{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:37:41Z","timestamp":1792841861566,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rbmojournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive BioMedicine Online"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.rbmo.2026.105844","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:42:00Z","timestamp":1782949320000},"page":"105844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical implications of zygotes showing 2.1 pronuclei: an ASPIRE Embryology Special Interest Group committee opinion"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-9302","authenticated-orcid":false,"given":"Tammy","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Tain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiencheng Arthur","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Chaitanya","family":"Mantravadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan Thi Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ezoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweelian","family":"Liow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rbmo.2026.105844_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104595","article-title":"Reassessing the conventional fertilization check: leveraging preimplantation genetic testing for aneuploidy to increase the number of transferrable embryos","volume":"50","author":"Al Hashimi","year":"2025","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105844_bib0002","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/der037","article-title":"The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting","volume":"26","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0003","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/humrep\/dex324","article-title":"The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos","volume":"32","author":"Babariya","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0004","doi-asserted-by":"crossref","first-page":"8739","DOI":"10.3390\/ijms25168739","article-title":"Molecular Basis of Hydatidiform Moles\u2014A Systematic Review","volume":"25","author":"Bahutair","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rbmo.2026.105844_bib0005","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaf097.103","article-title":"O-103 Incidence, development and ploidy of abnormally fertilized oocyte: implications for clinical practice","volume":"40","author":"Barberi","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0006","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1007\/s10815-025-03631-1","article-title":"Reconsidering the clinical value of 1PN-derived embryos: a systematic review and meta-analysis","volume":"42","author":"Bartolacci","year":"2025","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0007","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.rbmo.2017.03.013","article-title":"Clinical use of monopronucleated zygotes following blastocyst culture and preimplantation genetic screening, including verification of biparental chromosome inheritance","volume":"34","author":"Bradley","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105844_bib0008","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/humrep\/dead151","article-title":"Healthy live birth following embryo transfer of a blastocyst of tetrapronuclear (4PN) origin: a case report","volume":"38","author":"Bredbacka","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0009","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/genes15010018","article-title":"Healthy Live Births after the Transfer of Mosaic Embryos: Self-Correction or PGT-A Overestimation?","volume":"15","author":"Campos","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.rbmo.2026.105844_bib0010","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s10815-023-02830-y","article-title":"Assessing the clinical viability of micro 3 pronuclei zygotes","volume":"40","author":"Canon","year":"2023","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0011","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/humrep\/deae157","article-title":"An expert opinion on rescuing atypically pronucleated human zygotes by molecular genetic fertilization checks in IVF","volume":"39","author":"Capalbo","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0012","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.fertnstert.2017.08.004","article-title":"Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles","volume":"108","author":"Capalbo","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105844_bib0013","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/molehr\/gay043","article-title":"Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platform","volume":"24","author":"Chuang","year":"2018","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0014","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/humrep\/deaf097.107","article-title":"The Istanbul consensus update: a revised ESHRE\/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment","volume":"40","author":"Coticchio","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0015","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/humrep\/deab011","article-title":"Perturbations of morphogenesis at the compaction stage affect blastocyst implantation and live birth rates","volume":"36","author":"Coticchio","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0016","first-page":"42","article-title":"The Embryology Interest Group: updating ASEBIR's morphological scoring system for early embryos, morulae and blastocysts","volume":"5","author":"Cuevas Saiz","year":"2018","journal-title":"Med. Reprod. Embriol. Cl\u00edn."},{"key":"10.1016\/j.rbmo.2026.105844_bib0017","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/humrep\/dew016","article-title":"Revised guidelines for good practice in IVF laboratories (2015)","volume":"31","author":"De los Santos","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0018","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/genes16020134","article-title":"Trophectoderm Biopsy: Present State of the Art","volume":"16","author":"De Vos","year":"2025","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.rbmo.2026.105844_bib0019","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaf097.886","article-title":"P-580 Impact of third pronucleus size as a predictive marker for genetic outcomes in 349 zygotes with three pronuclei (3PN)","volume":"40","author":"Escriba","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0020","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1093\/humrep\/deac177","article-title":"Human 1PN and 3PN zygotes recapitulate all morphokinetic events of normal fertilization but reveal novel developmental errors","volume":"37","author":"Ezoe","year":"2022","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0021","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1007\/s10815-024-03278-4","article-title":"Incidence of haploidy and triploidy in trophectoderm biopsies of blastocysts derived from normally and abnormally fertilized oocytes","volume":"41","author":"Girardi","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0022","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaf097.589","article-title":"P-281 Experience of culturing atypically pronucleated embryos derived from IVF and ICSI in a single large IVF clinic","volume":"40","author":"Glynn","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0023","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.fertnstert.2015.05.024","article-title":"Morphokinetics as a predictor of self-correction to diploidy in tripronucleated intracytoplasmic sperm injection-derived human embryos","volume":"104","author":"Grau","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105844_bib0024","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/humupd\/dmx035","article-title":"Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors","volume":"24","author":"Greaney","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.rbmo.2026.105844_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2024.08.304","article-title":"Ploidy anomalies revealed by analysis of chromosome dynamics from 3PN embryos containing small pronuclei","volume":"122","author":"Hashimoto","year":"2024","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105844_bib57","series-title":"LinkedIn Correspondence with Tammy Lee","author":"Hattori","year":"2026"},{"key":"10.1016\/j.rbmo.2026.105844_bib0026","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10815-024-03114-9","article-title":"The utility of human two plus one small pronucleated zygotes (2.1PN) based on clinical outcomes and the focused ploidy analysis","volume":"41","author":"Hattori","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0027","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaf097.102","article-title":"O-102 The utility of human two plus one small pronucleated zygotes (2.1pn) based on clinical outcomes and novel ploidy analysis","volume":"40","author":"Hattori","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0028","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017970","article-title":"Meiosis and maternal aging: insights from aneuploid oocytes and trisomy births","volume":"7","author":"Herbert","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.rbmo.2026.105844_bib0029","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1142\/S2661318222500049","article-title":"Value of Meiotic Spindle Imaging on Fertilization and Embryo Development Following Human Oocyte Piezo-ICSI","volume":"4","author":"Hiraoka","year":"2022","journal-title":"Fertility & Reproduction"},{"key":"10.1016\/j.rbmo.2026.105844_bib0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5653\/cerm.2015.42.1.14","article-title":"The parental origin correlates with the karyotype of human embryos developing from tripronuclear zygotes","volume":"42","author":"Joergensen","year":"2015","journal-title":"Clin Exp Reprod Med"},{"key":"10.1016\/j.rbmo.2026.105844_bib0031","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/humrep\/deg262","article-title":"Normal birth after microsurgical enucleation of tripronuclear human zygotes: case report","volume":"18","author":"Kattera","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2025.105080","article-title":"To discard or not to discard 1PNs? A systematic review and meta-analysis on 291,474 embryos","volume":"52","author":"Lee","year":"2026","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105844_bib0033","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.repbio.2014.08.003","article-title":"Time-lapse videography of human oocytes following intracytoplasmic sperm injection: events up to the first cleavage division","volume":"14","author":"Liu","year":"2014","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.rbmo.2026.105844_bib0034","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.fertnstert.2014.07.1235","article-title":"Prevalence, consequence, and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time-lapse video system","volume":"102","author":"Liu","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105844_bib0035","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.fertnstert.2025.10.007","article-title":"Reproductive potential of abnormal embryos with whole and segmental chromosome aneuploidies diagnosed by next-generation sequencing based preimplantation genetic testing for aneuploidy","volume":"125","author":"Madjunkov","year":"2026","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105844_bib0036","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/cge.14003","article-title":"Triploid pregnancy\u2014Clinical implications","volume":"100","author":"Massalska","year":"2021","journal-title":"Clin. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0037","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/pd.5895","article-title":"Genome-wide abnormalities in embryos: Origins and clinical consequences","volume":"41","author":"Masset","year":"2021","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.rbmo.2026.105844_bib0038","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1017\/S0967199420000027","article-title":"Morphokinetics and in vitro developmental potential of monopronucleated ICSI zygotes until the blastocyst stage","volume":"28","author":"Mateo","year":"2020","journal-title":"Zygote"},{"key":"10.1016\/j.rbmo.2026.105844_bib0039","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s10815-025-03467-9","article-title":"Scoping review on the embryonic developmental potential of tripronuclear zygotes and their use for clinical and research purposes","volume":"42","author":"Mayeur","year":"2025","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0040","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.devcel.2021.07.022","article-title":"Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse","volume":"56","author":"Mihajlovi\u0107","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.rbmo.2026.105844_bib0041","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/dead093.1053","article-title":"P-734 Blastocysts derived from tripronuclear zygote including small pronuclear zygote have high diploid and euploid rate with NGS and SNP analysis","volume":"38","author":"Mizuta","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0042","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12958-020-00650-8","article-title":"Do human embryos have the ability of self-correction?","volume":"18","author":"Orvieto","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.rbmo.2026.105844_bib0043","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/ror.0.0020019","article-title":"The human sperm centrosome is responsible for normal syngamy and early embryonic development","volume":"2","author":"Palermo","year":"1997","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0044","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1472-6483(10)60261-1","article-title":"Relationship between visualization of meiotic spindle in human oocytes and ICSI outcomes: a meta-analysis","volume":"18","author":"Petersen","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105844_bib0045","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1472-6483(10)60940-6","article-title":"Meiotic spindle visualization in living human oocytes","volume":"10","author":"Rienzi","year":"2005","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105844_bib0046","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.fertnstert.2012.07.1135","article-title":"Limited implantation success of direct-cleaved human zygotes: a time-lapse study","volume":"98","author":"Rubio","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.rbmo.2026.105844_bib0047","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1262\/jrd.2018-056","article-title":"Destabilization of spindle assembly checkpoint causes aneuploidy during meiosis II in murine post-ovulatory aged oocytes","volume":"65","author":"Shimoi","year":"2019","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.rbmo.2026.105844_bib0048","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaf097.054","article-title":"O-054 Assessing the ploidy status of atypically fertilised embryos \u2013 recovery of embryos for potential clinical use","volume":"40","author":"Stock-Myer","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.rbmo.2026.105844_bib0049","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0002-9378(78)90829-3","article-title":"The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations","volume":"131","author":"Szulman","year":"1978","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2026.105844_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12462","article-title":"Are tri-pronuclear embryos that show two normal-sized pronuclei and additional smaller pronuclei useful for embryo transfer?","volume":"21","author":"Takahashi","year":"2022","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.rbmo.2026.105844_bib0051","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.rbmo.2019.03.028","article-title":"Aneuploidy concordance between trophectoderm and inner cell mass by next-generation sequencing in 100 blastocysts","volume":"38","author":"Victor","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.rbmo.2026.105844_bib0052","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s10815-024-03113-w","article-title":"Evaluating the developmental potential of 2.1PN-derived embryos and associated chromosomal analysis","volume":"41","author":"Wang","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0053","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1007\/s10815-025-03626-y","article-title":"Novel homozygous variants in ASTL and WEE2 responsible for female infertility characterized by abnormal fertilization","volume":"42","author":"Xie","year":"2025","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.rbmo.2026.105844_bib0054","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13048-025-01816-x","article-title":"Healthy live birth after microsurgical enucleation of tripronuclear human zygote derived from ICSI: a case report","volume":"18","author":"Xu","year":"2025","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.rbmo.2026.105844_bib0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4274\/tjod.45144","article-title":"Live birth after transfer of a tripronuclear embryo: An intracytoplasmic sperm injection as a combination of microarray and time-lapse technology","volume":"13","author":"Yal\u00e7\u0131nkaya","year":"2016","journal-title":"Turk. J. Obstet. Gynecol."},{"key":"10.1016\/j.rbmo.2026.105844_bib0056","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1093\/hmg\/ddad070","article-title":"Bi-allelic variants in ASTL cause abnormal fertilization or oocyte maturation defects","volume":"32","author":"Zeng","year":"2023","journal-title":"Hum. Mol. Genet."}],"container-title":["Reproductive BioMedicine Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648326003858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472648326003858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:03:12Z","timestamp":1792839792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472648326003858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1472648326003858"],"URL":"https:\/\/doi.org\/10.1016\/j.rbmo.2026.105844","relation":{},"ISSN":["1472-6483"],"issn-type":[{"value":"1472-6483","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical implications of zygotes showing 2.1 pronuclei: an ASPIRE Embryology Special Interest Group committee opinion","name":"articletitle","label":"Article Title"},{"value":"Reproductive BioMedicine Online","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rbmo.2026.105844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105844"}}