{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:37:31Z","timestamp":1790653051042,"version":"4.1.0"},"reference-count":164,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004271","name":"University of Rome La Sapienza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.rbmo.2026.105734","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:10:16Z","timestamp":1777129816000},"page":"105734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age-related female infertility: aetiological mechanisms and evidence-based and experimental interventions"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-8295","authenticated-orcid":false,"given":"Stefano","family":"Palomba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Seminara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sarica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2026.105734_bib0001","doi-asserted-by":"crossref","DOI":"10.1177\/1179558119848007","article-title":"Female fertility preservation through stem cell-based ovarian tissue reconstitution in vitro and ovarian regeneration in vivo","volume":"13","author":"Akahori","year":"2019","journal-title":"Clin. Med. Insights Reprod. Health."},{"key":"10.1016\/j.rbmo.2026.105734_bib0002","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000477353","article-title":"A review of platelet-rich plasma: history, biology, mechanism of action, and classification","volume":"4","author":"Alves","year":"2018","journal-title":"Skin Appendage Disord."},{"key":"10.1016\/j.rbmo.2026.105734_bib0003","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1111\/1471-0528.16025","article-title":"Elective egg freezing for non-medical reasons: Scientific Impact Paper No. 63","volume":"127","author":"Anderson","year":"2020","journal-title":"BJOG"},{"key":"10.1016\/j.rbmo.2026.105734_bib0004","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/0284185120933983","article-title":"Documentation of normal shape and measurements of the uterine fundus at reproductive age","volume":"62","author":"Aouad","year":"2021","journal-title":"Acta Radiol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.2025.2975","article-title":"Endometriosis: A Review","volume":"334","author":"As-Sanie","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.rbmo.2026.105734_bib0006","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/humrep\/deab106","article-title":"Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?","volume":"36","author":"Atkinson","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0007","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/humrep\/deae038","article-title":"Intraovarian platelet-rich plasma injection and IVF outcomes in patients with poor ovarian response: a double-blind randomized controlled trial","volume":"39","author":"Barrenetxea","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0008","first-page":"753","article-title":"The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: A randomized controlled trial","volume":"20","author":"Baybordi","year":"2022","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.rbmo.2026.105734_bib0009","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/acel.12368","article-title":"Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging","volume":"14","author":"Ben-Meir","year":"2015","journal-title":"Aging Cell."},{"key":"10.1016\/j.rbmo.2026.105734_bib0010","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1093\/oxfordjournals.humrep.a138005","article-title":"Oestrogen and progesterone receptors in endometriotic tissue and endometrium: comparison of different cycle phases and ages","volume":"8","author":"Bergqvist","year":"1993","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0011","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/humrep\/deu026","article-title":"Is unilateral oophorectomy associated with age at menopause? A population study (the HUNT2 Survey)","volume":"29","author":"Bjelland","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0012","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/humrep\/dem046","article-title":"International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care","volume":"22","author":"Boivin","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0013","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/humrep\/dev114","article-title":"Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells","volume":"30","author":"Boucret","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0014","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31274","article-title":"Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium","volume":"6","author":"Brighton","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.rbmo.2026.105734_bib0015","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/s41419-020-03183-5","article-title":"Quercetin promotes in vitro maturation of oocytes from humans and aged mice","volume":"11","author":"Cao","year":"2020","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.rbmo.2026.105734_bib0016","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0140-6736(86)90989-X","article-title":"Pregnancy after human oocyte cryopreservation","volume":"1","author":"Chen","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.rbmo.2026.105734_bib0017","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s10815-021-02222-0","article-title":"Oocyte cryopreservation versus ovarian tissue cryopreservation for adult female oncofertility patients: a cost-effectiveness study","volume":"38","author":"Chung","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105734_bib0018","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.222570","article-title":"Nutrient regulation of mTORC1 at a glance","volume":"132","author":"Condon","year":"2019","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.rbmo.2026.105734_bib0019","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13048-023-01330-y","article-title":"Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment","volume":"17","author":"Cui","year":"2024","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.rbmo.2026.105734_bib0020","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1055\/s-0036-1584205","article-title":"Salidroside promotes random skin flap survival in rats by enhancing angiogenesis and inhibiting apoptosis","volume":"32","author":"Deheng","year":"2016","journal-title":"J. Reconstr. Microsurg."},{"key":"10.1016\/j.rbmo.2026.105734_bib0021","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/bioengineering10070832","article-title":"Bioengineered 3D ovarian models as paramount technology for female health management and reproduction","volume":"10","author":"Del Valle","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0022","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/humrep\/deac112","article-title":"Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells","volume":"37","author":"Deryabin","year":"2022","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0023","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00018-019-03374-0","article-title":"The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balance","volume":"77","author":"Deryabin","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.rbmo.2026.105734_bib0024","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.fertnstert.2017.11.018","article-title":"Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study","volume":"109","author":"Diaz-Garcia","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104704","article-title":"Elective uterine preservation: a novel concept to tackle reproductive ageing. Fertility preservation beyond ovaries","volume":"50","author":"Di Spiezio Sardo","year":"2025","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105734_bib0026","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3390\/nu17132101","article-title":"The role of lifestyle intervention in female fertility: A modifiable factor for preconception health","volume":"17","author":"Donato","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.rbmo.2026.105734_bib0027","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJMra1614676","article-title":"Fertility preservation in women","volume":"377","author":"Donnez","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0028","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.rbmo.2026.105734_bib0029","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ogc.2012.09.006","article-title":"Tubal factor infertility: diagnosis and management in the era of assisted reproductive technology","volume":"39","author":"Dun","year":"2012","journal-title":"Obstet, Gynecol. Clin. North Am."},{"key":"10.1016\/j.rbmo.2026.105734_bib0030","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S1472-6483(10)60889-9","article-title":"How should the clinical efficiency of oocyte cryopreservation be measured?","volume":"14","author":"Edgar","year":"2007","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105734_bib0031","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000323777","article-title":"Evaluation of endometrial and subendometrial vascularization and endometrial volume by 3-D power Doppler ultrasound and its relationship with age and pregnancy in intrauterine insemination cycles","volume":"72","author":"Engels","year":"2011","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.rbmo.2026.105734_bib0032","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ajog.2024.04.012","article-title":"Perinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis","volume":"231","author":"Erden","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0033","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejogrb.2005.01.012","article-title":"Is endometrial apoptosis evidence of endometrial aging in unexplained infertility? a preliminary report","volume":"121","author":"Erel","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0034","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.fertnstert.2023.12.030","article-title":"Planned oocyte cryopreservation to preserve future reproductive potential: an Ethics Committee opinion","volume":"121","year":"2024","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/qua.25423","article-title":"Magnesium sulfate against oxidative damage of membrane lipids: A theoretical model","author":"Fern\u00e0ndez","year":"2017","journal-title":"Int. J. Quantum Chem."},{"key":"10.1016\/j.rbmo.2026.105734_bib0036","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1007\/s10815-020-01906-3","article-title":"Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials","volume":"37","author":"Florou","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105734_bib0037","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/humupd\/dmac025","article-title":"Bioengineering trends in female reproduction: a systematic review","volume":"28","author":"Franc\u00e9s-Herrero","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0038","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0015-0282(02)03133-3","article-title":"N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome","volume":"77","author":"Fulghesu","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0039","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC-1alpha","volume":"26","author":"Gerhart-Hines","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.rbmo.2026.105734_bib0040","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3390\/medicina61101794","article-title":"Fertility preservation strategies in female cancer patients: Current approaches and future directions","volume":"61","author":"Gic\u0103","year":"2025","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0041","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.beem.2006.03.005","article-title":"Endometrium in PCOS: implantation and predisposition to endocrine CA","volume":"20","author":"Giudice","year":"2006","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rbmo.2026.105734_bib0042","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJMcp0912024","article-title":"Clinical practice. Functional hypothalamic amenorrhea","volume":"363","author":"Gordon","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0043","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.cmet.2023.12.007","article-title":"Human trials exploring anti-aging medicines","volume":"36","author":"Guarente","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.rbmo.2026.105734_bib0044","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/humupd\/dmae020","article-title":"Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage","volume":"30","author":"Guo","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/00016347309158301","article-title":"Metabolism of glucose in the human endometrium with special reference to fertility and contraception","volume":"52","author":"Hackl","year":"1973","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.rbmo.2026.105734_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.974775","article-title":"Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases","volume":"13","author":"Han","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0047","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/rmb2.12236","article-title":"Guideline for cryopreservation of unfertilized eggs and ovarian tissues in Japan Society of Reproductive Medicine: Ethics Committee in Japan Society of Reproductive Medicine","volume":"18","author":"Harada","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0048","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.rbmo.2026.105734_bib0049","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1017\/S0967199423000461","article-title":"The effect of coenzyme Q10 on mitochondrial biogenesis in mouse ovarian follicles during in vitro culture","volume":"32","author":"Harsini","year":"2024","journal-title":"Zygote"},{"key":"10.1016\/j.rbmo.2026.105734_bib0050","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1226889","article-title":"Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice","volume":"338","author":"Hayashi","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.rbmo.2026.105734_bib0051","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/humrep\/deae093","article-title":"Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial","volume":"39","author":"Herlihy","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0052","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.fertnstert.2018.01.004","article-title":"Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion","volume":"109","author":"Herraiz","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0053","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature20104","article-title":"Reconstitution in vitro of the entire cycle of the mouse female germ line","volume":"539","author":"Hikabe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.rbmo.2026.105734_bib0054","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/humupd\/dmae009","article-title":"Planned oocyte cryopreservation: a systematic review and meta-regression analysis","volume":"30","author":"Hirsch","year":"2024","journal-title":"Hum. Reprod. Update"},{"issue":"4 Suppl","key":"10.1016\/j.rbmo.2026.105734_bib0055","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.fertnstert.2008.02.127","article-title":"Oocyte vitrification \u2013 women's emancipation set in stone","volume":"91","author":"Homburg","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0056","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fendo.2020.00160","article-title":"Melatonin application in assisted reproductive technology: a systematic review and meta-analysis of randomized trials","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.rbmo.2026.105734_bib0057","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1126\/science.1083452","article-title":"Derivation of oocytes from mouse embryonic stem cells","volume":"300","author":"H\u00fcbner","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.rbmo.2026.105734_bib0058","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0940-9602(04)80014-1","article-title":"Morphometrical changes of the human uterine tubes according to aging and menstrual cycle","volume":"186","author":"Hwang","year":"2004","journal-title":"Ann. Anat."},{"key":"10.1016\/j.rbmo.2026.105734_bib0059","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/aogs.13569","article-title":"A brief history of oocyte cryopreservation: arguments and facts","volume":"98","author":"Iussig","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.rbmo.2026.105734_bib0060","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2005.06.031","article-title":"Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood","volume":"122","author":"Johnson","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.rbmo.2026.105734_bib0061","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nature02316","article-title":"Germline stem cells and follicular renewal in the postnatal mammalian ovary","volume":"428","author":"Johnson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.rbmo.2026.105734_bib0062","doi-asserted-by":"crossref","first-page":"426.e1","DOI":"10.1016\/j.ajog.2023.12.037","article-title":"Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation","volume":"230","author":"Johnson","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0063","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1546041","article-title":"Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation","volume":"16","author":"Ju","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0064","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15680","article-title":"In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells","volume":"8","author":"Jung","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.rbmo.2026.105734_bib0065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10545-016-9930-4","article-title":"The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome","volume":"39","author":"Kanabus","year":"2016","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.rbmo.2026.105734_bib0066","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1093\/humrep\/deac144","article-title":"Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?","volume":"37","author":"Kasaven","year":"2022","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0067","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/humupd\/dmu011","article-title":"Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis","volume":"20","author":"Kasius","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0068","doi-asserted-by":"crossref","first-page":"gaaa078","DOI":"10.1093\/molehr\/gaaa078","article-title":"Identification of genes associated with endometrial cell ageing","volume":"27","author":"Kawamura","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0069","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0029665112002765","article-title":"Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies","volume":"72","author":"Khan","year":"2013","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.rbmo.2026.105734_bib0070","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humupd\/dmac003","article-title":"Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis","volume":"28","author":"Khattak","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0071","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.fertnstert.2024.06.025","article-title":"Return rates and pregnancy outcomes after oocyte preservation for planned fertility delay: a systematic review and meta-analysis","volume":"122","author":"Kirubarajan","year":"2024","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0072","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3892\/etm.2020.9308","article-title":"Endometrial changes in estrogen and progesterone receptor expression during implantation in an oocyte donation program","volume":"20","author":"Klonos","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0073","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S1470-2045(09)70317-1","article-title":"Surviving childhood and reproductive-age malignancy: effects on fertility and future parenthood","volume":"11","author":"Knopman","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0074","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.fertnstert.2014.07.1233","article-title":"Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform","volume":"102","author":"Konstantinidis","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0075","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/humrep\/14.12.3077","article-title":"Birth following vitrification of a small number of human oocytes: case report","volume":"14","author":"Kuleshova","year":"1999","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0076","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000492415","article-title":"Platelet-rich plasma in tissue engineering: hype and hope","volume":"59","author":"Lang","year":"2018","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.rbmo.2026.105734_bib0077","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5653\/cerm.2024.07003","article-title":"Preservation of ovarian function using human pluripotent stem cell-derived mesenchymal progenitor cells","volume":"52","author":"Lee","year":"2025","journal-title":"Clin. Exp. Reprod. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0078","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13048-020-0615-0","article-title":"Decreased ovarian function and autophagy gene methylation in aging rats","volume":"13","author":"Li","year":"2020","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.rbmo.2026.105734_bib0079","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ygyno.2013.09.018","article-title":"Secretory cell expansion with aging: risk for pelvic serous carcinogenesis","volume":"131","author":"Li","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/REP-22-0095","article-title":"Nicotinamide riboside supplementation ameliorated post-ovulatory oocyte quality decline","volume":"165","author":"Li","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.rbmo.2026.105734_bib0081","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/humrep\/deae292","article-title":"Global, regional, and national prevalence and trends of infertility among individuals of reproductive age (15\u201349 years) from 1990 to 2021, with projections to 2040","volume":"40","author":"Liang","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.707584","article-title":"Platelet-rich plasma as a potential new strategy in the endometrium treatment in assisted reproductive technology","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0083","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jogc.2016.12.004","article-title":"No. 346-Advanced reproductive age and fertility","volume":"39","author":"Liu","year":"2017","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.rbmo.2026.105734_bib0084","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/humrep\/des437","article-title":"Resveratrol protects against age-associated infertility in mice","volume":"28","author":"Liu","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0085","doi-asserted-by":"crossref","DOI":"10.1177\/1179558119867357","article-title":"Ovarian tissue transplantation: experience from Germany and worldwide efficacy","volume":"13","author":"Lotz","year":"2019","journal-title":"Clin. Med. Insights Reprod. Health."},{"key":"10.1016\/j.rbmo.2026.105734_bib0086","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/13697139809080683","article-title":"Microanatomy of the female reproductive organs in postmenopause by scanning electron microscopy","volume":"1","author":"Makabe","year":"1998","journal-title":"Climacteric"},{"key":"10.1016\/j.rbmo.2026.105734_bib0087","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12958-024-01323-6","article-title":"Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis","volume":"22","author":"Marti-Garcia","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0088","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/humrep\/deaa343","article-title":"Live birth and perinatal outcomes using cryopreserved oocytes: an analysis of the Human Fertilisation and Embryology Authority database from 2000 to 2016 using three clinical models","volume":"36","author":"Mascarenhas","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107987","article-title":"Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes","volume":"32","author":"Miao","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.rbmo.2026.105734_bib0090","doi-asserted-by":"crossref","first-page":"eadl0788","DOI":"10.1126\/sciadv.adl0788","article-title":"FOXL2 interaction with different binding partners regulates the dynamics of ovarian development","volume":"10","author":"Migale","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.rbmo.2026.105734_bib0091","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41467-024-55509-y","article-title":"Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice","volume":"16","author":"Mu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.rbmo.2026.105734_bib0092","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jemt.1070250207","article-title":"Characteristics of uterine aging","volume":"25","author":"Mulholland","year":"1993","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.rbmo.2026.105734_bib0093","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.fertnstert.2019.02.008","article-title":"Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity","volume":"111","author":"Munro","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0094","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3390\/jcm10020351","article-title":"Immune tolerance of the human decidua","volume":"10","author":"Murata","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0095","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1324802","article-title":"Evaluation of women's aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling","volume":"12","author":"Nassir","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0096","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/humrep\/dei442","article-title":"Factors affecting endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound during IVF treatment","volume":"21","author":"Ng","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0097","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-057132","article-title":"Worldwide prevalence, risk factors and psychological impact of infertility among women: a systematic review and meta-analysis","volume":"12","author":"Nik Hazlina","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.rbmo.2026.105734_bib0098","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1472-6483(10)60025-9","article-title":"Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies","volume":"18","author":"Noyes","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105734_bib0099","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2021.01.005","article-title":"Delaying reproductive aging by ovarian tissue cryopreservation and transplantation: is it prime time?","volume":"27","author":"Oktay","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13287-023-03397-2","article-title":"Comparison of the therapeutic effects between stem cells and exosomes in primary ovarian insufficiency: as promising as cells but different persistency and dosage","volume":"14","author":"Park","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.rbmo.2026.105734_bib0101","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5653\/cerm.2021.04917","article-title":"Lifetime changes of the oocyte pool: contributing factors with a focus on ovulatory inflammation","volume":"49","author":"Park","year":"2022","journal-title":"Clin. Exp. Reprod. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0102","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.fertnstert.2013.07.1978","article-title":"Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1\/5\/8 signaling","volume":"100","author":"Park","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0103","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/humupd\/dmad019","article-title":"Endometrial receptivity in women of advanced age: an underrated factor in infertility","volume":"29","author":"Pathare","year":"2023","journal-title":"Hum. Reprod. Update"},{"issue":"Suppl. 1","key":"10.1016\/j.rbmo.2026.105734_bib0104","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.2215\/CJN.05910809","article-title":"Calcium metabolism in health and disease","author":"Peacock","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0105","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fgene.2015.00308","article-title":"Genetics of the ovarian reserve","volume":"6","author":"Pelosi","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.rbmo.2026.105734_bib0106","first-page":"36","article-title":"Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos donated for research","volume":"1","author":"P\u00e9rez-S\u00e1nchez","year":"2020","journal-title":"F. S. Sci."},{"key":"10.1016\/j.rbmo.2026.105734_bib0107","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1007\/s11357-023-00861-y","article-title":"The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)","volume":"45","author":"Pharaoh","year":"2023","journal-title":"Geroscience"},{"key":"10.1016\/j.rbmo.2026.105734_bib0108","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s12913-025-12348-x","article-title":"Epidemiological disease burden and annual, nationwide health insurance treatment cost of female infertility based on real-world health insurance claims data in Hungary","volume":"25","author":"P\u00f3nusz-Kov\u00e1cs","year":"2025","journal-title":"BMC Health Serv. Res."},{"key":"10.1016\/j.rbmo.2026.105734_bib0109","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/humrep\/dez077","article-title":"Initial steps in reconstruction of the human ovary: survival of pre-antral stage follicles in a decellularized human ovarian scaffold","volume":"34","author":"Pors","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0110","doi-asserted-by":"crossref","first-page":"S248","DOI":"10.1016\/j.fertnstert.2006.08.024","article-title":"Aging and infertility in women","volume":"86","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0111","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.fertnstert.2012.09.028","article-title":"Mature oocyte cryopreservation: a guideline","volume":"99","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105734_bib0112","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12929-016-0253-4","article-title":"Impact of stress on oocyte quality and reproductive outcome","volume":"23","author":"Prasad","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.rbmo.2026.105734_bib0113","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/s41467-024-45143-z","article-title":"Effect of aging on the human myometrium at single-cell resolution","volume":"15","author":"Punzon-Jimenez","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.rbmo.2026.105734_bib0114","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/humrep\/deh056","article-title":"Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three-dimensional power Doppler angiography","volume":"19","author":"Raine-Fenning","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111567","article-title":"Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing","volume":"199","author":"Reiten","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.rbmo.2026.105734_bib0116","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"Rienzi","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0117","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12733","article-title":"Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract","volume":"17","author":"Rodriguez-Garcia","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.rbmo.2026.105734_bib0118","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/humrep\/det422","article-title":"Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology","volume":"29","author":"Saller","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0119","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01204440","article-title":"Evaluating the effect of age on endometrial responsiveness to hormone replacement therapy: a histologic ultrasonographic, and tissue receptor analysis","volume":"10","author":"Sauer","year":"1993","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105734_bib0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/humupd\/dmr040","article-title":"Demographic and medical consequences of the postponement of parenthood","volume":"18","author":"Schmidt","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0121","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1001\/jama.2024.18207","article-title":"Ovarian Aging and Fertility","volume":"332","author":"Seifer","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.rbmo.2026.105734_bib0122","doi-asserted-by":"crossref","first-page":"49","DOI":"10.18632\/aging.100002","article-title":"Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival","volume":"1","author":"Selesniemi","year":"2008","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2024.100273","article-title":"Antioxidants and fertility in women with ovarian aging: a systematic review and meta-analysis","volume":"15","author":"Shang","year":"2024","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.rbmo.2026.105734_bib0124","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13287-024-03684-6","article-title":"Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging","volume":"15","author":"Shin","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.rbmo.2026.105734_bib0125","article-title":"Antioxidants for female subfertility","volume":"8","author":"Showell","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.rbmo.2026.105734_bib0126","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190805","article-title":"Autologous activated platelet-rich plasma injection into adult human ovary tissue: molecular mechanism, analysis, and discussion of reproductive response","volume":"39","author":"Sills","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.rbmo.2026.105734_bib0127","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/humrep\/dev052","article-title":"Engineering the ovarian cycle using in vitro follicle culture","volume":"30","author":"Skory","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0128","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmaf026","article-title":"Female fertility preservation: 25 years of progress, expanding indications and future prospects","volume":"32","author":"Sonmezer","year":"2026","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0129","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJMcp2116488","article-title":"Primary Ovarian Insufficiency","volume":"388","author":"Stuenkel","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0130","first-page":"3815","article-title":"Loss of tubal ciliated cells as a risk for \u2018ovarian\u2019 or pelvic serous carcinoma","volume":"10","author":"Tao","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.rbmo.2026.105734_bib0131","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167987","article-title":"Pharmacologic interventions targeting ovarian aging, cancer, and mitochondrial dysfunction: An updated evidence","volume":"1871","author":"Teppa-Garr\u00e1n","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.rbmo.2026.105734_bib0132","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.actbio.2021.03.041","article-title":"Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation","volume":"132","author":"Tomaszewski","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.rbmo.2026.105734_bib0133","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mce.2016.10.012","article-title":"Ovarian regeneration: The potential for stem cell contribution in the postnatal ovary to sustained endocrine function","volume":"445","author":"Truman","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0134","article-title":"Autologous platelet-rich plasma for assisted reproduction","volume":"4","author":"Vaidakis","year":"2024","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.rbmo.2026.105734_bib0135","first-page":"2348","article-title":"The clinical application of platelet-rich plasma in the female reproductive system: a narrative review","volume":"13","author":"Vali","year":"2023","journal-title":"Life (Basel)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0136","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/humupd\/dmac044","article-title":"A systematic review and evidence assessment of monogenic gene-disease relationships in human female infertility and differences in sex development","volume":"29","author":"Van Der Kelen","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105734_bib0137","first-page":"7","article-title":"A study on development and morphometric changes of fallopian tubes","volume":"18","author":"Veerraju","year":"2019","journal-title":"Dent. Med. Sci."},{"key":"10.1016\/j.rbmo.2026.105734_bib0138","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/uog.12538","article-title":"Normative data for uterine size according to age and gravidity and possible role of the classical golden ratio","volume":"42","author":"Verguts","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0139","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s00464-002-9208-9","article-title":"Abdominal adhesions: intestinal obstruction, pain, and infertility","volume":"17","author":"Vrijland","year":"2003","journal-title":"Surg. Endosc."},{"key":"10.1016\/j.rbmo.2026.105734_bib0140","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/09513590.2019.1611763","article-title":"Importance of ovarian tissue cryopreservation in fertility preservation and anti-aging treatment","volume":"35","author":"Vukovi\u0107","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008772","article-title":"Human ovarian reserve from conception to the menopause","volume":"5","author":"Wallace","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2026.105734_bib0142","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcdb.2025.103614","article-title":"The role of granulosa cells in oocyte development and aging: Mechanisms and therapeutic opportunities","volume":"171","author":"Wang","year":"2025","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0143","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1038\/s41467-021-24516-8","article-title":"Translocation of vaginal microbiota is involved in impairment and protection of uterine health","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.rbmo.2026.105734_bib0144","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12905-020-00979-7","article-title":"Fecundity disorders in older women: declines in follicular development and endometrial receptivity","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Womens Health."},{"key":"10.1016\/j.rbmo.2026.105734_bib0145","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/cc.9.2.10447","article-title":"Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads","volume":"9","author":"Wang","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.rbmo.2026.105734_bib0146","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/humrep\/dew005","article-title":"Human single follicle growth in vitro from cryopreserved ovarian tissue after slow freezing or vitrification","volume":"31","author":"Wang","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0147","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2669","article-title":"Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women","volume":"18","author":"White","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.rbmo.2026.105734_bib0148","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/genes9050265","article-title":"Influence of maternal aging on mitochondrial heterogeneity, inheritance, and function in oocytes and preimplantation embryos","volume":"9","author":"Woods","year":"2018","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0149","series-title":"Ten critical topics in reproductive medicine","first-page":"10","article-title":"Germline stem cells in adult mammalian ovaries","author":"Woods","year":"2013"},{"key":"10.1016\/j.rbmo.2026.105734_bib0150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13048-025-01633-2","article-title":"Follicular metabolic dysfunction, oocyte aneuploidy and ovarian aging: a review","volume":"18","author":"Wu","year":"2025","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.rbmo.2026.105734_bib0151","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s43587-024-00607-1","article-title":"Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1","volume":"4","author":"Wu","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.rbmo.2026.105734_bib0152","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139824","article-title":"Intraovarian transplantation of female germline stem cells rescue ovarian function in chemotherapy-injured ovaries","volume":"10","author":"Xiong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rbmo.2026.105734_bib0153","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1093\/humrep\/deab003","article-title":"Matrix-free 3D culture supports human follicular development from the unilaminar to the antral stage in vitro yielding morphologically normal metaphase II oocytes","volume":"36","author":"Xu","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105734_bib0154","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12958-018-0343-0","article-title":"Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial","volume":"16","author":"Xu","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0155","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2023.2237121","article-title":"Rapid reduction of adenomyosis coexisting with leiomyoma volume during treatment with Relugolix","volume":"39","author":"Yamanaka","year":"2023","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.rbmo.2026.105734_bib0156","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1126\/science.aat1674","article-title":"Generation of human oogonia from induced pluripotent stem cells in vitro","volume":"362","author":"Yamashiro","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.rbmo.2026.105734_bib0157","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.ymthe.2020.02.003","article-title":"HucMSC-derived exosomes mitigate the age-related retardation of fertility in female mice","volume":"28","author":"Yang","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.rbmo.2026.105734_bib0158","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1089\/bio.2023.0078","article-title":"Effect of elamipretide on the vitrification of mouse ovarian tissue by freezing","volume":"22","author":"Yao","year":"2024","journal-title":"Biopreserv. Biobank"},{"key":"10.1016\/j.rbmo.2026.105734_bib0159","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1159\/000464113","article-title":"The Hippo signaling pathway regulates ovarian function via the proliferation of ovarian germline stem cells","volume":"41","author":"Ye","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.rbmo.2026.105734_bib0160","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe8873","article-title":"Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions","volume":"7","author":"Yoon","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.rbmo.2026.105734_bib0161","article-title":"Estrogen receptor function: impact on the human endometrium","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.rbmo.2026.105734_bib0162","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/molecules30040816","article-title":"The anti-aging mechanism of metformin: from molecular insights to clinical applications","volume":"30","author":"Zhang","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.rbmo.2026.105734_bib0163","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7150\/ijbs.30369","article-title":"Autophagy in ovarian follicular development and atresia","volume":"15","author":"Zhou","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.rbmo.2026.105734_bib0164","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ncb1869","article-title":"Production of offspring from a germline stem cell line derived from neonatal ovaries","volume":"11","author":"Zou","year":"2009","journal-title":"Nat. Cell Biol."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648326002750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648326002750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:31:35Z","timestamp":1784979095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648326002750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":164,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1472648326002750"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2026.105734","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-related female infertility: aetiological mechanisms and evidence-based and experimental interventions","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2026.105734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105734"}}