{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:48:30Z","timestamp":1787240910661,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Cl\u00ednica Espa\u00f1ola"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.rce.2011.04.009","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T07:08:46Z","timestamp":1309158526000},"page":"520-526","source":"Crossref","is-referenced-by-count":3,"title":["S\u00edndrome de hipergammaglobulinemia IgE con infecciones recurrentes: patog\u00e9nesis, diagn\u00f3stico y aproximaci\u00f3n terap\u00e9utica"],"prefix":"10.1016","volume":"211","author":[{"given":"P.","family":"Guisado Vasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fraile Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arechaga Uriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rce.2011.04.009_bib0005","doi-asserted-by":"crossref","first-page":"32R","DOI":"10.1203\/PDR.0b013e31819dc8c5","article-title":"Clinical manifestations, etiology, and patogenesis of the hyper-IgE syndromes","volume":"65","author":"Freeman","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.rce.2011.04.009_bib0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/ACI.0b013e3283184210","article-title":"Hyper IgE syndrome: an update on clinical aspects and the role of signal transducer and activator of transcription 3","volume":"8","author":"Paulson","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(74)92493-3","article-title":"Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections","volume":"1","author":"Hill","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.rce.2011.04.009_bib0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00005792-198307000-00001","article-title":"The hyperimmunoglobulin E recurrent-infection (Job\u0301s) syndrome: a review of the NIH experience and the literature","volume":"62","author":"Donabedian","year":"1983","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.rce.2011.04.009_bib0025","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM199903043400904","article-title":"Hyper-IgE syndrome with recurrent infections \u2013 an autosomal dominant multisystem disorder","volume":"340","author":"Grimbacher","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rce.2011.04.009_bib0030","doi-asserted-by":"crossref","first-page":"766","DOI":"10.7326\/0003-4819-82-6-766","article-title":"Familial neutrophil chemotaxis defect, recurrent bacterial infections, mucocutaneous candidiasis and hiperimmunoglobulinemia E","volume":"82","author":"Van Scoy","year":"1975","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rce.2011.04.009_bib0035","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(66)90119-X","article-title":"Job's syndrome: recurrent, \u201ccold\u201d, staphylococcal abscesses","volume":"1","author":"Davis","year":"1966","journal-title":"Lancet"},{"key":"10.1016\/j.rce.2011.04.009_bib0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.49.1.59","article-title":"Extreme Hyperimmunoglobulinemia E and undue susceptibility to infection","volume":"49","author":"Buckley","year":"1972","journal-title":"Pediatrics"},{"key":"10.1016\/j.rce.2011.04.009_bib0045","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(74)91942-4","article-title":"Defect in neutrophil granulocyte chemotaxis in Job\u2032s syndrome of recurrent \u201ccold\u201d staphylococcal abscesses","volume":"2","author":"Hill","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.rce.2011.04.009_bib0050","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.immuni.2006.09.009","article-title":"Human Tyrosine Kinasa 2 deficiency reveals its requisite roles in multiple cytokine signals envolved in innate and acquired immunity","volume":"25","author":"Minegishi","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.rce.2011.04.009_bib0055","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nature06096","article-title":"Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome","volume":"448","author":"Minegishi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.rce.2011.04.009_bib0060","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the Hyper-IgE syndrome","volume":"357","author":"Holland","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rce.2011.04.009_bib0065","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hiper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.rce.2011.04.009_bib0070","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.20080218","article-title":"Deficiency of Th17 cells in hiper IgE syndrome due to mutations in STAT3","volume":"205","author":"Ma","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.rce.2011.04.009_bib0075","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.coi.2009.07.013","article-title":"Hyper-IgE syndrome","volume":"21","author":"Minegishi","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-3476(03)00449-9","article-title":"Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity","volume":"144","author":"Brenner","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.rce.2011.04.009_bib0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1148\/132.1.71","article-title":"Hyperimmunoglobulinemia E syndrome: radiographic observations","volume":"132","author":"Merten","year":"1979","journal-title":"Radiology"},{"key":"10.1016\/j.rce.2011.04.009_bib0090","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1080\/10428190400004463","article-title":"Non-Hodgkin\u2032s lymphoma in Job\u2032s syndrome: a case report and literature review","volume":"45","author":"Leonard","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.rce.2011.04.009_bib0095","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clim.2006.10.005","article-title":"Coronary artery aneurysms in patients with hyper IgE recurrent infection syndrome","volume":"12","author":"Ling","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0100","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rce.2011.04.009_bib0105","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJMc076367","article-title":"STAT3 mutation in the original patient with Job's syndrome","volume":"357","author":"Renner","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rce.2011.04.009_bib0110","series-title":"Autosomal dominant hyper IgE syndrome. GeneReviews [Internet]","author":"Freeman","year":"1993"},{"key":"10.1016\/j.rce.2011.04.009_bib0115","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0120","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.coi.2007.07.020","article-title":"Th17: the third member of the effector T cell trilogy","volume":"19","author":"Bettelli","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jaci.2009.10.023","article-title":"Defect of regulatory T cell in patients with Omenn syndrome","volume":"125","author":"Cassani","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0130","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jaci.2009.06.009","article-title":"Com\u00e8l-Netherton syndrome defined as primary immunodeficiency","volume":"124","author":"Renner","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0135","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1086\/302547","article-title":"Genetic linkage of hyper-IgE syndrome to chromosome 4","volume":"65","author":"Grimbacher","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.rce.2011.04.009_bib0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jaci.2010.06.029","article-title":"Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis","volume":"126","author":"Schimke","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rce.2011.04.009_bib0145","unstructured":"Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 611521: 10\/11\/2007. Disponible en: http:\/\/www.ncbi.nlm.nih.gov\/omim\/611521."},{"key":"10.1016\/j.rce.2011.04.009_bib0150","unstructured":"Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 147060: 01\/07\/2010. Disponible en: http:\/\/www.ncbi.nlm.nih.gov\/omim\/147060."}],"container-title":["Revista Cl\u00ednica Espa\u00f1ola"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014256511002645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014256511002645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T16:24:44Z","timestamp":1686155084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014256511002645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0014256511002645"],"URL":"https:\/\/doi.org\/10.1016\/j.rce.2011.04.009","relation":{},"ISSN":["0014-2565"],"issn-type":[{"value":"0014-2565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}