{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:15:24Z","timestamp":1781010924983,"version":"3.54.1"},"reference-count":217,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Rheumatic Disease Clinics of North America"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.rdc.2014.01.005","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T05:45:26Z","timestamp":1392788726000},"page":"251-278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Comorbidities in Patients with Crystal Diseases and Hyperuricemia"],"prefix":"10.1016","volume":"40","author":[{"given":"Sebastian E.","family":"Sattui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasvinder A.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo L.","family":"Gaffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rdc.2014.01.005_bib1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.23176","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II","volume":"58","author":"Lawrence","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib2","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008","volume":"63","author":"Zhu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/rheumatology\/kep081","article-title":"An update on the epidemiology of calcium pyrophosphate dihydrate crystal deposition disease","volume":"48","author":"Richette","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rdc.2014.01.005_bib4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/ard.2007.081604","article-title":"Gout is associated with more comorbidities, poorer health-related quality of life and higher healthcare utilisation in US veterans","volume":"67","author":"Singh","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.amjmed.2011.09.033","article-title":"Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008","volume":"125","author":"Zhu","year":"2012","journal-title":"Am J Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib6","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/ard.2007.076232","article-title":"Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005","volume":"67","author":"Annemans","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib7","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/rheumatology\/kes253","article-title":"Hospital admissions associated with gout and their comorbidities in New Zealand and England 1999-2009","volume":"52","author":"Robinson","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rdc.2014.01.005_bib8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00296-008-0806-2","article-title":"Hyperuricemia and its related factors in an urban population, Izmir, Turkey","volume":"29","author":"Sari","year":"2009","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/art.1780150209","article-title":"The influence of temperature on the solubility of monosodium urate","volume":"15","author":"Loeb","year":"1972","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib10","doi-asserted-by":"crossref","first-page":"C1183","DOI":"10.1152\/ajpcell.00075.2008","article-title":"Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells","volume":"295","author":"Zharikov","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1523-1755.2005.00273.x","article-title":"Hyperuricemia induces endothelial dysfunction","volume":"67","author":"Khosla","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib12","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1016\/S0021-9258(18)93017-6","article-title":"Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression","volume":"266","author":"Rao","year":"1991","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rdc.2014.01.005_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/HJH.0b013e3282f240bf","article-title":"Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system","volume":"26","author":"Corry","year":"2008","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.rdc.2014.01.005_bib14","doi-asserted-by":"crossref","first-page":"F991","DOI":"10.1152\/ajprenal.00283.2001","article-title":"Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism","volume":"282","author":"Mazzali","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib15","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1745-7254.2008.00877.x","article-title":"Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells","volume":"29","author":"Chao","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.rdc.2014.01.005_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijcard.2008.09.004","article-title":"Uric acid activates extracellular signal-regulated kinases and thereafter endothelin-1 expression in rat cardiac fibroblasts","volume":"139","author":"Cheng","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate anion exchanger that regulates blood urate levels","volume":"417","author":"Enomoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.rdc.2014.01.005_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1523-1755.2005.00074.x","article-title":"Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats","volume":"67","author":"Sanchez-Lozada","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib19","doi-asserted-by":"crossref","first-page":"F1105","DOI":"10.1152\/ajprenal.00170.2002","article-title":"Mild hyperuricemia induces glomerular hypertension in normal rats","volume":"283","author":"Sanchez-Lozada","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib20","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/ndt\/gfm783","article-title":"Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia","volume":"23","author":"Sanchez-Lozada","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.rdc.2014.01.005_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000127837","article-title":"Effect of febuxostat on the progression of renal disease in 5\/6 nephrectomy rats with and without hyperuricemia","volume":"108","author":"Sanchez-Lozada","year":"2008","journal-title":"Nephron Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/hy1101.092839","article-title":"Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism","volume":"38","author":"Mazzali","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1751-7176.2012.00662.x","article-title":"The role of uric acid in the pathogenesis of hypertension in the young","volume":"14","author":"Feig","year":"2012","journal-title":"J\u00a0Clin Hypertens (Greenwich)"},{"key":"10.1016\/j.rdc.2014.01.005_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.HYP.0000150784.92944.9a","article-title":"Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence","volume":"45","author":"Sundstrom","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.HYP.0000254480.64564.b6","article-title":"Hyperuricemia and incidence of hypertension among men without metabolic syndrome","volume":"49","author":"Krishnan","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib26","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/01.HYP.0000091371.53502.D3","article-title":"Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation","volume":"42","author":"Masuo","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib27","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1161\/01.HYP.0000249768.26560.66","article-title":"Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study","volume":"48","author":"Mellen","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1291\/hypres.27.835","article-title":"Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan","volume":"27","author":"Nagahama","year":"2004","journal-title":"Hypertens Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1023\/A:1024600905574","article-title":"Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers","volume":"18","author":"Nakanishi","year":"2003","journal-title":"Eur J Epidemiol"},{"issue":"8","key":"10.1016\/j.rdc.2014.01.005_bib30","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1136\/annrheumdis-2012-201916","article-title":"Serum urate association with hypertension in young adults: analysis from the Coronary Artery Risk Development in Young Adults cohort","volume":"72","author":"Gaffo","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/01.HYP.0000248752.08807.4c","article-title":"Uric acid and the development of hypertension: the normative aging study","volume":"48","author":"Perlstein","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/acr.20344","article-title":"Hyperuricemia and incident hypertension: a systematic review and meta-analysis","volume":"63","author":"Grayson","year":"2011","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib33","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1373\/clinchem.2009.124891","article-title":"Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis","volume":"55","author":"Zhang","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.rdc.2014.01.005_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/01.HYP.0000085858.66548.59","article-title":"Hyperuricemia in childhood primary hypertension","volume":"42","author":"Feig","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib35","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1542\/peds.2013-0047","article-title":"Serum uric acid and blood pressure in children at cardiovascular risk","volume":"132","author":"Viazzi","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.rdc.2014.01.005_bib36","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1253\/circj.CJ-09-0837","article-title":"Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students","volume":"74","author":"Hongo","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.rdc.2014.01.005_bib37","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jama.300.8.924","article-title":"Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial","volume":"300","author":"Feig","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.rdc.2014.01.005_bib38","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/HYPERTENSIONAHA.112.196980","article-title":"Uric acid reduction rectifies prehypertension in obese adolescents","volume":"60","author":"Soletsky","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib39","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2215\/CJN.11451210","article-title":"A\u00a0randomized study of allopurinol on endothelial function and estimated glomerular filtration rate in asymptomatic hyperuricemic subjects with normal renal function","volume":"6","author":"Kanbay","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.rdc.2014.01.005_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008652.pub2","article-title":"Pharmacotherapy for hyperuricemia in hypertensive patients","author":"Gois","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.rdc.2014.01.005_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1749-6632.1996.tb33318.x","article-title":"Identification of uric acid in aortic aneurysms and atherosclerotic artery","volume":"800","author":"Patetsios","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.rdc.2014.01.005_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11739-007-0004-3","article-title":"Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women","volume":"2","author":"Montalcini","year":"2007","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.atherosclerosis.2007.03.008","article-title":"Uric acid level and its association with carotid intima-media thickness in patients with hypertension","volume":"197","author":"Tavil","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.rdc.2014.01.005_bib44","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3899\/jrheum.080646","article-title":"Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study","volume":"36","author":"Neogi","year":"2009","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3899\/jrheum.100639","article-title":"Serum urate is not associated with coronary artery calcification: the NHLBI Family Heart Study","volume":"38","author":"Neogi","year":"2011","journal-title":"J\u00a0Rheumatol"},{"issue":"6","key":"10.1016\/j.rdc.2014.01.005_bib46","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/joim.12120","article-title":"Longitudinal association between serum urate and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) study","volume":"274","author":"Wang","year":"2013","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.ATV.0000196554.85799.77","article-title":"Endothelial nitric oxide synthase: host defense enzyme of the endothelium?","volume":"26","author":"Rabelink","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rdc.2014.01.005_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1755-5922.2011.00277.x","article-title":"Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis","volume":"30","author":"Higgins","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.rdc.2014.01.005_bib49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","article-title":"Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study","volume":"131","author":"Culleton","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib50","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1136\/ard.2009.122770","article-title":"Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based study","volume":"69","author":"De Vera","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/rheumatology\/kes169","article-title":"Risk of myocardial infarction among patients with gout: a nationwide population-based study","volume":"52","author":"Kuo","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rdc.2014.01.005_bib52","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1371\/journal.pmed.0020076","article-title":"Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis","volume":"2","author":"Wheeler","year":"2005","journal-title":"PLoS Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib53","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/acr.20065","article-title":"Hyperuricemia and coronary heart disease: a systematic review and meta-analysis","volume":"62","author":"Kim","year":"2010","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib54","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.atherosclerosis.2006.12.029","article-title":"Association between serum uric acid level and peripheral arterial disease","volume":"196","author":"Shankar","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.rdc.2014.01.005_bib55","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/0003319707303444","article-title":"Serum uric acid level and risk for peripheral arterial disease: analysis of data from the multiple risk factor intervention trial","volume":"58","author":"Baker","year":"2007","journal-title":"Angiology"},{"key":"10.1016\/j.rdc.2014.01.005_bib56","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0021-9150(03)00093-5","article-title":"Serum uric acid in hypertensive patients with and without peripheral arterial disease","volume":"168","author":"Langlois","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.rdc.2014.01.005_bib57","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1464-5491.2004.01239.x","article-title":"Independent association of uric acid levels with peripheral arterial disease in Taiwanese patients with type 2 diabetes","volume":"21","author":"Tseng","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib58","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijcard.2009.01.010","article-title":"Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study","volume":"142","author":"Ekundayo","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib59","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/CIRCHEARTFAILURE.108.797662","article-title":"Hyperuricemia and incident heart failure","volume":"2","author":"Krishnan","year":"2009","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.rdc.2014.01.005_bib60","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2007.11.094","article-title":"Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study","volume":"125","author":"Strasak","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib61","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1373\/clinchem.2007.094425","article-title":"Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men","volume":"54","author":"Strasak","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.rdc.2014.01.005_bib62","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/art.24164","article-title":"Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study","volume":"61","author":"Chen","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib63","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/eurheartj\/ehq473","article-title":"Hyperuricaemia, chronic kidney disease, and outcomes in heart failure: potential mechanistic insights from epidemiological data","volume":"32","author":"Filippatos","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rdc.2014.01.005_bib64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1751-7133.2011.00200.x","article-title":"Uric acid as a predictor of all-cause mortality in heart failure: a meta-analysis","volume":"17","author":"Tamariz","year":"2011","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.rdc.2014.01.005_bib65","doi-asserted-by":"crossref","first-page":"e000282","DOI":"10.1136\/bmjopen-2011-000282","article-title":"Gout and the risk for incident heart failure and systolic dysfunction","volume":"2","author":"Krishnan","year":"2012","journal-title":"BMJ Open"},{"key":"10.1016\/j.rdc.2014.01.005_bib66","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/eurjhf\/hfp042","article-title":"Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure","volume":"11","author":"Bergamini","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.rdc.2014.01.005_bib67","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.jacc.2008.01.068","article-title":"Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study","volume":"51","author":"Hare","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib68","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cardfail.2006.05.005","article-title":"The effect of xanthine oxidase inhibition upon ejection fraction in heart failure patients: La Plata Study","volume":"12","author":"Cingolani","year":"2006","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.rdc.2014.01.005_bib69","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/CIRCULATIONAHA.106.651117","article-title":"High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid","volume":"114","author":"George","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.rdc.2014.01.005_bib70","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0140-6736(10)60391-1","article-title":"Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial","volume":"375","author":"Noman","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.rdc.2014.01.005_bib71","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/CIRCHEARTFAILURE.109.868604","article-title":"Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study","volume":"3","author":"Ogino","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.rdc.2014.01.005_bib72","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/01.wnl.0000277468.10236.f1","article-title":"Serum uric acid and brain ischemia in normal elderly adults","volume":"69","author":"Schretlen","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.rdc.2014.01.005_bib73","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1053\/euhj.2001.2970","article-title":"Urate predicts subsequent cardiac death in stroke survivors","volume":"23","author":"Wong","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rdc.2014.01.005_bib74","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.STR.0000081983.34771.D2","article-title":"Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke","volume":"34","author":"Weir","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.rdc.2014.01.005_bib75","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/art.24612","article-title":"Hyperuricemia and risk of stroke: a systematic review and meta-analysis","volume":"61","author":"Kim","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib76","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1161\/STROKEAHA.108.519793","article-title":"Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial","volume":"39","author":"Muir","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.rdc.2014.01.005_bib77","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1755-5922.2008.00057.x","article-title":"Allopurinol treatment reduces arterial wave reflection in stroke survivors","volume":"26","author":"Khan","year":"2008","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.rdc.2014.01.005_bib78","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1365-2125.2009.03497.x","article-title":"The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial","volume":"68","author":"Dawson","year":"2009","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.rdc.2014.01.005_bib79","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/15257770600890954","article-title":"Uric acid and renal disease","volume":"25","author":"Cameron","year":"2006","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.rdc.2014.01.005_bib80","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ucl.2007.05.001","article-title":"Uric acid nephrolithiasis","volume":"34","author":"Cameron","year":"2007","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.rdc.2014.01.005_bib81","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00861588","article-title":"Gout, uric acid and purine metabolism in paediatric nephrology","volume":"7","author":"Cameron","year":"1993","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib82","doi-asserted-by":"crossref","first-page":"F1134","DOI":"10.1152\/ajprenal.00104.2008","article-title":"Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia","volume":"295","author":"Sanchez-Lozada","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib83","doi-asserted-by":"crossref","first-page":"F1238","DOI":"10.1152\/ajprenal.00164.2006","article-title":"Effects of acute and chronic L-arginine treatment in experimental hyperuricemia","volume":"292","author":"Sanchez-Lozada","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib84","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000066303","article-title":"Hyperuricemia causes glomerular hypertrophy in the rat","volume":"23","author":"Nakagawa","year":"2003","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib85","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1159\/000345509","article-title":"Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations","volume":"121","author":"Sanchez-Lozada","year":"2012","journal-title":"Nephron Exp Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib86","doi-asserted-by":"crossref","first-page":"C584","DOI":"10.1152\/ajpcell.00600.2006","article-title":"Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative\/nitrosative stress","volume":"293","author":"Sautin","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib87","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2","volume":"41","author":"Kanellis","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib88","doi-asserted-by":"crossref","first-page":"F471","DOI":"10.1152\/ajprenal.00560.2012","article-title":"Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease","volume":"304","author":"Ryu","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib89","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00109-003-0517-9","article-title":"The role of epithelial-to-mesenchymal transition in renal fibrosis","volume":"82","author":"Zeisberg","year":"2004","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.rdc.2014.01.005_bib90","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1097\/01.ASN.0000034910.58454.FD","article-title":"A\u00a0role for uric acid in the progression of renal disease","volume":"13","author":"Kang","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib91","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1159\/000330274","article-title":"Use of uric acid-lowering agents limits experimental cyclosporine nephropathy","volume":"120","author":"Mazali","year":"2012","journal-title":"Nephron Exp Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib92","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/00007890-200104150-00014","article-title":"Hyperuricemia exacerbates chronic cyclosporine nephropathy","volume":"71","author":"Mazzali","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.rdc.2014.01.005_bib93","doi-asserted-by":"crossref","first-page":"F481","DOI":"10.1152\/ajprenal.00092.2009","article-title":"Effect of lowering uric acid on renal disease in the type 2 diabetic db\/db mice","volume":"297","author":"Kosugi","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib94","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1001\/archinternmed.2008.605","article-title":"Risk factors for end-stage renal disease: 25-year follow-up","volume":"169","author":"Hsu","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib95","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1681\/ASN.2008010080","article-title":"Elevated uric acid increases the risk for kidney disease","volume":"19","author":"Obermayr","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib96","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1681\/ASN.2007101075","article-title":"Uric acid and incident kidney disease in the community","volume":"19","author":"Weiner","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib97","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0272-6386(04)00934-5","article-title":"Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort","volume":"44","author":"Iseki","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib98","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1291\/hypres.24.691","article-title":"Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects","volume":"24","author":"Iseki","year":"2001","journal-title":"Hypertens Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib99","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000045939","article-title":"Serum uric acid and renal prognosis in patients with IgA nephropathy","volume":"87","author":"Ohno","year":"2001","journal-title":"Nephron"},{"key":"10.1016\/j.rdc.2014.01.005_bib100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ndt\/15.1.34","article-title":"Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy","volume":"15","author":"Syrjanen","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.rdc.2014.01.005_bib101","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000331453","article-title":"Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial","volume":"35","author":"Shi","year":"2012","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib102","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.2337\/db09-0014","article-title":"Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study","volume":"58","author":"Hovind","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.rdc.2014.01.005_bib103","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/ndt\/gfp740","article-title":"Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study","volume":"25","author":"Jalal","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.rdc.2014.01.005_bib104","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2337\/dc10-0227","article-title":"High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up","volume":"33","author":"Ficociello","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rdc.2014.01.005_bib105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2337\/dc11-1346","article-title":"Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function","volume":"35","author":"Zoppini","year":"2012","journal-title":"Diabetes care"},{"key":"10.1016\/j.rdc.2014.01.005_bib106","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/MAJ.0b013e3181db6e16","article-title":"Hyperuricemia as an independent risk factor of chronic kidney disease in middle-aged and elderly population","volume":"339","author":"Chang","year":"2010","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.rdc.2014.01.005_bib107","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.ajkd.2007.05.013","article-title":"Relationship of uric acid with progression of kidney disease","volume":"50","author":"Chonchol","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib108","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1053\/j.ajkd.2008.12.021","article-title":"Uric acid and long-term outcomes in CKD","volume":"53","author":"Madero","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib109","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/ki.1997.260","article-title":"Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study","volume":"51","author":"Hunsicker","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib110","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exger.2008.01.006","article-title":"Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study","volume":"43","author":"Sturm","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.rdc.2014.01.005_bib111","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1471-2369-14-164","article-title":"The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality","volume":"14","author":"Gustafsson","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib112","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11255-007-9253-3","article-title":"Effect of treatment of hyperuricemia\u00a0with allopurinol on blood pressure, creatinine clearance, and proteinuria in patients with normal renal functions","volume":"39","author":"Kanbay","year":"2007","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib113","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.ajkd.2005.10.006","article-title":"Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level","volume":"47","author":"Siu","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib114","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2215\/CJN.01580210","article-title":"Effect of allopurinol in chronic kidney disease progression and cardiovascular risk","volume":"5","author":"Goicoechea","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib115","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000105142","article-title":"The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease","volume":"27","author":"Talaat","year":"2007","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib116","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/HYPERTENSIONAHA.111.171488","article-title":"Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial","volume":"58","author":"Miao","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.rdc.2014.01.005_bib117","first-page":"128","article-title":"Effect of allopurinol in decreasing proteinuria in type 2 diabetic patients","volume":"4","author":"Momeni","year":"2010","journal-title":"Iran J Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib118","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000238824","article-title":"Uric acid: a novel risk factor for acute kidney injury in high-risk cardiac surgery patients?","volume":"30","author":"Ejaz","year":"2009","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib119","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jtcvs.2008.12.052","article-title":"Uric acid levels and outcome from coronary artery bypass grafting","volume":"138","author":"Hillis","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.rdc.2014.01.005_bib120","doi-asserted-by":"crossref","first-page":"302.e9","DOI":"10.1016\/j.amjmed.2011.06.021","article-title":"Elevated uric acid increases the risk for acute kidney injury","volume":"125","author":"Lapsia","year":"2012","journal-title":"Am J Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib121","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11255-012-0192-2","article-title":"Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery","volume":"45","author":"Ejaz","year":"2013","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib122","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1053\/j.ackd.2012.07.014","article-title":"Uric acid stones and hyperuricosuria","volume":"19","author":"Mehta","year":"2012","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib123","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1046\/j.1523-1755.2002.00197.x","article-title":"Studies on the pathophysiology of the low urine pH in patients with uric acid stones","volume":"61","author":"Kamel","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib124","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1523-1755.2002.00508.x","article-title":"Pathophysiologic basis for normouricosuric uric acid nephrolithiasis","volume":"62","author":"Sakhaee","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib125","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1046\/j.1523-1755.2003.t01-2-00171.x","article-title":"The association between gout and nephrolithiasis in men: the Health Professionals' Follow-Up Study","volume":"64","author":"Kramer","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.rdc.2014.01.005_bib126","first-page":"2189","article-title":"Prevalence and risk factors for urolithiasis in primary gout: is a reappraisal needed?","volume":"32","author":"Alvarez-Nemegyei","year":"2005","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib127","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1001\/jama.1991.03470210076036","article-title":"Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration","volume":"266","author":"Facchini","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.rdc.2014.01.005_bib128","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0272-6386(97)90106-2","article-title":"The kidney: an unwilling accomplice in syndrome X","volume":"30","author":"Reaven","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib129","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/ajcn\/79.4.537","article-title":"Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity","volume":"79","author":"Bray","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.rdc.2014.01.005_bib130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.107.689935","article-title":"Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community","volume":"116","author":"Dhingra","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.rdc.2014.01.005_bib131","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(00)04041-1","article-title":"Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis","volume":"357","author":"Ludwig","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.rdc.2014.01.005_bib132","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jpeds.2009.01.015","article-title":"Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents","volume":"154","author":"Nguyen","year":"2009","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.rdc.2014.01.005_bib133","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.2337\/dc10-1079","article-title":"Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis","volume":"33","author":"Malik","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rdc.2014.01.005_bib134","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0026-0495(72)90120-5","article-title":"Studies on the mechanism of fructose-induced hyperuricemia in man","volume":"21","author":"Fox","year":"1972","journal-title":"Metabolism"},{"key":"10.1016\/j.rdc.2014.01.005_bib135","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/bj1620601","article-title":"The mechanism of adenosine triphosphate depletion in the liver after a load of fructose. A kinetic study of liver adenylate deaminase","volume":"162","author":"van den Berghe","year":"1977","journal-title":"Biochem J"},{"key":"10.1016\/j.rdc.2014.01.005_bib136","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.semnephrol.2011.08.004","article-title":"The epidemiology of uric acid and fructose","volume":"31","author":"Rho","year":"2011","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib137","doi-asserted-by":"crossref","first-page":"F712","DOI":"10.1152\/ajprenal.00433.2009","article-title":"Dietary fructose causes tubulointerstitial injury in the normal rat kidney","volume":"298","author":"Nakayama","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib138","doi-asserted-by":"crossref","first-page":"F423","DOI":"10.1152\/ajprenal.00124.2006","article-title":"Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats","volume":"292","author":"Sanchez-Lozada","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib139","doi-asserted-by":"crossref","first-page":"F625","DOI":"10.1152\/ajprenal.00140.2005","article-title":"A\u00a0causal role for uric acid in fructose-induced metabolic syndrome","volume":"290","author":"Nakagawa","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib140","doi-asserted-by":"crossref","first-page":"F710","DOI":"10.1152\/ajprenal.00454.2007","article-title":"Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome","volume":"294","author":"Sanchez-Lozada","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib141","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.semnephrol.2011.08.006","article-title":"Uric acid and fructose: potential biological mechanisms","volume":"31","author":"Lanaspa","year":"2011","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib142","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/07853890500415358","article-title":"Is insulin resistance the cause of the metabolic syndrome?","volume":"38","author":"Ferrannini","year":"2006","journal-title":"Annu Mediaev"},{"key":"10.1016\/j.rdc.2014.01.005_bib143","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/msj.20212","article-title":"Insulin resistance in obesity as the underlying cause for the metabolic syndrome","volume":"77","author":"Gallagher","year":"2010","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib144","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.mcna.2007.06.012","article-title":"Insulin resistance as the underlying cause for the metabolic syndrome","volume":"91","author":"Lann","year":"2007","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.rdc.2014.01.005_bib145","first-page":"E692","article-title":"Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in\u00a0vivo is NO dependent","volume":"274","author":"Roy","year":"1998","journal-title":"Am J Phys"},{"key":"10.1016\/j.rdc.2014.01.005_bib146","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1517\/14728222.2012.723694","article-title":"The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome","volume":"16","author":"Simao","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.rdc.2014.01.005_bib147","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2337\/db10-0916","article-title":"Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome","volume":"60","author":"Baldwin","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.rdc.2014.01.005_bib148","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.rdc.2014.01.005_bib149","first-page":"25","article-title":"Hyperuricemia and insulin resistance","volume":"78","author":"Vuorinen-Markkola","year":"1994","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.rdc.2014.01.005_bib150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00592-010-0231-3","article-title":"The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects","volume":"48","author":"Meshkani","year":"2011","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.rdc.2014.01.005_bib151","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1253\/circj.69.928","article-title":"Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome","volume":"69","author":"Yoo","year":"2005","journal-title":"Circ J"},{"key":"10.1016\/j.rdc.2014.01.005_bib152","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/aje\/kws002","article-title":"Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study","volume":"176","author":"Krishnan","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib153","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/aje\/kwg260","article-title":"Risk factors for progression to incident hyperinsulinemia: the Atherosclerosis Risk in Communities Study, 1987-1998","volume":"158","author":"Carnethon","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib154","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.amjmed.2010.03.027","article-title":"Serum uric acid levels and the risk of type 2\u00a0diabetes: a prospective study","volume":"123","author":"Bhole","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib155","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.2337\/dc09-0275","article-title":"Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study","volume":"32","author":"Kramer","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rdc.2014.01.005_bib156","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2337\/diacare.29.03.06.dc05-1465","article-title":"Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance: the Finnish Diabetes Prevention Study","volume":"29","author":"Niskanen","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.rdc.2014.01.005_bib157","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1373\/clinchem.2007.095190","article-title":"Plasma uric acid and the risk of type 2 diabetes in a Chinese community","volume":"54","author":"Chien","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.rdc.2014.01.005_bib158","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/rheumatology\/ken305","article-title":"Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile","volume":"47","author":"Choi","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rdc.2014.01.005_bib159","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1097\/00004872-200107000-00005","article-title":"Serum uric acid and the risk for hypertension and type 2 diabetes in Japanese men: the Osaka Health Survey","volume":"19","author":"Taniguchi","year":"2001","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.rdc.2014.01.005_bib160","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/rheumatology\/ken066","article-title":"Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels\u2013the Third National Health and Nutrition Examination Survey","volume":"47","author":"Choi","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rdc.2014.01.005_bib161","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1136\/ard.2010.130013","article-title":"Impact of diabetes against the future risk of developing gout","volume":"69","author":"Rodriguez","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib162","doi-asserted-by":"crossref","first-page":"604715","DOI":"10.1155\/2011\/604715","article-title":"Association between serum uric acid levels and diabetes mellitus","volume":"2011","author":"Bandaru","year":"2011","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.rdc.2014.01.005_bib163","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1464-5491.2007.02302.x","article-title":"Serum uric acid, mortality and glucose control in patients with type 2 diabetes mellitus: a PreCIS database study","volume":"24","author":"Ioachimescu","year":"2007","journal-title":"Diabet Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib164","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.amjmed.2006.06.040","article-title":"Prevalence of the metabolic syndrome in individuals with hyperuricemia","volume":"120","author":"Choi","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib165","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1475-2840-10-72","article-title":"Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes","volume":"10","author":"Li","year":"2011","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.rdc.2014.01.005_bib166","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.metabol.2009.09.027","article-title":"Serum uric acid and metabolic syndrome in Taiwanese adults","volume":"59","author":"Liu","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.rdc.2014.01.005_bib167","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1161\/CIRCULATIONAHA.106.657627","article-title":"Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents","volume":"115","author":"Ford","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.rdc.2014.01.005_bib168","first-page":"1882","article-title":"Serum uric acid levels and risk for vascular diseases in patients with metabolic syndrome","volume":"34","author":"Hjortnaes","year":"2007","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib169","first-page":"181","article-title":"Association between serum uric acid level and metabolic syndrome","volume":"45","author":"Lee","year":"2012","journal-title":"J\u00a0Prev Med Public Health"},{"key":"10.1016\/j.rdc.2014.01.005_bib170","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.archger.2012.03.004","article-title":"Significance and association of serum uric acid (UA) levels with components of metabolic syndrome (MS) in the elderly","volume":"55","author":"Chiou","year":"2012","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.rdc.2014.01.005_bib171","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/art.23121","article-title":"Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study","volume":"58","author":"Ioachimescu","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib172","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/15257770802138582","article-title":"Serum urate, metabolic syndrome, and cardiovascular risk factors. A population-based study","volume":"27","author":"Puig","year":"2008","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.rdc.2014.01.005_bib173","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/acr.21791","article-title":"Body mass index, obesity, and prevalent gout in the United States in 1988-1994 and 2007-2010","volume":"65","author":"Juraschek","year":"2013","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib174","first-page":"418094","article-title":"Adiponectinemia is associated with uricemia but not with proinflammatory status in women with metabolic syndrome","volume":"2012","author":"Simao","year":"2012","journal-title":"J\u00a0Nutr Metab"},{"key":"10.1016\/j.rdc.2014.01.005_bib175","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/acr.21824","article-title":"Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study","volume":"65","author":"Chen","year":"2013","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.rdc.2014.01.005_bib176","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2217\/bmm.10.94","article-title":"Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis","volume":"4","author":"Cipriani","year":"2010","journal-title":"Biomark Med"},{"key":"10.1016\/j.rdc.2014.01.005_bib177","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.semnephrol.2011.08.002","article-title":"Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations","volume":"31","author":"Johnson","year":"2011","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.rdc.2014.01.005_bib178","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/175683a0","article-title":"The origin of man","volume":"175","author":"Orowan","year":"1955","journal-title":"Nature"},{"key":"10.1016\/j.rdc.2014.01.005_bib179","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis","volume":"78","author":"Ames","year":"1981","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"10.1016\/j.rdc.2014.01.005_bib180","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1749-6632.2002.tb04072.x","article-title":"A\u00a0reassessment of the peroxynitrite scavenging activity of uric acid","volume":"962","author":"Whiteman","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.rdc.2014.01.005_bib181","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/taap.1999.8637","article-title":"Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals","volume":"156","author":"Regoli","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.rdc.2014.01.005_bib182","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0014-5793(84)81094-7","article-title":"Inhibition of free radical-induced DNA damage by uric acid","volume":"174","author":"Cohen","year":"1984","journal-title":"FEBS Lett"},{"key":"10.1016\/j.rdc.2014.01.005_bib183","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","article-title":"Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease","volume":"80","author":"Duan","year":"2002","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.rdc.2014.01.005_bib184","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1471-4159.2009.06040.x","article-title":"Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization","volume":"109","author":"Guerreiro","year":"2009","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.rdc.2014.01.005_bib185","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0361-9230(94)90285-2","article-title":"Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation","volume":"33","author":"Church","year":"1994","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.rdc.2014.01.005_bib186","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/aje\/kwm127","article-title":"Plasma urate and risk of Parkinson's disease","volume":"166","author":"Weisskopf","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib187","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/aje\/kwp033","article-title":"Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study","volume":"169","author":"Chen","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.rdc.2014.01.005_bib188","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1212\/01.wnl.0000279518.10072.df","article-title":"Gout and risk of Parkinson disease: a prospective study","volume":"69","author":"Alonso","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.rdc.2014.01.005_bib189","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/art.24193","article-title":"Gout and the risk of Parkinson's disease: a cohort study","volume":"59","author":"De Vera","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib190","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1468-1331.2002.00384.x","article-title":"Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction","volume":"9","author":"Toncev","year":"2002","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.rdc.2014.01.005_bib191","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/mds.22907","article-title":"The relationship between uric acid levels and Huntington's disease progression","volume":"25","author":"Auinger","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.rdc.2014.01.005_bib192","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/135245850100700507","article-title":"Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease","volume":"7","author":"Spitsin","year":"2001","journal-title":"Mult Scler"},{"key":"10.1016\/j.rdc.2014.01.005_bib193","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/1759720X11432559","article-title":"Treatment and management of pseudogout: insights for the clinician","volume":"4","author":"Macmullan","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib194","first-page":"1040","article-title":"The crowned dens syndrome as a cause of neck pain: clinical and computed tomography study in patients with calcium pyrophosphate dihydrate deposition disease","volume":"26","author":"Salaffi","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib195","first-page":"1241","article-title":"The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study","volume":"16","author":"Felson","year":"1989","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib196","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/ard.52.6.418","article-title":"Prevalence of articular chondrocalcinosis in elderly subjects in a rural area of Catalonia","volume":"52","author":"Sanmarti","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib197","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/ard.62.6.513","article-title":"UK community prevalence of knee chondrocalcinosis: evidence that correlation with osteoarthritis is through a shared association with osteophyte","volume":"62","author":"Neame","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib198","first-page":"981","article-title":"Prevalence of chondrocalcinosis in Italian subjects from northeastern Italy. The Pro.V.A. (PROgetto Veneto Anziani) study","volume":"27","author":"Ramonda","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib199","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/ard.2010.139105","article-title":"European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis","volume":"70","author":"Zhang","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib200","first-page":"207","article-title":"Epidemiology of gout and chondrocalcinosis","volume":"63","author":"Ciancio","year":"2011","journal-title":"Reumatismo"},{"key":"10.1016\/j.rdc.2014.01.005_bib201","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.joca.2012.07.017","article-title":"Intracellular calcium oscillations in articular chondrocytes induced by basic calcium phosphate crystals lead to cartilage degradation","volume":"20","author":"Nguyen","year":"2012","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.rdc.2014.01.005_bib202","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/BOR.0b013e3283432d1f","article-title":"Crystals, inflammation, and osteoarthritis","volume":"23","author":"Rosenthal","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib203","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/01.bor.0000209433.43978.a8","article-title":"Basic calcium phosphate crystals: pathways to joint degeneration","volume":"18","author":"Molloy","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib204","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jbspin.2004.01.011","article-title":"The ANKH gene and familial calcium pyrophosphate dihydrate deposition disease","volume":"71","author":"Netter","year":"2004","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.rdc.2014.01.005_bib205","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/ar2968","article-title":"Calcium deposition in osteoarthritic meniscus and meniscal cell culture","volume":"12","author":"Sun","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.rdc.2014.01.005_bib206","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.21903","article-title":"Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoarthritis: results of two prospective longitudinal magnetic resonance imaging studies","volume":"54","author":"Neogi","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib207","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/1529-0131(199904)42:4<799::AID-ANR25>3.0.CO;2-4","article-title":"Elevated parathyroid hormone 44-68 and osteoarticular changes in patients with genetic hemochromatosis","volume":"42","author":"Pawlotsky","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib208","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/ard.29.5.469","article-title":"Arthropathy of haemochromatosis. Clinical and radiological analysis of 63 patients with iron overload","volume":"29","author":"Dymock","year":"1970","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib209","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/ard.61.8.745","article-title":"Genetic testing for haemochromatosis in patients with chondrocalcinosis","volume":"61","author":"Timms","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib210","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1507\/endocrj1954.38.457","article-title":"Prevalence of chondrocalcinosis in patients with primary hyperparathyroidism in Japan","volume":"38","author":"Yashiro","year":"1991","journal-title":"Endocrinol Jpn"},{"key":"10.1016\/j.rdc.2014.01.005_bib211","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11926-002-0014-0","article-title":"Rheumatic manifestations of primary hyperparathyroidism and parathyroid hormone therapy","volume":"4","author":"Rubin","year":"2002","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.rdc.2014.01.005_bib212","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/art.23106","article-title":"Hypomagnesemia associated with chondrocalcinosis: a cross-sectional study","volume":"57","author":"Richette","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib213","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/ard.57.12.748","article-title":"Chondrocalcinosis and Gitelman's syndrome. A new association?","volume":"57","author":"Cobeta-Garcia","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rdc.2014.01.005_bib214","first-page":"571","article-title":"Chondrocalcinosis is a feature of Gitelman's variant of Bartter's syndrome. A new look at the hypomagnesemia associated with calcium pyrophosphate dihydrate crystal deposition disease","volume":"65","author":"Punzi","year":"1998","journal-title":"Rev Rhum Engl Ed"},{"key":"10.1016\/j.rdc.2014.01.005_bib215","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.berh.2011.10.013","article-title":"Miscellaneous non-inflammatory musculoskeletal conditions. Bartter's and Gitelman's diseases","volume":"25","author":"Favero","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.rdc.2014.01.005_bib216","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0049-0172(92)90019-A","article-title":"Diseases associated with calcium pyrophosphate deposition disease","volume":"22","author":"Jones","year":"1992","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.rdc.2014.01.005_bib217","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig","year":"2008","journal-title":"N\u00a0Engl J Med"}],"container-title":["Rheumatic Disease Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889857X14000064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889857X14000064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:12:40Z","timestamp":1760181160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889857X14000064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":217,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0889857X14000064"],"URL":"https:\/\/doi.org\/10.1016\/j.rdc.2014.01.005","relation":{},"ISSN":["0889-857X"],"issn-type":[{"value":"0889-857X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comorbidities in Patients with Crystal Diseases and Hyperuricemia","name":"articletitle","label":"Article Title"},{"value":"Rheumatic Disease Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rdc.2014.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}