{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:51:13Z","timestamp":1787615473594,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.rbmo.2025.105045","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T20:57:09Z","timestamp":1746737829000},"page":"105045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of hormone replacement therapy on serum thyroid-stimulating hormone: a retrospective analysis"],"prefix":"10.1016","volume":"51","author":[{"given":"Pietro","family":"Molinaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego D","family":"Fasulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Galliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-2357","authenticated-orcid":false,"given":"Mauro","family":"Cozzolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2025.105045_bib0001","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/09513590701259542","article-title":"Subclinical hypothyroidism and thyroid autoimmunity in women with infertility","volume":"23","author":"Abalovich","year":"2007","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.rbmo.2025.105045_bib0002","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the Postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"key":"10.1016\/j.rbmo.2025.105045_bib0004","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1056\/NEJM200106073442302","article-title":"Increased need for thyroxine in women with hypothyroidism during estrogen therapy","volume":"344","author":"Arafah","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rbmo.2025.105045_bib0005","article-title":"ESHRE guideline: recurrent pregnancy loss: an update in 2022","volume":"2023","author":"Atik","year":"2023","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.rbmo.2025.105045_bib0006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/09513599809015542","article-title":"Thyroid profile modifications during oral hormone replacement therapy in postmenopausal women","volume":"12","author":"Benencia","year":"1998","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.rbmo.2025.105045_bib0007","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fertnstert.2021.01.029","article-title":"Thyroid function modifications in women undergoing controlled ovarian hyperstimulation for in vitro fertilization: a systematic review and meta-analysis","volume":"116","author":"Busnelli","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2025.105045_bib0008","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/cen.13329","article-title":"Preconception TSH and pregnancy outcomes: a population-based cohort study in 184 611 women","volume":"86","author":"Chen","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"Suppl 2","key":"10.1016\/j.rbmo.2025.105045_bib0009","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12325-019-01080-8","article-title":"Hypothyroidism in context: where we\u2019ve been and where we\u2019re going","volume":"36","author":"Chiovato","year":"2019","journal-title":"Adv Ther"},{"key":"10.1016\/j.rbmo.2025.105045_bib0010","doi-asserted-by":"crossref","unstructured":"Cimadomo, D., De Los Santos, M.J., Griesinger, G., Lainas, G., Le Clef, N., Mclernon, D.J., Montjean, D., Toth, B., Vermeulen, N., Macklon, N.; ESHRE Working Group on Recurrent Implantation Failure. n.d. ESHRE good practice recommendations on recurrent implantation failure. Hum Reprod Open 2023: hoad023.https:\/\/doi.org\/10.1093\/hropen\/hoad023","DOI":"10.1093\/hropen\/hoad023"},{"key":"10.1016\/j.rbmo.2025.105045_bib0011","first-page":"552","article-title":"Hipotireoidismo subcl\u00ednico e resultados de Inje\u00e7\u00e3o intracitoplasm\u00e1tica de espermatozoide","volume":"38","author":"Coelho Neto","year":"2016","journal-title":"Revista Brasileira de Ginecologia e Obstetricia"},{"key":"10.1016\/j.rbmo.2025.105045_bib0012","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/humupd\/dmu028","article-title":"Molecular basis of thyrotropin and thyroid hormone action during implantation and early development","volume":"20","author":"Colicchia","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"11","key":"10.1016\/j.rbmo.2025.105045_bib0013","doi-asserted-by":"crossref","first-page":"102876","DOI":"10.1016\/j.dsx.2023.102876","article-title":"Thyroid dysfunction and female infertility. A comprehensive review","volume":"17","author":"Concepci\u00f3n-Zavaleta","year":"2023","journal-title":"Diabetes and Metabolic Syndrome: Clinical Research and Reviews"},{"key":"10.1016\/j.rbmo.2025.105045_bib0014","doi-asserted-by":"crossref","unstructured":"De Groot, L., Abalovich, M., Alexander, E.K., Amino, N., Barbour, L., Cobin, R.H., Eastman, C.J., Lazarus, J.H., Luton, D., Mandel, S.J., Mestman, J., Rovet, J., Sullivan, S., 2012. Management of thyroid dysfunction during pregnancy and postpartum: An Endocrine Society Clinical Practice Guideline 97 (8), 2543\u20132565. https:\/\/doi.org\/10.1210\/jc.2011-2803","DOI":"10.1210\/jc.2011-2803"},{"key":"10.1016\/j.rbmo.2025.105045_bib0015","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.steroids.2012.02.018","article-title":"Nongenomic effects of thyroid hormones on the immune system cells: new targets, old players","volume":"77","author":"De Vito","year":"2012","journal-title":"Steroids"},{"issue":"6","key":"10.1016\/j.rbmo.2025.105045_bib0016","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.beem.2008.09.019","article-title":"Epidemiology of thyroid nodules","volume":"22","author":"Dean","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.rbmo.2025.105045_bib0017","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1365-2265.2003.01681.x","article-title":"Laboratory medicine practice guidelines: Laboratory support for the diagnosis and monitoring of thyroid disease","volume":"58","author":"Demers","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.rbmo.2025.105045_bib0018","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S2213-8587(20)30061-9","article-title":"Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis","volume":"8","author":"Derakhshan","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"10.1016\/j.rbmo.2025.105045_bib0019","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1515\/cclm-2016-1123","article-title":"Data mining for age-related TSH reference intervals in adulthood","volume":"55","author":"Farrell","year":"2017","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"10.1016\/j.rbmo.2025.105045_bib0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4065\/84.1.65","article-title":"Subclinical hypothyroidism: An update for primary care physicians","volume":"84","author":"Fatourechi","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.rbmo.2025.105045_bib0021","doi-asserted-by":"crossref","DOI":"10.4158\/EP12280.GL","article-title":"Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association","author":"Garber","year":"2012","journal-title":"Endocrine Practice"},{"key":"10.1016\/j.rbmo.2025.105045_bib0022","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s10815-015-0549-4","article-title":"Investigating the optimal preconception TSH range for patients undergoing IVF when controlling for embryo quality","volume":"32","author":"Green","year":"2015","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"10.1016\/j.rbmo.2025.105045_bib0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S2213-8587(18)30371-1","article-title":"Reference intervals in the diagnosis of thyroid dysfunction: treating patients not numbers","volume":"7","author":"Jonklaas","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.rbmo.2025.105045_bib0023","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/GME.0000000000001811","article-title":"Effects of oral versus transdermal estradiol plus micronized progesterone on thyroid hormones, hepatic proteins, lipids, and quality of life in menopausal women with hypothyroidism: a clinical trial","volume":"28","author":"Kaminski","year":"2021","journal-title":"Menopause"},{"key":"10.1016\/j.rbmo.2025.105045_bib0024","article-title":"Impact of preconceptional serum thyroid stimulating hormone values ranging between 2.5 and 4.5 mIU\/L on live birth rates following ovulation induction and intrauterine insemination treatment for unexplained infertility","volume":"21,162","author":"Karakis","year":"2021","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.rbmo.2025.105045_bib0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2010.00911.x","article-title":"Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures","volume":"65","author":"Kim","year":"2011","journal-title":"American Journal of Reproductive Immunology"},{"key":"10.1016\/j.rbmo.2025.105045_bib0026","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/jama.2019.10931","article-title":"Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity with Preterm Birth: a systematic review and meta-analysis","volume":"322","author":"Korevaar","year":"2019","journal-title":"JAMA - Journal of the American Medical Association"},{"key":"10.1016\/j.rbmo.2025.105045_bib0027","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/thy.2012.0392","article-title":"Impact of enhanced detection on the increase in thyroid cancer incidence in the United States: review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980-2008","volume":"23","author":"Li","year":"2013","journal-title":"Thyroid"},{"key":"10.1016\/j.rbmo.2025.105045_bib0028","doi-asserted-by":"crossref","first-page":"E2591","DOI":"10.1210\/jc.2014-1505","article-title":"Maternal early-pregnancy thyroid function is associated with subsequent hypertensive disorders of pregnancy: the generation R study","volume":"99","author":"Medici","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.rbmo.2025.105045_bib0029","doi-asserted-by":"crossref","first-page":"100132","DOI":"10.1016\/j.endmts.2023.100132","article-title":"Age-related thyroid hormone resistance: a friend or foe","volume":"11","author":"Mooradian","year":"2023","journal-title":"Endocrine and Metabolic Science"},{"key":"10.1016\/j.rbmo.2025.105045_bib0030","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1210\/jc.2005-1603","article-title":"Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications","volume":"91","author":"Negro","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.rbmo.2025.105045_bib0031","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/13697137.2020.1804547","article-title":"Premature ovarian insufficiency: an International Menopause Society White Paper","volume":"23","author":"Panay","year":"2020","journal-title":"Climacteric"},{"key":"10.1016\/j.rbmo.2025.105045_bib0032","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.fertnstert.2015.05.028","article-title":"Subclinical hypothyroidism in the infertile female population: a guideline","volume":"104","author":"Pfeifer","year":"2015","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.rbmo.2025.105045_bib0033","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2010.11.011","article-title":"Thyroid hormone as a regulator of tumor induced angiogenesis","volume":"301","author":"Pinto","year":"2011","journal-title":"Cancer Lett"},{"key":"10.1016\/j.rbmo.2025.105045_bib0034","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1210\/jc.2016-1049","article-title":"Subclinical hypothyroidism and thyroid autoimmunity are not associated with fecundity, pregnancy loss, or live birth","volume":"101","author":"Plowden","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.rbmo.2025.105045_bib0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/humupd\/dmg012","article-title":"Thyroid autoimmunity and hypothyroidism before and during pregnancy","volume":"9","author":"Poppe","year":"2003","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.rbmo.2025.105045_bib0036","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1016\/j.fertnstert.2010.06.041","article-title":"What is a normal thyroid-stimulating hormone (TSH) level? Effects of stricter TSH thresholds on pregnancy outcomes after in vitro fertilization","volume":"94","author":"Reh","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.rbmo.2025.105045_bib0037","doi-asserted-by":"crossref","first-page":"875125","DOI":"10.4061\/2011\/875125","article-title":"Role of estrogen in thyroid function and growth regulation","volume":"2011","author":"Santin","year":"2011","journal-title":"J Thyroid Res"},{"key":"10.1016\/j.rbmo.2025.105045_bib0038","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/gme.0b013e31803867a","article-title":"A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women","volume":"14","author":"Shifren","year":"2007","journal-title":"Menopause"},{"key":"10.1016\/j.rbmo.2025.105045_bib0039","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.fertnstert.2023.12.038","article-title":"Subclinical hypothyroidism in the infertile female population: a guideline","volume":"121","year":"2024","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.rbmo.2025.105045_bib0041","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/humupd\/dmr024","article-title":"Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review","volume":"17","author":"van den Boogaard","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.rbmo.2025.105045_bib0042","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S2213-8587(22)00045-6","article-title":"Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"10","author":"van Dijk","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.rbmo.2025.105045_bib0043","article-title":"Thyroid disease assessment and management: Summary of NICE guidance","volume":"368","author":"Vasileiou","year":"2020","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.rbmo.2025.105045_bib0044","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0015-0282(16)55974-3","article-title":"Thyroid hormones in human follicular fluid and thyroid hormone receptors in human granulosa cells","volume":"59","author":"Wakim","year":"1993","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.rbmo.2025.105045_bib0045","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2016-1506","article-title":"Low Thyroid Hormone in Early pregnancy is associated with an increased risk of gestational diabetes mellitus","volume":"101","author":"Yang","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rbmo.2025.105045_bib0046","doi-asserted-by":"crossref","unstructured":"Zamwar, U.M., Muneshwar, K.N., 2023. Epidemiology, types, causes, clinical presentation, diagnosis, and treatment of hypothyroidism. 15(9), e46241. https:\/\/doi.org\/10.7759\/cureus.46241","DOI":"10.7759\/cureus.46241"},{"key":"10.1016\/j.rbmo.2025.105045_bib0047","article-title":"Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: a systematic review and meta-analysis","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"issue":"111","key":"10.1016\/j.rbmo.2025.105045_bib0049","article-title":"Meta-analysis of ART outcomes in women with different preconception TSH levels","volume":"16","author":"Zhao","year":"2018","journal-title":"Reproductive Biology and Endocrinology"}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648325002524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648325002524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:51:20Z","timestamp":1775119880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648325002524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1472648325002524"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2025.105045","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of hormone replacement therapy on serum thyroid-stimulating hormone: a retrospective analysis","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2025.105045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105045"}}