{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:48:34Z","timestamp":1787194114466,"version":"build-2736575974"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T00:00:00Z","timestamp":1630195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Exploratory Research in Clinical and Social Pharmacy"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.rcsop.2021.100067","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T02:14:02Z","timestamp":1630635242000},"page":"100067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Do medicines commonly used by older adults impact their nutrient status?"],"prefix":"10.1016","volume":"3","author":[{"given":"Rui Qi","family":"Chong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Gelissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Chaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Penm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet MY","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rcsop.2021.100067_bb0005","author":"Greg McIntosh"},{"key":"10.1016\/j.rcsop.2021.100067_bb0010","series-title":"Department of Economic and Social Affairs, Population Division (2020). World Population Ageing 2019 (ST\/ESA\/SER.A\/444)","author":"United Nations","year":"2020"},{"key":"10.1016\/j.rcsop.2021.100067_bb0015","author":"Australian Institute of Health and Welfare Health of older people"},{"issue":"9","key":"10.1016\/j.rcsop.2021.100067_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/pds.5093","article-title":"A national study on prescribed medicine use in Australia on a typical day","volume":"29","author":"Wylie","year":"2020","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"11","key":"10.1016\/j.rcsop.2021.100067_bb0025","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ejcn.2013.175","article-title":"Nutritional risk of European elderly","volume":"67","author":"de Morais","year":"2013","journal-title":"Eur J Clin Nutr"},{"issue":"8","key":"10.1016\/j.rcsop.2021.100067_bb0030","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1017\/S0007114515000203","article-title":"Micronutrient intakes and potential inadequacies of community-dwelling older adults: a systematic review","volume":"113","author":"ter Borg","year":"2015","journal-title":"Br J Nutr"},{"key":"10.1016\/j.rcsop.2021.100067_bb0035","series-title":"Krause\u2019s Food and Nutrition Therapy, Edition 12th","author":"Mahan","year":"2016"},{"key":"10.1016\/j.rcsop.2021.100067_bb0040","series-title":"Nutrition, Aging, and the Elderly","first-page":"363","article-title":"Drug-nutrient interactions in the elderly","author":"Roe","year":"1989"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2125.2004.02095.x","article-title":"Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin","volume":"58","author":"Lilja","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.rcsop.2021.100067_bb0050","series-title":"Vol representing consumers on national health issues: Consumers Health Forum of Australia","first-page":"47","author":"Consumers Health Forum of Australia Annual Report 2011\u20132012","year":"2012"},{"key":"10.1016\/j.rcsop.2021.100067_bb0055","author":"World Health Organisation"},{"key":"10.1016\/j.rcsop.2021.100067_bb0060","author":"World Health Organisation"},{"key":"10.1016\/j.rcsop.2021.100067_bb0065","series-title":"Expenditure and Prescriptions Report1 July 2018 to 30 June 2019","article-title":"Pharmaceutical Benefit Scheme 2019","author":"Australian Government Department of Health","year":"2019"},{"key":"10.1016\/j.rcsop.2021.100067_bb0070","unstructured":"Australian Medicines Handbook. AMH Pty Ltd 2020: https:\/\/amhonline.amh.net.au\/."},{"key":"10.1016\/j.rcsop.2021.100067_bb0075","series-title":"Australian Pharmaceutical Formulary and Handbook","author":"Sansom","year":"2018"},{"key":"10.1016\/j.rcsop.2021.100067_bb0080","author":"MIMS Online"},{"key":"10.1016\/j.rcsop.2021.100067_bb0085","author":"Integrative Medicine Gateway Interaction Database"},{"key":"10.1016\/j.rcsop.2021.100067_bb0090","author":"Natural Medicines"},{"key":"10.1016\/j.rcsop.2021.100067_bb0095","author":"PubMed"},{"issue":"28","key":"10.1016\/j.rcsop.2021.100067_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta15280","article-title":"A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database","volume":"15","author":"Coupland","year":"2011","journal-title":"Health Technol Assess"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afaa195","article-title":"Awareness of the use of hyponatraemia-inducing medications in older adults with hyponatraemia: a study of their prevalent use and association with recurrent symptomatic or severe hyponatraemia","volume":"50","author":"Jun","year":"2020","journal-title":"Age Ageing"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0110","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/bcp.12499","article-title":"A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?","volume":"79","author":"Barber","year":"2015","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.maturitas.2013.08.010","article-title":"Characteristics, prevalence, risk factors, and underlying mechanism of hyponatremia in elderly patients treated with antidepressants: a cross-sectional study","volume":"76","author":"Mannesse","year":"2013","journal-title":"Maturitas."},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1053\/j.ajkd.2019.07.011","article-title":"Thiazide-associated hyponatremia: clinical manifestations and pathophysiology","volume":"75","author":"Filippone","year":"2020","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.rcsop.2021.100067_bb0125","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/00048670701261202","article-title":"Venlafaxine hyponatraemia: incidence, mechanism and management","volume":"41","author":"Roxanas","year":"2007","journal-title":"Aust N Z J Psychiatry"},{"issue":"9","key":"10.1016\/j.rcsop.2021.100067_bb0130","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/1753-0407.12900","article-title":"Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta-analysis","volume":"11","author":"Yang","year":"2019","journal-title":"J Diab"},{"issue":"44","key":"10.1016\/j.rcsop.2021.100067_bb0135","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017788","article-title":"Proton pump inhibitors and hypomagnesemia: a meta-analysis of observational studies","volume":"98","author":"Srinutta","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/j.rcsop.2021.100067_bb0140","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2036.2012.05201.x","article-title":"Systematic review: hypomagnesaemia induced by proton pump inhibition","volume":"36","author":"Hess","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0145","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.atherosclerosis.2014.08.053","article-title":"Effect of a hydrophilic and a hydrophobic statin on cardiac salvage after ST-elevated acute myocardial infarction - a pilot study","volume":"237","author":"Chitose","year":"2014","journal-title":"Atherosclerosis."},{"issue":"15","key":"10.1016\/j.rcsop.2021.100067_bb0150","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jacc.2010.02.075","article-title":"Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure)","volume":"56","author":"McMurray","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0155","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5551\/jat.12.111","article-title":"Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients","volume":"12","author":"Mabuchi","year":"2005","journal-title":"J Atheroscler Thromb"},{"issue":"6","key":"10.1016\/j.rcsop.2021.100067_bb0160","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archneur.61.6.889","article-title":"Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke","volume":"61","author":"Rundek","year":"2004","journal-title":"Arch Neurol"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/bcp.12687","article-title":"Myopathy in older people receiving statin therapy: a systematic review and meta-analysis","volume":"80","author":"Iwere","year":"2015","journal-title":"Br J Clin Pharmacol"},{"issue":"7","key":"10.1016\/j.rcsop.2021.100067_bb0170","first-page":"801","article-title":"Hydrochlorothiazide-amiloride versus hydrochlorothiazide alone for essential hypertension: effects on blood pressure and serum potassium level","volume":"132","author":"Larochelle","year":"1985","journal-title":"Can Med Assoc J"},{"issue":"7","key":"10.1016\/j.rcsop.2021.100067_bb0175","first-page":"485","article-title":"The efficacy and tolerability of amlodipine and hydrochlorothiazide in Nigerians with essential hypertension","volume":"87","author":"Ajayi","year":"1995","journal-title":"J Natl Med Assoc"},{"issue":"S647","key":"10.1016\/j.rcsop.2021.100067_bb0180","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0954-6820.1981.tb02640.x","article-title":"Thiazide diuretics, hypokalemia and cardiac arrhythmias","volume":"209","author":"Hollifield","year":"1981","journal-title":"Acta Medica Scandinavica"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0185","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1152\/japplphysiol.00680.2017","article-title":"Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol","volume":"125","author":"Atanasovska","year":"2018","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0190","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1046\/j.1365-2125.2001.01362.x","article-title":"Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol","volume":"51","author":"Fowler","year":"2001","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"10.1016\/j.rcsop.2021.100067_bb0195","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1365-2125.1989.tb03447.x","article-title":"Systemic beta-adrenoceptor responses to salbutamol given by metered-dose inhaler alone and with pear shaped spacer attachment: comparison of electrocardiographic, hypokalaemic and haemodynamic effects","volume":"27","author":"Lipworth","year":"1989","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2125.1987.tb03010.x","article-title":"The mechanism of salbutamol-induced hypokalaemia","volume":"23","author":"Whyte","year":"1987","journal-title":"Br J Clin Pharmacol"},{"issue":"5","key":"10.1016\/j.rcsop.2021.100067_bb0205","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2125.1987.tb03224.x","article-title":"Hypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteers","volume":"24","author":"Scheinin","year":"1987","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0210","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1365-2125.1984.tb02520.x","article-title":"Cardiovascular and biochemical responses to nebulised salbutamol in normal subjects","volume":"18","author":"Smith","year":"1984","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0215","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2125.1981.tb01124.x","article-title":"The metabolic actions of intravenous salbutamol and aminophylline singly and in combination","volume":"11","author":"Jenkins","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.rcsop.2021.100067_bb0220","series-title":"Medicines Safety Update Vol 2, No 2, April 2011 Drug-induced hyponatraemia","author":"Therapeutic Goods Administration","year":"2011"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0225","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2125.2002.01550.x","article-title":"Association between antidepressant drug use and hyponatraemia: a case-control study","volume":"53","author":"Movig","year":"2002","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"10.1016\/j.rcsop.2021.100067_bb0230","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/cpt.1562","article-title":"Severe Hyponatremia is often Drug induced: 10-year results of a prospective Pharmacovigilance program","volume":"106","author":"Ram\u00edrez","year":"2019","journal-title":"Clin Pharmacol Therap"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0235","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00228-002-0438-5","article-title":"Serotonergic antidepressants associated with an increased risk for hyponatraemia in the elderly","volume":"58","author":"Movig","year":"2002","journal-title":"Eur J Clin Pharmacol"},{"issue":"10","key":"10.1016\/j.rcsop.2021.100067_bb0240","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am J Med"},{"key":"10.1016\/j.rcsop.2021.100067_bb0245","series-title":"Rang and Dale's Pharmacology. Ninth Edition. Ed","author":"Ritter","year":"2020"},{"key":"10.1016\/j.rcsop.2021.100067_bb0250","author":"Electrolyte abnormalities"},{"key":"10.1016\/j.rcsop.2021.100067_bb0255","series-title":"Table 6 - Reference intervals for harmonised chemical pathology*","volume":"Vol 2020","author":"Australasian Royal College of Pathology","year":"2018"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0260","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1258\/jrsm.2012.120137","article-title":"A practical guide to monitoring for adverse drug reactions during antihypertensive drug therapy","volume":"106","author":"McDowell","year":"2013","journal-title":"J R Soc Med"},{"key":"10.1016\/j.rcsop.2021.100067_bb0265","series-title":"Health Do, ed","article-title":"Australian Adverse Drug Reactions Bulletin, Vol 22, No 3- Hyponatraemia with SSRIs","volume":"Vol 22","author":"Therapeutic Drug Administration","year":"2003"},{"key":"10.1016\/j.rcsop.2021.100067_bb0270","series-title":"Australian Adverse Drug Reactions Bulletin, Vol 27, No 5- Drug-induced hyponatraemia","author":"Therapeutic Drug Administration","year":"2008"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152846","article-title":"Correction: Hyponatremia improvement is associated with a reduced risk of mortality: evidence from a Meta-analysis","volume":"11","author":"Corona","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0280","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00134-014-3210-2","article-title":"Clinical practice guideline on diagnosis and treatment of hyponatraemia","volume":"40","author":"Spasovski","year":"2014","journal-title":"Intensive Care Med"},{"issue":"10 Suppl 1","key":"10.1016\/j.rcsop.2021.100067_bb0285","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0290","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/ageing\/afu145","article-title":"STOPP\/START criteria for potentially inappropriate prescribing in older people: version 2","volume":"44","author":"O\u2019Mahony","year":"2015","journal-title":"Age Ageing"},{"issue":"10","key":"10.1016\/j.rcsop.2021.100067_bb0295","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3181\/0703-MR-67","article-title":"Vitamin B12 sources and bioavailability","volume":"232","author":"Watanabe","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"issue":"7","key":"10.1016\/j.rcsop.2021.100067_bb0300","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1742-1241.2009.02026.x","article-title":"Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature","volume":"63","author":"Vogel","year":"2009","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.rcsop.2021.100067_bb0305","series-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline","author":"Pitkin","year":"2000"},{"issue":"6","key":"10.1016\/j.rcsop.2021.100067_bb0310","first-page":"384","article-title":"Vitamin B12 deficiency: recognition and management","volume":"96","author":"Langan","year":"2017","journal-title":"Am Fam Physician"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0315","first-page":"155","article-title":"Vitamin B12 deficiency in the elderly: is it worth screening?","volume":"21","author":"Wong","year":"2015","journal-title":"Hong Kong Med J"},{"issue":"12","key":"10.1016\/j.rcsop.2021.100067_bb0320","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.3390\/nu5125031","article-title":"Neuroenhancement with vitamin B12\u2014underestimated neurological significance","volume":"5","author":"Gr\u00f6ber","year":"2013","journal-title":"Nutrients."},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0325","first-page":"155","article-title":"Vitamin B12 deficiency in the elderly: is it worth screening","volume":"21","author":"Wong","year":"2015","journal-title":"Hong Kong Med J"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0330","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/10408398.2018.1522613","article-title":"Important drug-micronutrient interactions: a selection for clinical practice","volume":"60","author":"Gr\u00f6ber","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0335","doi-asserted-by":"crossref","first-page":"382","DOI":"10.18433\/J3PK7P","article-title":"Metformin and vitamin B12 deficiency: where do we stand?","volume":"19","author":"Ahmed","year":"2016","journal-title":"J Pharm Pharm Sci"},{"issue":"9","key":"10.1016\/j.rcsop.2021.100067_bb0340","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2337\/diacare.23.9.1227","article-title":"Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin","volume":"23","author":"Bauman","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rcsop.2021.100067_bb0345","series-title":"Vitamin B12 (cobalamin): total B12 and holotranscobalamin (active B12)","article-title":"Pathology Handbook","author":"SonicHealthCare","year":"2016"},{"issue":"2 Suppl","key":"10.1016\/j.rcsop.2021.100067_bb0350","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1177\/15648265080292S129","article-title":"Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies","volume":"29","author":"de Benoist","year":"2008","journal-title":"Food Nutr Bull"},{"issue":"7","key":"10.1016\/j.rcsop.2021.100067_bb0355","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.4103\/jfmpc.jfmpc_416_19","article-title":"Vitamin B12 deficiency and the knowledge and practice of physicians regarding screening for vitamin B12 deficiency among type 2 diabetic patients on metformin in selected hospitals in Riyadh, Saudi Arabia","volume":"8","author":"Alshammari","year":"2019","journal-title":"J Family Med Prim Care"},{"issue":"suppl 1","key":"10.1016\/j.rcsop.2021.100067_bb0360","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.2337\/dc20-S003","article-title":"Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes-2020","volume":"43","author":"American Diabetes Association 3","year":"2020","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0365","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/bjh.12959","article-title":"Guidelines for the diagnosis and treatment of cobalamin and folate disorders","volume":"166","author":"Devalia","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rcsop.2021.100067_bb0370","article-title":"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency","volume":"3","author":"Vidal-Alaball","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.rcsop.2021.100067_bb0375","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood-2008-03-040253","article-title":"How I treat cobalamin (vitamin B12) deficiency","volume":"112","author":"Carmel","year":"2008","journal-title":"Blood."},{"key":"10.1016\/j.rcsop.2021.100067_bb0380","series-title":"Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride","author":"Intakes IoMSCotSEoDR","year":"1997"},{"key":"10.1016\/j.rcsop.2021.100067_bb0385","series-title":"Modern nutrition in health and disease","author":"Shils","year":"2006"},{"key":"10.1016\/j.rcsop.2021.100067_bb0390","series-title":"Present Knowledge in Nutrition","author":"Erdman","year":"2012"},{"issue":"9","key":"10.1016\/j.rcsop.2021.100067_bb0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001736","article-title":"Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study","volume":"11","author":"Zipursky","year":"2014","journal-title":"PLoS Med"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0400","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5527\/wjn.v5.i2.152","article-title":"Proton-pump inhibitor-induced hypomagnesemia: current research and proposed mechanisms","volume":"5","author":"William","year":"2016","journal-title":"World J Nephrol"},{"issue":"12","key":"10.1016\/j.rcsop.2021.100067_bb0405","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.3748\/wjg.v17.i12.1574","article-title":"Omeprazole decreases magnesium transport across Caco-2 monolayers","volume":"17","author":"Thongon","year":"2011","journal-title":"World J Gastroenterol: WJG"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0410","doi-asserted-by":"crossref","first-page":"79","DOI":"10.18773\/austprescr.2017.019","article-title":"Proton pump inhibitor-associated hypomagnesaemia and hypocalcaemia","volume":"40","author":"Morris","year":"2017","journal-title":"Aust Prescr"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0415","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/j.gastro.2017.01.031","article-title":"The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association","volume":"152","author":"Freedberg","year":"2017","journal-title":"Gastroenterology."},{"key":"10.1016\/j.rcsop.2021.100067_bb0420","series-title":"TGA update","article-title":"Medicines Safety Update Vol 2, No 3, June 2011- Risk of hypomagnesaemia with proton pump inhibitors","volume":"Vol 2","author":"Therapeutic Drugs Administration (TGA)","year":"2011"},{"key":"10.1016\/j.rcsop.2021.100067_bb0425","series-title":"Drug Safety Communication: Low magnesium levels can be associated with long-term use of Proton Pump Inhibitor drugs (PPIs)","volume":"Vol 2020","author":"US Food Drug Administration","year":"2011"},{"issue":"10","key":"10.1016\/j.rcsop.2021.100067_bb0430","first-page":"329","article-title":"Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole","volume":"68","author":"Fern\u00e1ndez-Fern\u00e1ndez","year":"2010","journal-title":"Neth J Med"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0435","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/php.12583","article-title":"Accelerated regeneration of ATP level after irradiation in human skin fibroblasts by coenzyme Q10","volume":"92","author":"Schniertshauer","year":"2016","journal-title":"Photochem Photobiol"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0440","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1038\/s41598-017-08899-7","article-title":"Coenzyme Q10 improves lipid metabolism and ameliorates obesity by regulating CaMKII-mediated PDE4 inhibition","volume":"7","author":"Xu","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.rcsop.2021.100067_bb0445","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.bbamem.2018.02.015","article-title":"Effect of ubiquinone-10 on the stability of biomimetic membranes of relevance for the inner mitochondrial membrane","volume":"1860","author":"Eriksson","year":"2018","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.rcsop.2021.100067_bb0450","doi-asserted-by":"crossref","first-page":"104201","DOI":"10.1016\/j.phrs.2019.03.010","article-title":"Mechanisms of statin-associated skeletal muscle-associated symptoms","volume":"154","author":"Bouitbir","year":"2020","journal-title":"Pharmacol Res"},{"issue":"23","key":"10.1016\/j.rcsop.2021.100067_bb0455","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2007.02.049","article-title":"The role of coenzyme Q10 in statin-associated myopathy: a systematic review","volume":"49","author":"Marcoff","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0460","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/ATV.0000000000000073","article-title":"Statin safety and associated adverse events: a scientific statement from the American Heart Association","volume":"39","author":"Newman","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rcsop.2021.100067_bb0465","series-title":"NPS MedicineWise","article-title":"Statin-associated muscle symptoms (SAMS)","author":"MedicineWise","year":"2017"},{"key":"10.1016\/j.rcsop.2021.100067_bb0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.03.006","article-title":"Effect of coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: a systematic review and meta-analysis","volume":"299","author":"Kennedy","year":"2020","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.rcsop.2021.100067_bb0475","doi-asserted-by":"crossref","first-page":"g4356","DOI":"10.1136\/bmj.g4356","article-title":"Lipid modification and cardiovascular risk assessment for the primary and secondary prevention of cardiovascular disease: summary of updated NICE guidance","volume":"349","author":"Rabar","year":"2014","journal-title":"Bmj."},{"issue":"17","key":"10.1016\/j.rcsop.2021.100067_bb0480","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/eurheartj\/ehv043","article-title":"Statin-associated muscle symptoms: impact on statin therapy-European atherosclerosis society consensus panel statement on assessment, aetiology and management","volume":"36","author":"Stroes","year":"2015","journal-title":"Eur Heart J"},{"issue":"19","key":"10.1016\/j.rcsop.2021.100067_bb0485","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009835","article-title":"Effects of coenzyme Q10 on statin-induced myopathy: an updated Meta-analysis of randomized controlled trials","volume":"7","author":"Qu","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0490","first-page":"35","article-title":"Drug-induced hypokalaemia","volume":"2","author":"Isaac","year":"1992","journal-title":"DrugsAging"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0495","first-page":"e96","article-title":"Hypokalemia and sudden cardiac death","volume":"15","author":"Kjeldsen","year":"2010","journal-title":"Exp Clin Cardiol"},{"issue":"9","key":"10.1016\/j.rcsop.2021.100067_bb0505","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091284","article-title":"Diuretics, Ca-Antagonists, and Angiotensin-Converting Enzyme Inhibitors Affect Zinc Status in Hypertensive Patients on Monotherapy: A Randomized Trial","volume":"10","author":"Suliburska","year":"2018","journal-title":"Nutrients"},{"issue":"40","key":"10.1016\/j.rcsop.2021.100067_bb0510","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.3748\/wjg.v13.i40.5380","article-title":"Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis","volume":"13","author":"Chen","year":"2007","journal-title":"World J Gastroenterol: WJG"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0515","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/07315724.1998.10720459","article-title":"Effects of captopril and enalapril on zinc metabolism in hypertensive patients","volume":"17","author":"Golik","year":"1998","journal-title":"J Am Coll Nutr"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0520","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF02685997","article-title":"Zinc balance normalization","volume":"115","author":"Tubek","year":"2007","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0525","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.amjhyper.2004.09.019","article-title":"The effect of losartan and losartan\/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: a prospective open-label study","volume":"18","author":"Koren-Michowitz","year":"2005","journal-title":"Am J Hypertens"},{"issue":"12","key":"10.1016\/j.rcsop.2021.100067_bb0530","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1080\/14740338.2020.1836151","article-title":"Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients","volume":"19","author":"Borghi","year":"2020","journal-title":"Expert Opin Drug Saf"},{"issue":"2\u20133","key":"10.1016\/j.rcsop.2021.100067_bb0535","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02783187","article-title":"Type II diabetes mellitus, congestive heart failure, and zinc metabolism","volume":"39","author":"Golik","year":"1993","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0540","first-page":"58","article-title":"The influence of antihypertensive drugs on mineral status in hypertensive patients","volume":"18","author":"Suliburska","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0545","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0009-8981(01)00549-6","article-title":"Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients","volume":"311","author":"Oranje","year":"2001","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0550","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/j.ajkd.2016.08.020","article-title":"Second-generation antidepressants and hyponatremia risk: a population-based cohort study of older adults","volume":"69","author":"Gandhi","year":"2017","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"10.1016\/j.rcsop.2021.100067_bb0555","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3748\/wjg.v23.i7.1268","article-title":"Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: a clinical observation study","volume":"23","author":"Yang","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0560","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/gps.591","article-title":"Hyponatraemia in elderly psychiatric patients treated with selective serotonin reuptake inhibitors and venlafaxine: a retrospective controlled study in an inpatient unit","volume":"17","author":"Kirby","year":"2002","journal-title":"Int J Geriatr Psychiatry"},{"issue":"2","key":"10.1016\/j.rcsop.2021.100067_bb0565","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-2125.1999.00872.x","article-title":"Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people","volume":"47","author":"Wilkinson","year":"1999","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.rcsop.2021.100067_bb0570","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/01639360903574734","article-title":"Vitamin B(12) deficiency is linked with long-term use of proton pump inhibitors in institutionalized older adults: could a cyanocobalamin nasal spray be beneficial?","volume":"29","author":"Rozgony","year":"2010","journal-title":"J Nutr Elder"},{"issue":"3","key":"10.1016\/j.rcsop.2021.100067_bb0575","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jamda.2007.10.004","article-title":"Do acid-lowering agents affect vitamin B12 status in older adults?","volume":"9","author":"Dharmarajan","year":"2008","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.rcsop.2021.100067_bb0580","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.archger.2018.07.019","article-title":"Association of metformin use with vitamin B12 deficiency in the institutionalized elderly","volume":"79","author":"Wong","year":"2018","journal-title":"Arch Gerontol Geriatr"},{"issue":"4","key":"10.1016\/j.rcsop.2021.100067_bb0585","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1210\/jc.2015-3754","article-title":"Long-term metformin use and vitamin B12 deficiency in the diabetes prevention program outcomes study","volume":"101","author":"Aroda","year":"2016","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Exploratory Research in Clinical and Social Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667276621000676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667276621000676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:28:34Z","timestamp":1757406514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667276621000676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":116,"alternative-id":["S2667276621000676"],"URL":"https:\/\/doi.org\/10.1016\/j.rcsop.2021.100067","relation":{},"ISSN":["2667-2766"],"issn-type":[{"value":"2667-2766","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do medicines commonly used by older adults impact their nutrient status?","name":"articletitle","label":"Article Title"},{"value":"Exploratory Research in Clinical and Social Pharmacy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rcsop.2021.100067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100067"}}