{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:48:26Z","timestamp":1782989306426,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004313","name":"General Electric Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiologic Clinics of North America"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.rcl.2020.09.005","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T05:41:27Z","timestamp":1605850887000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Overdiagnosis and Risks of Breast Cancer Screening"],"prefix":"10.1016","volume":"59","author":[{"given":"Colleen H.","family":"Neal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Helvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rcl.2020.09.005_bib1","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.rcl.2020.09.005_bib2","first-page":"7","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.rcl.2020.09.005_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/jama.2017.19130","article-title":"Association of screening and treatment with breast cancer mortality by molecular subtype in US women, 2000-2012","volume":"319","author":"Plevritis","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.rcl.2020.09.005_bib4","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/cncr.28784","article-title":"Reduction in late-stage breast cancer incidence in the\u00a0mammography era: implications for overdiagnosis of invasive cancer","volume":"120","author":"Helvie","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib5","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/cncr.31954","article-title":"Breast cancer deaths averted over 3 decades","volume":"125","author":"Hendrick","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/cncr.31840","article-title":"The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening","volume":"125","author":"Tab\u00e1r","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.7326\/M18-2147","article-title":"Screening for breast cancer in average risk women: a guidance statement from the American College of Physicians","volume":"170","author":"Qaseem","year":"2019","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib8","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/jamainternmed.2015.3043","article-title":"Breast cancer screening, incidence, and mortality across US counties","volume":"175","author":"Harding","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1148\/radiol.2017171622","article-title":"Obligate overdiagnosis due to mammographic screening: a direct estimate for US women","volume":"287","author":"Hendrick","year":"2018","journal-title":"Radiology"},{"key":"10.1016\/j.rcl.2020.09.005_bib10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jacr.2017.01.038","article-title":"Persistent untreated screening-detected breast cancer: an argument against delaying screening or increasing the interval between screenings","volume":"14","author":"Arleo","year":"2017","journal-title":"J\u00a0Am Coll Radiol"},{"key":"10.1016\/j.rcl.2020.09.005_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2214\/AJR.17.18629","article-title":"Current issues in the overdiagnosis and overtreatment of breast cancer","volume":"210","author":"Monticciolo","year":"2018","journal-title":"AJR Am J Roentgenol"},{"issue":"Suppl1","key":"10.1016\/j.rcl.2020.09.005_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1258\/jms.2012.012082","article-title":"Overdiagnosis in mammographic screening for breast cancer in Europe: a literature review","volume":"19","author":"Puliti","year":"2012","journal-title":"J\u00a0Med Screen"},{"key":"10.1016\/j.rcl.2020.09.005_bib13","doi-asserted-by":"crossref","first-page":"b2587","DOI":"10.1136\/bmj.b2587","article-title":"Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends","volume":"339","author":"J\u00f8rgensen","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.rcl.2020.09.005_bib14","first-page":"278","article-title":"Perspectives on the overdiagnosis of breast cancer associated with mammographic screening","volume":"1","author":"Helvie","year":"2019","journal-title":"J\u00a0Breast Imaging"},{"key":"10.1016\/j.rcl.2020.09.005_bib15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/bmj.38764.572569.7C","article-title":"Rate of over-diagnosis of breast cancer 15 years after end of Malm\u00f6 mammographic screening trial: follow-up study","volume":"332","author":"Zackrisson","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.rcl.2020.09.005_bib16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1148\/radiol.11110716","article-title":"Mammographic screening and \u201coverdiagnosis.\u201d","volume":"260","author":"Kopans","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.rcl.2020.09.005_bib17","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1002\/cncr.27580","article-title":"Long-term incidence of breast cancer by trial arm in one county of the Swedish Two-County trial of mammographic screening","volume":"118","author":"Yen","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib18","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1038\/bjc.2013.177","article-title":"The benefits and harms of breast cancer screening: an independent review","volume":"108","author":"Marmot","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ypmed.2016.06.033","article-title":"Revised estimates of overdiagnosis from the Canadian national breast screening study","volume":"90","author":"Baines","year":"2016","journal-title":"Prev Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/epirev\/mxr009","article-title":"Interpreting overdiagnosis estimates in population-based mammography screening","volume":"33","author":"de Gelder","year":"2011","journal-title":"Epidemiol Rev"},{"key":"10.1016\/j.rcl.2020.09.005_bib21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/bcr1354","article-title":"Overdiagnosis and overtreatment of breast cancer: estimates of overdiagnosis from two trials of mammographic screening for breast cancer","volume":"7","author":"Duffy","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.rcl.2020.09.005_bib22","doi-asserted-by":"crossref","first-page":"f1064","DOI":"10.1136\/bmj.f1064","article-title":"Overdiagnosis in screening mammography in Denmark: population based cohort study","volume":"346","author":"Njor","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.rcl.2020.09.005_bib23","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1001\/jama.2015.12783","article-title":"Breast cancer screening for women at average risk: 2015 guideline update from the American Cancer Society","volume":"314","author":"Oeffinger","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.rcl.2020.09.005_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/GRF.0000000000000239","article-title":"Breast cancer epidemiology and risk factors","volume":"59","author":"Rojas","year":"2016","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.rcl.2020.09.005_bib25","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1056\/NEJMoa1206809","article-title":"Effect of three decades of screening mammography on breast-cancer incidence","volume":"3 67","author":"Bleyer","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/jama.2013.776","article-title":"Incidence of breast cancer with distant involvement among women in the United States, 1976 to 2009","volume":"309","author":"Johnson","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.rcl.2020.09.005_bib27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/bcr1314","article-title":"Overdiagnosis in randomized controlled trials of breast cancer screening","volume":"7","author":"Moss","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.rcl.2020.09.005_bib28","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/cncr.20979","article-title":"Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses\u2019 Health Study","volume":"103","author":"Collins","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib29","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0959-8049(03)00259-4","article-title":"The Relative contributions of screen-detected in situ and invasive breast carcinomas in reducing mortality from the disease","volume":"39","author":"Duffy","year":"2003","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1016\/j.rcl.2020.09.005_bib30","first-page":"e46","article-title":"Screen detection of ductal carcinoma in situ and subsequent incidence of invasive interval breast cancers: a retrospective population-based study","volume":"17","author":"Duffy","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.rcl.2020.09.005_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.7326\/M15-2886","article-title":"Screening for breast cancer: U.S. preventive services task force recommendation statement","volume":"164","author":"Siu","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1148\/radiol.2402050107","article-title":"Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use","volume":"240","author":"Blanchard","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.rcl.2020.09.005_bib33","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1002\/cncr.30842","article-title":"Comparison of recommendations for screening mammography using CISNET models","volume":"123","author":"Arleo","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.rcl.2020.09.005_bib34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.7326\/M15-0969","article-title":"Effectiveness of breast cancer screening: systematic review and meta-analysis to update the 2009 U.S. Preventive services task force recommendation","volume":"164","author":"Nelson","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7326\/0003-4819-155-8-201110180-00004","article-title":"Cumulative probability of false-positive recall or biopsy recommendation after 10 years of screening mammography: a cohort study","volume":"155","author":"Hubbard","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib36","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/bmj.320.7250.1635","article-title":"US women\u2019s attitudes to false-positive mammography results and detection of ductal carcinoma in situ: cross-sectional survey","volume":"320","author":"Schwartz","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.rcl.2020.09.005_bib37","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0140-6736(93)91067-V","article-title":"Breast cancer screening with mammography: overview of Swedish randomised trials","volume":"341","author":"Nystr\u00f6m 1","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.rcl.2020.09.005_bib38","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1001\/jamainternmed.2014.981","article-title":"Consequences of false-positive screening mammograms","volume":"174","author":"Tosteson","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00330-017-5024-4","article-title":"Radiation dose with digital breast tomosynthesis compared to digital mammography: per-view analysis","volume":"28","author":"Gennaro","year":"2018","journal-title":"Eur Radiol"},{"key":"10.1016\/j.rcl.2020.09.005_bib40","first-page":"1","article-title":"Radiation doses and risks in breast screening","author":"Hendrick","year":"2020","journal-title":"J\u00a0Breast Imaging"},{"key":"10.1016\/j.rcl.2020.09.005_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.7326\/M15-1241","article-title":"Radiation-induced breast cancer incidence and mortality from digital mammography screening. a modeling study","volume":"164","author":"Miglioretti","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rcl.2020.09.005_bib42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1148\/radiol.10100655","article-title":"Risk of radiation-induced breast cancer from mammographic screening","volume":"258","author":"Yaffe","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.rcl.2020.09.005_bib43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1258\/jms.2009.009094","article-title":"Absolute numbers of lives saved and overdiagnosis in breast cancer screening, from a randomized trial and from the breast screening programme in England","volume":"17","author":"Duffy","year":"2010","journal-title":"J\u00a0Med Screen"}],"container-title":["Radiologic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033838920301196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033838920301196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:51:35Z","timestamp":1758502295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0033838920301196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0033838920301196"],"URL":"https:\/\/doi.org\/10.1016\/j.rcl.2020.09.005","relation":{},"ISSN":["0033-8389"],"issn-type":[{"value":"0033-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overdiagnosis and Risks of Breast Cancer Screening","name":"articletitle","label":"Article Title"},{"value":"Radiologic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rcl.2020.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}