{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:13:27Z","timestamp":1788480807503,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.rbmo.2026.105767","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:38:30Z","timestamp":1778341110000},"page":"105767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of abnormal cleavage patterns in conventional IVF versus ICSI: a retrospective analysis of 125,570 normally fertilised embryos"],"prefix":"10.1016","volume":"53","author":[{"given":"Weiwei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoni","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2026.105767_bib0001","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/der037","article-title":"The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting","volume":"26","year":"2011","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.rbmo.2026.105767_bib0002","doi-asserted-by":"crossref","first-page":"hoaa008","DOI":"10.1093\/hropen\/hoaa008","article-title":"Good practice recommendations for the use of time-lapse technology","volume":"2020","author":"Apter","year":"2020","journal-title":"Hum Reprod Open."},{"issue":"1","key":"10.1016\/j.rbmo.2026.105767_bib0003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/humrep\/dead237","article-title":"A comparison of morphokinetic models and morphological selection for prioritizing euploid embryos: a multicentre cohort study","volume":"39","author":"Bamford","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105767_bib0004","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.fertnstert.2016.11.014","article-title":"Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of specific, in-house morphokinetic selection algorithms","volume":"107","author":"Barrie","year":"2017","journal-title":"Fertil Steril"},{"issue":"7","key":"10.1016\/j.rbmo.2026.105767_bib0005","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1007\/s43032-020-00334-z","article-title":"Male Factors: the Role of Sperm in Preimplantation Embryo Quality","volume":"28","author":"Bashiri","year":"2021","journal-title":"REPROD SCI"},{"issue":"11","key":"10.1016\/j.rbmo.2026.105767_bib0006","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1093\/humrep\/dew232","article-title":"Population trends and live birth rates associated with common ART treatment strategies","volume":"31","author":"Chambers","year":"2016","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.rbmo.2026.105767_bib0007","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/humrep\/deab198","article-title":"International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2014\u2020","volume":"36","author":"Chambers","year":"2021","journal-title":"HUM REPROD."},{"issue":"8","key":"10.1016\/j.rbmo.2026.105767_bib0008","article-title":"Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with normal total sperm count and motility","volume":"8","author":"Cutting","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.rbmo.2026.105767_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2025.06.003","article-title":"International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2019","author":"Dyer","year":"2025","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.rbmo.2026.105767_bib0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13048-022-01026-9","article-title":"Incidence, dynamics and recurrences of reverse cleavage in aneuploid, mosaic and euploid blastocysts, and its relationship with embryo quality","volume":"15","author":"Jin","year":"2022","journal-title":"J Ovarian Res"},{"issue":"21","key":"10.1016\/j.rbmo.2026.105767_bib0011","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/hmg\/ddm187","article-title":"Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients","volume":"16","author":"Kobayashi","year":"2007","journal-title":"HUM MOL GENET."},{"issue":"4","key":"10.1016\/j.rbmo.2026.105767_bib0012","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"CELL."},{"issue":"9","key":"10.1016\/j.rbmo.2026.105767_bib0013","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10815-012-9801-3","article-title":"Predictive value of DNA integrity analysis in idiopathic recurrent pregnancy loss following spontaneous conception","volume":"29","author":"Kumar","year":"2012","journal-title":"J ASSIST REPROD GEN."},{"issue":"5","key":"10.1016\/j.rbmo.2026.105767_bib0014","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/humrep\/deae062","article-title":"Abnormal cleavage up to Day 3 does not compromise live birth and neonatal outcomes of embryos that have achieved full blastulation: a retrospective cohort study","volume":"39","author":"Lee","year":"2024","journal-title":"Hum. Reprod."},{"issue":"9","key":"10.1016\/j.rbmo.2026.105767_bib0015","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrg887","article-title":"Chromatin modification and epigenetic reprogramming in mammalian development","volume":"3","author":"Li","year":"2002","journal-title":"NAT REV GENET."},{"issue":"4","key":"10.1016\/j.rbmo.2026.105767_bib0016","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.fertnstert.2020.04.058","article-title":"Obstetric and perinatal outcomes of intracytoplasmic sperm injection versus conventional in vitro fertilization in couples with nonsevere male infertility","volume":"114","author":"Liu","year":"2020","journal-title":"FERTIL STERIL."},{"issue":"1","key":"10.1016\/j.rbmo.2026.105767_bib0017","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/14647273.2013.859746","article-title":"Short co-incubation of gametes combined with early rescue ICSI: an optimal strategy for complete fertilization failure after IVF","volume":"17","author":"Liu","year":"2014","journal-title":"Hum Fertil."},{"issue":"1","key":"10.1016\/j.rbmo.2026.105767_bib0018","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1095\/biolreprod.104.031245","article-title":"Centrosome reduction during gametogenesis and its significance","volume":"72","author":"Manandhar","year":"2005","journal-title":"BIOL REPROD."},{"issue":"2","key":"10.1016\/j.rbmo.2026.105767_bib0019","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0378-1119(99)00324-8","article-title":"A complex population of RNAs exists in human ejaculate spermatozoa: implications for understanding molecular aspects of spermiogenesis","volume":"237","author":"Miller","year":"1999","journal-title":"GENE"},{"key":"10.1016\/j.rbmo.2026.105767_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1398684","article-title":"Two types of cleavage, from zygote to three cells, result in different clinical outcomes and should be treated differently","volume":"12","author":"Nemerovsky","year":"2024","journal-title":"Front Cell Dev Biol."},{"issue":"6988","key":"10.1016\/j.rbmo.2026.105767_bib0021","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/429154a","article-title":"Reproductive biology: delivering spermatozoan RNA to the oocyte","volume":"429","author":"Ostermeier","year":"2004","journal-title":"NATURE."},{"issue":"8810","key":"10.1016\/j.rbmo.2026.105767_bib0022","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo","year":"1992","journal-title":"LANCET."},{"issue":"9","key":"10.1016\/j.rbmo.2026.105767_bib0023","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.4161\/epi.21556","article-title":"Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development","volume":"7","author":"Paradowska","year":"2012","journal-title":"Epigenetics."},{"issue":"9","key":"10.1016\/j.rbmo.2026.105767_bib0024","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1093\/humrep\/17.9.2344","article-title":"A pathology of the sperm centriole responsible for defective sperm aster formation, syngamy and cleavage","volume":"17","author":"Rawe","year":"2002","journal-title":"HUM REPROD."},{"issue":"10","key":"10.1016\/j.rbmo.2026.105767_bib0025","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/humrep\/des261","article-title":"The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis","volume":"27","author":"Robinson","year":"2012","journal-title":"Hum Reprod."},{"issue":"9","key":"10.1016\/j.rbmo.2026.105767_bib0026","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s10815-024-03183-w","article-title":"Total gonadotropin dose did not affect euploid blastocyst rates: an analysis of more than 19,000 oocytes","volume":"41","author":"Shuai","year":"2024","journal-title":"J Assist Reprod Gen."},{"issue":"3","key":"10.1016\/j.rbmo.2026.105767_bib0027","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/humrep\/dez301","article-title":"ICSI does not improve reproductive outcomes in autologous ovarian response cycles with non-male factor subfertility","volume":"35","author":"Supramaniam","year":"2020","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.rbmo.2026.105767_bib0028","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cell.2019.01.043","article-title":"Genomic Imprinting and Physiological Processes in Mammals","volume":"176","author":"Tucci","year":"2019","journal-title":"Cell"},{"issue":"10430","key":"10.1016\/j.rbmo.2026.105767_bib0029","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0140-6736(23)02416-9","article-title":"Intracytoplasmic sperm injection versus conventional in-vitro fertilisation for couples with infertility with non-severe male factor: a multicentre, open-label, randomised controlled trial","volume":"403","author":"Wang","year":"2024","journal-title":"LANCET"},{"issue":"1","key":"10.1016\/j.rbmo.2026.105767_bib0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/molehr\/gap080","article-title":"Function of sperm chromatin structural elements in fertilization and development","volume":"16","author":"Ward","year":"2010","journal-title":"MOL HUM REPROD."},{"issue":"12","key":"10.1016\/j.rbmo.2026.105767_bib0031","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s10815-011-9630-9","article-title":"Effects of cumulus cells removal after 6 h co-incubation of gametes on the outcomes of human IVF","volume":"28","author":"Xiong","year":"2011","journal-title":"J Assist Reprod Gen."},{"issue":"5","key":"10.1016\/j.rbmo.2026.105767_bib0032","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10815-011-9544-6","article-title":"Is sperm DNA damage associated with IVF embryo quality? A systematic review","volume":"28","author":"Zini","year":"2011","journal-title":"J Assist Reprod Genet."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648326003081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648326003081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:44:26Z","timestamp":1788479066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648326003081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1472648326003081"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2026.105767","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence of abnormal cleavage patterns in conventional IVF versus ICSI: a retrospective analysis of 125,570 normally fertilised embryos","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2026.105767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105767"}}