{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:02:58Z","timestamp":1780304578912,"version":"3.54.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Cl\u00ednica Espa\u00f1ola (English Edition)"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.rceng.2026.502547","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:59:35Z","timestamp":1777161575000},"page":"502547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of the FIB-4 and FIB-5 indices in patients hospitalised for acute heart failure. Analysis of the RICA-2 registry"],"prefix":"10.1016","volume":"226","author":[{"given":"G.","family":"Ropero-Luis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"M\u00e9ndez-Bail\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ruiz-Hueso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Armengou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ll\u00e1cer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yebra-Yebra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chivite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"S\u00e1nchez-Marteles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"P\u00e9rez-Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Trull\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"36","key":"10.1016\/j.rceng.2026.502547_bib0005","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"issue":"21","key":"10.1016\/j.rceng.2026.502547_bib0010","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1001\/jama.2010.748","article-title":"Trends in length of stay and short-term outcomes among medicare patients hospitalized for heart failure, 1993\u20132006","volume":"303","author":"Bueno","year":"2010","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.rceng.2026.502547_bib0015","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ejhf.289","volume":"17","author":"Mebazaa","year":"2015","journal-title":"Eur J Heart Fail"},{"issue":"10","key":"10.1016\/j.rceng.2026.502547_bib0020","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/eurheartj\/ehs332","article-title":"Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure","volume":"34","author":"Nikolaou","year":"2013","journal-title":"Eur Heart J"},{"issue":"24","key":"10.1016\/j.rceng.2026.502547_bib0025","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.jacc.2013.03.042","article-title":"Cardiohepatic interactions in heart failure","volume":"61","author":"Samsky","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.rceng.2026.502547_bib0030","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.rceng.2026.502547_bib0035","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/ajg.2016.453","article-title":"Age as a confounding factor for the accurate non-invasive diagnosis of advanced NAFLD fibrosis","volume":"112","author":"McPherson","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.rceng.2026.502547_bib0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s12072-017-9796-z","article-title":"A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-significant and significant fibrosis in patients with chronic hepatitis C","volume":"11","author":"Shiha","year":"2017","journal-title":"Hepatol Int"},{"issue":"3","key":"10.1016\/j.rceng.2026.502547_bib0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00380-019-01505-y","article-title":"Fibrosis-4 index reflects right-sided filling pressure in patients with heart failure","volume":"35","author":"Maeda","year":"2020","journal-title":"Heart Vessels"},{"issue":"2","key":"10.1016\/j.rceng.2026.502547_bib0050","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/ehf2.13829","article-title":"Prognostic value of the liver fibrosis marker fibrosis\u20105 index in patients with acute heart failure","volume":"9","author":"Maeda","year":"2022","journal-title":"ESC Heart Fail"},{"issue":"10","key":"10.1016\/j.rceng.2026.502547_bib0055","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00380-023-02273-6","article-title":"Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure","volume":"38","author":"Maeda","year":"2023","journal-title":"Heart Vessels"},{"issue":"1","key":"10.1016\/j.rceng.2026.502547_bib0060","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2017-000598","article-title":"Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure","volume":"4","author":"Sato","year":"2017","journal-title":"Open Heart"},{"issue":"4","key":"10.1016\/j.rceng.2026.502547_bib0065","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5114\/ceh.2020.102157","article-title":"FIB-5 vs FIB-4 index for assessment of hepatic fibrosis in chronic hepatitis B affected patients","volume":"6","author":"Metwally","year":"2020","journal-title":"Clin Exp Hepatol"},{"issue":"5","key":"10.1016\/j.rceng.2026.502547_bib0070","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cardfail.2014.01.016","article-title":"Hypoalbuminemia in acute heart failure patients: causes and its impact on hospital and long-term mortality","volume":"20","author":"Bonilla-Palomas","year":"2014","journal-title":"J Card Fail"},{"issue":"8","key":"10.1016\/j.rceng.2026.502547_bib0075","first-page":"522","article-title":"The RICA-2 registry: design and baseline characteristics of the first 1,000 patients","volume":"224","author":"Trull\u00e0s","year":"2024","journal-title":"Rev Cl\u00ednica Esp Engl Ed"},{"issue":"37","key":"10.1016\/j.rceng.2026.502547_bib0080","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rceng.2026.502547_bib0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijcard.2020.11.002","article-title":"Prevalence of advanced heart failure and use of palliative care in admitted patients: findings from the EPICTER study","volume":"327","author":"Fern\u00e1ndez-Martinez","year":"2021","journal-title":"Int J Cardiol"},{"issue":"11","key":"10.1016\/j.rceng.2026.502547_bib0090","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/eurheartj\/ehs444","article-title":"Clinical course and predictive value of congestion during hospitalization in patients admitted for worsening signs and symptoms of heart failure with reduced ejection fraction: findings from the EVEREST trial","volume":"34","author":"Ambrosy","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rceng.2026.502547_bib0095","series-title":"RStudio: integrated development for R [Internet]","year":"2025"},{"key":"10.1016\/j.rceng.2026.502547_bib0100","series-title":"R: a language and environment for statistical computing [Internet]","year":"2025"},{"issue":"1","key":"10.1016\/j.rceng.2026.502547_bib0105","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s12872-023-03530-2","article-title":"Prognostic value of fibrosis-5 index combined with C-reactive protein in patients with acute decompensated heart failure","volume":"23","author":"Wang","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"issue":"9","key":"10.1016\/j.rceng.2026.502547_bib0110","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00380-023-02268-3","article-title":"Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with severe isolated tricuspid regurgitation: comparison with fibrosis-4 index","volume":"38","author":"Nakashima","year":"2023","journal-title":"Heart Vessels"},{"key":"10.1016\/j.rceng.2026.502547_bib0115","article-title":"Clinical utility of the Fibrosis-4 index for predicting mortality in patients with heart failure with or without metabolic dysfunction-associated steatotic liver disease: a prospective cohort study","volume":"48","author":"Boeckmans","year":"2025","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.rceng.2026.502547_bib0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijcard.2020.09.056","article-title":"Impact of predictive value of fibrosis-4 index in patients hospitalized for acute heart failure","volume":"324","author":"Shibata","year":"2021","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.rceng.2026.502547_bib0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.69944\/pjc.fb2544e880","article-title":"Predictive value of liver stiffness using FIB-4 Index in Mortality of Heart Failure Patients (Philippine Heart Failure Registry)","volume":"47","author":"Benitez","year":"2019","journal-title":"Philipp J Cardiol"},{"issue":"3","key":"10.1016\/j.rceng.2026.502547_bib0130","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/ehf2.13317","article-title":"Fibrosis\u20104 index reflects right ventricular function and prognosis in heart failure with preserved ejection fraction","volume":"8","author":"Nakashima","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"5","key":"10.1016\/j.rceng.2026.502547_bib0135","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1002\/ehf2.13351","article-title":"Prognostic significance of liver stiffness assessed by fibrosis\u20104 index in patients with heart failure","volume":"8","author":"Takae","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"2","key":"10.1016\/j.rceng.2026.502547_bib0140","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/ehf2.13195","article-title":"Prognostic value of impaired hepato\u2010renal function and liver fibrosis in patients admitted for acute heart failure","volume":"8","author":"Kawahira","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.rceng.2026.502547_bib0145","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejim.2016.07.022","article-title":"Validation of PROFUND prognostic index over a four-year follow-up period","volume":"36","author":"Bernabeu-Wittel","year":"2016","journal-title":"Eur J Intern Med"},{"issue":"11","key":"10.1016\/j.rceng.2026.502547_bib0150","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/ejhf.3722","article-title":"Liver stiffness measurement for non\u2010invasive assessment of central venous pressure in patients with heart failure: a multicentre pilot study","volume":"27","author":"Girerd","year":"2025","journal-title":"Eur J Heart Fail"}],"container-title":["Revista Cl\u00ednica Espa\u00f1ola (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S225488742600086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S225488742600086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:10:08Z","timestamp":1780301408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S225488742600086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S225488742600086X"],"URL":"https:\/\/doi.org\/10.1016\/j.rceng.2026.502547","relation":{},"ISSN":["2254-8874"],"issn-type":[{"value":"2254-8874","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of the FIB-4 and FIB-5 indices in patients hospitalised for acute heart failure. Analysis of the RICA-2 registry","name":"articletitle","label":"Article Title"},{"value":"Revista Cl\u00ednica Espa\u00f1ola (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rceng.2026.502547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.rce.2026.502547","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Espa\u00f1a, S.L.U. and Sociedad Espa\u00f1ola de Medicina Interna (SEMI). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"502547"}}