{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:41:50Z","timestamp":1762954910282},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Cl\u00ednica Espa\u00f1ola"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.rce.2010.02.008","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T08:18:11Z","timestamp":1274775491000},"page":"323-331","source":"Crossref","is-referenced-by-count":5,"title":["Factores predictores de mortalidad en pacientes con enfermedad pulmonar obstructiva cr\u00f3nica y exacerbaciones frecuentes"],"prefix":"10.1016","volume":"210","author":[{"given":"M.","family":"Palop Cervera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"de Diego Dami\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Le\u00f3n F\u00e1bregas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.J.","family":"Bravo Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Compte Torrego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rce.2010.02.008_bib1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.163.5.2101039","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI\/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary","volume":"163","author":"Pauwels","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0002-9149(02)03095-3","article-title":"Predictors of cardiac and noncardiac mortality among 14,697 patients with coronary heart disease","volume":"91","author":"Dankner","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.rce.2010.02.008_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1164\/arrd.1983.128.3.491","article-title":"The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation","volume":"128","author":"Peto","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.rce.2010.02.008_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1164\/arrd.1986.133.1.14","article-title":"Prognosis in chronic obstructive pulmonary disease","volume":"133","author":"Anthonisen","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.rce.2010.02.008_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejcts.2004.09.010","article-title":"Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung cancer","volume":"27","author":"L\u00f3pez-Encuentra","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.rce.2010.02.008_bib6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1164\/rccm.200407-867OC","article-title":"Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease","volume":"171","author":"Casanova","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1378\/chest.128.3.1209","article-title":"Effects of acute on chronic respiratory failure on hypercapnia and 3-month survival","volume":"128","author":"Vitacca","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.rce.2010.02.008_bib8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa063070","article-title":"Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease","volume":"356","author":"Calvery","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rce.2010.02.008_bib9","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1183\/09031936.01.17509820","article-title":"Epidemiology of chronic obstructive pulmonary disease","volume":"17","author":"Anto","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rce.2010.02.008_bib10","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1183\/09031936.02.00303702","article-title":"Health status measured with the CRQ does not predict mortality in COPD","volume":"20","author":"Oga","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rce.2010.02.008_bib11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1378\/chest.121.5.1434","article-title":"Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD","volume":"121","author":"Nishimura","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.rce.2010.02.008_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1378\/chest.124.2.459","article-title":"Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD","volume":"124","author":"Groenewegen","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.rce.2010.02.008_bib13","first-page":"3","article-title":"Epidemiolog\u00eda hospitalaria de la EPOC en Espa\u00f1a","volume":"207","author":"San Rom\u00e1n Ter\u00e1n","year":"2007","journal-title":"Rev Clin Esp"},{"key":"10.1016\/j.rce.2010.02.008_bib14","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1183\/09031936.06.00109605","article-title":"C-reactive protein levels and clinically important predictive outcomes in stable COPD patients","volume":"27","author":"De Torres","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rce.2010.02.008_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa021322","article-title":"The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease","volume":"350","author":"Celli","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rce.2010.02.008_bib16","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1164\/rccm.200510-1677OC","article-title":"Predictors of mortality in patients with emphysema and severe airflow obstruction","volume":"173","author":"Mart\u00ednez","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib17","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1001\/jama.274.23.1852","article-title":"Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease","volume":"274","author":"Seneff","year":"1995","journal-title":"Jama"},{"key":"10.1016\/j.rce.2010.02.008_bib18","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1164\/ajrccm.157.5.9709032","article-title":"Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease","volume":"157","author":"Seemungal","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.rce.2010.02.008_bib20","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/thx.2005.040527","article-title":"Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease","volume":"60","author":"Soler-Cataluna","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.rce.2010.02.008_bib21","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/thx.54.7.581","article-title":"Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease","volume":"54","author":"Bestall","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.rce.2010.02.008_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.rce.2010.02.008_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1164\/ajrccm.154.4.8887592","article-title":"Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)","volume":"154","author":"Connors","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib24","first-page":"11","article-title":"Problemas metodol\u00f3gicos m\u00e1s relevantes en los estudios de mortalidad y progresi\u00f3n de la enfermedad en pacientes con EPOC","volume":"44","author":"Mart\u00ednez","year":"2008","journal-title":"Arch Bronconeumolo"},{"key":"10.1016\/j.rce.2010.02.008_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/thorax.58.2.100","article-title":"Risk factors of readmission to hospital for a COPD exacerbation: A prospective study","volume":"58","author":"Garc\u00eda-Aymerich","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.rce.2010.02.008_bib26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1164\/rccm.200408-1054OC","article-title":"Exacerbations and time spent outdoors in chronic obstructive pulmonary disease","volume":"171","author":"Donaldson","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib27","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1164\/rccm.200206-583OC","article-title":"Analysis of the factors related to mortality in chronic obstructive pulmonary disease: Role of exercise capacity and health status","volume":"167","author":"Oga","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rce.2010.02.008_bib28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1183\/09031936.03.00034603","article-title":"The 6-min walk distance: Change over time and value as a predictor of survival in severe COPD","volume":"23","author":"Pinto-Plata","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rce.2010.02.008_bib29","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1183\/09031936.99.14510159","article-title":"Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease","volume":"14","author":"Soler","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rce.2010.02.008_bib30","first-page":"8","article-title":"Factores pron\u00f3sticos en la EPOC. El papel de la comorbilidad","volume":"207","author":"Almagro Mena","year":"2007","journal-title":"Rev Clin Esp"}],"container-title":["Revista Cl\u00ednica Espa\u00f1ola"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014256510002304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014256510002304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:07:34Z","timestamp":1559131654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014256510002304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0014256510002304"],"URL":"https:\/\/doi.org\/10.1016\/j.rce.2010.02.008","relation":{},"ISSN":["0014-2565"],"issn-type":[{"value":"0014-2565","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}