{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:16:56Z","timestamp":1793722616189,"version":"4.6.1"},"reference-count":99,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Rheumatic Disease Clinics of North America"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.rdc.2006.07.004","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T11:42:40Z","timestamp":1169466160000},"page":"759-773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Inflammation-Induced Bone Loss: Can it Be Prevented?"],"prefix":"10.1016","volume":"32","author":[{"given":"Evange","family":"Romas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rdc.2006.07.004_bib1","series-title":"Primer of the metabolic bone diseases and disorders of mineral metabolism","first-page":"379","article-title":"Osteoporosis and rheumatic diseases","author":"Goldring","year":"2003"},{"issue":"9","key":"10.1016\/j.rdc.2006.07.004_bib2","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/1529-0131(199909)42:9<1854::AID-ANR9>3.0.CO;2-F","article-title":"Long-term course and outcome of functional capacity in rheumatoid arthritis: the effect of disease activity and radiologic damage over time","volume":"42","author":"Drossaers-Bakker","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/ard.62.7.617","article-title":"Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis","volume":"62","author":"Forsblad D'Elia","year":"2003","journal-title":"Ann Rheum Dis"},{"issue":"8914","key":"10.1016\/j.rdc.2006.07.004_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(94)91049-9","article-title":"Generalised bone loss in patients with early rheumatoid arthritis","volume":"344","author":"Gough","year":"1994","journal-title":"Lancet"},{"issue":"Suppl 2","key":"10.1016\/j.rdc.2006.07.004_bib5","first-page":"ii11","article-title":"Pathogenesis of bone and cartilage destruction in rheumatoid arthritis","volume":"42","author":"Goldring","year":"2003","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib6","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"Gravallese","year":"1998","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib7","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/art.10097","article-title":"Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin","volume":"46","author":"Redlich","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.rdc.2006.07.004_bib8","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1172\/JCI0215582","article-title":"Osteoclasts are essential for TNF-alpha-mediated joint destruction","volume":"110","author":"Redlich","year":"2002","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib9","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/art.11150","article-title":"Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice","volume":"48","author":"Schett","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/art.11487","article-title":"Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction","volume":"50","author":"Zwerina","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib11","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0002-9440(10)63016-7","article-title":"TRANCE\/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis","volume":"159","author":"Pettit","year":"2001","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib12","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0002-9440(10)64417-3","article-title":"Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis","volume":"161","author":"Romas","year":"2002","journal-title":"Am J Pathol"},{"issue":"6053","key":"10.1016\/j.rdc.2006.07.004_bib13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/319516a0","article-title":"Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors","volume":"319","author":"Bertolini","year":"1986","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib14","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/art.20384","article-title":"Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis","volume":"50","author":"Herrak","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib15","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.20382","article-title":"Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis","volume":"50","author":"Sims","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrd1109","article-title":"Therapeutic strategies for rheumatoid arthritis","volume":"2","author":"Smolen","year":"2003","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib17","first-page":"2541","article-title":"The skeleton in rheumatoid arthritis: common mechanisms for bone erosion and osteoporosis?","volume":"27","author":"Sambrook","year":"2000","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/08916930400022582","article-title":"Autoantibodies to citrullinated proteins: ACPA","volume":"38","author":"Vincent","year":"2005","journal-title":"Autoimmunity"},{"issue":"24","key":"10.1016\/j.rdc.2006.07.004_bib19","doi-asserted-by":"crossref","first-page":"21971","DOI":"10.1074\/jbc.M200434200","article-title":"Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B","volume":"277","author":"Cappellen","year":"2002","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.rdc.2006.07.004_bib20","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1002\/art.11076","article-title":"New radiographic bone erosions in the wrists of patients with rheumatoid arthritis are detectable with magnetic resonance imaging a median of two years earlier","volume":"48","author":"Ostergaard","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/rheumatology\/38.4.329","article-title":"A preliminary study of ultrasound aspiration of bone erosion in early rheumatoid arthritis","volume":"38","author":"Mc Gonagle","year":"1999","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/art.1780280105","article-title":"Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis","volume":"28","author":"Shimizu","year":"1985","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib23","first-page":"1282","article-title":"Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis","volume":"25","author":"Gough","year":"1998","journal-title":"J Rheumatol"},{"issue":"6717","key":"10.1016\/j.rdc.2006.07.004_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"6759","key":"10.1016\/j.rdc.2006.07.004_bib25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P","article-title":"Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor","volume":"43","author":"Gravallese","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/1529-0131(200002)43:2<259::AID-ANR4>3.0.CO;2-W","article-title":"Involvement of receptor activator of nuclear factor kappaB ligand\/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis","volume":"43","author":"Takayanagi","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/bbrc.1999.1623","article-title":"Activated T lymphocytes support osteoclast formation in vitro","volume":"265","author":"Horwood","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.rdc.2006.07.004_bib29","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/rheumatology\/kel045","article-title":"RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis","volume":"45","author":"Pettit","year":"2006","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib30","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI200316069","article-title":"Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis","volume":"111","author":"Ritchlin","year":"2003","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/art.11419","article-title":"Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic\u00a0mice","volume":"50","author":"Li","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"17","key":"10.1016\/j.rdc.2006.07.004_bib32","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1074\/jbc.M512624200","article-title":"TNF increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-fms expression","volume":"281","author":"Yao","year":"2006","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib33","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/1529-0131(200011)43:11<2523::AID-ANR20>3.0.CO;2-Z","article-title":"Expression of osteoclast differentiation factor in rheumatoid arthritis","volume":"43","author":"Shigeyama","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib34","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/art.10607","article-title":"Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis","volume":"46","author":"Lubberts","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.rdc.2006.07.004_bib35","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1002\/art.21343","article-title":"Analysis of the kinetics of osteoclastogenesis in arthritic rats","volume":"52","author":"Schett","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"5484","key":"10.1016\/j.rdc.2006.07.004_bib36","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","article-title":"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families","volume":"20","author":"Suda","year":"1999","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib38","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1006\/bbrc.2000.3577","article-title":"Interferon-gamma directly inhibits TRANCE-induced osteoclastogenesis","volume":"276","author":"Fox","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.rdc.2006.07.004_bib39","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1074\/jbc.M104957200","article-title":"Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling","volume":"277","author":"Wei","year":"2002","journal-title":"J Biol Chem"},{"issue":"6812","key":"10.1016\/j.rdc.2006.07.004_bib40","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"issue":"6882","key":"10.1016\/j.rdc.2006.07.004_bib41","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/416744a","article-title":"RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta","volume":"416","author":"Takayanagi","year":"2002","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib42","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bone.2004.04.022","article-title":"Effects of activated T cells on osteoclastogenesis depend on how they are activated","volume":"35","author":"Wyzga","year":"2004","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.rdc.2006.07.004_bib43","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI11176","article-title":"TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand","volume":"106","author":"Lam","year":"2000","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.rdc.2006.07.004_bib44","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"Kotake","year":"1999","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib45","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","article-title":"IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae","volume":"169","author":"Palmqvist","year":"2002","journal-title":"J\u00a0Immunol"},{"issue":"6984","key":"10.1016\/j.rdc.2006.07.004_bib46","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature02444","article-title":"Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis","volume":"428","author":"Koga","year":"2004","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib47","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev Cell"},{"issue":"25","key":"10.1016\/j.rdc.2006.07.004_bib48","doi-asserted-by":"crossref","first-page":"26475","DOI":"10.1074\/jbc.M313973200","article-title":"Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos","volume":"279","author":"Matsuo","year":"2004","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib49","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.emboj.7600564","article-title":"RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis","volume":"24","author":"Gohda","year":"2005","journal-title":"EMBO J"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1172\/JCI16923","article-title":"Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice","volume":"111","author":"Kaifu","year":"2003","journal-title":"J Clin Invest"},{"issue":"16","key":"10.1016\/j.rdc.2006.07.004_bib51","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1073\/pnas.0401602101","article-title":"The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase","volume":"101","author":"Mocsai","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00109-004-0612-6","article-title":"Mechanistic insight into osteoclast differentiation in osteoimmunology","volume":"83","author":"Takayanagi","year":"2005","journal-title":"J\u00a0Mol Med"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib53","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.175.4.2579","article-title":"Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis","volume":"175","author":"Jimenez-Boj","year":"2005","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib54","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1002\/art.21377","article-title":"Involvement of subchondral bone marrow in rheumatoid arthritis: lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment","volume":"52","author":"Bugatti","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib55","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S8756-3282(01)00682-2","article-title":"Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis","volume":"30","author":"Romas","year":"2002","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib56","first-page":"518","article-title":"Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid","volume":"24","author":"Partsch","year":"1997","journal-title":"J Rheumatol"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib57","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1172\/JCI119679","article-title":"Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor","volume":"100","author":"Abu-Amer","year":"1997","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nm0297-189","article-title":"Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis","volume":"3","author":"McInnes","year":"1997","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib59","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0008-8749(87)90326-1","article-title":"Regulation of tumor necrosis factor (TNF) expression: interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages","volume":"109","author":"Koerner","year":"1987","journal-title":"Cell Immunol"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib60","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.4049\/jimmunol.141.4.1197","article-title":"Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes","volume":"141","author":"Debets","year":"1988","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib61","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis","volume":"115","author":"Wei","year":"2005","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.rdc.2006.07.004_bib62","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1172\/JCI26132","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib63","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/art.20982","volume":"52","author":"Smolen","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.rdc.2006.07.004_bib64","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1073\/pnas.1035999100","article-title":"IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist","volume":"100","author":"Nakae","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.rdc.2006.07.004_bib65","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/1529-0131(199812)41:12<2117::AID-ART6>3.0.CO;2-P","article-title":"Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis","volume":"41","author":"Takagi","year":"1998","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib66","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/art.21537","article-title":"Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis","volume":"54","author":"Wong","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"Suppl 3","key":"10.1016\/j.rdc.2006.07.004_bib67","first-page":"iii10","article-title":"The role of interleukin-1 in bone resorption in rheumatoid arthritis","volume":"43","author":"Strand","year":"2004","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib68","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/art.1780390513","article-title":"Anticytokine treatment of established type II collagen-induced arthritis in DBA\/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha\/beta, and IL-1Ra","volume":"39","author":"Joosten","year":"1996","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib69","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/art.20159","article-title":"Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate","volume":"50","author":"Maini","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2006.07.004_bib70","unstructured":"Pincus T, Yazici Y, Sokka T, et\u00a0al. Methotrexate as the \u201canchor drug\u201d for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol 2003;21(5)(Suppl 31)S179\u201385."},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib71","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/1529-0131(199811)41:11<2032::AID-ART19>3.0.CO;2-J","article-title":"Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes","volume":"41","author":"Seitz","year":"1998","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib72","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1359\/JBMR.0301233","article-title":"RANK signaling is not required for TNFalpha-mediated\u00a0increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis","volume":"19","author":"Li","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.rdc.2006.07.004_bib73","first-page":"44","article-title":"Bone and joint destruction in rheumatoid arthritis: what is really happening?","volume":"65","author":"Goldring","year":"2002","journal-title":"J\u00a0Rheumatol Suppl"},{"issue":"7033","key":"10.1016\/j.rdc.2006.07.004_bib74","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature03417","article-title":"ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro","volume":"434","author":"Stanton","year":"2005","journal-title":"Nature"},{"issue":"7033","key":"10.1016\/j.rdc.2006.07.004_bib75","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.rdc.2006.07.004_bib76","first-page":"30","article-title":"Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system","volume":"208","author":"Tanaka","year":"2005","journal-title":"Immunol\u00a0Rev"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib77","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1359\/JBMR.040305","article-title":"A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women","volume":"19","author":"Bekker","year":"2004","journal-title":"J\u00a0Bone Miner Res"},{"issue":"8","key":"10.1016\/j.rdc.2006.07.004_bib78","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJMoa044459","article-title":"Denosumab in postmenopausal women with low bone mineral density","volume":"354","author":"McClung","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib79","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s007740200038","article-title":"A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders","volume":"20","author":"Juji","year":"2002","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib80","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S8756-3282(99)00116-7","article-title":"Bisphosphonates: from the laboratory to the clinic and back again","volume":"25","author":"Russell","year":"1999","journal-title":"Bone"},{"issue":"Suppl 4","key":"10.1016\/j.rdc.2006.07.004_bib81","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/theoncologist.9-90004-3","article-title":"Bisphosphonates: preclinical review","volume":"9","author":"Green","year":"2004","journal-title":"Oncologist"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib82","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF01782979","article-title":"Effect of clodronate on established collagen-induced arthritis in rats","volume":"44","author":"Osterman","year":"1995","journal-title":"Inflamm Res"},{"issue":"3","key":"10.1016\/j.rdc.2006.07.004_bib83","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s000110050093","article-title":"A comparison of clodronate and indomethacin in the treatment of adjuvant arthritis","volume":"46","author":"Osterman","year":"1997","journal-title":"Inflamm Res"},{"issue":"12","key":"10.1016\/j.rdc.2006.07.004_bib84","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/art.1780381211","article-title":"Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes","volume":"38","author":"Kinne","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2006.07.004_bib85","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/03009749509100907","article-title":"Treatment of rat arthritides with clodronate-containing\u00a0liposomes","volume":"101","author":"Kinne","year":"1995","journal-title":"Scand J Rheumatol Suppl"},{"issue":"6","key":"10.1016\/j.rdc.2006.07.004_bib86","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.berh.2005.06.008","article-title":"Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates","volume":"19","author":"Romas","year":"2005","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib87","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/art.21824","article-title":"Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis","volume":"54","author":"Jarrett","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib88","first-page":"1102","article-title":"Repair of erosions in rheumatoid arthritis does occur. Results from 2 studies by the OMERACT Subcommittee on Healing of Erosions","volume":"30","author":"Sharp","year":"2003","journal-title":"J\u00a0Rheumatol"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib89","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmed.2004.12.004","article-title":"Osteoclast-derived activity in the coupling of bone formation to resorption","volume":"11","author":"Martin","year":"2005","journal-title":"Trends Mol Med"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib90","doi-asserted-by":"crossref","first-page":"E1011","DOI":"10.1152\/ajpendo.00534.2004","article-title":"The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis","volume":"288","author":"Gilbert","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.rdc.2006.07.004_bib91","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1074\/jbc.M106339200","article-title":"Expression of the osteoblast differentiation factor RUNX2 (Cbfa1\/AML3\/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha","volume":"277","author":"Gilbert","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib92","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/er.2004-0006","article-title":"Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use","volume":"26","author":"Hodsman","year":"2005","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib93","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0002-9440(10)63144-6","article-title":"Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis","volume":"164","author":"Redlich","year":"2004","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.rdc.2006.07.004_bib94","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/art.21021","article-title":"Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models","volume":"52","author":"Schett","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2006.07.004_bib95","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM200401083500219","article-title":"Effects of parathyroid hormone and alendronate alone or in combination in osteoporosis","volume":"350","author":"Sugiyama","year":"2004","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib96","first-page":"2109","article-title":"Safety and efficacy of rituximab in patients with rheumatoid arthritis refractory to disease modifying antirheumatic drugs and anti-tumor necrosis factor-alpha treatment","volume":"32","author":"Higashida","year":"2005","journal-title":"J Rheumatol"},{"issue":"11","key":"10.1016\/j.rdc.2006.07.004_bib97","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJMoa050524","article-title":"Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition","volume":"353","author":"Genovese","year":"2005","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.rdc.2006.07.004_bib98","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/art.20383","article-title":"Bisphosphonates: environmental protection for the joint?","volume":"50","author":"Goldring","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.rdc.2006.07.004_bib99","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.mlg.0000187398.51857.3c","article-title":"Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates","volume":"116","author":"Farrugia","year":"2006","journal-title":"Laryngoscope"}],"container-title":["Rheumatic Disease Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889857X06000688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889857X06000688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:05:18Z","timestamp":1760180718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889857X06000688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":99,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0889857X06000688"],"URL":"https:\/\/doi.org\/10.1016\/j.rdc.2006.07.004","relation":{},"ISSN":["0889-857X"],"issn-type":[{"value":"0889-857X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-Induced Bone Loss: Can it Be Prevented?","name":"articletitle","label":"Article Title"},{"value":"Rheumatic Disease Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rdc.2006.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}