{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:30:48Z","timestamp":1778830248748,"version":"3.51.4"},"reference-count":6,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FPU23\/01576"],"award-info":[{"award-number":["FPU23\/01576"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MTBLS11207"],"award-info":[{"award-number":["MTBLS11207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006393","name":"Universidad de Granada","doi-asserted-by":"publisher","award":["PID2021-12728OB-100"],"award-info":[{"award-number":["PID2021-12728OB-100"]}],"id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006393","name":"Universidad de Granada","doi-asserted-by":"publisher","award":["CNS2022-135999"],"award-info":[{"award-number":["CNS2022-135999"]}],"id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.rbmo.2025.104856","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:59:17Z","timestamp":1738583957000},"page":"104856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Refining the seminal biomarker detection: metabolome profiles before and after the liquefaction procedure"],"prefix":"10.1016","volume":"51","author":[{"given":"Celia M.","family":"Tenorio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea M.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Rodr\u00edguez-Guirado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Fern\u00e1ndez-Godino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-1865","authenticated-orcid":false,"given":"Signe","family":"Altm\u00e4e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caridad","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2025.104856_bib0001","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/humupd\/dmad028","article-title":"Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature","volume":"30","author":"Fauser","year":"2024","journal-title":"Hum Reprod Update"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104856_bib0002","doi-asserted-by":"crossref","first-page":"e1541","DOI":"10.1002\/ctm2.1541","article-title":"Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis","volume":"14","author":"Gonz\u00e1lez-Olmedo","year":"2024","journal-title":"Clinical and Translational Medicine"},{"issue":"7","key":"10.1016\/j.rbmo.2025.104856_bib0003","doi-asserted-by":"crossref","DOI":"10.1111\/and.13311","article-title":"Post-ejaculatory increase in human semen osmolality in vitro","volume":"51","author":"Holmes","year":"2019","journal-title":"Andrologia"},{"key":"10.1016\/j.rbmo.2025.104856_bib0004","first-page":"1","article-title":"Metabolomic characterization of semen from asthenozoospermic patients using ultra-high-performance liquid chromatography\u2013tandem quadrupole time-of-flight mass spectrometry","volume":"34","author":"Li","year":"2020","journal-title":"Biomedical Chromatography"},{"key":"10.1016\/j.rbmo.2025.104856_bib0005","article-title":"Metabolomics of male infertility","volume":"556","author":"Oluwaloseyi","year":"2024","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.rbmo.2025.104856_bib0006","series-title":"WHO laboratory manual for the examination and processing of human semen","year":"2021"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264832500063X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147264832500063X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:23:49Z","timestamp":1762547029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147264832500063X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S147264832500063X"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2025.104856","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Refining the seminal biomarker detection: metabolome profiles before and after the liquefaction procedure","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2025.104856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104856"}}