{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:32:56Z","timestamp":1791361976913,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017501","name":"Science Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["2023MSXM008"],"award-info":[{"award-number":["2023MSXM008"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.rbmo.2025.104949","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T05:54:39Z","timestamp":1742450079000},"page":"104949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Patients with mutations in DNAH2, DNAH6 and DNAH10 causing multiple morphological abnormalities of human sperm flagella achieve good ICSI outcomes"],"prefix":"10.1016","volume":"51","author":[{"given":"Xueqi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunhua","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwenyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guicen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyuan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0001","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ajhg.2013.11.017","article-title":"Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella","volume":"94","author":"Ben Khelifa","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1016\/j.rbmo.2025.104949_bib0002","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202109014","article-title":"Consensus nomenclature for dyneins and associated assembly factors","volume":"221","author":"Braschi","year":"2022","journal-title":"Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.rbmo.2025.104949_bib0003","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"5","key":"10.1016\/j.rbmo.2025.104949_bib0004","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/01485010390219656","article-title":"Asthenozoospermia: analysis of a large population","volume":"49","author":"Curi","year":"2003","journal-title":"Arch Androl"},{"issue":"2","key":"10.1016\/j.rbmo.2025.104949_bib0005","article-title":"DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia","volume":"12","author":"Dutcher","year":"2016","journal-title":"PLoS Genetics"},{"issue":"5","key":"10.1016\/j.rbmo.2025.104949_bib0006","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.rbmo.2021.01.011","article-title":"Novel bi-allelic variants in DNAH2 cause severe asthenoteratozoospermia with multiple morphological abnormalities of the flagella","volume":"42","author":"Gao","year":"2021","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"10.1016\/j.rbmo.2025.104949_bib0007","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humupd\/3.4.367","article-title":"Culture and selection of viable blastocysts: a feasible proposition for human IVF?","volume":"3","author":"Gardner","year":"1997","journal-title":"Hum Reprod Update"},{"issue":"21","key":"10.1016\/j.rbmo.2025.104949_bib0008","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1242\/jcs.03176","article-title":"The dynein family at a glance","volume":"119","author":"H\u00f6\u00f6k","year":"2006","journal-title":"Journal of Cell Science"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/humupd\/dmab030","article-title":"A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships","volume":"28","author":"Houston","year":"2021","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.rbmo.2025.104949_bib0010","article-title":"A novel frameshift mutation in DNAH6 associated with male infertility and asthenoteratozoospermia","volume":"14","author":"Huang","year":"2023","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.rbmo.2025.104949_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.662903","article-title":"Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice","volume":"9","author":"Hwang","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"10.1016\/j.rbmo.2025.104949_bib0012","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/molehr\/gar034","article-title":"Sperm flagella: comparative and phylogenetic perspectives of protein components","volume":"17","author":"Inaba","year":"2011","journal-title":"Mol Hum Reprod"},{"issue":"6 Pt 1","key":"10.1016\/j.rbmo.2025.104949_bib0013","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1083\/jcb.107.6.2253","article-title":"Mutations at twelve independent loci result in absence of outer dynein arms in Chylamydomonas reinhardtii","volume":"107","author":"Kamiya","year":"1988","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0014","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1083\/jcb.201304099","article-title":"Big steps toward understanding dynein","volume":"202","author":"Kikkawa","year":"2013","journal-title":"J Cell Biol"},{"issue":"14","key":"10.1016\/j.rbmo.2025.104949_bib0015","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0016","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10815-021-02306-x","article-title":"Bi-allelic variants in DNAH10 cause asthenoteratozoospermia and male infertility","volume":"39","author":"Li","year":"2022","journal-title":"J Assist Reprod Genet"},{"issue":"5","key":"10.1016\/j.rbmo.2025.104949_bib0017","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/cge.13525","article-title":"DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella","volume":"95","author":"Li","year":"2019","journal-title":"Clin Genet"},{"issue":"5","key":"10.1016\/j.rbmo.2025.104949_bib0018","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ncb2939","article-title":"Structural mechanism of the dynein power stroke","volume":"16","author":"Lin","year":"2014","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.rbmo.2025.104949_bib0019","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/andr.13476","article-title":"Novel biallelic variants in DNAH1 cause multiple morphological abnormalities of sperm flagella with favorable outcomes of fertility after ICSI in Han Chinese males","volume":"12","author":"Long","year":"2024","journal-title":"Andrology"},{"issue":"5","key":"10.1016\/j.rbmo.2025.104949_bib0020","doi-asserted-by":"crossref","first-page":"564","DOI":"10.4103\/aja2022118","article-title":"Patients with MMAF induced by novel biallelic CFAP43 mutations have good fertility outcomes after intracytoplasmic sperm injection","volume":"25","author":"Ma","year":"2023","journal-title":"Asian J Androl"},{"issue":"9","key":"10.1016\/j.rbmo.2025.104949_bib0021","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"issue":"4","key":"10.1016\/j.rbmo.2025.104949_bib0022","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/humupd\/dmaa004","article-title":"Haploid male germ cells-the Grand Central Station of protein transport","volume":"26","author":"Pleuger","year":"2020","journal-title":"Hum Reprod Update"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0023","first-page":"18","article-title":"Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts","volume":"32","author":"Punab","year":"2017","journal-title":"Hum Reprod"},{"issue":"11","key":"10.1016\/j.rbmo.2025.104949_bib0024","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrm3667","article-title":"Functions and mechanics of dynein motor proteins","volume":"14","author":"Roberts","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/aja202328","article-title":"Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella (MMAF) and ICSI outcomes","volume":"26","author":"Shao","year":"2024","journal-title":"Asian Journal of Andrology"},{"issue":"9","key":"10.1016\/j.rbmo.2025.104949_bib0026","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1007\/s10815-023-02873-1","article-title":"A novel variant in CFAP69 causes asthenoteratozoospermia with treatable ART outcomes and a literature review","volume":"40","author":"Tang","year":"2023","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"10.1016\/j.rbmo.2025.104949_bib0027","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/oxfordjournals.humrep.a137433","article-title":"Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989)","volume":"6","author":"Thonneau","year":"1991","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00439-020-02113-x","article-title":"The genetic architecture of morphological abnormalities of the sperm tail","volume":"140","author":"Tour\u00e9","year":"2021","journal-title":"Hum Genet"},{"issue":"8","key":"10.1016\/j.rbmo.2025.104949_bib0029","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.ajhg.2021.06.010","article-title":"Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice","volume":"108","author":"Tu","year":"2021","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.rbmo.2025.104949_bib0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52436-7","article-title":"Identification of DNAH6 mutations in infertile men with multiple morphological abnormalities of the sperm flagella","volume":"9","author":"Tu","year":"2019","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.rbmo.2025.104949_bib0031","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018325","article-title":"Ciliary Motility: Regulation of Axonemal Dynein Motors","volume":"9","author":"Viswanadha","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"16","key":"10.1016\/j.rbmo.2025.104949_bib0032","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.rbmo.2025.104949_bib0033","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s11684-023-0988-8","article-title":"Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice","volume":"17","author":"Wang","year":"2023","journal-title":"Front Med"},{"issue":"2","key":"10.1016\/j.rbmo.2025.104949_bib0034","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41419-023-05653-y","article-title":"DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.rbmo.2025.104949_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006996","article-title":"Chlamydomonas DYX1C1\/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms","volume":"13","author":"Yamamoto","year":"2017","journal-title":"PLoS Genet"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648325001567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648325001567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:24:12Z","timestamp":1762547052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648325001567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1472648325001567"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2025.104949","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patients with mutations in DNAH2, DNAH6 and DNAH10 causing multiple morphological abnormalities of human sperm flagella achieve good ICSI outcomes","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2025.104949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104949"}}