{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:30:38Z","timestamp":1773811838812,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Cl\u00ednica Espa\u00f1ola (English Edition)"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.rceng.2024.10.009","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T05:02:30Z","timestamp":1730437350000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective study of restless legs syndrome in a blood donors\u2019 sample"],"prefix":"10.1016","volume":"225","author":[{"given":"L.","family":"Lillo-Triguero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Del Castillo-Rueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Bell\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Peraita-Adrados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rceng.2024.10.009_bib0005","first-page":"862","article-title":"Restless legs","volume":"48","author":"Ekbom","year":"1951","journal-title":"Sven Lakartidn"},{"key":"10.1016\/j.rceng.2024.10.009_bib0010","first-page":"619","article-title":"La sindrome delle gambe senza riposo (restless legs) [The restless leg syndrome (restless legs)]","volume":"44","author":"Coccagna","year":"1966","journal-title":"Omnia Med Ther"},{"key":"10.1016\/j.rceng.2024.10.009_bib0015","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","article-title":"Restless legs syndrome prevalence and impact: REST general population study","volume":"165","author":"Allen","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0020","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1212\/01.WNL.0000163996.64461.A3","article-title":"Restless legs syndrome: a community-based study of prevalence, severity, and risk factors","volume":"64","author":"H\u00f6gl","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.rceng.2024.10.009_bib0025","first-page":"647","article-title":"Prevalence of restless legs syndrome at the office in primary health care","volume":"44","author":"P\u00e9rez-Romero","year":"2007","journal-title":"Rev Neurol"},{"key":"10.1016\/j.rceng.2024.10.009_bib0030","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3389\/fnins.2017.00722","article-title":"Pivotal role of adenosine neurotransmission in restless legs syndrome","volume":"11","author":"Ferr\u00e9","year":"2018","journal-title":"Front Neurosci"},{"key":"10.1016\/j.rceng.2024.10.009_bib0035","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.sleep.2014.05.009","article-title":"Altered brain iron homeostasis and dopaminergic function in restless legs syndrome (Willis-Ekbom disease)","volume":"15","author":"Earley","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/1073858418791763","article-title":"New insights into the neurobiology of restless legs syndrome","volume":"25","author":"Ferr\u00e9","year":"2019","journal-title":"Neuroscientist"},{"key":"10.1016\/j.rceng.2024.10.009_bib0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1212\/WNL.56.2.263","article-title":"MRI measurement of brain iron in patients with restless legs syndrome","volume":"56","author":"Allen","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.rceng.2024.10.009_bib0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jns.2006.04.008","article-title":"Is ferroportin-hepcidin signaling altered in restless legs syndrome?","volume":"247","author":"Clardy","year":"2006","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.rceng.2024.10.009_bib0055","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/brain\/awr012","article-title":"Profile of altered brain iron acquisition in restless legs syndrome","volume":"134","author":"Connor","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.rceng.2024.10.009_bib0060","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jsmc.2011.04.006","article-title":"Genetics of restless legs syndrome: mendelian, complex, and everything in between","volume":"6","author":"Schormair","year":"2011","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.rceng.2024.10.009_bib0065","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.sleep.2010.08.006","article-title":"Prevalence of restless legs syndrome among adults in Iceland and Sweden: lung function, comorbidity, ferritin, biomarkers and quality of life","volume":"11","author":"Benediktsdottir","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0070","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/jnc.15819","article-title":"Brain iron acquisition: an overview of homeostatic regulation and disease dysregulation","volume":"165","author":"Baringer","year":"2023","journal-title":"J Neurochem"},{"key":"10.1016\/j.rceng.2024.10.009_bib0075","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/trf.15179","article-title":"Association of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative study","volume":"59","author":"Patel","year":"2019","journal-title":"Transfusion"},{"issue":"S1","key":"10.1016\/j.rceng.2024.10.009_bib0080","doi-asserted-by":"crossref","DOI":"10.1111\/tme.12477","article-title":"Iron deficiency among blood donors: experience from the Danish Blood Donor Study and from the Copenhagen ferritin monitoring scheme","volume":"29","author":"Rigas","year":"2019","journal-title":"Transfus Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0085","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4065\/78.1.52","article-title":"Multiple blood donations associated with iron deficiency in patients with restless legs syndrome","volume":"78","author":"Silber","year":"2003","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.rceng.2024.10.009_bib0090","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.msom.2010.08.002","article-title":"Fr\u00e9quence et s\u00e9v\u00e9rit\u00e9 du syndrome des jambes sans repos apr\u00e8s don de sang une \u00e9tude cas-t\u00e9moins","volume":"7","author":"Allard","year":"2010","journal-title":"Med du Sommeil"},{"key":"10.1016\/j.rceng.2024.10.009_bib0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.sleep.2017.04.014","article-title":"Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study","volume":"36","author":"Didriksen","year":"2017","journal-title":"Sleep Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0100","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/mds.23110","article-title":"Prevalence of restless legs syndrome in blood donors","volume":"25","author":"Arunthari","year":"2010","journal-title":"Mov Disord"},{"issue":"2","key":"10.1016\/j.rceng.2024.10.009_bib0105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","article-title":"Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health","volume":"4","author":"Allen","year":"2003","journal-title":"Sleep Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0110","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.sleep.2014.03.025","article-title":"Restless legs syndrome\/Willis\u2013Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria \u2013\u2014 history, rationale, description, and significance","volume":"15","author":"Allen","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1212\/01.wnl.0000168910.48309.4a","article-title":"Epidemiology of restless legs syndrome in French adults \u2014 a nationwide survey: the INSTANT study","volume":"65","author":"Tison","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.rceng.2024.10.009_bib0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tracli.2023.04.002","article-title":"Reduced levels of hepcidin associated with lower ferritin concentration and increased number of previous donations in periodic blood donors: a pilot study","volume":"30","author":"Vasco","year":"2023","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.rceng.2024.10.009_bib0125","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/trf.15906","article-title":"First results of a ferritin-based blood donor deferral policy in the Netherlands","volume":"60","author":"Vinkenoog","year":"2020","journal-title":"Transfusion"},{"key":"10.1016\/j.rceng.2024.10.009_bib0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/vox.13377","article-title":"Impact of donor ferritin testing on iron deficiency prevention and blood availability in France: a cohort simulation study","volume":"118","author":"Richard","year":"2023","journal-title":"Vox Sang"},{"issue":"1","key":"10.1016\/j.rceng.2024.10.009_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2009.03.010","article-title":"What is the evidence for gender differences in ferritin and haemoglobin?","volume":"73","author":"Rushton","year":"2010","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.rceng.2024.10.009_bib0140","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.sleep.2014.03.018","article-title":"Brain iron accumulation in dysmetabolic iron overload syndrome with restless legs syndrome","volume":"15","author":"Lillo-Triguero","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.rceng.2024.10.009_bib0145","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archinte.164.2.196","article-title":"Sex and the risk of restless legs syndrome in the general population","volume":"164","author":"Berger","year":"2004","journal-title":"Arch Intern Med"}],"container-title":["Revista Cl\u00ednica Espa\u00f1ola (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2254887424001395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2254887424001395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:28:56Z","timestamp":1736756936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2254887424001395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2254887424001395"],"URL":"https:\/\/doi.org\/10.1016\/j.rceng.2024.10.009","relation":{},"ISSN":["2254-8874"],"issn-type":[{"value":"2254-8874","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective study of restless legs syndrome in a blood donors\u2019 sample","name":"articletitle","label":"Article Title"},{"value":"Revista Cl\u00ednica Espa\u00f1ola (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rceng.2024.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.rce.2024.07.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Espa\u00f1a, S.L.U. and Sociedad Espa\u00f1ola de Medicina Interna (SEMI). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}