{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:10:48Z","timestamp":1767373848990,"version":"build-2065373602"},"reference-count":93,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Rheumatic Disease Clinics of North America"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.rdc.2008.08.004","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T03:17:21Z","timestamp":1226287041000},"page":"833-845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["New Concepts in the Pathogenesis of Sj\u00f6gren's Syndrome"],"prefix":"10.1016","volume":"34","author":[{"given":"Nicolas","family":"Delaleu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin V.","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Appel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rdc.2008.08.004_bib1","series-title":"Arthritis and allied conditions","first-page":"1681","article-title":"Sj\u00f6gren's syndrome","author":"Jonsson","year":"2005"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0722.2004.00183.x","article-title":"Sj\u00f6gren's syndrome","volume":"113","author":"Delaleu","year":"2005","journal-title":"Eur J Oral Sci"},{"issue":"7","key":"10.1016\/j.rdc.2008.08.004_bib3","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/rheumatology\/kel067","article-title":"Sj\u00f6gren's syndrome\u2014the non-apoptotic model of glandular hypofunction","volume":"45","author":"Dawson","year":"2006","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/art.21990","article-title":"Quality of life and psychological status in patients with primary Sj\u00f6gren's syndrome and sicca symptoms without autoimmune features","volume":"55","author":"Champey","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib5","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/art.20176","article-title":"Mortality and causes of death in primary Sj\u00f6gren's syndrome: a prospective cohort study","volume":"50","author":"Theander","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/ard.2005.041186","article-title":"Lymphoma and other malignancies in primary Sj\u00f6gren's syndrome: a cohort study on cancer incidence and lymphoma predictors","volume":"65","author":"Theander","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib7","first-page":"49","article-title":"Epstein-Barr virus and the lacrimal gland pathology of Sj\u00f6gren's syndrome","volume":"143","author":"Pflugfelder","year":"1993","journal-title":"Am J Pathol"},{"issue":"6237","key":"10.1016\/j.rdc.2008.08.004_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/341072a0","article-title":"Exocrinopathy resembling Sj\u00f6gren's syndrome in HTLV-1 tax transgenic mice","volume":"341","author":"Green","year":"1989","journal-title":"Nature"},{"issue":"8789","key":"10.1016\/j.rdc.2008.08.004_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0140-6736(92)91645-O","article-title":"Lymphocytic sialadenitis of Sj\u00f6gren's syndrome associated with chronic hepatitis C virus liver disease","volume":"339","author":"Haddad","year":"1992","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/0167-5699(92)90024-2","article-title":"The cognitive paradigm and the immunological homunculus","volume":"13","author":"Cohen","year":"1992","journal-title":"Immunol Today"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/ar599","article-title":"Genetic aspects of Sj\u00f6gren's syndrome","volume":"4","author":"Bolstad","year":"2002","journal-title":"Arthritis Res"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/eji.200425406","article-title":"Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sj\u00f6gren's syndrome","volume":"35","author":"Harangi","year":"2005","journal-title":"Eur J Immunol"},{"issue":"10","key":"10.1016\/j.rdc.2008.08.004_bib13","first-page":"2397","article-title":"Fas and Fas ligand gene polymorphisms in primary Sj\u00f6gren's syndrome","volume":"27","author":"Bolstad","year":"2000","journal-title":"J Rheumatol"},{"issue":"1\u20132","key":"10.1016\/j.rdc.2008.08.004_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-3083.2001.00965.x","article-title":"Cytokine polymorphisms in systemic lupus erythematosus and Sj\u00f6gren's syndrome","volume":"54","author":"Magnusson","year":"2001","journal-title":"Scand J Immunol"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib15","doi-asserted-by":"crossref","first-page":"R24","DOI":"10.1186\/ar2136","article-title":"CTLA-4 +49A\/G and CT60 gene polymorphisms in primary Sj\u00f6gren syndrome","volume":"9","author":"Gottenberg","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib16","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1136\/ard.2007.071167","article-title":"Tumour necrosis factor receptor 2 (TNFRSF1B) association study in Sj\u00f6gren's syndrome","volume":"66","author":"Miceli-Richard","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2008.08.004_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2156-8-33","article-title":"Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sj\u00f6gren's syndrome and systemic sclerosis","volume":"8","author":"Kahlmann","year":"2007","journal-title":"BMC Genet"},{"issue":"9","key":"10.1016\/j.rdc.2008.08.004_bib18","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1002\/art.20463","article-title":"Evidence for coxsackievirus infection in primary Sj\u00f6gren's syndrome","volume":"50","author":"Triantafyllopoulou","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib19","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/art.21906","article-title":"Failure to confirm coxsackievirus infection in primary Sj\u00f6gren's syndrome","volume":"54","author":"Gottenberg","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.rdc.2008.08.004_bib20","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/art.21006","article-title":"Gene expression profiling of minor salivary glands clearly distinguishes primary Sj\u00f6gren's syndrome patients from healthy control subjects","volume":"52","author":"Hjelmervik","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.rdc.2008.08.004_bib21","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/ar2300","article-title":"The influence of the NOD Nss1\/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice","volume":"9","author":"Hjelmervik","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib22","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/labinvest.3700487","article-title":"Early pathogenic events associated with Sj\u00f6gren's syndrome (SjS)-like disease of the NOD mouse using microarray analysis","volume":"86","author":"Killedar","year":"2006","journal-title":"Lab Invest"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/art.20998","article-title":"Activation of the type I interferon system in primary Sj\u00f6gren's syndrome: a possible etiopathogenic mechanism","volume":"52","author":"B\u00e5ve","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib24","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1002\/art.21893","article-title":"Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sj\u00f6gren's syndrome autoantigen-associated RNA","volume":"54","author":"Lovgren","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.rdc.2008.08.004_bib25","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/art.22828","article-title":"Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sj\u00f6gren's syndrome","volume":"56","author":"Laine","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"34","key":"10.1016\/j.rdc.2008.08.004_bib26","doi-asserted-by":"crossref","first-page":"12628","DOI":"10.1073\/pnas.0405099101","article-title":"Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sj\u00f6gren's syndrome","volume":"101","author":"Shim","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib27","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/ard.61.12.1041","article-title":"Detection of maternal-fetal microchimerism in the inflammatory lesions of patients with Sj\u00f6gren's syndrome","volume":"61","author":"Kuroki","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/1529-0131(200103)44:3<693::AID-ANR119>3.0.CO;2-7","article-title":"Elevated proapoptotic Bax and caspase 3 activation in the NOD.scid model of Sj\u00f6gren's syndrome","volume":"44","author":"Masago","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.immuni.2004.08.013","article-title":"A T cell intrinsic role of Id3 in a mouse model for primary Sj\u00f6gren's syndrome","volume":"21","author":"Li","year":"2004","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2567.2007.02614.x","article-title":"B-lymphocyte depletion ameliorates Sj\u00f6gren's syndrome in Id3 knockout mice","volume":"122","author":"Hayakawa","year":"2007","journal-title":"Immunology"},{"issue":"6673","key":"10.1016\/j.rdc.2008.08.004_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1073\/pnas.231606698","article-title":"Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance","volume":"99","author":"Steinman","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.rdc.2008.08.004_bib33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(04)00108-6","article-title":"Autoimmunity through cytokine-induced dendritic cell activation","volume":"20","author":"Banchereau","year":"2004","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.smim.2006.01.009","article-title":"The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity","volume":"18","author":"Tarbell","year":"2006","journal-title":"Semin Immunol"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.imlet.2005.01.011","article-title":"Dendritic cells in tolerance induction","volume":"99","author":"Enk","year":"2005","journal-title":"Immunol Lett"},{"issue":"8","key":"10.1016\/j.rdc.2008.08.004_bib36","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1084\/jem.188.8.1493","article-title":"Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue","volume":"188","author":"Ludewig","year":"1998","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4049\/jimmunol.163.1.32","article-title":"Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis","volume":"163","author":"Dittel","year":"1999","journal-title":"J Immunol"},{"issue":"5764","key":"10.1016\/j.rdc.2008.08.004_bib38","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1122545","article-title":"Dendritic cell apoptosis in the maintenance of immune tolerance","volume":"311","author":"Chen","year":"2006","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.rdc.2008.08.004_bib39","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1182\/blood-2006-11-056424","article-title":"Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity","volume":"109","author":"Chen","year":"2007","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.rdc.2008.08.004_bib40","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1073\/pnas.0510837103","article-title":"Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sj\u00f6gren's syndrome","volume":"103","author":"Gottenberg","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-3083.2006.01811.x","article-title":"Role of dendritic cells in Sj\u00f6gren's syndrome","volume":"64","author":"Vogelsang","year":"2006","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib42","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/ar2375","article-title":"Biomarker profiles in serum and saliva of experimental Sj\u00f6gren's syndrome: associations with specific autoimmune manifestations","volume":"10","author":"Delaleu","year":"2008","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib43","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/art.21062","article-title":"Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sj\u00f6gren's syndrome","volume":"52","author":"Barone","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/01.LAB.0000059930.92336.E2","article-title":"Attenuated apoptosis of B cell activating factor-expressing cells in primary Sj\u00f6gren's syndrome","volume":"83","author":"Szodoray","year":"2003","journal-title":"Lab Invest"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib45","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N Engl J Med"},{"issue":"1\u20132","key":"10.1016\/j.rdc.2008.08.004_bib46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1365-3083.2001.00970.x","article-title":"Chemokines and cell trafficking in Sj\u00f6gren's syndrome","volume":"54","author":"Amft","year":"2001","journal-title":"Scand J Immunol"},{"issue":"11","key":"10.1016\/j.rdc.2008.08.004_bib47","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1002\/art.11311","article-title":"Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sj\u00f6gren's syndrome","volume":"48","author":"Salomonsson","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.rdc.2008.08.004_bib48","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1002\/art.23656","article-title":"Inhibition of experimental Sj\u00f6gren's syndrome through immunization with HSP60 and its peptide amino acids 437\u2013460","volume":"58","author":"Delaleu","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib49","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-3083.2005.01698.x","article-title":"Elevated serum levels of soluble E-cadherin in patients with primary Sj\u00f6gren's syndrome","volume":"62","author":"Jonsson","year":"2005","journal-title":"Scand J Immunol"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib50","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1002\/art.23073","volume":"56","author":"Manoussakis","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib51","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2249.2006.03311.x","article-title":"Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sj\u00f6gren's syndrome","volume":"147","author":"Spachidou","year":"2007","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"10.1016\/j.rdc.2008.08.004_bib52","first-page":"1019","article-title":"Toll-like receptor in salivary glands from patients with Sj\u00f6gren's syndrome: functional analysis by human salivary gland cell line","volume":"34","author":"Kawakami","year":"2007","journal-title":"J Rheumatol"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib53","first-page":"2438","article-title":"T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sj\u00f6gren's syndrome","volume":"34","author":"Li","year":"2007","journal-title":"J Rheumatol"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib54","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jaut.2006.11.003","article-title":"Novel animal models for Sj\u00f6gren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice","volume":"27","author":"Sharma","year":"2006","journal-title":"J Autoimmun"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaut.2005.01.015","article-title":"CD4 CD25high regulatory T cells are not impaired in patients with primary Sj\u00f6gren's syndrome","volume":"24","author":"Gottenberg","year":"2005","journal-title":"J Autoimmun"},{"issue":"8","key":"10.1016\/j.rdc.2008.08.004_bib56","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.4049\/jimmunol.173.8.4908","article-title":"E2f1 mutation induces early onset of diabetes and Sj\u00f6gren's syndrome in nonobese diabetic mice","volume":"173","author":"Salam","year":"2004","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib57","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.coi.2006.09.004","article-title":"Immune therapies of autoimmune diseases: are we approaching a real cure?","volume":"18","author":"Chatenoud","year":"2006","journal-title":"Curr Opin Immunol"},{"issue":"8","key":"10.1016\/j.rdc.2008.08.004_bib58","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nri2134","article-title":"CD3-specific antibodies: a portal to the treatment of autoimmunity","volume":"7","author":"Chatenoud","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib59","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1002\/art.23050","article-title":"Drug-specific and time-dependent risks of bacterial infection among patients with rheumatoid arthritis who were exposed to tumor necrosis factor alpha antagonists","volume":"56","author":"Curtis","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.rdc.2008.08.004_bib60","first-page":"2044","article-title":"Serological implications of germinal center-like structures in primary Sj\u00f6gren's syndrome","volume":"34","author":"Jonsson","year":"2007","journal-title":"J Rheumatol"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib61","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.clim.2005.06.016","article-title":"Distinct profiles of Sj\u00f6gren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF","volume":"117","author":"Szodoray","year":"2005","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib62","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10875-005-4091-5","article-title":"Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sj\u00f6gren's syndrome","volume":"25","author":"Jonsson","year":"2005","journal-title":"J Clin Immunol"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib63","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/art.10221","article-title":"Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sj\u00f6gren's syndrome","volume":"46","author":"Ioannidis","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib64","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4049\/jimmunol.167.2.1072","article-title":"Lymphoid neogenesis in rheumatoid synovitis","volume":"167","author":"Takemura","year":"2001","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib65","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0002-9440(10)61762-2","article-title":"Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers","volume":"159","author":"Armengol","year":"2001","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.rdc.2008.08.004_bib66","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1172\/JCI7830","article-title":"BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma","volume":"104","author":"Mazzucchelli","year":"1999","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.rdc.2008.08.004_bib67","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nri802","article-title":"Development of anti-TNF therapy for rheumatoid arthritis","volume":"2","author":"Feldmann","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib68","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/art.20146","article-title":"Inefficacy of infliximab in primary Sj\u00f6gren's syndrome: results of the randomized, controlled trial of remicade in primary Sj\u00f6gren's syndrome (TRIPSS)","volume":"50","author":"Mariette","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib69","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/030097499442577","article-title":"T(H)1 cytokines are produced in labial salivary glands in Sj\u00f6gren's syndrome, but also in healthy individuals","volume":"28","author":"Konttinen","year":"1999","journal-title":"Scand J\u00a0Rheumatol"},{"issue":"11","key":"10.1016\/j.rdc.2008.08.004_bib70","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.4049\/jimmunol.152.11.5532","article-title":"Cytokine mRNA expression in salivary gland biopsies of Sj\u00f6gren's syndrome","volume":"152","author":"Fox","year":"1994","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/clim.2002.5189","article-title":"Pathogenesis of Sj\u00f6gren's syndrome: characteristics of different mouse models for autoimmune exocrinopathy","volume":"103","author":"van Blokland","year":"2002","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib72","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1046\/j.1365-2249.2002.01869.x","article-title":"The Th1\/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sj\u00f6gren's syndrome","volume":"128","author":"Mitsias","year":"2002","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"10.1016\/j.rdc.2008.08.004_bib73","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1002\/art.21945","article-title":"Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland","volume":"54","author":"Jonsson","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jaut.2005.11.004","article-title":"Sj\u00f6gren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease","volume":"26","author":"Gao","year":"2006","journal-title":"J Autoimmun"},{"issue":"1-2","key":"10.1016\/j.rdc.2008.08.004_bib75","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-3083.2001.00958.x","article-title":"IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sj\u00f6gren's syndrome","volume":"54","author":"Brayer","year":"2001","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib76","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4049\/jimmunol.179.1.382","article-title":"IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sj\u00f6gren's syndrome-like disease of the nonobese diabetic mouse","volume":"179","author":"Nguyen","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.rdc.2008.08.004_bib77","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"10.1016\/j.rdc.2008.08.004_bib78","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/art.23214","article-title":"Salivary gland tissue expression of interleukin\u201323 and interleukin\u201317 in Sj\u00f6gren's syndrome: findings in humans and mice","volume":"58","author":"Nguyen","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.rdc.2008.08.004_bib79","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren's syndrome: a revised version of the European criteria proposed by the American-European consensus group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.rdc.2008.08.004_bib80","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1002\/art.22954","article-title":"Salivary proteomic and genomic biomarkers for primary Sj\u00f6gren's syndrome","volume":"56","author":"Hu","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib81","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jchromb.2006.09.004","article-title":"Global and targeted quantitative proteomics for biomarker discovery","volume":"847","author":"Veenstra","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib82","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sj\u00f6gren's syndrome","volume":"109","author":"Groom","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.rdc.2008.08.004_bib83","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF AND APRIL: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib84","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/ard.62.2.168","article-title":"The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sj\u00f6gren's syndrome","volume":"62","author":"Mariette","year":"2003","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib85","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/art.22458","article-title":"Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sj\u00f6gren's syndrome","volume":"56","author":"Daridon","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.rdc.2008.08.004_bib86","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/ard.2006.060772","article-title":"Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production","volume":"66","author":"Lavie","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.rdc.2008.08.004_bib87","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/art.22536","article-title":"Improvement of Sj\u00f6gren's syndrome after two infusions of rituximab (anti-CD20)","volume":"57","author":"Devauchelle-Pensec","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.rdc.2008.08.004_bib88","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.4049\/jimmunol.176.10.6277","article-title":"The Sj\u00f6gren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death","volume":"176","author":"Espinosa","year":"2006","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.rdc.2008.08.004_bib89","doi-asserted-by":"crossref","first-page":"8409","DOI":"10.4049\/jimmunol.175.12.8409","article-title":"Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sj\u00f6gren's syndrome","volume":"175","author":"Scofield","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.rdc.2008.08.004_bib90","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/03009748809096775","article-title":"Circulating IgM rheumatoid factors in patients with primary Sj\u00f6gren's syndrome","volume":"75","author":"Muller","year":"1988","journal-title":"Scand J Rheumatol Suppl"},{"issue":"1","key":"10.1016\/j.rdc.2008.08.004_bib91","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/ard.2003.019794","article-title":"Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sj\u00f6gren's syndrome","volume":"64","author":"Gottenberg","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.rdc.2008.08.004_bib92","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/art.21764","article-title":"Antimuscarinic antibodies in primary Sj\u00f6gren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells","volume":"54","author":"Dawson","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"13","key":"10.1016\/j.rdc.2008.08.004_bib93","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1073\/pnas.95.13.7538","article-title":"Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sj\u00f6gren's syndrome","volume":"95","author":"Robinson","year":"1998","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Rheumatic Disease Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889857X08000756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889857X08000756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:07:44Z","timestamp":1760180864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889857X08000756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":93,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0889857X08000756"],"URL":"https:\/\/doi.org\/10.1016\/j.rdc.2008.08.004","relation":{},"ISSN":["0889-857X"],"issn-type":[{"type":"print","value":"0889-857X"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New Concepts in the Pathogenesis of Sj\u00f6gren's Syndrome","name":"articletitle","label":"Article Title"},{"value":"Rheumatic Disease Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rdc.2008.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}