{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:16:37Z","timestamp":1783671397188,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Cl\u00ednica Espa\u00f1ola (English Edition)"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.rceng.2026.502509","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:41:51Z","timestamp":1773765711000},"page":"502509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Action taken upon the detection of sickle cell trait (heterozygous hemoglobinopathy S) in newborn screening in Spain"],"prefix":"10.1016","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5668-7190","authenticated-orcid":false,"given":"A.","family":"Gondra Sangroniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-7362","authenticated-orcid":false,"given":"S.","family":"Pay\u00e1n-Pern\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.","family":"Bard\u00f3n Cancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Collado Gimbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ruiz Llobet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Ma\u00f1\u00fa Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cela de Juli\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.rceng.2026.502509_bib0005","first-page":"241.e1","article-title":"Hemoglobinopat\u00edas: talasemia y drepanocitosis","volume":"XXV","author":"Jim\u00e9nez Cobo","year":"2021","journal-title":"Pediatr Integral"},{"issue":"4","key":"10.1016\/j.rceng.2026.502509_bib0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.nefro.2020.10.012","article-title":"Nefropat\u00eda falciforme. Manifestaciones cl\u00ednicas y nuevos mecanismos implicados en el da\u00f1o renal","volume":"41","author":"Pay\u00e1n-Pern\u00eda","year":"2021","journal-title":"Nefrolog\u00eda"},{"key":"10.1016\/j.rceng.2026.502509_bib0015","series-title":"Enfermedad de c\u00e9lulas falciformes. Gu\u00eda de pr\u00e1ctica cl\u00ednica","author":"Cela","year":"2019"},{"issue":"6","key":"10.1016\/j.rceng.2026.502509_bib0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2018-10-880575","article-title":"Decreased median survival of adults with sickle cell disease after adjusting for left truncation bias: a pooled analysis","volume":"133","author":"DeBaun","year":"2019","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.rceng.2026.502509_bib0025","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1016\/S2352-3026(23)00118-7","article-title":"Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000\u20132021: a systematic analysis from the Global Burden of Disease Study 2021","volume":"10","author":"Thomson","year":"2023","journal-title":"Lancet Haematol"},{"issue":"8","key":"10.1016\/j.rceng.2026.502509_bib0030","doi-asserted-by":"crossref","first-page":"e687","DOI":"10.1016\/S2352-3026(23)00182-5","article-title":"Sickle cell disease landscape and challenges in the EU: the ERN-EuroBloodNet perspective","volume":"10","author":"Ma\u00f1\u00fa Pereira","year":"2023","journal-title":"Lancet Haematol"},{"issue":"8","key":"10.1016\/j.rceng.2026.502509_bib0035","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s00277-024-05788-8","article-title":"Haemoglobinopathies and other rare anemias in Spain: ten years of a nationwide registry (REHem-AR)","volume":"103","author":"Marco S\u00e1nchez","year":"2024","journal-title":"Ann Hematol"},{"issue":"4","key":"10.1016\/j.rceng.2026.502509_bib0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/ijns10040069","article-title":"Newborn screening for sickle cell disease in catalonia between 2015 and 2022\u2014epidemiology and impact on clinical events","volume":"10","author":"Gonz\u00e1lez de Aledo-Castillo","year":"2024","journal-title":"Int J Neonatal Screen"},{"key":"10.1016\/j.rceng.2026.502509_bib0045","series-title":"Enfermedad de C\u00e9lulas Falciformes. Gu\u00eda de Pr\u00e1ctica Cl\u00ednica. SEHOP","first-page":"13","article-title":"Cribado neonatal","author":"Cela","year":"2019"},{"key":"10.1016\/j.rceng.2026.502509_bib0050","unstructured":"Grupo de trabajo de protocolos de cribado neonatal de la ponencia de cribado poblacional. Protocolo de Cribado Neonatal de Anemia Falciforme. 2024 [accessed 22 Jul 2025]. Available from: https:\/\/www.sanidad.gob.es\/areas\/promocionPrevencion\/cribado\/cribadoNeonatal\/enfermedadesEndocrinoMetabolicas\/protocolosConsensuados.htm."},{"issue":"4","key":"10.1016\/j.rceng.2026.502509_bib0055","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/bjh.15600","article-title":"Newborn screening for sickle cell disease in Europe: recommendations from a Pan-European Consensus Conference","volume":"183","author":"Lobitz","year":"2018","journal-title":"Br J Haematol"},{"issue":"7","key":"10.1016\/j.rceng.2026.502509_bib0060","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00277-020-04044-z","article-title":"Fifteen years of newborn sickle cell disease screening in Madrid, Spain: an emerging disease in a European country","volume":"99","author":"Garc\u00eda-Mor\u00edn","year":"2020","journal-title":"Ann Hematol"},{"key":"10.1016\/j.rceng.2026.502509_bib0065","unstructured":"Grupo de trabajo del sistema de informaci\u00f3n del programa de cribado neonatal del Sistema Nacional de Salud. Programa de Cribado Neonatal Del Sistema Nacional de Salud. Informe de Evaluaci\u00f3n. A\u00f1o 2020. 2023 [accessed 21 Jul 2025]. Available from: https:\/\/www.sanidad.gob.es\/areas\/promocionPrevencion\/cribado\/cribadoNeonatal\/enfermedadesEndocrinoMetabolicas\/evaluacionProgramacribado.htm."},{"key":"10.1016\/j.rceng.2026.502509_bib0070","unstructured":"Grupo de trabajo del sistema de informaci\u00f3n del programa de cribado neonatal del Sistema Nacional de Salud. Informe de Evaluaci\u00f3n Del Programa de Cribado Neonatal Del Sistema Nacional de Salud. A\u00f1o 2021. 2024 [accessed 21 Jul 2025]. Available from: https:\/\/www.sanidad.gob.es\/areas\/promocionPrevencion\/cribado\/cribadoNeonatal\/enfermedadesEndocrinoMetabolicas\/evaluacionProgramacribado.htm."},{"issue":"9","key":"10.1016\/j.rceng.2026.502509_bib0075","doi-asserted-by":"crossref","first-page":"619","DOI":"10.7326\/M18-1161","article-title":"Clinical outcomes associated with sickle cell trait: A systematic review","volume":"169","author":"Naik","year":"2018","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rceng.2026.502509_bib0080","unstructured":"Grupo de trabajo del sistema de informaci\u00f3n del programa de cribado neonatal del Sistema Nacional de Salud. Informe de Evaluaci\u00f3n Del Programa de Cribado Neonatal Del Sistema Nacional de Salud. A\u00f1o 2023. 2025 [accessed 21 Jul 2025]. Available from: https:\/\/www.sanidad.gob.es\/areas\/promocionPrevencion\/cribado\/cribadoNeonatal\/enfermedadesEndocrinoMetabolicas\/evaluacionProgramacribado.htm."},{"issue":"21","key":"10.1016\/j.rceng.2026.502509_bib0085","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMp2408196","article-title":"Sickle cell trait, inequity, and the need for change","volume":"391","author":"Carney","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rceng.2026.502509_bib0090","unstructured":"Comiss\u00e3o Executiva do Programa, Vilarinho L, Garcia P, Pinho e Costa P. Programa Nacional de Rastreio Neonatal: Relat\u00f3rio 2024. 2025 [accessed 21 Jul 2025]. Available from: https:\/\/repositorio.insa.pt\/entities\/publication\/e4ba16c4-c3cd-4b79-a799-adb3f3408215."},{"key":"10.1016\/j.rceng.2026.502509_bib0095","unstructured":"Newborn screening \u2013 Guiadance. Jul 2025 [accessed 22 Jul 2025]. Available from: https:\/\/www.gov.uk\/government\/publications\/handbook-for-sickle-cell-and-thalassaemia-screening\/newborn-screening?utm."},{"key":"10.1016\/j.rceng.2026.502509_bib0100","doi-asserted-by":"crossref","DOI":"10.1155\/ah\/3854629","article-title":"Variability in notification of positive newborn screening results for sickle cell trait across the United States","volume":"2024","author":"Scott","year":"2024","journal-title":"Adv Hematol"},{"key":"10.1016\/j.rceng.2026.502509_bib0105","series-title":"Enfermedad de C\u00e9lulas Falciformes. Gu\u00eda de Pr\u00e1ctica Cl\u00ednica","first-page":"138","article-title":"Asesoramiento gen\u00e9tico","author":"Ropero","year":"2019"},{"key":"10.1016\/j.rceng.2026.502509_bib0110","unstructured":"Report at a Glance: Sickle Cell Disease. 2023 [accessed 22 Jul 2025]. Available from: https:\/\/icer.org\/news-insights\/press-releases\/icer-publishes-final-evidence-report-on-gene-therapies-for-sickle-cell-disease\/."},{"issue":"2","key":"10.1016\/j.rceng.2026.502509_bib0115","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0031-3955(16)33859-7","article-title":"Unstable hemoglobins, hemoglobins with altered oxygen affinity, and M-hemoglobins","volume":"27","author":"Vichinsky","year":"1980","journal-title":"Pediatr Clin North Am"},{"issue":"2","key":"10.1016\/j.rceng.2026.502509_bib0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/bjh.14851","article-title":"The super sickling haemoglobin HbS-Oman: a study of red cell sickling, K+ permeability and associations with disease severity in patients heterozygous for HbA and HbS-Oman (HbA\/S-Oman genotype)","volume":"179","author":"Al Balushi","year":"2017","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rceng.2026.502509_bib0125","series-title":"Haemoglobinopathy diagnosis","author":"Bain","year":"2020"},{"issue":"6","key":"10.1016\/j.rceng.2026.502509_bib0130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/bjh.18794","article-title":"Significant haemoglobinopathies: a Guideline for screening and diagnosis: a British Society for Haematology Guideline","volume":"201","author":"Bain","year":"2023","journal-title":"Br J Haematol"},{"issue":"S 01","key":"10.1016\/j.rceng.2026.502509_bib0135","doi-asserted-by":"crossref","first-page":"E893","DOI":"10.1055\/s-0042-1759646","article-title":"Neonatal screening for sickle cell disease in Western Andalusia: results and lessons learnt after 3 years of implementation","volume":"41","author":"N\u00fa\u00f1ez-Jurado","year":"2024","journal-title":"Am J Perinatol"},{"issue":"4","key":"10.1016\/j.rceng.2026.502509_bib0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/ijns9040055","article-title":"A newborn screening program for sickle cell disease in Murcia (Spain)","volume":"9","author":"S\u00e1nchez-Villalobos","year":"2023","journal-title":"Int J Neonatal Screen"},{"issue":"4","key":"10.1016\/j.rceng.2026.502509_bib0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ejhg.2014.126","article-title":"Parents\u2019 responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening","volume":"23","author":"Ulph","year":"2015","journal-title":"Eur J Hum Genet"}],"container-title":["Revista Cl\u00ednica Espa\u00f1ola (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2254887426000561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2254887426000561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:48:11Z","timestamp":1783669691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2254887426000561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2254887426000561"],"URL":"https:\/\/doi.org\/10.1016\/j.rceng.2026.502509","relation":{},"ISSN":["2254-8874"],"issn-type":[{"value":"2254-8874","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Action taken upon the detection of sickle cell trait (heterozygous hemoglobinopathy S) in newborn screening in Spain","name":"articletitle","label":"Article Title"},{"value":"Revista Cl\u00ednica Espa\u00f1ola (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rceng.2026.502509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.rce.2026.502509","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Espa\u00f1a, S.L.U. and Sociedad Espa\u00f1ola de Medicina Interna (SEMI). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"502509"}}