Resistant Ovary Syndrome Presented with Secondary Amenorrhea and Infertility: A Case Report","volume":"45","author":"Samsami","year":"2020","journal-title":"Iran J Med Sci"},{"key":"10.1016\/j.rbmo.2024.104733_bib0035","first-page":"193","article-title":"Novel inactivating follicle-stimulating hormone receptor mutations in a patient with premature ovarian insufficiency identified by next-generation sequencing gene panel analysis","volume":"1","author":"Sassi","year":"2020","journal-title":"F S Rep"},{"issue":"Suppl 1","key":"10.1016\/j.rbmo.2024.104733_bib0036","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1472-6483(12)60007-8","article-title":"In-vitro maturation of oocytes from unstimulated polycystic ovaries","volume":"4","author":"Tan","year":"2002","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.rbmo.2024.104733_bib0037","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1210\/mend.13.11.0370","article-title":"New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype","volume":"13","author":"Touraine","year":"1999","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.rbmo.2024.104733_bib0038","doi-asserted-by":"crossref","first-page":"e534","DOI":"10.1210\/clinem\/dgaa782","article-title":"A Novel Mutation in the FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure","volume":"106","author":"Zari\u00f1\u00e1n","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2024.104733_bib0039","article-title":"Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF","volume":"103","author":"Zhao","year":"2024","journal-title":"Medicine (Baltimore)"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648324009222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648324009222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:54:26Z","timestamp":1778615666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648324009222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1472648324009222"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2024.104733","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Women with FSHR-inactivating mutations causing resistant ovarian syndrome benefit from oocyte in-vitro maturation","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2024.104733","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104733"}}